Novel Therapeutic Approaches Targeting the Renin-Angiotensin System and Associated Peptides in Hypertension and Heart Failure
Published 2019 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
Novel Therapeutic Approaches Targeting the Renin-Angiotensin System and Associated Peptides in Hypertension and Heart Failure
Authors
Keywords
-
Journal
PHARMACOLOGICAL REVIEWS
Volume 71, Issue 4, Pages 539-570
Publisher
American Society for Pharmacology & Experimental Therapeutics (ASPET)
Online
2019-09-19
DOI
10.1124/pr.118.017129
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- Treating Disease at the RNA Level with Oligonucleotides
- (2019) Arthur A. Levin NEW ENGLAND JOURNAL OF MEDICINE
- PIONEERing the In-Hospital Initiation of Sacubitril–Valsartan
- (2019) John Jarcho NEW ENGLAND JOURNAL OF MEDICINE
- Concurrent neprilysin inhibition and renin-angiotensin system modulations prevented diabetic nephropathy
- (2019) Vajir Malek et al. LIFE SCIENCES
- The Renin-Angiotensin System: Going Beyond the Classical Paradigms
- (2019) Robson A. Souza Santos et al. AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
- A microanalytical capillary electrophoresis mass spectrometry assay for quantifying angiotensin peptides in the brain
- (2019) Camille Lombard-Banek et al. ANALYTICAL AND BIOANALYTICAL CHEMISTRY
- Structural basis for the C-domain selective angiotensin converting enzyme inhibition by bradykinin-potentiating peptide b (BPPb)
- (2019) Edward D Sturrock et al. BIOCHEMICAL JOURNAL
- Cardiovascular biomarkers in patients with acute decompensated heart failure randomized to sacubitril-valsartan or enalapril in the PIONEER-HF trial
- (2019) David A Morrow et al. EUROPEAN HEART JOURNAL
- Design, Synthesis, and Actions of an Innovative Bispecific Designer Peptide
- (2019) Laura M.G. Meems et al. HYPERTENSION
- Strong and Sustained Antihypertensive Effect of Small Interfering RNA Targeting Liver Angiotensinogen
- (2019) Estrellita Uijl et al. HYPERTENSION
- CRRL269: a novel designer and renal-enhancing pGC-A peptide activator
- (2018) Yang Chen et al. AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY
- Novel mechanisms of G-protein-coupled receptors functions: AT 1 angiotensin receptor acts as a signaling hub and focal point of receptor cross-talk
- (2018) András D. Tóth et al. BEST PRACTICE & RESEARCH CLINICAL ENDOCRINOLOGY & METABOLISM
- Angiotensin (1–7) does not interact directly with MAS1, but can potently antagonize signaling from the AT1 receptor
- (2018) Ibragim Gaidarov et al. CELLULAR SIGNALLING
- Effects of Sacubitril/Valsartan Versus Irbesartan in Patients with Chronic Kidney Disease: A Randomised Double-Blind Trial
- (2018) Richard Haynes et al. CIRCULATION
- (Pro)renin Receptor Inhibition Reprograms Hepatic Lipid Metabolism and Protects Mice From Diet-Induced Obesity and HepatosteatosisNovelty and Significance
- (2018) Liwei Ren et al. CIRCULATION RESEARCH
- Renin–Angiotensin System Inhibitors to Mitigate Cancer Treatment–Related Adverse Events
- (2018) Matthias Pinter et al. CLINICAL CANCER RESEARCH
- Angiotensin generation in the brain: a re-evaluation
- (2018) Estrellita Uijl et al. CLINICAL SCIENCE
- Effect of sacubitril/valsartan on recurrent events in the Prospective comparison of ARNI with ACEI to Determine Impact on Global Mortality and morbidity in Heart Failure trial (PARADIGM-HF)
- (2018) Ulrik M. Mogensen et al. EUROPEAN JOURNAL OF HEART FAILURE
- Angiotensin receptor neprilysin inhibition provides superior cardioprotection compared to angiotensin converting enzyme inhibition after experimental myocardial infarction
- (2018) Andrew R. Kompa et al. INTERNATIONAL JOURNAL OF CARDIOLOGY
- Effects of dual angiotensin type 1 receptor/neprilysin inhibition vs. angiotensin type 1 receptor inhibition on target organ injury in the stroke-prone spontaneously hypertensive rat
- (2018) Speranza Rubattu et al. JOURNAL OF HYPERTENSION
- Central antihypertensive effects of chronic treatment with RB150
- (2018) Yannick Marc et al. JOURNAL OF HYPERTENSION
- 2017 ACC/AHA/AAPA/ABC/ACPM/AGS/APhA/ASH/ASPC/NMA/PCNA Guideline for the Prevention, Detection, Evaluation, and Management of High Blood Pressure in Adults
- (2018) Paul K. Whelton et al. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
- The ACE2/Angiotensin-(1–7)/MAS Axis of the Renin-Angiotensin System: Focus on Angiotensin-(1–7)
- (2018) Robson Augusto Souza Santos et al. PHYSIOLOGICAL REVIEWS
- Effect of neprilysin inhibition on renal function in patients with type 2 diabetes and chronic heart failure who are receiving target doses of inhibitors of the renin-angiotensin system: a secondary analysis of the PARADIGM-HF trial
- (2018) Milton Packer et al. Lancet Diabetes & Endocrinology
- Renal Effects and Associated Outcomes During Angiotensin-Neprilysin Inhibition in Heart Failure
- (2018) Kevin Damman et al. JACC-Heart Failure
- Hypertension
- (2018) Suzanne Oparil et al. Nature Reviews Disease Primers
- ACE Inhibitor-Induced Angioedema: a Review
- (2018) William J. Kostis et al. CURRENT HYPERTENSION REPORTS
- Angiotensinogen and Megalin Interactions Contribute to Atherosclerosis
- (2018) Feiming Ye et al. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
- Practical guidance on the use of sacubitril/valsartan for heart failure
- (2018) Andrew J. Sauer et al. HEART FAILURE REVIEWS
- The Meaning of Mas
- (2018) Michael Bader et al. HYPERTENSION
- Molecular Basis for Multiple Omapatrilat Binding Sites within the ACE C-Domain: Implications for Drug Design
- (2018) Gyles E. Cozier et al. JOURNAL OF MEDICINAL CHEMISTRY
- Sacubitril/Valsartan Averts Adverse Post-Infarction Ventricular Remodeling and Preserves Systolic Function in Rabbits
- (2018) Juan Torrado et al. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
- Angiotensin–Neprilysin Inhibition in Acute Decompensated Heart Failure
- (2018) Eric J. Velazquez et al. NEW ENGLAND JOURNAL OF MEDICINE
- Estimated 5-Year Number Needed to Treat to Prevent Cardiovascular Death or Heart Failure Hospitalization With Angiotensin Receptor-Neprilysin Inhibition vs Standard Therapy for Patients With Heart Failure With Reduced Ejection Fraction
- (2018) Pratyaksh K. Srivastava et al. JAMA Cardiology
- Brain Renin–Angiotensin SystemNovelty and Significance
- (2017) Bibi S. van Thiel et al. HYPERTENSION
- No Brain Renin–Angiotensin System
- (2017) Curt D. Sigmund et al. HYPERTENSION
- Blood Pressure Lowering and Safety Improvements With Liver Angiotensinogen Inhibition in Models of Hypertension and Kidney InjuryNovelty and Significance
- (2017) Adam E. Mullick et al. HYPERTENSION
- The Angiotensin-Converting-Enzyme-Induced Angioedema
- (2017) Murat Bas IMMUNOLOGY AND ALLERGY CLINICS OF NORTH AMERICA
- Angiotensin-converting Enzyme Inhibitor and Other Drug-associated Angioedema
- (2017) Cosby Stone et al. IMMUNOLOGY AND ALLERGY CLINICS OF NORTH AMERICA
- Effect of bradykinin receptor antagonism on ACE inhibitor-associated angioedema
- (2017) Brittany T. Straka et al. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
- [OP.4A.08] A RANDOMIZED DOUBLE-BLIND PLACEBO CONTROLLED CROSSOVER STUDY TO COMPARE QGC001, A BRAIN AMINOPEPTIDASE A INHIBITOR, WITH PLACEBO IN PATIENTS WITH GRADE I/ II ESSENTIAL HYPERTENSION
- (2017) M. Azizi et al. JOURNAL OF HYPERTENSION
- The Design and Development of a Potent and Selective Novel Diprolyl Derivative That Binds to the N-Domain of Angiotensin-I Converting Enzyme
- (2017) Stephen Fienberg et al. JOURNAL OF MEDICINAL CHEMISTRY
- Angioedema Spotlight: A Closer Examination of Sacubitril/Valsartan Safety Results
- (2017) Ryan E. Owens et al. Journal of the American Board of Family Medicine
- 2017 ACC/AHA/HFSA Focused Update of the 2013 ACCF/AHA Guideline for the Management of Heart Failure
- (2017) Clyde W. Yancy et al. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
- Roles of Angiotensin Peptides and Recombinant Human ACE2 in Heart Failure
- (2017) Ratnadeep Basu et al. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
- Structural basis for selectivity and diversity in angiotensin II receptors
- (2017) Haitao Zhang et al. NATURE
- Inclisiran in Patients at High Cardiovascular Risk with Elevated LDL Cholesterol
- (2017) Kausik K. Ray et al. NEW ENGLAND JOURNAL OF MEDICINE
- Renin angiotensin aldosterone inhibition in the treatment of cardiovascular disease
- (2017) Carlos M. Ferrario et al. PHARMACOLOGICAL RESEARCH
- Centrally Mediated Cardiovascular Actions of the Angiotensin II Type 2 Receptor
- (2017) U. Muscha Steckelings et al. TRENDS IN ENDOCRINOLOGY AND METABOLISM
- Angiotensin Receptor Neprilysin Inhibition in Heart Failure With Preserved Ejection Fraction
- (2017) Scott D. Solomon et al. JACC-Heart Failure
- Long-Term Effect of Endothelin Receptor Antagonism With Bosentan on the Morbidity and Mortality of Patients With Severe Chronic Heart Failure
- (2017) Milton Packer et al. JACC-Heart Failure
- Dual inhibition of renin-angiotensin-aldosterone system and endothelin-1 in treatment of chronic kidney disease
- (2016) Radko Komers et al. AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY
- The effect of LCZ696 (sacubitril/valsartan) on amyloid-β concentrations in cerebrospinal fluid in healthy subjects
- (2016) Thomas H. Langenickel et al. BRITISH JOURNAL OF CLINICAL PHARMACOLOGY
- Role of the ACE2/Angiotensin 1–7 Axis of the Renin–Angiotensin System in Heart Failure
- (2016) Vaibhav B. Patel et al. CIRCULATION RESEARCH
- Blood pressure-independent renoprotection in diabetic rats treated with AT1 receptor-neprilysin inhibition compared with AT1 receptor blockade alone
- (2016) L. C. W. Roksnoer et al. CLINICAL SCIENCE
- 2016 ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure
- (2016) Piotr Ponikowski et al. EUROPEAN HEART JOURNAL
- Dementia-related adverse events in PARADIGM-HF and other trials in heart failure with reduced ejection fraction
- (2016) Jane A. Cannon et al. EUROPEAN JOURNAL OF HEART FAILURE
- Cardioprotective Angiotensin-(1–7) Peptide Acts as a Natural-Biased Ligand at the Angiotensin II Type 1 ReceptorNovelty and Significance
- (2016) Ségolène Galandrin et al. HYPERTENSION
- On the Origin of Urinary ReninNovelty and Significance
- (2016) Lodi C.W. Roksnoer et al. HYPERTENSION
- G-Protein–Coupled Receptor MrgD Is a Receptor for Angiotensin-(1–7) Involving Adenylyl Cyclase, cAMP, and Phosphokinase ANovelty and Significance
- (2016) Anja Tetzner et al. HYPERTENSION
- Gene Therapy With Angiotensin-(1-9) Preserves Left Ventricular Systolic Function After Myocardial Infarction
- (2016) Caroline Fattah et al. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
- 2016 ACC/AHA/HFSA Focused Update on New Pharmacological Therapy for Heart Failure: An Update of the 2013 ACCF/AHA Guideline for the Management of Heart Failure
- (2016) Clyde W. Yancy et al. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
- Long-term neprilysin inhibition — implications for ARNIs
- (2016) Duncan J. Campbell Nature Reviews Cardiology
- Angiotensin-(1-5), an active mediator of renin-angiotensin system, stimulates ANP secretion via Mas receptor
- (2016) Lamei Yu et al. PEPTIDES
- Long-term administration of angiotensin (1⿿7) prevents heart and lung dysfunction in a mouse model of type 2 diabetes ( db/db ) by reducing oxidative stress, inflammation and pathological remodeling
- (2016) Anna M. Papinska et al. PHARMACOLOGICAL RESEARCH
- Molecular Physiology of Membrane Guanylyl Cyclase Receptors
- (2016) Michaela Kuhn PHYSIOLOGICAL REVIEWS
- Monitoring G protein-coupled receptor and β-arrestin trafficking in live cells using enhanced bystander BRET
- (2016) Yoon Namkung et al. Nature Communications
- Clinical Adverse Effects of Endothelin Receptor Antagonists: Insights From the Meta‐Analysis of 4894 Patients From 24 Randomized Double‐Blind Placebo‐Controlled Clinical Trials
- (2016) Anhua Wei et al. Journal of the American Heart Association
- Potential Mortality Reduction With Optimal Implementation of Angiotensin Receptor Neprilysin Inhibitor Therapy in Heart Failure
- (2016) Gregg C. Fonarow et al. JAMA Cardiology
- Structure of neprilysin in complex with the active metabolite of sacubitril
- (2016) Nikolaus Schiering et al. Scientific Reports
- Structure of the Angiotensin Receptor Revealed by Serial Femtosecond Crystallography
- (2015) Haitao Zhang et al. CELL
- New Approaches in the Treatment of Hypertension
- (2015) S. Oparil et al. CIRCULATION RESEARCH
- Influence of Glycosylation on Diagnostic and Prognostic Accuracy of N-Terminal Pro-B-Type Natriuretic Peptide in Acute Dyspnea: Data from the Akershus Cardiac Examination 2 Study
- (2015) H. Rosjo et al. CLINICAL CHEMISTRY
- Pre-treatment with LCZ696, an orally active angiotensin receptor neprilysin inhibitor, prevents ischemic brain damage
- (2015) Hui-Yu Bai et al. EUROPEAN JOURNAL OF PHARMACOLOGY
- Association Studies Suggest a Key Role for Endothelin-1 in the Pathogenesis of Preeclampsia and the Accompanying Renin–Angiotensin–Aldosterone System SuppressionNovelty and Significance
- (2015) Koen Verdonk et al. HYPERTENSION
- Angiotensin-(1-7) Protects against the Development of Aneurysmal Subarachnoid Hemorrhage in Mice
- (2015) Kenji Shimada et al. JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
- Treatment of Hypertension in Patients With Coronary Artery Disease
- (2015) Clive Rosendorff et al. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
- Pharmacodynamic effects of C-domain-specific ACE inhibitors on the renin-angiotensin system in myocardial infarcted rats
- (2015) Sarah Sharp et al. JOURNAL OF THE RENIN-ANGIOTENSIN-ALDOSTERONE SYSTEM
- Optimum AT1 receptor-neprilysin inhibition has superior cardioprotective effects compared with AT1 receptor blockade alone in hypertensive rats
- (2015) Lodi C.W. Roksnoer et al. KIDNEY INTERNATIONAL
- A Randomized Trial of Icatibant in ACE-Inhibitor–Induced Angioedema
- (2015) Murat Baş et al. NEW ENGLAND JOURNAL OF MEDICINE
- Elevated Plasma B-Type Natriuretic Peptide Concentrations Directly Inhibit Circulating Neprilysin Activity in Heart Failure
- (2015) Nicolas Vodovar et al. JACC-Heart Failure
- NorLeu3-Angiotensin (1-7) [DSC127] as a Therapy for the Healing of Diabetic Foot Ulcers
- (2015) Kathleen E. Rodgers et al. Advances in Wound Care
- Relative affinity of angiotensin peptides and novel ligands at AT1and AT2receptors
- (2015) Sanja Bosnyak et al. CLINICAL SCIENCE
- Angiotensin 1–7 Ameliorates Diabetic Cardiomyopathy and Diastolic Dysfunction in db/db Mice by Reducing Lipotoxicity and Inflammation
- (2014) Jun Mori et al. Circulation-Heart Failure
- Effects of a domain-selective ACE inhibitor in a mouse model of chronic angiotensin II-dependent hypertension
- (2014) Dylan Burger et al. CLINICAL SCIENCE
- AT2 Receptor and Tissue Injury: Therapeutic Implications
- (2014) Pawel Namsolleck et al. CURRENT HYPERTENSION REPORTS
- New Antihypertensive Drugs Under Development
- (2014) J. Tamargo et al. CURRENT MEDICINAL CHEMISTRY
- Angiotensin-(1-7) as a strategy in the treatment of hypertension?
- (2014) Daan J.L. van Twist et al. CURRENT OPINION IN NEPHROLOGY AND HYPERTENSION
- Multiple Ascending Dose Study With the New Renin Inhibitor VTP-27999
- (2014) Joanna Balcarek et al. HYPERTENSION
- Oral Delivery of Angiotensin-Converting Enzyme 2 and Angiotensin-(1-7) Bioencapsulated in Plant Cells Attenuates Pulmonary Hypertension
- (2014) Vinayak Shenoy et al. HYPERTENSION
- Angiotensin-(1–9) reverses experimental hypertension and cardiovascular damage by inhibition of the angiotensin converting enzyme/Ang II axis
- (2014) Maria Paz Ocaranza et al. JOURNAL OF HYPERTENSION
- Angiotensin-converting enzyme 2 and angiotensin 1–7: novel therapeutic targets
- (2014) Fan Jiang et al. Nature Reviews Cardiology
- Angiotensin–Neprilysin Inhibition versus Enalapril in Heart Failure
- (2014) John J.V. McMurray et al. NEW ENGLAND JOURNAL OF MEDICINE
- New Perspectives in the Renin-Angiotensin-Aldosterone System (RAAS) II: Albumin Suppresses Angiotensin Converting Enzyme (ACE) Activity in Human
- (2014) Miklós Fagyas et al. PLoS One
- Atypical Signaling and Functional Desensitization Response of MAS Receptor to Peptide Ligands
- (2014) Kalyan C. Tirupula et al. PLoS One
- Combined Neprilysin and Renin-Angiotensin System Inhibition for the Treatment of Heart Failure
- (2014) Orly Vardeny et al. JACC-Heart Failure
- Discovery and Characterization of Alamandine
- (2013) Roberto Queiroga Lautner et al. CIRCULATION RESEARCH
- Randomised, Double-Blind, Placebo-Controlled, Dose-Escalating Phase I Study of QGC001, a Centrally Acting Aminopeptidase A Inhibitor Prodrug
- (2013) Fabrice Balavoine et al. CLINICAL PHARMACOKINETICS
- Pharmacokinetics and Pharmacodynamics of Recombinant Human Angiotensin-Converting Enzyme 2 in Healthy Human Subjects
- (2013) Manuel Haschke et al. CLINICAL PHARMACOKINETICS
- Fragment-based design for the development of N-domain-selective angiotensin-1-converting enzyme inhibitors
- (2013) Ross G. Douglas et al. CLINICAL SCIENCE
- Dual angiotensin receptor and neprilysin inhibition as an alternative to angiotensin-converting enzyme inhibition in patients with chronic systolic heart failure: rationale for and design of the Prospective comparison of ARNI with ACEI to Determine Impact
- (2013) John J. V. McMurray et al. EUROPEAN JOURNAL OF HEART FAILURE
- Crystal structures of highly specific phosphinic tripeptide enantiomers in complex with the angiotensin-I converting enzyme
- (2013) Geoffrey Masuyer et al. FEBS Journal
- Possible Role of Angiotensin-Converting Enzyme 2 and Activation of Angiotensin II Type 2 Receptor by Angiotensin-(1–7) in Improvement of Vascular Remodeling by Angiotensin II Type 1 Receptor Blockade
- (2013) Kousei Ohshima et al. HYPERTENSION
- Targeting of hepatic angiotensinogen using chemically modified siRNAs results in significant and sustained blood pressure lowering in a rat model of hypertension
- (2013) Jeffrey Olearczyk et al. HYPERTENSION RESEARCH
- Control of Adipogenesis by the Autocrine Interplays between Angiotensin 1–7/Mas Receptor and Angiotensin II/AT1Receptor Signaling Pathways
- (2013) Aung Than et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Structural Insights into Central Hypertension Regulation by Human Aminopeptidase A
- (2013) Yang Yang et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Podocyte injury enhances filtration of liver-derived angiotensinogen and renal angiotensin II generation
- (2013) Taiji Matsusaka et al. KIDNEY INTERNATIONAL
- The Novel Mas agonist, CGEN-856S, Attenuates Isoproterenol-Induced Cardiac Remodeling and Myocardial Infarction Injury in Rats
- (2013) Sílvia Q. Savergnini et al. PLoS One
- Atrial natriuretic peptide suppresses Th17 development through regulation of cGMP-dependent protein kinase and PI3K–Akt signaling pathways
- (2013) Libing Ma et al. REGULATORY PEPTIDES
- Inhibition of brain angiotensin III attenuates sympathetic hyperactivity and cardiac dysfunction in rats post-myocardial infarction
- (2012) Bing S. Huang et al. CARDIOVASCULAR RESEARCH
- Central Antihypertensive Effects of Orally Active Aminopeptidase A Inhibitors in Spontaneously Hypertensive Rats
- (2012) Yannick Marc et al. HYPERTENSION
- The past, present and future of renin–angiotensin aldosterone system inhibition
- (2012) Robert J. Mentz et al. INTERNATIONAL JOURNAL OF CARDIOLOGY
- Cardiac natriuretic peptides act via p38 MAPK to induce the brown fat thermogenic program in mouse and human adipocytes
- (2012) Marica Bordicchia et al. JOURNAL OF CLINICAL INVESTIGATION
- Angiotensin-converting enzyme 2, angiotensin-(1–7) and Mas: new players of the renin–angiotensin system
- (2012) Robson A S Santos et al. JOURNAL OF ENDOCRINOLOGY
- Novel Protein Therapeutics for Systolic Heart Failure
- (2012) Horng H. Chen et al. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
- Human Hypertension Is Characterized by a Lack of Activation of the Antihypertensive Cardiac Hormones ANP and BNP
- (2012) Fima Macheret et al. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
- Liver Angiotensinogen Is the Primary Source of Renal Angiotensin II
- (2012) T. Matsusaka et al. JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
- The angiotensin receptor neprilysin inhibitor LCZ696 in heart failure with preserved ejection fraction: a phase 2 double-blind randomised controlled trial
- (2012) Scott D Solomon et al. LANCET
- Molecular recognition and regulation of human angiotensin-I converting enzyme (ACE) activity by natural inhibitory peptides
- (2012) Geoffrey Masuyer et al. Scientific Reports
- Inhibition of Mas G-protein signaling improves coronary blood flow, reduces myocardial infarct size, and provides long-term cardioprotection
- (2011) Tong Zhang et al. AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
- Novel mechanism of inhibition of human angiotensin-I-converting enzyme (ACE) by a highly specific phosphinic tripeptide
- (2011) Mohd Akif et al. BIOCHEMICAL JOURNAL
- Synthesis and evaluation of heteroarylalanine diacids as potent and selective neutral endopeptidase inhibitors
- (2011) Melanie S. Glossop et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- Long-Term Cardiac pro-B-Type Natriuretic Peptide Gene Delivery Prevents the Development of Hypertensive Heart Disease in Spontaneously Hypertensive Rats
- (2011) Alessandro Cataliotti et al. CIRCULATION
- Angioprotectin: an angiotensin II-like peptide causing vasodilatory effects
- (2011) Vera Jankowski et al. FASEB JOURNAL
- Natriuretic peptide metabolism, clearance and degradation
- (2011) Lincoln R. Potter FEBS Journal
- Angiotensin II Binding to Angiotensin I–Converting Enzyme Triggers Calcium Signaling
- (2011) Paola B. Guimarães et al. HYPERTENSION
- Angiotensin-(1-9) Attenuates Cardiac Fibrosis in the Stroke-Prone Spontaneously Hypertensive Rat via the Angiotensin Type 2 Receptor
- (2011) Monica Flores-Munoz et al. HYPERTENSION
- Angiotensin-(1-7) through Mas receptor up-regulates neuronal norepinephrine transporter via Akt and Erk1/2-dependent pathways
- (2011) María A. Lopez Verrilli et al. JOURNAL OF NEUROCHEMISTRY
- Silencing disease genes in the laboratory and the clinic
- (2011) Jonathan K Watts et al. JOURNAL OF PATHOLOGY
- AT2 receptors recruit c-Src, SHP-1 and FAK upon activation by Ang II in PND15 rat hindbrain
- (2011) Leonardo R. Seguin et al. NEUROCHEMISTRY INTERNATIONAL
- Effect of Nesiritide in Patients with Acute Decompensated Heart Failure
- (2011) C.M. O'Connor et al. NEW ENGLAND JOURNAL OF MEDICINE
- Characterization of domain-selective inhibitor binding in angiotensin-converting enzyme using a novel derivative of lisinopril
- (2010) Jean M. Watermeyer et al. BIOCHEMICAL JOURNAL
- Kininogens: More than cysteine protease inhibitors and kinin precursors
- (2010) Gilles Lalmanach et al. BIOCHIMIE
- Different in vivo functions of the two catalytic domains of angiotensin-converting enzyme (ACE)
- (2010) Kenneth E Bernstein et al. CURRENT OPINION IN PHARMACOLOGY
- Vascular Relaxation, Antihypertensive Effect, and Cardioprotection of a Novel Peptide Agonist of the Mas Receptor
- (2010) Silvia Quintão Savergnini et al. HYPERTENSION
- A Computational Approach to the Study of the Binding Mode of Dual ACE/NEP Inhibitors
- (2010) Nikolaos Dimitropoulos et al. Journal of Chemical Information and Modeling
- Angiotensin-(1–9) regulates cardiac hypertrophy in vivo and in vitro
- (2010) Maria Paz Ocaranza et al. JOURNAL OF HYPERTENSION
- Angiotensin1-9 antagonises pro-hypertrophic signalling in cardiomyocytes via the angiotensin type 2 receptor
- (2010) M. Flores-Muñoz et al. JOURNAL OF PHYSIOLOGY-LONDON
- Developmental changes in AT1 and AT2 receptor-protein expression in rats
- (2010) Li Yu et al. JOURNAL OF THE RENIN-ANGIOTENSIN-ALDOSTERONE SYSTEM
- Blood-pressure reduction with LCZ696, a novel dual-acting inhibitor of the angiotensin II receptor and neprilysin: a randomised, double-blind, placebo-controlled, active comparator study
- (2010) Luis Miguel Ruilope et al. LANCET
- Teaching old receptors new tricks: biasing seven-transmembrane receptors
- (2010) Sudarshan Rajagopal et al. NATURE REVIEWS DRUG DISCOVERY
- Distribution of a novel binding site for angiotensins II and III in mouse tissues
- (2010) Felicia M. Rabey et al. REGULATORY PEPTIDES
- Investigating the Domain Specificity of Phosphinic Inhibitors RXPA380 and RXP407 in Angiotensin-Converting Enzyme
- (2009) Wendy L. Kröger et al. BIOCHEMISTRY
- The impact of left ventricular assist device-induced left ventricular unloading on the myocardial renin-angiotensin-aldosterone system: therapeutic consequences?
- (2009) S. Klotz et al. EUROPEAN HEART JOURNAL
- The role of angiotensin-(1-7) receptor Mas in spermatogenesis in mice and rats
- (2009) Marcelo C. Leal et al. JOURNAL OF ANATOMY
- Soluble Angiotensin-Converting Enzyme 2 in Human Heart Failure: Relation With Myocardial Function and Clinical Outcomes
- (2009) Slava Epelman et al. JOURNAL OF CARDIAC FAILURE
- Pharmacokinetics and Pharmacodynamics of LCZ696, a Novel Dual-Acting Angiotensin Receptor-Neprilysin Inhibitor (ARNi)
- (2009) Jessie Gu et al. JOURNAL OF CLINICAL PHARMACOLOGY
- Phosphinic Tripeptides as Dual Angiotensin-Converting Enzyme C-Domain and Endothelin-Converting Enzyme-1 Inhibitors
- (2009) Nicolas Jullien et al. JOURNAL OF MEDICINAL CHEMISTRY
- The kallikrein–kinin system in health and in diseases of the kidney
- (2009) Masao Kakoki et al. KIDNEY INTERNATIONAL
- Asp218participates with Asp213to bind a Ca2+atom into the S1 subsite of aminopeptidase A: a key element for substrate specificity
- (2008) Cédric Claperon et al. BIOCHEMICAL JOURNAL
- Probing the Basis of Domain-Dependent Inhibition Using Novel Ketone Inhibitors of Angiotensin-Converting Enzyme†‡
- (2008) Jean M. Watermeyer et al. BIOCHEMISTRY
- The role of glycosylation and domain interactions in the thermal stability of human angiotensin-converting enzyme
- (2008) Hester G. O'Neill et al. BIOLOGICAL CHEMISTRY
- Effects of Carperitide on the Long-Term Prognosis of Patients With Acute Decompensated Chronic Heart Failure
- (2008) Noritake Hata et al. CIRCULATION JOURNAL
- Angiotensin-(1–7): Pharmacological properties and pharmacotherapeutic perspectives
- (2008) Dilek Iusuf et al. EUROPEAN JOURNAL OF PHARMACOLOGY
- A protein complex in the brush-border membrane explains a Hartnup disorder allele
- (2008) Sonja Kowalczuk et al. FASEB JOURNAL
- Orally Active Aminopeptidase A Inhibitors Reduce Blood Pressure
- (2008) Laurence Bodineau et al. HYPERTENSION
- Angiotensin-Converting Enzyme Inhibitors and Angioedema
- (2008) Michael A. Weber et al. HYPERTENSION
- Structure-Based Identification of Small-Molecule Angiotensin-Converting Enzyme 2 Activators as Novel Antihypertensive Agents
- (2008) José A. Hernández Prada et al. HYPERTENSION
- Discovery and Validation of Novel Peptide Agonists for G-protein-coupled Receptors
- (2008) Ronen Shemesh et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Structure of human Endothelin-converting Enzyme I Complexed with Phosphoramidon
- (2008) Henk Schulz et al. JOURNAL OF MOLECULAR BIOLOGY
- Detection of Soluble Angiotensin-Converting Enzyme 2 in Heart Failure
- (2008) Slava Epelman et al. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
- Angiotensin metabolites can stimulate receptors of the Mas-related genes family
- (2008) Florian Gembardt et al. MOLECULAR AND CELLULAR BIOCHEMISTRY
- Unknown
- (2008) Rodrigo Fraga-Silva et al. MOLECULAR MEDICINE
- Telmisartan, Ramipril, or Both in Patients at High Risk for Vascular Events
- (2008) NEW ENGLAND JOURNAL OF MEDICINE
- Effect of bradykinin metabolism inhibitors on evoked hypotension in rats: rank efficacy of enzymes associated with bradykinin-mediated angioedema
- (2007) R M Fryer et al. BRITISH JOURNAL OF PHARMACOLOGY
- Angiotensin-Converting Enzyme C-Terminal Catalytic Domain Is the Main Site of Angiotensin I Cleavage In Vivo
- (2007) Sebastien Fuchs et al. HYPERTENSION
Find Funding. Review Successful Grants.
Explore over 25,000 new funding opportunities and over 6,000,000 successful grants.
ExplorePublish scientific posters with Peeref
Peeref publishes scientific posters from all research disciplines. Our Diamond Open Access policy means free access to content and no publication fees for authors.
Learn More