Relationships Between Immune Landscapes, Genetic Subtypes and Responses to Immunotherapy in Colorectal Cancer

Patterns of TIGIT Expression in Lymphatic Tissue, Inflammation, and Cancer

(2019) Niclas C. Blessin et al.   DISEASE MARKERS

Approaches to treat immune hot, altered and cold tumours with combination immunotherapies

(2019) Jérôme Galon et al.   NATURE REVIEWS DRUG DISCOVERY

TIM-3 dictates functional orientation of the immune infiltrate in ovarian cancer

(2019) Jitka Fucikova et al.   CLINICAL CANCER RESEARCH

Expression analysis and significance of PD-1, LAG-3 and TIM-3 in human non-small cell lung cancer using spatially-resolved and multiparametric single-cell analysis.

(2019) Ila J Datar et al.   CLINICAL CANCER RESEARCH

First-in-human study of REGN3767 (R3767), a human LAG-3 monoclonal antibody (mAb), ± cemiplimab in patients (pts) with advanced malignancies.

(2019) Kyriakos P. Papadopoulos et al.   JOURNAL OF CLINICAL ONCOLOGY

Split tolerance permits safe Ad5-GUCY2C-PADRE vaccine-induced T-cell responses in colon cancer patients

(2019) Adam E. Snook et al.   Journal for ImmunoTherapy of Cancer

Distinct prognostic value of circulating anti-telomerase CD4+ Th1 immunity and exhausted PD-1+/TIM-3+ T cells in lung cancer

(2019) Caroline Laheurte et al.   BRITISH JOURNAL OF CANCER

Immunotherapy of colorectal cancer: Challenges for therapeutic efficacy

(2019) Davide Ciardiello et al.   CANCER TREATMENT REVIEWS

Patient-Derived Cancer Organoid Cultures to Predict Sensitivity to Chemotherapy and Radiation

(2019) Cheri A. Pasch et al.   CLINICAL CANCER RESEARCH

Intrinsic Resistance to Immune Checkpoint Blockade in a Mismatch Repair–Deficient Colorectal Cancer

(2019) Carino Gurjao et al.   Cancer Immunology Research

Myeloid-Derived Suppressor Cells: Not Only in Tumor Immunity

(2019) Graham Pawelec et al.   Frontiers in Immunology

Patient-derived organoids can predict response to chemotherapy in metastatic colorectal cancer patients

(2019) Salo N. Ooft et al.   Science Translational Medicine

Cytotoxic T lymphocyte response to peptide vaccination predicts survival in stage III colorectal cancer

(2018) Junichiro Kawamura et al.   CANCER SCIENCE

Durable Clinical Benefit With Nivolumab Plus Ipilimumab in DNA Mismatch Repair–Deficient/Microsatellite Instability–High Metastatic Colorectal Cancer

(2018) Michael J. Overman et al.   JOURNAL OF CLINICAL ONCOLOGY

The perfect personalized cancer therapy: cancer vaccines against neoantigens

(2018) Luigi Aurisicchio et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

The Heterogeneity Between Lynch-Associated and Sporadic MMR Deficiency in Colorectal Cancers

(2018) Guo-Chen Liu et al.   JNCI-Journal of the National Cancer Institute

International validation of the consensus Immunoscore for the classification of colon cancer: a prognostic and accuracy study

(2018) Franck Pagès et al.   LANCET

Patient-derived organoids model treatment response of metastatic gastrointestinal cancers

(2018) Georgios Vlachogiannis et al.   SCIENCE

The commensal microbiome is associated with anti–PD-1 efficacy in metastatic melanoma patients

(2018) Vyara Matson et al.   SCIENCE

Multicenter, phase II clinical trial of peptide vaccination with oral chemotherapy following curative resection for stage�III colorectal cancer

(2018) Junichiro Kawamura et al.   Oncology Letters

Genetic Mechanisms of Immune Evasion in Colorectal Cancer

(2018) Catherine S. Grasso et al.   Cancer Discovery

The Heterogeneity Between Lynch-Associated and Sporadic MMR Deficiency in Colorectal Cancers

(2018) Guo-Chen Liu et al.   JNCI-Journal of the National Cancer Institute

Multiplexed Immunofluorescence Analysis and Quantification of Intratumoral PD-1+ Tim-3+ CD8+ T Cells

(2018) Clémence Granier et al.   Jove-Journal of Visualized Experiments

Complex pattern of immune evasion in MSI colorectal cancer

(2018) Mine Ozcan et al.   OncoImmunology

Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries

(2018) Freddie Bray et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Expression of the inhibitory B7 family molecule VISTA in human colorectal carcinoma tumors

(2018) Shan Xie et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Profiles of immune infiltration in colorectal cancer and their clinical significant: A gene expression-based study

(2018) Yongfu Xiong et al.   Cancer Medicine

The Immunoscore is a Superior Prognostic Tool in Stages II and III Colorectal Cancer and is Significantly Correlated with Programmed Death-Ligand 1 (PD-L1) Expression on Tumor-Infiltrating Mononuclear Cells

(2018) Takato Yomoda et al.   ANNALS OF SURGICAL ONCOLOGY

The nature of the human T cell response to the cancer antigen 5T4 is determined by the balance of regulatory and inflammatory T cells of the same antigen-specificity: implications for vaccine design

(2018) Matthieu Besneux et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Organoid Modeling of the Tumor Immune Microenvironment

(2018) James T. Neal et al.   CELL

Actively personalized vaccination trial for newly diagnosed glioblastoma

(2018) Norbert Hilf et al.   NATURE

Neoantigen vaccine generates intratumoral T cell responses in phase Ib glioblastoma trial

(2018) Derin B. Keskin et al.   NATURE

Immunological differences between colorectal cancer and normal mucosa uncover a prognostically relevant immune cell profile

(2018) Katharina Strasser et al.   OncoImmunology

Hypermutated tumours in the era of immunotherapy: The paradigm of personalised medicine

(2017) Laetitia Nebot-Bral et al.   EUROPEAN JOURNAL OF CANCER

Response to PD-1 Blockade in Microsatellite Stable Metastatic Colorectal Cancer Harboring aPOLEMutation

(2017) Jun Gong et al.   Journal of the National Comprehensive Cancer Network

Nivolumab in patients with metastatic DNA mismatch repair-deficient or microsatellite instability-high colorectal cancer (CheckMate 142): an open-label, multicentre, phase 2 study

(2017) Michael J Overman et al.   LANCET ONCOLOGY

Phase I Escalating-Dose Trial of CAR-T Therapy Targeting CEA + Metastatic Colorectal Cancers

(2017) Chengcheng Zhang et al.   MOLECULAR THERAPY

Personalized RNA mutanome vaccines mobilize poly-specific therapeutic immunity against cancer

(2017) Ugur Sahin et al.   NATURE

An immunogenic personal neoantigen vaccine for patients with melanoma

(2017) Patrick A. Ott et al.   NATURE

Tumour-associated macrophages as treatment targets in oncology

(2017) Alberto Mantovani et al.   Nature Reviews Clinical Oncology

Mismatch repair deficiency predicts response of solid tumors to PD-1 blockade

(2017) Dung T. Le et al.   SCIENCE

Gut microbiome modulates response to anti–PD-1 immunotherapy in melanoma patients

(2017) V. Gopalakrishnan et al.   SCIENCE

Gut microbiome influences efficacy of PD-1–based immunotherapy against epithelial tumors

(2017) Bertrand Routy et al.   SCIENCE

Molecular dissection of colorectal cancer in pre-clinical models identifies biomarkers predicting sensitivity to EGFR inhibitors

(2017) Moritz Schütte et al.   Nature Communications

Personalized In Vitro and In Vivo Cancer Models to Guide Precision Medicine

(2017) Chantal Pauli et al.   Cancer Discovery

Immunological landscape of consensus clusters in colorectal cancer

(2017) Pawel Karpinski et al.   Oncotarget

Programmed cell death-ligand 1 expression and immunoscore in stage II and III non-small cell lung cancer patients receiving adjuvant chemotherapy

(2017) Hidenobu Ishii et al.   Oncotarget

Combined prognostic effect of PD-L1 expression and immunoscore in microsatellite-unstable advanced gastric cancers

(2017) Kyung-Ju Kim et al.   Oncotarget

Genomic Analysis of Tumor Microenvironment Immune Types across 14 Solid Cancer Types: Immunotherapeutic Implications

(2017) Yu-Pei Chen et al.   Theranostics

Interferon Receptor Signaling Pathways Regulating PD-L1 and PD-L2 Expression

(2017) Angel Garcia-Diaz et al.   Cell Reports

Multilevel genomics of colorectal cancers with microsatellite instability—clinical impact of JAK1 mutations and consensus molecular subtype 1

(2017) Anita Sveen et al.   Genome Medicine

Analysis of 100,000 human cancer genomes reveals the landscape of tumor mutational burden

(2017) Zachary R. Chalmers et al.   Genome Medicine

Impact Of Circulating T Helper 1 And 17 Cells in the Blood on Regional Lymph Node Invasion in Colorectal Cancer

(2017) Ji Yeon Lee et al.   Journal of Cancer

POLE somatic mutations in advanced colorectal cancer

(2017) Joana Guerra et al.   Cancer Medicine

Guanylate cyclase C as a target for prevention, detection, and therapy in colorectal cancer

(2017) Allison A. Aka et al.   Expert Review of Clinical Pharmacology

Maturation of tertiary lymphoid structures and recurrence of stage II and III colorectal cancer

(2017) Florian Posch et al.   OncoImmunology

Tumor-associated macrophages remodeling EMT and predicting survival in colorectal carcinoma

(2017) Si Li et al.   OncoImmunology

High numbers of PDCD1 (PD-1)-positive T cells and B2M mutations in microsatellite-unstable colorectal cancer

(2017) Jonas Janikovits et al.   OncoImmunology

Assessment of tumor-infiltrating TCRVγ9Vδ2 γδ lymphocyte abundance by deconvolution of human cancers microarrays

(2017) Marie Tosolini et al.   OncoImmunology

Distinctive features of tumor-infiltrating γδ T lymphocytes in human colorectal cancer

(2017) S. Meraviglia et al.   OncoImmunology

Association of DNA Mismatch Repair and Mutations in BRAF and KRAS With Survival After Recurrence in Stage III Colon Cancers

(2017) Frank A. Sinicrope et al.   JAMA Oncology

Loss of function JAK1 mutations occur at high frequency in cancers with microsatellite instability and are suggestive of immune evasion

(2017) Lee A. Albacker et al.   PLoS One

Cancer immunotherapy: the beginning of the end of cancer?

(2016) Sofia Farkona et al.   BMC Medicine

Accumulation of MDSC and Th17 Cells in Patients with Metastatic Colorectal Cancer Predicts the Efficacy of a FOLFOX–Bevacizumab Drug Treatment Regimen

(2016) Emeric Limagne et al.   CANCER RESEARCH

Dendritic cell-based immunotherapy

(2016) Rachel L Sabado et al.   CELL RESEARCH

Regression of Chemotherapy-Resistant Polymerase   (POLE) Ultra-Mutated and MSH6 Hyper-Mutated Endometrial Tumors with Nivolumab

(2016) A. D. Santin et al.   CLINICAL CANCER RESEARCH

Immune and Stromal Classification of Colorectal Cancer Is Associated with Molecular Subtypes and Relevant for Precision Immunotherapy

(2016) Etienne Becht et al.   CLINICAL CANCER RESEARCH

Cancer vaccines in colon and rectal cancer over the last decade: lessons learned and future directions

(2016) John Berry et al.   Expert Review of Clinical Immunology

Transcriptional Landscape of Human Tissue Lymphocytes Unveils Uniqueness of Tumor-Infiltrating T Regulatory Cells

(2016) Marco De Simone et al.   IMMUNITY

Integrative Analyses of Colorectal Cancer Show Immunoscore Is a Stronger Predictor of Patient Survival Than Microsatellite Instability

(2016) Bernhard Mlecnik et al.   IMMUNITY

The present status and future prospects of peptide-based cancer vaccines

(2016) Masatoshi Hirayama et al.   INTERNATIONAL IMMUNOLOGY

Immune activation and response to pembrolizumab in POLE-mutant endometrial cancer

(2016) Janice M. Mehnert et al.   JOURNAL OF CLINICAL INVESTIGATION

Nivolumab alone and nivolumab plus ipilimumab in recurrent small-cell lung cancer (CheckMate 032): a multicentre, open-label, phase 1/2 trial

(2016) Scott J Antonia et al.   LANCET ONCOLOGY

Designer vaccine nanodiscs for personalized cancer immunotherapy

(2016) Rui Kuai et al.   NATURE MATERIALS

Two FOXP3+CD4+ T cell subpopulations distinctly control the prognosis of colorectal cancers

(2016) Takuro Saito et al.   NATURE MEDICINE

T-Cell Transfer Therapy Targeting Mutant KRAS in Cancer

(2016) Eric Tran et al.   NEW ENGLAND JOURNAL OF MEDICINE

Analysis of tumor-infiltrating gamma delta T cells in rectal cancer

(2016) Liang Rong et al.   WORLD JOURNAL OF GASTROENTEROLOGY

Dysfunctions in the Mature Dendritic Cells Are Associated with the Presence of Metastases of Colorectal Cancer in the Surrounding Lymph Nodes

(2016) Anna Pryczynicz et al.   Gastroenterology Research and Practice

Primary Resistance to PD-1 Blockade Mediated by JAK1/2 Mutations

(2016) Daniel Sanghoon Shin et al.   Cancer Discovery

Microsatellite instability derived JAK1 frameshift mutations are associated with tumor immune evasion in endometrioid endometrial cancer

(2016) Ellen Stelloo et al.   Oncotarget

Genomic Correlates of Immune-Cell Infiltrates in Colorectal Carcinoma

(2016) Marios Giannakis et al.   Cell Reports

Pretreatment Immune Status Correlates with Progression-Free Survival in Chemotherapy-Treated Metastatic Colorectal Cancer Patients

(2016) K. Tada et al.   Cancer Immunology Research

Colorectal cancer development and advances in screening

(2016) Vanessa Balchen et al.   Clinical Interventions in Aging

Phenotypic and Functional Dysregulated Blood NK Cells in Colorectal Cancer Patients Can Be Activated by Cetuximab Plus IL-2 or IL-15

(2016) Yamila Sol Rocca et al.   Frontiers in Immunology

Regulatory T cells with multiple suppressive and potentially pro-tumor activities accumulate in human colorectal cancer

(2016) Eleonora Timperi et al.   OncoImmunology

Immunoprevalence and magnitude of HLA-DP4 versus HLA-DR-restricted spontaneous CD4+Th1 responses against telomerase in cancer patients

(2016) Caroline Laheurte et al.   OncoImmunology

Enrichment of Inflammatory IL-17 and TNF-α Secreting CD4+ T Cells within Colorectal Tumors despite the Presence of Elevated CD39+ T Regulatory Cells and Increased Expression of the Immune Checkpoint Molecule, PD-1

(2016) Margaret R. Dunne et al.   Frontiers in Oncology

Phase I/II study of adjuvant immunotherapy with sentinel lymph node T lymphocytes in patients with colorectal cancer

(2015) Yun-Huan Zhen et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Prospective Derivation of a Living Organoid Biobank of Colorectal Cancer Patients

(2015) Marc van de Wetering et al.   CELL

TIGIT and PD-1 impair tumor antigen–specific CD8+ T cells in melanoma patients

(2015) Joe-Marc Chauvin et al.   JOURNAL OF CLINICAL INVESTIGATION

Tumor-Infiltrating Dendritic Cells in Cancer Pathogenesis

(2015) Jo Marie Tran Janco et al.   JOURNAL OF IMMUNOLOGY

Tumor-induced myeloid-derived suppressor cells promote tumor progression through oxidative metabolism in human colorectal cancer

(2015) Li-Ying OuYang et al.   Journal of Translational Medicine

Mutant MHC class II epitopes drive therapeutic immune responses to cancer

(2015) Sebastian Kreiter et al.   NATURE

The consensus molecular subtypes of colorectal cancer

(2015) Justin Guinney et al.   NATURE MEDICINE

PD-1 Blockade in Tumors with Mismatch-Repair Deficiency

(2015) Dung T. Le et al.   NEW ENGLAND JOURNAL OF MEDICINE

Preserved genetic diversity in organoids cultured from biopsies of human colorectal cancer metastases

(2015) Fleur Weeber et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Neoantigens in cancer immunotherapy

(2015) T. N. Schumacher et al.   SCIENCE

Circulating and tumor-infiltrating Tim-3 in patients with colorectal cancer

(2015) Benling Xu et al.   Oncotarget

Apoptosis of tumor infiltrating effector TIM-3+CD8+ T cells in colon cancer

(2015) Chiao-Wen Kang et al.   Scientific Reports

Characterization of the immunophenotypes and antigenomes of colorectal cancers reveals distinct tumor escape mechanisms and novel targets for immunotherapy

(2015) Mihaela Angelova et al.   GENOME BIOLOGY

Phenotyping of tumor-associated macrophages in colorectal cancer: Impact on single cell invasion (tumor budding) and clinicopathological outcome

(2015) Viktor H. Koelzer et al.   OncoImmunology

Association of Polymerase e–Mutated and Microsatellite-Instable Endometrial Cancers With Neoantigen Load, Number of Tumor-Infiltrating Lymphocytes, and Expression of PD-1 and PD-L1

(2015) Brooke E. Howitt et al.   JAMA Oncology

Molecular phenotypes of colorectal cancer and potential clinical applications

(2015) Jonathan M. Kocarnik et al.   Gastroenterology Report

Association of high CD4-positive T cell infiltration with mutations in HLA class II-regulatory genes in microsatellite-unstable colorectal cancer

(2014) Eva-Maria Surmann et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Macrophage Activation and Polarization: Nomenclature and Experimental Guidelines

(2014) Peter J. Murray et al.   IMMUNITY

Survival, Durable Tumor Remission, and Long-Term Safety in Patients With Advanced Melanoma Receiving Nivolumab

(2014) Suzanne L. Topalian et al.   JOURNAL OF CLINICAL ONCOLOGY

Predicting immunogenic tumour mutations by combining mass spectrometry and exome sequencing

(2014) Mahesh Yadav et al.   NATURE

Cancer-associated fibroblast and M2 macrophage markers together predict outcome in colorectal cancer patients

(2013) Mercedes Herrera et al.   CANCER SCIENCE

Interleukin-17: A Promoter in Colorectal Cancer Progression

(2013) Dang Wu et al.   Clinical & Developmental Immunology

Spatiotemporal Dynamics of Intratumoral Immune Cells Reveal the Immune Landscape in Human Cancer

(2013) Gabriela Bindea et al.   IMMUNITY

Exploiting the curative potential of adoptive T-cell therapy for cancer

(2013) Christian S. Hinrichs et al.   IMMUNOLOGICAL REVIEWS

Characteristics and significance of colorectal cancer associated lymphoid reaction

(2013) Juha P. Väyrynen et al.   INTERNATIONAL JOURNAL OF CANCER

Colorectal cancer intrinsic subtypes predict chemotherapy benefit, deficient mismatch repair and epithelial-to-mesenchymal transition

(2013) Paul Roepman et al.   INTERNATIONAL JOURNAL OF CANCER

Gene expression patterns unveil a new level of molecular heterogeneity in colorectal cancer

(2013) Eva Budinska et al.   JOURNAL OF PATHOLOGY

Towards the introduction of the ‘Immunoscore’ in the classification of malignant tumours

(2013) Jérôme Galon et al.   JOURNAL OF PATHOLOGY

Comprehensive analysis of the percentage of surface receptors and cytotoxic granules positive natural killer cells in patients with pancreatic cancer, gastric cancer, and colorectal cancer

(2013) Yun-Peng Peng et al.   Journal of Translational Medicine

Highly prevalent colorectal cancer-infiltrating LAP+ Foxp3− T cells exhibit more potent immunosuppressive activity than Foxp3+ regulatory T cells

(2013) M Scurr et al.   Mucosal Immunology

Signatures of mutational processes in human cancer

(2013) Ludmil B. Alexandrov et al.   NATURE

Poor-prognosis colon cancer is defined by a molecularly distinct subtype and develops from serrated precursor lesions

(2013) Felipe De Sousa E Melo et al.   NATURE MEDICINE

A colorectal cancer classification system that associates cellular phenotype and responses to therapy

(2013) Anguraj Sadanandam et al.   NATURE MEDICINE

Chimeric Antigen Receptor–Modified T Cells for Acute Lymphoid Leukemia

(2013) Stephan A. Grupp et al.   NEW ENGLAND JOURNAL OF MEDICINE

Circulating and Tumor-Infiltrating Myeloid-Derived Suppressor Cells in Patients with Colorectal Carcinoma

(2013) Bin Zhang et al.   PLoS One

Gene Expression Classification of Colon Cancer into Molecular Subtypes: Characterization, Validation, and Prognostic Value

(2013) Laetitia Marisa et al.   PLOS MEDICINE

Escalating Regulation of 5T4-Specific IFN- + CD4+ T Cells Distinguishes Colorectal Cancer Patients from Healthy Controls and Provides a Target for In Vivo Therapy

(2013) M. Scurr et al.   Cancer Immunology Research

Subtypes of primary colorectal tumors correlate with response to targeted treatment in colorectal cell lines

(2012) Andreas Schlicker et al.   BMC Medical Genomics

MUC1 Vaccine for Individuals with Advanced Adenoma of the Colon: A Cancer Immunoprevention Feasibility Study

(2012) T. Kimura et al.   Cancer Prevention Research

Durable Cancer Regression Off-Treatment and Effective Reinduction Therapy with an Anti-PD-1 Antibody

(2012) E. J. Lipson et al.   CLINICAL CANCER RESEARCH

Different affinity windows for virus and cancer-specific T-cell receptors: Implications for therapeutic strategies

(2012) Milos Aleksic et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Altered phenotype in peripheral blood and tumor-associated NK cells from colorectal cancer patients

(2012) Yamila S Rocca et al.   Innate Immunity

Activated but not resting regulatory T cells accumulated in tumor microenvironment and correlated with tumor progression in patients with colorectal cancer

(2012) Yung-Chang Lin et al.   INTERNATIONAL JOURNAL OF CANCER

The Distribution of Macrophages with a M1 or M2 Phenotype in Relation to Prognosis and the Molecular Characteristics of Colorectal Cancer

(2012) Sofia Edin et al.   PLoS One

IL-17 is associated with poor prognosis and promotes angiogenesis via stimulating VEGF production of cancer cells in colorectal carcinoma

(2011) Jiankun Liu et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Viral Vector-Based Therapeutic Cancer Vaccines

(2011) Cecilia Larocca et al.   CANCER JOURNAL

Clinical Impact of Different Classes of Infiltrating T Cytotoxic and Helper Cells (Th1, Th2, Treg, Th17) in Patients with Colorectal Cancer

(2011) Marie Tosolini et al.   CANCER RESEARCH

Immunogenic enhancement and clinical effect by type-I interferon of anti-apoptotic protein, survivin-derived peptide vaccine, in advanced colorectal cancer patients

(2011) Hidekazu Kameshima et al.   CANCER SCIENCE

Role of dendritic cells in progression and clinical outcome of colon cancer

(2011) Maya V. Gulubova et al.   INTERNATIONAL JOURNAL OF COLORECTAL DISEASE

Exhaustion of tumor-specific CD8+ T cells in metastases from melanoma patients

(2011) Lukas Baitsch et al.   JOURNAL OF CLINICAL INVESTIGATION

Histopathologic-Based Prognostic Factors of Colorectal Cancers Are Associated With the State of the Local Immune Reaction

(2011) Bernhard Mlecnik et al.   JOURNAL OF CLINICAL ONCOLOGY

Pilot Study of Sentinel-Node-Based Adoptive Immunotherapy in Advanced Colorectal Cancer

(2010) Mona Karlsson et al.   ANNALS OF SURGICAL ONCOLOGY

The Chromosomal Instability Pathway in Colon Cancer

(2010) Maria S. Pino et al.   GASTROENTEROLOGY

Microsatellite Instability in Colorectal Cancer

(2010) C. Richard Boland et al.   GASTROENTEROLOGY

Immune evasion of microsatellite unstable colorectal cancers

(2010) Matthias Kloor et al.   INTERNATIONAL JOURNAL OF CANCER

Phase I Study of Single-Agent Anti–Programmed Death-1 (MDX-1106) in Refractory Solid Tumors: Safety, Clinical Activity, Pharmacodynamics, and Immunologic Correlates

(2010) Julie R. Brahmer et al.   JOURNAL OF CLINICAL ONCOLOGY

Case Report of a Serious Adverse Event Following the Administration of T Cells Transduced With a Chimeric Antigen Receptor Recognizing ERBB2

(2010) Richard A Morgan et al.   MOLECULAR THERAPY

T Cells Targeting Carcinoembryonic Antigen Can Mediate Regression of Metastatic Colorectal Cancer but Induce Severe Transient Colitis

(2010) Maria R Parkhurst et al.   MOLECULAR THERAPY

Macrophage plasticity and interaction with lymphocyte subsets: cancer as a paradigm

(2010) Subhra K Biswas et al.   NATURE IMMUNOLOGY

Improved Survival with Ipilimumab in Patients with Metastatic Melanoma

(2010) F. Stephen Hodi et al.   NEW ENGLAND JOURNAL OF MEDICINE

Tumor-infiltrating NY-ESO-1–specific CD8+T cells are negatively regulated by LAG-3 and PD-1 in human ovarian cancer

(2010) Junko Matsuzaki et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Phase I clinical trial of a novel peptide vaccine in combination with UFT/LV for metastatic colorectal cancer

(2010) KIYOTAKA OKUNO et al.   Experimental and Therapeutic Medicine

Lack of HLA class II antigen expression in microsatellite unstable colorectal carcinomas is caused by mutations in HLA class II regulatory genes

(2009) Sara Michel et al.   INTERNATIONAL JOURNAL OF CANCER

In Situ Cytotoxic and Memory T Cells Predict Outcome in Patients With Early-Stage Colorectal Cancer

(2009) Franck Pagès et al.   JOURNAL OF CLINICAL ONCOLOGY

Tumor-Infiltrating FOXP3+ T Regulatory Cells Show Strong Prognostic Significance in Colorectal Cancer

(2008) Paul Salama et al.   JOURNAL OF CLINICAL ONCOLOGY