Immunological differences between colorectal cancer and normal mucosa uncover a prognostically relevant immune cell profile

Cancer statistics, 2018

(2018) Rebecca L. Siegel et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Human intestinal pro-inflammatory CD11chighCCR2+CX3CR1+ macrophages, but not their tolerogenic CD11c−CCR2−CX3CR1− counterparts, are expanded in inflammatory bowel disease

(2018) D. Bernardo et al.   Mucosal Immunology

Expression of Programmed Death-Ligand 1 by Human Colonic CD90+ Stromal Cells Differs Between Ulcerative Colitis and Crohn’s Disease and Determines Their Capacity to Suppress Th1 Cells

(2018) Ellen J. Beswick et al.   Frontiers in Immunology

Tumor-associated macrophage infiltration is highly associated with PD-L1 expression in gastric adenocarcinoma

(2017) Kazuto Harada et al.   Gastric Cancer

Fc-Optimized Anti-CD25 Depletes Tumor-Infiltrating Regulatory T Cells and Synergizes with PD-1 Blockade to Eradicate Established Tumors

(2017) Frederick Arce Vargas et al.   IMMUNITY

The clinical impact of tumour-infiltrating lymphocytes in colorectal cancer differs by anatomical subsite: A cohort study

(2017) Jonna Berntsson et al.   INTERNATIONAL JOURNAL OF CANCER

Transcriptional and functional profiling defines human small intestinal macrophage subsets

(2017) Anna Bujko et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Regulatory T cells with superior immunosuppressive capacity emigrate from the inflamed colon to draining lymph nodes

(2017) Y Nakanishi et al.   Mucosal Immunology

Regulatory T cells in cancer immunotherapy

(2016) Atsushi Tanaka et al.   CELL RESEARCH

Human CD39hi regulatory T cells present stronger stability and function under inflammatory conditions

(2016) Jian Gu et al.   Cellular & Molecular Immunology

Phenotypical characterization of regulatory T cells in humans and rodents

(2016) A. L. Rodríguez-Perea et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Tumour-associated macrophages correlate with microvascular bed extension in colorectal cancer patients

(2016) Ilaria Marech et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Two FOXP3+CD4+ T cell subpopulations distinctly control the prognosis of colorectal cancers

(2016) Takuro Saito et al.   NATURE MEDICINE

The tumor microenvironment and Immunoscore are critical determinants of dissemination to distant metastasis

(2016) Bernhard Mlecnik et al.   Science Translational Medicine

Regulatory T Cells from Colon Cancer Patients Inhibit Effector T-cell Migration through an Adenosine-Dependent Mechanism

(2016) P. Sundstro m et al.   Cancer Immunology Research

TCGA2STAT: simple TCGA data access for integrated statistical analysis in R

(2015) Ying-Wooi Wan et al.   BIOINFORMATICS

Deficiency of Interferon-Gamma or Its Receptor Promotes Colorectal Cancer Development

(2015) Lu Wang et al.   JOURNAL OF INTERFERON AND CYTOKINE RESEARCH

The consensus molecular subtypes of colorectal cancer

(2015) Justin Guinney et al.   NATURE MEDICINE

limma powers differential expression analyses for RNA-sequencing and microarray studies

(2015) Matthew E. Ritchie et al.   NUCLEIC ACIDS RESEARCH

The Microsatellite Instable Subset of Colorectal Cancer Is a Particularly Good Candidate for Checkpoint Blockade Immunotherapy

(2015) Yanping Xiao et al.   Cancer Discovery

Helios, and not FoxP3, is the marker of activated Tregs expressing GARP/LAP

(2015) Eyad Elkord et al.   Oncotarget

Prognostic value of tumor-infiltrating FoxP3+ regulatory T cells in cancers: a systematic review and meta-analysis

(2015) Bin Shang et al.   Scientific Reports

CD69 Is the Crucial Regulator of Intestinal Inflammation: A New Target Molecule for IBD Treatment?

(2015) Katarina Radulovic et al.   Journal of Immunology Research

Phenotyping of tumor-associated macrophages in colorectal cancer: Impact on single cell invasion (tumor budding) and clinicopathological outcome

(2015) Viktor H. Koelzer et al.   OncoImmunology

TLR4 Activation Enhances the PD-L1–Mediated Tolerogenic Capacity of Colonic CD90+Stromal Cells

(2014) Ellen J. Beswick et al.   JOURNAL OF IMMUNOLOGY

The Vigorous Immune Microenvironment of Microsatellite Instable Colon Cancer Is Balanced by Multiple Counter-Inhibitory Checkpoints

(2014) Nicolas J. Llosa et al.   Cancer Discovery

IFN-γ–Driven Intratumoral Microenvironment Exhibits Superior Prognostic Effect Compared with an IFN-α–Driven Microenvironment in Patients with Colon Carcinoma

(2013) Sandra Grenz et al.   AMERICAN JOURNAL OF PATHOLOGY

The density of macrophages in colorectal cancer is inversely correlated to TGF-β1 expression and patients’ survival

(2013) Maya Gulubova et al.   JOURNAL OF MOLECULAR HISTOLOGY

Highly prevalent colorectal cancer-infiltrating LAP+ Foxp3− T cells exhibit more potent immunosuppressive activity than Foxp3+ regulatory T cells

(2013) M Scurr et al.   Mucosal Immunology

ESMO Consensus Guidelines for management of patients with colon and rectal cancer. A personalized approach to clinical decision making

(2012) H. J. Schmoll et al.   ANNALS OF ONCOLOGY

Distribution and Compartmentalization of Human Circulating and Tissue-Resident Memory T Cell Subsets

(2012) Taheri Sathaliyawala et al.   IMMUNITY

Resident and pro-inflammatory macrophages in the colon represent alternative context-dependent fates of the same Ly6Chi monocyte precursors

(2012) C C Bain et al.   Mucosal Immunology

Comprehensive molecular characterization of human colon and rectal cancer

(2012)   NATURE

Safety and Activity of Anti–PD-L1 Antibody in Patients with Advanced Cancer

(2012) Julie R. Brahmer et al.   NEW ENGLAND JOURNAL OF MEDICINE

Safety, Activity, and Immune Correlates of Anti–PD-1 Antibody in Cancer

(2012) Suzanne L. Topalian et al.   NEW ENGLAND JOURNAL OF MEDICINE

The Distribution of Macrophages with a M1 or M2 Phenotype in Relation to Prognosis and the Molecular Characteristics of Colorectal Cancer

(2012) Sofia Edin et al.   PLoS One

Carcinoma origin dictates differential skewing of monocyte function

(2012) Marijn Bögels et al.   OncoImmunology

Clinical Impact of Different Classes of Infiltrating T Cytotoxic and Helper Cells (Th1, Th2, Treg, Th17) in Patients with Colorectal Cancer

(2011) Marie Tosolini et al.   CANCER RESEARCH

Macrophages in human colorectal cancer are pro-inflammatory and prime T cells towards an anti-tumour type-1 inflammatory response

(2011) Siew-Min Ong et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Type and location of tumor-infiltrating macrophages and lymphatic vessels predict survival of colorectal cancer patients

(2011) Annika Ålgars et al.   INTERNATIONAL JOURNAL OF CANCER

Histopathologic-Based Prognostic Factors of Colorectal Cancers Are Associated With the State of the Local Immune Reaction

(2011) Bernhard Mlecnik et al.   JOURNAL OF CLINICAL ONCOLOGY

RNAscope

(2011) Fay Wang et al.   JOURNAL OF MOLECULAR DIAGNOSTICS

Balancing acts: the role of TGF-β in the mucosal immune system

(2011) Joanne E. Konkel et al.   TRENDS IN MOLECULAR MEDICINE

Interferon-γ Regulates Intestinal Epithelial Homeostasis through Converging β-Catenin Signaling Pathways

(2010) Porfirio Nava et al.   IMMUNITY

Intraepithelial Effector (CD3+)/Regulatory (FoxP3+) T-Cell Ratio Predicts a Clinical Outcome of Human Colon Carcinoma

(2009) Frank A. Sinicrope et al.   GASTROENTEROLOGY

Interleukin-10 and interferon-γ modulate surface expression of fractalkine-receptor (CX3CR1) via PI3K in monocytes

(2009) María V. Ramos et al.   IMMUNOLOGY

PD-1 Ligand Expression by Human Colonic Myofibroblasts/Fibroblasts Regulates CD4+ T-Cell Activity

(2008) Irina V. Pinchuk et al.   GASTROENTEROLOGY

Angiostatic immune reaction in colorectal carcinoma: Impact on survival and perspectives for antiangiogenic therapy

(2008) Elisabeth Naschberger et al.   INTERNATIONAL JOURNAL OF CANCER