Immunoprevalence and magnitude of HLA-DP4 versus HLA-DR-restricted spontaneous CD4+Th1 responses against telomerase in cancer patients

Mutant MHC class II epitopes drive therapeutic immune responses to cancer

(2015) Sebastian Kreiter et al.   NATURE

TERTpromoter mutations and telomerase reactivation in urothelial cancer

(2015) Sumit Borah et al.   SCIENCE

HLA-DP1 matching: are we there yet?

(2014) A. Nagler   BLOOD

Noncanonical Functions of Telomerase: Implications in Telomerase-Targeted Cancer Therapies

(2014) Yinghui Li et al.   CANCER RESEARCH

Comprehensive Analysis of HLA-DR- and HLA-DP4-Restricted CD4+ T Cell Response Specific for the Tumor-Shared Antigen Survivin in Healthy Donors and Cancer Patients

(2014) X.-F. Wang et al.   JOURNAL OF IMMUNOLOGY

Systematic analysis of noncoding somatic mutations and gene expression alterations across 14 tumor types

(2014) Nils J Fredriksson et al.   NATURE GENETICS

High-throughput epitope discovery reveals frequent recognition of neo-antigens by CD4+ T cells in human melanoma

(2014) Carsten Linnemann et al.   NATURE MEDICINE

CD4 T-cell Subsets and Tumor Immunity: The Helpful and the Not-so-Helpful

(2014) H.-J. Kim et al.   Cancer Immunology Research

Th1 epitope selection for clinically effective cancer vaccines

(2014) Mary L Disis et al.   OncoImmunology

Tumor-Specific T-cell Help Is Associated with Improved Survival in Melanoma

(2013) K. Woods et al.   CLINICAL CANCER RESEARCH

A Randomized Phase II Trial of Multiepitope Vaccination with Melanoma Peptides for Cytotoxic T Cells and Helper T Cells for Patients with Metastatic Melanoma (E1602)

(2013) C. L. Slingluff et al.   CLINICAL CANCER RESEARCH

Highly Recurrent TERT Promoter Mutations in Human Melanoma

(2013) F. W. Huang et al.   SCIENCE

Targeting antitumor CD4 helper T cells with universal tumor-reactive helper peptides derived from telomerase for cancer vaccine

(2013) Olivier Adotévi et al.   Human Vaccines & Immunotherapeutics

CD4+ T Effectors Specific for the Tumor Antigen NY-ESO-1 Are Highly Enriched at Ovarian Cancer Sites and Coexist with, but Are Distinct from, Tumor-Associated Treg

(2013) M. Ayyoub et al.   Cancer Immunology Research

Targeting CD4+ T-Helper Cells Improves the Induction of Antitumor Responses in Dendritic Cell-Based Vaccination

(2012) E. H. J. G. Aarntzen et al.   CANCER RESEARCH

Universal Cancer Peptide-Based Therapeutic Vaccine Breaks Tolerance against Telomerase and Eradicates Established Tumor

(2012) M. Dosset et al.   CLINICAL CANCER RESEARCH

Analysis of Spontaneous Tumor-Specific CD4 T-cell Immunity in Lung Cancer Using Promiscuous HLA-DR Telomerase-Derived Epitopes: Potential Synergistic Effect with Chemotherapy Response

(2012) Y. Godet et al.   CLINICAL CANCER RESEARCH

Development of a Humanized HLA-A2.1/DP4 Transgenic Mouse Model and the Use of This Model to Map HLA-DP4-Restricted Epitopes of HBV Envelope Protein

(2012) Zhitao Ru et al.   PLoS One

Is preexisting antitumor CD4 T cell response indispensable for the chemotherapy induced immune regression of cancer?

(2012) Yann Godet et al.   OncoImmunology

Widespread CD4+ T-cell reactivity to novel hTERT epitopes following vaccination of cancer patients with a single hTERT peptide GV1001

(2012) Else-Marit Inderberg-Suso et al.   OncoImmunology

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

Telomerase Peptide Vaccination in NSCLC: A Phase II Trial in Stage III Patients Vaccinated after Chemoradiotherapy and an 8-Year Update on a Phase I/II Trial

(2011) P. F. Brunsvig et al.   CLINICAL CANCER RESEARCH

Promiscuous survivin peptide induces robust CD4+ T-cell responses in the majority of vaccinated cancer patients

(2011) Melanie Widenmeyer et al.   INTERNATIONAL JOURNAL OF CANCER

CD4+ T Cells Contribute to the Remodeling of the Microenvironment Required for Sustained Tumor Regression upon Oncogene Inactivation

(2010) Kavya Rakhra et al.   CANCER CELL

CD4+ T-Cell Help in the Tumor Milieu Is Required for Recruitment and Cytolytic Function of CD8+ T Lymphocytes

(2010) R. Bos et al.   CANCER RESEARCH

Epitope Hierarchy of Spontaneous CD4+ T Cell Responses to LAGE-1

(2010) P. Kudela et al.   JOURNAL OF IMMUNOLOGY

Five HLA-DP Molecules Frequently Expressed in the Worldwide Human Population Share a Common HLA Supertypic Binding Specificity

(2010) John Sidney et al.   JOURNAL OF IMMUNOLOGY

Telomeres and telomerase in cancer

(2009) S. E. Artandi et al.   CARCINOGENESIS

Characterization of Preexisting MAGE-A3-Specific CD4+ T Cells in Cancer Patients and Healthy Individuals and Their Activation by Protein Vaccination

(2009) T. Tsuji et al.   JOURNAL OF IMMUNOLOGY

Development and dynamics of robust T-cell responses to CML under imatinib treatment

(2008) C. I-U. Chen et al.   BLOOD

Multiple roles for CD4+T cells in anti-tumor immune responses

(2008) Richard Kennedy et al.   IMMUNOLOGICAL REVIEWS