Myeloid-Derived Suppressor Cells: Not Only in Tumor Immunity

Targeting myeloid-derived suppressor cells for cancer immunotherapy

(2018) Yijun Liu et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Inhibiting HSP90 prevents the induction of myeloid-derived suppressor cells by melanoma cells

(2018) Nicole Janssen et al.   CELLULAR IMMUNOLOGY

Myeloid derived-suppressor cells: their role in cancer and obesity

(2018) Suzanne Ostrand-Rosenberg   CURRENT OPINION IN IMMUNOLOGY

Phenotypic and functional alterations of myeloid-derived suppressor cells during the disease course of multiple sclerosis

(2018) Ellen Iacobaeus et al.   IMMUNOLOGY AND CELL BIOLOGY

Myeloid-Derived Suppressor Cells: Immune-Suppressive Cells That Impair Antitumor Immunity and Are Sculpted by Their Environment

(2018) Suzanne Ostrand-Rosenberg et al.   JOURNAL OF IMMUNOLOGY

Frontline Science: High fat diet and leptin promote tumor progression by inducing myeloid-derived suppressor cells

(2018) Virginia K. Clements et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Myeloid-derived suppressor cells coming of age

(2018) Filippo Veglia et al.   NATURE IMMUNOLOGY

A new cancer immunotherapy suffers a setback

(2018) Ken Garber   SCIENCE

Immune regulation by monocytes

(2018) Peter J. Murray   SEMINARS IN IMMUNOLOGY

Persistent accumulation of circulating monocytic myeloid-derived suppressor cells contributes to post-infectious immunosuppression in renal transplant recipients with bacterial infection: A pilot study

(2018) Yihang Jiang et al.   TRANSPLANT IMMUNOLOGY

The Expansion of Myeloid-Derived Suppressor Cells Is Associated with Joint Inflammation in Rheumatic Patients with Arthritis

(2018) Junqing Zhu et al.   Biomed Research International

Parameters of the Immune System and Vitamin D Levels in Old Individuals

(2018) Amanda Soares Alves et al.   Frontiers in Immunology

Targeting myeloid-derived suppressor cells using all-trans retinoic acid in melanoma patients treated with Ipilimumab

(2018) Richard P. Tobin et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Role of myeloid regulatory cells (MRCs) in maintaining tissue homeostasis and promoting tolerance in autoimmunity, inflammatory disease and transplantation

(2018) Giada Amodio et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

MDSCs in infectious diseases: regulation, roles, and readjustment

(2018) Anca Dorhoi et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Functional alterations of myeloid cells during the course of Alzheimer’s disease

(2018) Aaron D. Thome et al.   Molecular Neurodegeneration

Paradoxical effects of obesity on T cell function during tumor progression and PD-1 checkpoint blockade

(2018) Ziming Wang et al.   NATURE MEDICINE

Granulocytic myeloid-derived suppressor cells from human cord blood modulate T-helper cell response towards an anti-inflammatory phenotype

(2017) Natascha Köstlin et al.   IMMUNOLOGY

Role of myeloid-derived suppressor cells in allogeneic hematopoietic cell transplantation

(2017) Brent H. Koehn et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Mass cytometry deep phenotyping of human mononuclear phagocytes and myeloid-derived suppressor cells from human blood and bone marrow

(2017) Mikael Roussel et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Increased abundance of myeloid-derived suppressor cells and Th17 cells in peripheral blood of newly-diagnosed Parkinson’s disease patients

(2017) Siyuan Chen et al.   NEUROSCIENCE LETTERS

Myeloid-Derived Suppressor Cells and their Potential Application in Transplantation

(2017) Joseph R. Scalea et al.   TRANSPLANTATION

Emerging Concepts Linking Obesity with the Hallmarks of Cancer

(2017) Claire L. Donohoe et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Myeloid-Derived Suppressor Cells

(2017) Dmitry I. Gabrilovich   Cancer Immunology Research

Differential Phenotypes of Myeloid-Derived Suppressor and T Regulatory Cells and Cytokine Levels in Amnestic Mild Cognitive Impairment Subjects Compared to Mild Alzheimer Diseased Patients

(2017) Aurélie Le Page et al.   Frontiers in Immunology

Generation and functional characterization of MDSC-like cells

(2017) Annkristin Heine et al.   OncoImmunology

Exogenous lipid uptake induces metabolic and functional reprogramming of tumor-associated myeloid-derived suppressor cells

(2017) Amir A. Al-Khami et al.   OncoImmunology

Toward harmonized phenotyping of human myeloid-derived suppressor cells by flow cytometry: results from an interim study

(2016) Susanna Mandruzzato et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Expansion of a BDCA1+CD14+ Myeloid Cell Population in Melanoma Patients May Attenuate the Efficacy of Dendritic Cell Vaccines

(2016) G. Bakdash et al.   CANCER RESEARCH

Obesity and Cancer: The Oil that Feeds the Flame

(2016) Joan Font-Burgada et al.   Cell Metabolism

A clinical and biological perspective of human myeloid-derived suppressor cells in cancer

(2016) Christopher Shipp et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Increases in Absolute Lymphocytes and Circulating CD4+ and CD8+ T Cells Are Associated with Positive Clinical Outcome of Melanoma Patients Treated with Ipilimumab

(2016) A. Martens et al.   CLINICAL CANCER RESEARCH

Mechanisms of liver-induced tolerance

(2016) Demetrios Moris et al.   Current Opinion in Organ Transplantation

Peripheral blood myeloid-derived suppressor cells reflect disease status in idiopathic pulmonary fibrosis

(2016) Isis E. Fernandez et al.   EUROPEAN RESPIRATORY JOURNAL

Myeloid derived suppressor cells and autoimmunity

(2016) Peter Boros et al.   HUMAN IMMUNOLOGY

Myeloid-Derived Suppressor Cell Survival and Function Are Regulated by the Transcription Factor Nrf2

(2016) Daniel W. Beury et al.   JOURNAL OF IMMUNOLOGY

Establishing High Dimensional Immune Signatures from Peripheral Blood via Mass Cytometry in a Discovery Cohort of Stage IV Melanoma Patients

(2016) Kilian Wistuba-Hamprecht et al.   JOURNAL OF IMMUNOLOGY

Induction of Myeloid-Derived Suppressor Cells in Cryopyrin-Associated Periodic Syndromes

(2016) Marlene Ballbach et al.   Journal of Innate Immunity

Myeloid-derived suppressor cells are essential for maintaining feto-maternal immunotolerance via STAT3 signaling in mice

(2016) Ting Pan et al.   JOURNAL OF LEUKOCYTE BIOLOGY

TNFα-induced M-MDSCs promote transplant immune tolerance via nitric oxide

(2016) Fan Yang et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Granulocytic myeloid-derived suppressor cells maintain feto-maternal tolerance by inducing Foxp3 expression in CD4+CD25−T cells by activation of the TGF-β/β-catenin pathway

(2016) Xiaomin Kang et al.   MOLECULAR HUMAN REPRODUCTION

Stromal senescence establishes an immunosuppressive microenvironment that drives tumorigenesis

(2016) Megan K. Ruhland et al.   Nature Communications

Recommendations for myeloid-derived suppressor cell nomenclature and characterization standards

(2016) Vincenzo Bronte et al.   Nature Communications

In vitro-generated MDSCs prevent murine GVHD by inducing type 2 T cells without disabling antitumor cytotoxicity

(2015) J. J. Messmann et al.   BLOOD

Subsets of airway myeloid-derived regulatory cells distinguish mild asthma from chronic obstructive pulmonary disease

(2015) Jessy S. Deshane et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Δ9 -Tetrahydrocannabinol attenuates allogeneic host-versus-graft response and delays skin graft rejection through activation of cannabinoid receptor 1 and induction of myeloid-derived suppressor cells

(2015) Jessica M. Sido et al.   JOURNAL OF LEUKOCYTE BIOLOGY

JAK inhibition alleviates the cellular senescence-associated secretory phenotype and frailty in old age

(2015) Ming Xu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Dynamic changes in myeloid derived suppressor cell subsets following renal transplant: A prospective study

(2015) Barry D. Hock et al.   TRANSPLANT IMMUNOLOGY

Expansion of myeloid-derived suppressor cells with arginase activity lasts longer in aged than in young mice after CpG-ODN plus IFA treatment

(2015) María F. Harman et al.   Oncotarget

Age and Cancer Risk

(2014) Mary C. White et al.   AMERICAN JOURNAL OF PREVENTIVE MEDICINE

Reduced Myeloid-derived Suppressor Cells in the Blood and Endometrium is Associated with Early Miscarriage

(2014) Rohini R. Nair et al.   AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY

Identification of myeloid-derived suppressor cells in the synovial fluid of patients with rheumatoid arthritis: a pilot study

(2014) Júlia Kurkó et al.   BMC MUSCULOSKELETAL DISORDERS

Adverse Immunoregulatory Effects of 5FU and CPT11 Chemotherapy on Myeloid-Derived Suppressor Cells and Colorectal Cancer Outcomes

(2014) J. Kanterman et al.   CANCER RESEARCH

Granulocytic myeloid derived suppressor cells expand in human pregnancy and modulate T-cell responses

(2014) Natascha Köstlin et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Clinical Significance of Myeloid-Derived Suppressor Cells in Human Renal Transplantation with Acute T Cell-Mediated Rejection

(2014) Fanhang Meng et al.   INFLAMMATION

Myeloid-Derived Suppressor Cells Regulate Immune Response in Patients with Chronic Hepatitis B Virus Infection through PD-1–Induced IL-10

(2014) Ang Huang et al.   JOURNAL OF IMMUNOLOGY

Regulatory T Cells: New Keys for Further Unlocking the Enigma of Fetal Tolerance and Pregnancy Complications

(2014) T. T. Jiang et al.   JOURNAL OF IMMUNOLOGY

Dexamethasone potentiates myeloid-derived suppressor cell function in prolonging allograft survival through nitric oxide

(2014) Jiongbo Liao et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Lack of Significant Elevation of Myeloid-Derived Suppressor Cells in Peripheral Blood of Chronically Hepatitis C Virus-Infected Individuals

(2014) J. Nonnenmann et al.   JOURNAL OF VIROLOGY

Increased monocytic CD14+HLADRlow/− myeloid-derived suppressor cells in obesity

(2014) YI BAO et al.   Molecular Medicine Reports

A Circulating Subpopulation of Monocytic Myeloid-Derived Suppressor Cells as an Independent Prognostic/Predictive Factor in Untreated Non-Small Lung Cancer Patients

(2014) Eleni-Kyriaki Vetsika et al.   Journal of Immunology Research

Monocytic myeloid-derived suppressor cells in advanced melanoma patients

(2014) Alexander Martens et al.   OncoImmunology

Targeting macrophages rescues age-related immune deficiencies in C57BL/6J geriatric mice

(2013) Connie Jackaman et al.   AGING CELL

Increased Frequency of Myeloid-derived Suppressor Cells during Active Tuberculosis and after RecentMycobacterium tuberculosisInfection Suppresses T-Cell Function

(2013) Nelita du Plessis et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Monocytic Myeloid-Derived Suppressor Cells Accumulate in Renal Transplant Patients and Mediate CD4+Foxp3+Treg Expansion

(2013) Y. Luan et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Granulocyte-Colony Stimulating Factor as Treatment Option in Patients with Recurrent Miscarriage

(2013) Claudia Santjohanser et al.   ARCHIVUM IMMUNOLOGIAE ET THERAPIAE EXPERIMENTALIS

Myeloid-derived suppressor cells are associated with disease progression and decreased overall survival in advanced-stage melanoma patients

(2013) Kimberly R. Jordan et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Melanoma-Educated CD14 + Cells Acquire a Myeloid-Derived Suppressor Cell Phenotype through COX-2–Dependent Mechanisms

(2013) Yumeng Mao et al.   CANCER RESEARCH

Polyunsaturated fatty acids promote the expansion of myeloid-derived suppressor cells by activating the JAK/STAT3 pathway

(2013) Dehong Yan et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Clinical Significance and Functional Studies of Myeloid-Derived Suppressor Cells in Chronic Hepatitis C Patients

(2013) Weiping Cai et al.   JOURNAL OF CLINICAL IMMUNOLOGY

Blood CD33(+)HLA-DR(−) myeloid-derived suppressor cells are increased with age and a history of cancer

(2013) Chris P. Verschoor et al.   JOURNAL OF LEUKOCYTE BIOLOGY

G-CSF stem cell mobilization in human donors induces polymorphonuclear and mononuclear myeloid-derived suppressor cells

(2012) Ariane Luyckx et al.   CLINICAL IMMUNOLOGY

T Cell Assays and MIATA: The Essential Minimum for Maximum Impact

(2012) C.M. Britten et al.   IMMUNITY

Granulocytic myeloid-derived suppressor cells are cryosensitive and their frequency does not correlate with serum concentrations of colony-stimulating factors in head and neck cancer

(2012) Sokratis Trellakis et al.   Innate Immunity

Transcriptomic Analysis Comparing Tumor-Associated Neutrophils with Granulocytic Myeloid-Derived Suppressor Cells and Normal Neutrophils

(2012) Zvi G. Fridlender et al.   PLoS One

Chemokine Gene Silencing in Decidual Stromal Cells Limits T Cell Access to the Maternal-Fetal Interface

(2012) P. Nancy et al.   SCIENCE

Changes in primary lymphoid organs with aging

(2012) Ivan K. Chinn et al.   SEMINARS IN IMMUNOLOGY

Positive feedback between PGE2 and COX2 redirects the differentiation of human dendritic cells toward stable myeloid-derived suppressor cells

(2011) N. Obermajer et al.   BLOOD

Psychological stress is associated with altered levels of myeloid-derived suppressor cells in breast cancer patients

(2011) Bethany L. Mundy-Bosse et al.   CELLULAR IMMUNOLOGY

The role of interleukin-12 on modulating myeloid-derived suppressor cells, increasing overall survival and reducing metastasis

(2011) Catherine E. Steding et al.   IMMUNOLOGY

Crucial Role of Granulocytic Myeloid-Derived Suppressor Cells in the Regulation of Central Nervous System Autoimmune Disease

(2011) M. Ioannou et al.   JOURNAL OF IMMUNOLOGY

Functional characterization of human Cd33+ And Cd11b+ myeloid-derived suppressor cell subsets induced from peripheral blood mononuclear cells co-cultured with a diverse set of human tumor cell lines

(2011) Melissa G Lechner et al.   Journal of Translational Medicine

Renal transplant recipients have elevated frequencies of circulating myeloid-derived suppressor cells

(2011) B. D. Hock et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

Myeloid-derived suppressor cells: more mechanisms for inhibiting antitumor immunity

(2010) Suzanne Ostrand-Rosenberg   CANCER IMMUNOLOGY IMMUNOTHERAPY

Immunity, Inflammation, and Cancer

(2010) Sergei I. Grivennikov et al.   CELL

In Vivo Induction of Myeloid Suppressor Cells and CD4+Foxp3+ T Regulatory Cells Prolongs Skin Allograft Survival in Mice

(2010) D. Adeegbe et al.   CELL TRANSPLANTATION

A Role for Immature Myeloid Cells in Immune Senescence

(2010) E. Y. Enioutina et al.   JOURNAL OF IMMUNOLOGY

Characterization of Cytokine-Induced Myeloid-Derived Suppressor Cells from Normal Human Peripheral Blood Mononuclear Cells

(2010) M. G. Lechner et al.   JOURNAL OF IMMUNOLOGY

Cancer-Associated Myeloproliferation: Old Association, New Therapeutic Target

(2010) Ryan A. Wilcox   MAYO CLINIC PROCEEDINGS

Use of granulocyte colony-stimulating factor for the treatment of unexplained recurrent miscarriage: a randomised controlled trial

(2009) F. Scarpellini et al.   HUMAN REPRODUCTION

Myeloid-Derived Suppressor Cells: Linking Inflammation and Cancer

(2009) S. Ostrand-Rosenberg et al.   JOURNAL OF IMMUNOLOGY

Myeloid-Derived Suppressor Cells Down-Regulate L-Selectin Expression on CD4+ and CD8+ T Cells

(2009) E. M. Hanson et al.   JOURNAL OF IMMUNOLOGY

Myeloid-Derived Suppressor Cells Promote Cross-Tolerance in B-Cell Lymphoma by Expanding Regulatory T Cells

(2008) P. Serafini et al.   CANCER RESEARCH

A New Population of Myeloid-Derived Suppressor Cells in Hepatocellular Carcinoma Patients Induces CD4+CD25+Foxp3+ T Cells

(2008) Bastian Hoechst et al.   GASTROENTEROLOGY

Conditions That Diminish Myeloid-Derived Suppressor Cell Activities Stimulate Cross-Protective Immunity

(2008) D. M. Heithoff et al.   INFECTION AND IMMUNITY