POLE somatic mutations in advanced colorectal cancer

Increased incidence ofFBXW7andPOLEproofreading domain mutations in young adult colorectal cancers

(2016) Nishi Kothari et al.   CANCER

The somatic POLE P286R mutation defines a unique subclass of colorectal cancer featuring hypermutation, representing a potential genomic biomarker for immunotherapy

(2016) Sung-Min Ahn et al.   Oncotarget

PARP inhibitors in the management of breast cancer: current data and future prospects

(2015) Luca Livraghi et al.   BMC Medicine

PD-1 Blockade in Tumors with Mismatch-Repair Deficiency

(2015) Dung T. Le et al.   NEW ENGLAND JOURNAL OF MEDICINE

A Common Cancer-Associated DNA Polymerase   Mutation Causes an Exceptionally Strong Mutator Phenotype, Indicating Fidelity Defects Distinct from Loss of Proofreading

(2014) D. P. Kane et al.   CANCER RESEARCH

Replicative DNA polymerase mutations in cancer

(2014) Ellen Heitzer et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

Exonuclease mutations in DNA polymerase epsilon reveal replication strand specific mutation patterns and human origins of replication

(2014) Eve Shinbrot et al.   GENOME RESEARCH

POLE exonuclease domain mutation predicts long progression-free survival in grade 3 endometrioid carcinoma of the endometrium

(2014) Bo Meng et al.   GYNECOLOGIC ONCOLOGY

DNA polymerase ε and its roles in genome stability

(2014) Erin E. Henninger et al.   IUBMB LIFE

Prognostic Significance of POLE Proofreading Mutations in Endometrial Cancer

(2014) David N. Church et al.   JNCI-Journal of the National Cancer Institute

Mutations in POLE and survival of colorectal cancer patients - link to disease stage and treatment

(2014) Albrecht Stenzinger et al.   Cancer Medicine

High resolution melting analysis of KRAS, BRAF and PIK3CA in KRASexon 2 wild-type metastatic colorectal cancer

(2013) Joana G Guedes et al.   BMC CANCER

Germline and somatic polymerase ϵ and δ mutations define a new class of hypermutated colorectal and endometrial cancers

(2013) Sarah Briggs et al.   JOURNAL OF PATHOLOGY

Integrated genomic characterization of endometrial carcinoma

(2013) Gad Getz et al.   NATURE

Molecular pathways in colorectal cancer

(2012) Sam Al-Sohaily et al.   JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY

Comprehensive molecular characterization of human colon and rectal cancer

(2012)   NATURE

Germline mutations affecting the proofreading domains of POLE and POLD1 predispose to colorectal adenomas and carcinomas

(2012) Claire Palles et al.   NATURE GENETICS

Colorectal carcinomas with microsatellite instability display a different pattern of target gene mutations according to large bowel site of origin

(2010) Manuela Pinheiro et al.   BMC CANCER

The Use of COLD-PCR and High-Resolution Melting Analysis Improves the Limit of Detection of KRAS and BRAF Mutations in Colorectal Cancer

(2010) Irene Mancini et al.   JOURNAL OF MOLECULAR DIAGNOSTICS