Split tolerance permits safe Ad5-GUCY2C-PADRE vaccine-induced T-cell responses in colon cancer patients

TCR Retrogenic Mice as a Model To Map Self-Tolerance Mechanisms to the Cancer Mucosa Antigen GUCY2C

(2019) Tara S. Abraham et al.   JOURNAL OF IMMUNOLOGY

Human GUCY2C-Targeted Chimeric Antigen Receptor (CAR)-Expressing T Cells Eliminate Colorectal Cancer Metastases

(2018) Michael S. Magee et al.   Cancer Immunology Research

Prime-Boost Immunization Eliminates Metastatic Colorectal Cancer by Producing High-Avidity Effector CD8+T Cells

(2017) Bo Xiang et al.   JOURNAL OF IMMUNOLOGY

Consistent expression of guanylyl cyclase-C in primary and metastatic gastrointestinal cancers

(2017) Hadi Danaee et al.   PLoS One

Mismatch repair deficiency predicts response of solid tumors to PD-1 blockade

(2017) Dung T. Le et al.   SCIENCE

Preclinical Evaluation of a Replication-Deficient Recombinant Adenovirus Serotype 5 Vaccine Expressing Guanylate Cyclase C and the PADRE T-helper Epitope

(2016) Adam E. Snook et al.   Human Gene Therapy Methods

GUCY2C-directed CAR-T cells oppose colorectal cancer metastases without autoimmunity

(2016) Michael S. Magee et al.   OncoImmunology

GUCY2C lysosomotropic endocytosis delivers immunotoxin therapy to metastatic colorectal cancer

(2015) Glen P. Marszalowicz et al.   Oncotarget

Selective antigen-specific CD4+T-cell, but not CD8+T- or B-cell, tolerance corrupts cancer immunotherapy

(2014) Adam E. Snook et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Tumor Radiation Therapy Creates Therapeutic Vaccine Responses to the Colorectal Cancer Antigen GUCY2C

(2014) Matthew Witek et al.   INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS

The effect of adenovirus-specific antibodies on adenoviral vector-induced, transgene product-specific T cell responses

(2014) Juliana C. Small et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Genetic Basis for Clinical Response to CTLA-4 Blockade in Melanoma

(2014) Alexandra Snyder et al.   NEW ENGLAND JOURNAL OF MEDICINE

Improvement of IFNg ELISPOT Performance Following Overnight Resting of Frozen PBMC Samples Confirmed Through Rigorous Statistical Analysis

(2014) Radleigh Santos et al.   Cells

Cancer Immunotherapy

(2013) J. Couzin-Frankel   SCIENCE

Epitope-targeted cytotoxic T cells mediate lineage-specific antitumor efficacy induced by the cancer mucosa antigen GUCY2C

(2011) Adam E. Snook et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

A uroguanylin-GUCY2C endocrine axis regulates feeding in mice

(2011) Michael A. Valentino et al.   JOURNAL OF CLINICAL INVESTIGATION

Adenovirus Serotype 5 Neutralizing Antibodies Target both Hexon and Fiber following Vaccination and Natural Infection

(2011) R. R. Bradley et al.   JOURNAL OF VIROLOGY

Role for the Membrane Receptor Guanylyl Cyclase-C in Attention Deficiency and Hyperactive Behavior

(2011) R. Gong et al.   SCIENCE

Bacterial Heat-Stable Enterotoxins: Translation of Pathogenic Peptides into Novel Targeted Diagnostics and Therapeutics

(2010) Jieru E. Lin et al.   Toxins

Lineage-Specific T-Cell Responses to Cancer Mucosa Antigen Oppose Systemic Metastases without Mucosal Inflammatory Disease

(2009) A. E. Snook et al.   CANCER RESEARCH

Association of GUCY2C Expression in Lymph Nodes With Time to Recurrence and Disease-Free Survival in pN0 Colorectal Cancer

(2009) Scott A. Waldman   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Cytokine Adjuvanation of Therapeutic Anti-tumor Immunity Targeted to Cancer Mucosa Antigens

(2008) Adam E. Snook et al.   CTS-Clinical and Translational Science

Colorectal Cancer Is a Paracrine Deficiency Syndrome Amenable to Oral Hormone Replacement Therapy

(2008) Peng Li et al.   CTS-Clinical and Translational Science

Guanylyl Cyclase C–Induced Immunotherapeutic Responses Opposing Tumor Metastases Without Autoimmunity

(2008) Adam E. Snook et al.   JNCI-Journal of the National Cancer Institute

The Immunogenicity of Adenovirus Vectors Limits the Multispecificity of CD8 T-cell Responses to Vector-encoded Transgenic Antigens

(2008) Reinhold Schirmbeck et al.   MOLECULAR THERAPY

Uroguanylin inhibits proliferation of pancreatic cancer cells

(2008) Oliver Kloeters et al.   SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY

Safety and immunogenicity of cytotoxic T-lymphocyte poly-epitope, DNA plasmid (EP HIV-1090) vaccine in healthy, human immunodeficiency virus type 1 (HIV-1)-uninfected adults

(2007) Geoffrey J. Gorse et al.   VACCINE