An Autocrine TNFα–Tumor Necrosis Factor Receptor 2 Loop Promotes Epigenetic Effects Inducing Human Treg Stability In Vitro

Analysis of EZH2 expression in regulatory T-cells

(2017) A. Velichkov et al.   JOURNAL OF REPRODUCTIVE IMMUNOLOGY

Single CD28 stimulation induces stable and polyclonal expansion of human regulatory T cells

(2017) Xuehui He et al.   Scientific Reports

TNF-α priming enhances CD4 + FoxP3 + regulatory T-cell suppressive function in murine GVHD prevention and treatment

(2016) Antonio Pierini et al.   BLOOD

Control of GVHD by regulatory T cells depends on TNF produced by T cells and TNFR2 expressed by regulatory T cells

(2016) M. Leclerc et al.   BLOOD

The Role of the Histone Methyltransferase Enhancer of Zeste Homolog 2 (EZH2) in the Pathobiological Mechanisms Underlying Inflammatory Bowel Disease (IBD)

(2016) Olga F. Sarmento et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Exogenous TNFR2 activation protects from acute GvHD via host T reg cell expansion

(2016) Martin Chopra et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Foxp3 and Toll-like receptor signaling balance Treg cell anabolic metabolism for suppression

(2016) Valerie A Gerriets et al.   NATURE IMMUNOLOGY

Suppressive activity of human regulatory T cells is maintained in the presence of TNF

(2016) Bruno Zaragoza et al.   NATURE MEDICINE

A TNFR2-Agonist Facilitates High Purity Expansion of Human Low Purity Treg Cells

(2016) Xuehui He et al.   PLoS One

Expression of TNFR2 by regulatory T cells in peripheral blood is correlated with clinical pathology of lung cancer patients

(2015) Fan Yan et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Targeting Treg signaling for the treatment of autoimmune diseases

(2015) Allyson Spence et al.   CURRENT OPINION IN IMMUNOLOGY

The Chromatin-Modifying Enzyme Ezh2 Is Critical for the Maintenance of Regulatory T Cell Identity after Activation

(2015) Michel DuPage et al.   IMMUNITY

T cell metabolism drives immunity

(2015) Michael D. Buck et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Divergent Phenotypes of Human Regulatory T Cells Expressing the Receptors TIGIT and CD226

(2015) Christopher A. Fuhrman et al.   JOURNAL OF IMMUNOLOGY

Coexpression of TIGIT and FCRL3 Identifies Helios+Human Memory Regulatory T Cells

(2015) Khalid Bin Dhuban et al.   JOURNAL OF IMMUNOLOGY

Stable inhibitory activity of regulatory T cells requires the transcription factor Helios

(2015) H.-J. Kim et al.   SCIENCE

Blockade of TNF-α signaling benefits cancer therapy by suppressing effector regulatory T cell expansion

(2015) Li-Yuan Chang et al.   OncoImmunology

c-Rel Regulates Ezh2 Expression in Activated Lymphocytes and Malignant Lymphoid Cells

(2014) Wen Hao Neo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Effector T Cells Boost Regulatory T Cell Expansion by IL-2, TNF, OX40, and Plasmacytoid Dendritic Cells Depending on the Immune Context

(2014) Audrey Baeyens et al.   JOURNAL OF IMMUNOLOGY

Ex Vivo–Expanded but Not In Vitro–Induced Human Regulatory T Cells Are Candidates for Cell Therapy in Autoimmune Diseases Thanks to Stable Demethylation of the FOXP3 Regulatory T Cell–Specific Demethylated Region

(2014) Maura Rossetti et al.   JOURNAL OF IMMUNOLOGY

Foxp3-mediated inhibition of Akt inhibits Glut1 (glucose transporter 1) expression in human T regulatory cells

(2014) Samik Basu et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Inflammation-induced repression of chromatin bound by the transcription factor Foxp3 in regulatory T cells

(2014) Aaron Arvey et al.   NATURE IMMUNOLOGY

Impaired Th1 immunity in ovarian cancer patients is mediated by TNFR2+ Tregs within the tumor microenvironment

(2013) Chindu Govindaraj et al.   CLINICAL IMMUNOLOGY

TNFR2 Is Critical for the Stabilization of the CD4+Foxp3+ Regulatory T Cell Phenotype in the Inflammatory Environment

(2013) X. Chen et al.   JOURNAL OF IMMUNOLOGY

Phosphorylation of FOXP3 controls regulatory T cell function and is inhibited by TNF-α in rheumatoid arthritis

(2013) Hong Nie et al.   NATURE MEDICINE

Homogeneous Expansion of Human T-Regulatory Cells Via Tumor Necrosis Factor Receptor 2

(2013) Yoshiaki Okubo et al.   Scientific Reports

Signal transduction by tumor necrosis factor receptors

(2012) Lucía Cabal-Hierro et al.   CELLULAR SIGNALLING

Differential effects of rapamycin and retinoic acid on expansion, stability and suppressive qualities of human CD4+CD25+FOXP3+ T regulatory cell subpopulations

(2012) C. Scotta et al.   HAEMATOLOGICA

T Cell Receptor Stimulation-Induced Epigenetic Changes and Foxp3 Expression Are Independent and Complementary Events Required for Treg Cell Development

(2012) Naganari Ohkura et al.   IMMUNITY

Molecular Mechanisms of Treg-Mediated T Cell Suppression

(2012) Angelika Schmidt et al.   Frontiers in Immunology

TNF optimally activatives regulatory T cells by inducing TNF receptor superfamily members TNFR2, 4-1BB and OX40

(2011) Ryoko Hamano et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Rapamycin-sensitive signals control TCR/CD28-drivenIfng,Il4andFoxp3transcription and promoter region methylation

(2011) Romana Tomasoni et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Stability of human rapamycin-expanded CD4+CD25+ T regulatory cells

(2011) E. Tresoldi et al.   HAEMATOLOGICA

NF-κB Signal Triggering and Termination by Tumor Necrosis Factor Receptor 2

(2011) Montserrat Rodríguez et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Regulatory T Cells Require Mammalian Target of Rapamycin Signaling To Maintain Both Homeostasis and Alloantigen-Driven Proliferation in Lymphocyte-Replete Mice

(2011) Y. Wang et al.   JOURNAL OF IMMUNOLOGY

Natural but Not Inducible Regulatory T Cells Require TNF-  Signaling for In Vivo Function

(2011) W. J. Housley et al.   JOURNAL OF IMMUNOLOGY

Retinoic Acid and Rapamycin Differentially Affect and Synergistically Promote the Ex Vivo Expansion of Natural Human T Regulatory Cells

(2011) Tatiana N. Golovina et al.   PLoS One

Regulatory T cells inhibit acute IFN-  synthesis without blocking T-helper cell type 1 (Th1) differentiation via a compartmentalized requirement for IL-10

(2011) D. K. Sojka et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Ligand-induced internalization of TNF receptor 2 mediated by a di-leucin motif is dispensable for activation of the NFκB pathway

(2010) Roman Fischer et al.   CELLULAR SIGNALLING

Co-expression of TNFR2 and CD25 identifies more of the functional CD4+FOXP3+regulatory T cells in human peripheral blood

(2010) Xin Chen et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Expression of Costimulatory TNFR2 Induces Resistance of CD4+FoxP3- Conventional T Cells to Suppression by CD4+FoxP3+ Regulatory T Cells

(2010) X. Chen et al.   JOURNAL OF IMMUNOLOGY

Induction of Colonic Regulatory T Cells by Indigenous Clostridium Species

(2010) K. Atarashi et al.   SCIENCE

Differential Responses of Human Regulatory T Cells (Treg) and Effector T Cells to Rapamycin

(2009) Laura Strauss et al.   PLoS One

Human memory FOXP3+ Tregs secrete IL-17 ex vivo and constitutively express the TH17 lineage-specific transcription factor ROR t

(2009) M. Ayyoub et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Identification of IL-17-producing FOXP3+ regulatory T cells in humans

(2009) K. S. Voo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Human CD25highFoxp3pos regulatory T cells differentiate into IL-17-producing cells

(2008) H. J. P. M. Koenen et al.   BLOOD

Rapamycin Monotherapy in Patients With Type 1 Diabetes Modifies CD4+CD25+FOXP3+ Regulatory T-Cells

(2008) P. Monti et al.   DIABETES

Ex Vivo Generation of Human Alloantigen-Specific Regulatory T Cells from CD4posCD25high T Cells for Immunotherapy

(2008) Jorieke H. Peters et al.   PLoS One

Selective death of autoreactive T cells in human diabetes by TNF or TNF receptor 2 agonism

(2008) L. Ban et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA