The Lupus Susceptibility GenePbx1Regulates the Balance between Follicular Helper T Cell and Regulatory T Cell Differentiation

Treg cells require the phosphatase PTEN to restrain TH1 and TFH cell responses

(2015) Sharad Shrestha et al.   NATURE IMMUNOLOGY

Normalization of CD4 + T cell metabolism reverses lupus

(2015) Yiming Yin et al.   Science Translational Medicine

Circulating Follicular Helper-Like T Cells in Systemic Lupus Erythematosus: Association With Disease Activity

(2015) Jin-Young Choi et al.   Arthritis & Rheumatology

Regulatory T cells in systemic lupus erythematosus

(2014) Kim Ohl et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

miR-155 Promotes T Follicular Helper Cell Accumulation during Chronic, Low-Grade Inflammation

(2014) Ruozhen Hu et al.   IMMUNITY

T Follicular Helper Cell Differentiation, Function, and Roles in Disease

(2014) Shane Crotty   IMMUNITY

Retinoic Acid Increases Foxp3+ Regulatory T Cells and Inhibits Development of Th17 Cells by Enhancing TGF- -Driven Smad3 Signaling and Inhibiting IL-6 and IL-23 Receptor Expression

(2014) S. Xiao et al.   JOURNAL OF IMMUNOLOGY

The Murine Pbx1-d Lupus Susceptibility Allele Accelerates Mesenchymal Stem Cell Differentiation and Impairs Their Immunosuppressive Function

(2014) Shun Lu et al.   JOURNAL OF IMMUNOLOGY

Increased Interleukin 21 and Follicular Helper T-like Cells and Reduced Interleukin 10+ B cells in Patients with New-onset Systemic Lupus Erythematosus

(2014) L. Wang et al.   JOURNAL OF RHEUMATOLOGY

Differential expression pattern of microRNAs in CD4+ and CD19+ cells from asymptomatic patients with systemic lupus erythematosus

(2014) R Martínez-Ramos et al.   LUPUS

Interleukin-21: a double-edged sword with therapeutic potential

(2014) Rosanne Spolski et al.   NATURE REVIEWS DRUG DISCOVERY

Cell Distance Mapping Identifies Functional T Follicular Helper Cells in Inflamed Human Renal Tissue

(2014) V. M. Liarski et al.   Science Translational Medicine

Mir-155, a central modulator of T-cell responses

(2013) Evan F. Lind et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Development and Maintenance of Regulatory T cells

(2013) Naganari Ohkura et al.   IMMUNITY

Control of TFH cell numbers: why and how?

(2013) Alvin Pratama et al.   IMMUNOLOGY AND CELL BIOLOGY

Therapeutic antagonists of microRNAs deplete leukemia-initiating cell activity

(2013) Chinavenmeni S. Velu et al.   JOURNAL OF CLINICAL INVESTIGATION

The Bcl6 target gene microRNA-21 promotes Th2 differentiation by a T cell intrinsic pathway

(2013) Deepali V. Sawant et al.   MOLECULAR IMMUNOLOGY

Deletion of microRNA-155 reduces autoantibody responses and alleviates lupus-like disease in the Faslpr mouse

(2013) T.-H. Thai et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Analysis of the DNA-Binding Profile and Function of TALE Homeoproteins Reveals Their Specialization and Specific Interactions with Hox Genes/Proteins

(2013) Dmitry Penkov et al.   Cell Reports

The SLE-associated Pbx1-d isoform acts as a dominant-negative transcriptional regulator

(2012) M Sengupta et al.   GENES AND IMMUNITY

TGF-β and retinoic acid induce the microRNA miR-10a, which targets Bcl-6 and constrains the plasticity of helper T cells

(2012) Hayato Takahashi et al.   NATURE IMMUNOLOGY

The development and fate of follicular helper T cells defined by an IL-21 reporter mouse

(2012) Katja Lüthje et al.   NATURE IMMUNOLOGY

Follicular helper T cells in immunity and systemic autoimmunity

(2012) Joseph E. Craft   Nature Reviews Rheumatology

MicroRNA 10a Marks Regulatory T Cells

(2012) Lukas T. Jeker et al.   PLoS One

Identification of novel microRNA signatures linked to human lupus disease activity and pathogenesis: miR-21 regulates aberrant T cell responses through regulation of PDCD4 expression

(2011) E. Stagakis et al.   ANNALS OF THE RHEUMATIC DISEASES

Molecular dissection of the miR-17-92 cluster's critical dual roles in promoting Th1 responses and preventing inducible Treg differentiation

(2011) S. Jiang et al.   BLOOD

A novel isoform of the Ly108 gene ameliorates murine lupus

(2011) Marton Keszei et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Pre-B Cell Leukemia Homeobox 1 Is Associated with Lupus Susceptibility in Mice and Humans

(2011) C. M. Cuda et al.   JOURNAL OF IMMUNOLOGY

Cooperative Transcriptional Activation by Klf4, Meis2, and Pbx1

(2011) G. A. Bjerke et al.   MOLECULAR AND CELLULAR BIOLOGY

Defective response of CD4+ T cells to retinoic acid and TGFβ in systemic lupus erythematosus

(2011) Eric S Sobel et al.   ARTHRITIS RESEARCH & THERAPY

Murine lupus susceptibility locus Sle1a requires the expression of two sub-loci to induce inflammatory T cells

(2010) C M Cuda et al.   GENES AND IMMUNITY

MicroRNA-21 and MicroRNA-148a Contribute to DNA Hypomethylation in Lupus CD4+ T Cells by Directly and Indirectly Targeting DNA Methyltransferase 1

(2010) W. Pan et al.   JOURNAL OF IMMUNOLOGY

Preferential Generation of Follicular B Helper T Cells from Foxp3+ T Cells in Gut Peyer's Patches

(2009) M. Tsuji et al.   SCIENCE

A Fundamental Role for Interleukin-21 in the Generation of T Follicular Helper Cells

(2008) Alexis Vogelzang et al.   IMMUNITY

ICOS-dependent extrafollicular helper T cells elicit IgG production via IL-21 in systemic autoimmunity

(2008) Jared M. Odegard et al.   JOURNAL OF EXPERIMENTAL MEDICINE

PBX proteins: much more than Hox cofactors

(2007) Audrey Laurent et al.   INTERNATIONAL JOURNAL OF DEVELOPMENTAL BIOLOGY