CD4+ Foxp3+ regulatory T cell-mediated immunomodulation by anti-depressants inhibiting acid sphingomyelinase

Types A and B Niemann-Pick disease

(2017) Edward H. Schuchman et al.   MOLECULAR GENETICS AND METABOLISM

Acid sphingomyelinase mediates human CD4+ T-cell signaling: potential roles in T-cell responses and diseases

(2017) Aiping Bai et al.   Cell Death & Disease

Antidepressant Drug, Desipramine, Alleviates Allergic Rhinitis by Regulating Treg and Th 17 Cells

(2017) Y. Zhang et al.   INTERNATIONAL JOURNAL OF IMMUNOPATHOLOGY AND PHARMACOLOGY

Acid Sphingomyelinase (ASM) is a Negative Regulator of Regulatory T Cell (Treg) Development

(2016) Yuetao Zhou et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Inhibition of Acid Sphingomyelinase Allows for Selective Targeting of CD4+Conventional versus Foxp3+Regulatory T Cells

(2016) Claudia Hollmann et al.   JOURNAL OF IMMUNOLOGY

Structure of Human Acid Sphingomyelinase Reveals the Role of the Saposin Domain in Activating Substrate Hydrolysis

(2016) Zi-Jian Xiong et al.   JOURNAL OF MOLECULAR BIOLOGY

Virus and Host Mechanics Support Membrane Penetration and Cell Entry

(2016) Urs F. Greber   JOURNAL OF VIROLOGY

Phosphatase PP2A is requisite for the function of regulatory T cells

(2016) Sokratis A Apostolidis et al.   NATURE IMMUNOLOGY

Types A and B Niemann-Pick disease

(2015) Edward H. Schuchman et al.   BEST PRACTICE & RESEARCH CLINICAL ENDOCRINOLOGY & METABOLISM

Deletion of CTLA-4 on regulatory T cells during adulthood leads to resistance to autoimmunity

(2015) Alison M. Paterson et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Lysosomal ceramide generated by acid sphingomyelinase triggers cytosolic cathepsin B-mediated degradation of X-linked inhibitor of apoptosis protein in natural killer/T lymphoma cell apoptosis

(2015) M Taniguchi et al.   Cell Death & Disease

Role of acid sphingomyelinase bioactivity in human CD4+ T-cell activation and immune responses

(2015) A Bai et al.   Cell Death & Disease

High sphingomyelin levels induce lysosomal damage and autophagy dysfunction in Niemann Pick disease type A

(2014) E Gabandé-Rodríguez et al.   CELL DEATH AND DIFFERENTIATION

Selective serotonin reuptake inhibitors as a novel class of immunosuppressants

(2014) Veerle Gobin et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

CD28 Costimulation Is Essential for Human T Regulatory Expansion and Function

(2014) T. N. Golovina et al.   JOURNAL OF IMMUNOLOGY

CD39 and CD161 Modulate Th17 Responses in Crohn's Disease

(2014) Aiping Bai et al.   JOURNAL OF IMMUNOLOGY

TCR signaling fuels Treg cell suppressor function

(2014) Jinfang Zhu et al.   NATURE IMMUNOLOGY

Continuous requirement for the TCR in regulatory T cell function

(2014) Andrew G Levine et al.   NATURE IMMUNOLOGY

The ceramide system as a novel antidepressant target

(2014) Johannes Kornhuber et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Neutral Sphingomyelinase in Physiological and Measles Virus Induced T Cell Suppression

(2014) Nora Mueller et al.   PLoS Pathogens

Role of regulatory T cells during virus infection

(2013) Tamara Veiga-Parga et al.   IMMUNOLOGICAL REVIEWS

Fluoxetine Reduces Murine Graft-Versus-Host Disease by Induction of T cell Immunosuppression

(2013) Veerle Gobin et al.   Journal of Neuroimmune Pharmacology

CCL20 Secretion from the Nucleus Pulposus Improves the Recruitment of CCR6-Expressing Th17 Cells to Degenerated IVD Tissues

(2013) Wen Zhang et al.   PLoS One

Cell-intrinsic and -extrinsic control of Treg-cell homeostasis and function revealed by inducedCD28deletion

(2012) Tea Gogishvili et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Fluoxetine Promotes Remission in Acute Experimental Autoimmune Encephalomyelitis in Rats

(2012) Xi-qiu Yuan et al.   NEUROIMMUNOMODULATION

Foxp3+ Regulatory T Cells Control Persistence of Viral CNS Infection

(2012) Dajana Reuter et al.   PLoS One

Cell surface ceramide controls translocation of transferrin receptor to clathrin-coated pits

(2011) Abo Bakr Abdel Shakor et al.   CELLULAR SIGNALLING

Cathepsin B Overexpression Due to Acid Sphingomyelinase Ablation Promotes Liver Fibrosis in Niemann-Pick Disease

(2011) Anna Moles et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Acid Sphingomyelinase Is Required for Protection of Effector Memory T Cells against Glucocorticoid-Induced Cell Death

(2011) D. Tischner et al.   JOURNAL OF IMMUNOLOGY

Primary Human CD4+ T Cells Have Diverse Levels of Membrane Lipid Order That Correlate with Their Function

(2011) L. Miguel et al.   JOURNAL OF IMMUNOLOGY

Regulation of the NPC2 protein-mediated cholesterol trafficking by membrane lipids

(2011) Hichem D. Gallala et al.   JOURNAL OF NEUROCHEMISTRY

Identification of Novel Functional Inhibitors of Acid Sphingomyelinase

(2011) Johannes Kornhuber et al.   PLoS One

Trans-Endocytosis of CD80 and CD86: A Molecular Basis for the Cell-Extrinsic Function of CTLA-4

(2011) O. S. Qureshi et al.   SCIENCE

Two modes of immune suppression by Foxp3+ regulatory T cells under inflammatory or non-inflammatory conditions

(2011) Tomoyuki Yamaguchi et al.   SEMINARS IN IMMUNOLOGY

DC-SIGN Mediated Sphingomyelinase-Activation and Ceramide Generation Is Essential for Enhancement of Viral Uptake in Dendritic Cells

(2011) Elita Avota et al.   PLoS Pathogens

Small Molecule Inhibitors of Acid Sphingomyelinase

(2010) Christoph Arenz   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Functional Inhibitors of Acid Sphingomyelinase (FIASMAs): A Novel Pharmacological Group of Drugs with Broad Clinical Applications

(2010) Johannes Kornhuber et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

PI3 kinase signalling blocks Foxp3 expression by sequestering Foxo factors: Figure 1.

(2010) Matthias Merkenschlager et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Regulatory T cells increased while IL-1β decreased during antidepressant therapy

(2010) Hubertus Himmerich et al.   JOURNAL OF PSYCHIATRIC RESEARCH

Involvement of Ceramide in the Propagation of Japanese Encephalitis Virus

(2010) H. Tani et al.   JOURNAL OF VIROLOGY

Biological Function of the Cellular Lipid BMP—BMP as a Key Activator for Cholesterol Sorting and Membrane Digestion

(2010) Hichem D. Gallala et al.   NEUROCHEMICAL RESEARCH

Altered expression of CD4+CD25+ regulatory T cells and its 5-HT1a receptor in patients with major depression disorder

(2009) Yi Li et al.   JOURNAL OF AFFECTIVE DISORDERS

Acid sphingomyelinase is a key regulator of cytotoxic granule secretion by primary T lymphocytes

(2009) Jasmin Herz et al.   NATURE IMMUNOLOGY

Induction of Membrane Ceramides: A Novel Strategy to Interfere with T Lymphocyte Cytoskeletal Reorganisation in Viral Immunosuppression

(2009) Evelyn Gassert et al.   PLoS Pathogens

The unexpected role of acid sphingomyelinase in cell death and the pathophysiology of common diseases

(2008) Eric L. Smith et al.   FASEB JOURNAL

TcR-induced regulated secretion leads to surface expression of CTLA-4 in CD4+CD25+ T cells

(2008) Marta Catalfamo et al.   IMMUNOLOGY

Effects of fluoxetine on disease activity in relapsing multiple sclerosis: a double-blind, placebo-controlled, exploratory study

(2008) J P Mostert et al.   JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY

Ceramide accumulation mediates inflammation, cell death and infection susceptibility in cystic fibrosis

(2008) Volker Teichgräber et al.   NATURE MEDICINE

Principles of bioactive lipid signalling: lessons from sphingolipids

(2008) Yusuf A. Hannun et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Effect of host cell lipid metabolism on alphavirus replication, virion morphogenesis, and infectivity

(2008) C. G. Ng et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

T cell receptor signaling controls Foxp3 expression via PI3K, Akt, and mTOR

(2008) S. Sauer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The hygiene hypothesis and psychiatric disorders

(2008) Graham A.W. Rook et al.   TRENDS IN IMMUNOLOGY

Ceramide enrichment of the plasma membrane induces CD81 internalization and inhibits hepatitis C virus entry

(2007) Cécile Voisset et al.   CELLULAR MICROBIOLOGY