Adipose Tissue Dysfunction as Determinant of Obesity-Associated Metabolic Complications

Adipogenesis and metabolic health

(2019) Alexandra L. Ghaben et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Biology and function of adipose tissue macrophages, dendritic cells and B cells

(2018) Stoyan Ivanov et al.   ATHEROSCLEROSIS

The effect of diet and exercise on lipid droplet dynamics in human muscle tissue

(2018) Sabine Daemen et al.   JOURNAL OF EXPERIMENTAL BIOLOGY

High glucose induces inflammatory responses in HepG2 cells via the oxidative stress-mediated activation of NF-κB, and MAPK pathways in HepG2 cells

(2018) Ghodratollah Panahi et al.   ARCHIVES OF PHYSIOLOGY AND BIOCHEMISTRY

Perivascular Adipose Tissue as a Relevant Fat Depot for Cardiovascular Risk in Obesity

(2018) Rafael M. Costa et al.   Frontiers in Physiology

Increased fat accumulation in liver may link insulin resistance with subcutaneous abdominal adipocyte enlargement, visceral adiposity, and hypoadiponectinemia in obese individuals

(2018) Juraj Koska et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

PPARs and Metabolic Disorders Associated with Challenged Adipose Tissue Plasticity

(2018) Patricia Corrales et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Impaired Adipogenesis and Dysfunctional Adipose Tissue in Human Hypertrophic Obesity

(2018) Ann Hammarstedt et al.   PHYSIOLOGICAL REVIEWS

PKCε contributes to lipid-induced insulin resistance through cross talk with p70S6K and through previously unknown regulators of insulin signaling

(2018) Brandon M. Gassaway et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Obesity and cardiovascular disease: revisiting an old relationship

(2018) Chrysi Koliaki et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

PPARγΔ5, a Naturally Occurring Dominant-Negative Splice Isoform, Impairs PPARγ Function and Adipocyte Differentiation

(2018) Marianna Aprile et al.   Cell Reports

Obesity Pathogenesis: An Endocrine Society Scientific Statement

(2017) Michael W Schwartz et al.   ENDOCRINE REVIEWS

Adipose Type One Innate Lymphoid Cells Regulate Macrophage Homeostasis through Targeted Cytotoxicity

(2017) Selma Boulenouar et al.   IMMUNITY

Influence of dietary macronutrients on liver fat accumulation and metabolism

(2017) Siôn A Parry et al.   JOURNAL OF INVESTIGATIVE MEDICINE

Ectopic fat accumulation in the pancreas and its clinical relevance: A systematic review, meta-analysis, and meta-regression

(2017) Ruma G. Singh et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Insulin action and resistance in obesity and type 2 diabetes

(2017) Michael P Czech   NATURE MEDICINE

Adapting to obesity with adipose tissue inflammation

(2017) Shannon M. Reilly et al.   Nature Reviews Endocrinology

Biological control of appetite: A daunting complexity

(2017) Paul S. MacLean et al.   Obesity

Genetic determination of body fat distribution and the attributive influence on metabolism

(2017) Ellen Fehlert et al.   Obesity

The Metabolic Phenotype in Obesity: Fat Mass, Body Fat Distribution, and Adipose Tissue Function

(2017) Gijs H. Goossens   Obesity Facts

Causes and mechanisms of adipocyte enlargement and adipose expansion

(2017) F. Haczeyni et al.   Obesity Reviews

Roles of Diacylglycerols and Ceramides in Hepatic Insulin Resistance

(2017) Max C. Petersen et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Impact of fat mass and distribution on lipid turnover in human adipose tissue

(2017) Kirsty L. Spalding et al.   Nature Communications

Mechanistic interplay between ceramide and insulin resistance

(2017) Federico Reali et al.   Scientific Reports

Flow cytometric single cell analysis reveals heterogeneity between adipose depots

(2017) Badwi B. Boumelhem et al.   Adipocyte

Association of epicardial adipose tissue with serum level of cystatin C in type 2 diabetes

(2017) Tomomi Murai et al.   PLoS One

Specific CpG hyper-methylation leads to Ankrd26 gene down-regulation in white adipose tissue of a mouse model of diet-induced obesity

(2017) Gregory A. Raciti et al.   Scientific Reports

Overexpressing the novel autocrine/endocrine adipokine WISP2 induces hyperplasia of the heart, white and brown adipose tissues and prevents insulin resistance

(2017) John R. Grünberg et al.   Scientific Reports

Increased inflammation, oxidative stress and mitochondrial respiration in brown adipose tissue from obese mice

(2017) Martín Alcalá et al.   Scientific Reports

Pathologic endoplasmic reticulum stress induced by glucotoxic insults inhibits adipocyte differentiation and induces an inflammatory phenotype

(2016) Michele Longo et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Zfp423 Maintains White Adipocyte Identity through Suppression of the Beige Cell Thermogenic Gene Program

(2016) Mengle Shao et al.   Cell Metabolism

Effects of Moderate and Subsequent Progressive Weight Loss on Metabolic Function and Adipose Tissue Biology in Humans with Obesity

(2016) Faidon Magkos et al.   Cell Metabolism

Lipid Use and Misuse by the Heart

(2016) P. Christian Schulze et al.   CIRCULATION RESEARCH

Adipose tissue inflammation: a cause or consequence of obesity-related insulin resistance?

(2016) M. Bluher   CLINICAL SCIENCE

Energy balance, body composition, sedentariness and appetite regulation: pathways to obesity

(2016) M. Hopkins et al.   CLINICAL SCIENCE

Adipose Cell Size and Regional Fat Deposition as Predictors of Metabolic Response to Overfeeding in Insulin-Resistant and Insulin-Sensitive Humans

(2016) Tracey McLaughlin et al.   DIABETES

Adipose tissue plasticity: how fat depots respond differently to pathophysiological cues

(2016) Vanessa Pellegrinelli et al.   DIABETOLOGIA

MECHANISMS IN ENDOCRINOLOGY: Skeletal muscle lipotoxicity in insulin resistance and type 2 diabetes: a causal mechanism or an innocent bystander?

(2016) Charlotte Brøns et al.   EUROPEAN JOURNAL OF ENDOCRINOLOGY

Global epidemiology of nonalcoholic fatty liver disease-Meta-analytic assessment of prevalence, incidence, and outcomes

(2016) Zobair M. Younossi et al.   HEPATOLOGY

Hoxa5 undergoes dynamic DNA methylation and transcriptional repression in the adipose tissue of mice exposed to high-fat diet

(2016) L Parrillo et al.   INTERNATIONAL JOURNAL OF OBESITY

Adipose Tissue Hypoxia, Inflammation, and Fibrosis in Obese Insulin-Sensitive and Obese Insulin-Resistant Subjects

(2016) Helen M. Lawler et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Adipose tissue hypoxia and insulin resistance

(2016) Neda Rasouli   JOURNAL OF INVESTIGATIVE MEDICINE

Worldwide trends in diabetes since 1980: a pooled analysis of 751 population-based studies with 4·4 million participants

(2016)   LANCET

Trends in adult body-mass index in 200 countries from 1975 to 2014: a pooled analysis of 1698 population-based measurement studies with 19·2 million participants

(2016)   LANCET

Inhibition of JNK suppresses autophagy and attenuates insulin resistance in a rat model of nonalcoholic fatty liver disease

(2016) Hua Yan et al.   Molecular Medicine Reports

Targeting adipose tissue in the treatment of obesity-associated diabetes

(2016) Christine M. Kusminski et al.   NATURE REVIEWS DRUG DISCOVERY

Adipose tissue fibrosis, hypertrophy, and hyperplasia: Correlations with diabetes in human obesity

(2016) Lindsey A. Muir et al.   Obesity

Visceral adiposity syndrome

(2016) Heno F. Lopes et al.   Diabetology & Metabolic Syndrome

The Macrophage Switch in Obesity Development

(2016) Angela Castoldi et al.   Frontiers in Immunology

Obesogenic memory can confer long-term increases in adipose tissue but not liver inflammation and insulin resistance after weight loss

(2016) J. Schmitz et al.   Molecular Metabolism

Adipose Tissue Remodeling: Its Role in Energy Metabolism and Metabolic Disorders

(2016) Sung Sik Choe et al.   Frontiers in Endocrinology

Roles of NF-κB in Cancer and Inflammatory Diseases and Their Therapeutic Approaches

(2016) Mi Park et al.   Cells

Mitochondrial fat oxidation is essential for lipid-induced inflammation in skeletal muscle in mice

(2016) Jaycob D. Warfel et al.   Scientific Reports

Lipid accumulation product and visceral adiposity index are effective markers for identifying the metabolically obese normal-weight phenotype

(2015) Tingting Du et al.   ACTA DIABETOLOGICA

Effects of Atorvastatin (80 mg) Therapy on Quantity of Epicardial Adipose Tissue in Patients Undergoing Pulmonary Vein Isolation for Atrial Fibrillation

(2015) Filip Soucek et al.   AMERICAN JOURNAL OF CARDIOLOGY

Is the Metabolically Healthy Obesity Phenotype an Irrelevant Artifact for Public Health?

(2015) Juan Pablo Rey-López et al.   AMERICAN JOURNAL OF EPIDEMIOLOGY

Human epicardial adipose tissue has a specific transcriptomic signature depending on its anatomical peri-atrial, peri-ventricular, or peri-coronary location

(2015) Bénédicte Gaborit et al.   CARDIOVASCULAR RESEARCH

Transplanted Bone Marrow-Derived Cells Contribute to Human Adipogenesis

(2015) Mikael Rydén et al.   Cell Metabolism

Targeted Induction of Ceramide Degradation Leads to Improved Systemic Metabolism and Reduced Hepatic Steatosis

(2015) Jonathan Y. Xia et al.   Cell Metabolism

Obesity-Induced Hypertension: Interaction of Neurohumoral and Renal Mechanisms

(2015) J. E. Hall et al.   CIRCULATION RESEARCH

BMP4 and BMP Antagonists Regulate Human White and Beige Adipogenesis

(2015) Birgit Gustafson et al.   DIABETES

The cell biology of fat expansion

(2015) Joseph M. Rutkowski et al.   JOURNAL OF CELL BIOLOGY

Lipid-Overloaded Enlarged Adipocytes Provoke Insulin Resistance Independent of Inflammation

(2015) Jong In Kim et al.   MOLECULAR AND CELLULAR BIOLOGY

Current review of genetics of human obesity: from molecular mechanisms to an evolutionary perspective

(2015) David Albuquerque et al.   MOLECULAR GENETICS AND GENOMICS

NK cells link obesity-induced adipose stress to inflammation and insulin resistance

(2015) Felix M Wensveen et al.   NATURE IMMUNOLOGY

Insulin resistance and impaired adipogenesis

(2015) Birgit Gustafson et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Associations of Different Adipose Tissue Depots with Insulin Resistance: A Systematic Review and Meta-analysis of Observational Studies

(2015) Mingzhi Zhang et al.   Scientific Reports

A novel criterion for identifying metabolically obese but normal weight individuals using the product of triglycerides and glucose

(2015) S-H Lee et al.   Nutrition & Diabetes

The cell size and distribution of adipocytes from subcutaneous and visceral fat is associated with type 2 diabetes mellitus in humans

(2015) Lingling Fang et al.   Adipocyte

Dietary determinants of hepatic steatosis and visceral adiposity in overweight and obese youth at risk of type 2 diabetes

(2014) R. C. Mollard et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Association of metabolically abnormal but normal weight (MANW) and metabolically healthy but obese (MHO) individuals with arterial stiffness and carotid atherosclerosis

(2014) Hye Jin Yoo et al.   ATHEROSCLEROSIS

Serum levels of retinol-binding protein-4 are associated with the presence and severity of coronary artery disease

(2014) Vaia Lambadiari et al.   Cardiovascular Diabetology

Increased Adipocyte O2 Consumption Triggers HIF-1α, Causing Inflammation and Insulin Resistance in Obesity

(2014) Yun Sok Lee et al.   CELL

Ablation of PRDM16 and Beige Adipose Causes Metabolic Dysfunction and a Subcutaneous to Visceral Fat Switch

(2014) Paul Cohen et al.   CELL

Loss of White Adipose Hyperplastic Potential Is Associated with Enhanced Susceptibility to Insulin Resistance

(2014) Soo M. Kim et al.   Cell Metabolism

A Smooth Muscle-Like Origin for Beige Adipocytes

(2014) Jonathan Z. Long et al.   Cell Metabolism

Angiotensin 1–7 Ameliorates Diabetic Cardiomyopathy and Diastolic Dysfunction in db/db Mice by Reducing Lipotoxicity and Inflammation

(2014) Jun Mori et al.   Circulation-Heart Failure

Macrophage HIF-2  Ameliorates Adipose Tissue Inflammation and Insulin Resistance in Obesity

(2014) S. S. Choe et al.   DIABETES

Ectopic fat storage in the pancreas using 1H-MRS: importance of diabetic status and modulation with bariatric surgery-induced weight loss

(2014) B Gaborit et al.   INTERNATIONAL JOURNAL OF OBESITY

The Novel Secreted Adipokine WNT1-inducible Signaling Pathway Protein 2 (WISP2) Is a Mesenchymal Cell Activator of Canonical WNT

(2014) John R. Grünberg et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Diacylglycerol Acyltransferase-2 (DGAT2) and Monoacylglycerol Acyltransferase-2 (MGAT2) Interact to Promote Triacylglycerol Synthesis

(2014) Youzhi Jin et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Adipocyte Size Threshold Matters: Link with Risk of Type 2 Diabetes and Improved Insulin Resistance After Gastric Bypass

(2014) Aurelie Cotillard et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Roles of Chronic Low-Grade Inflammation in the Development of Ectopic Fat Deposition

(2014) Lulu Liu et al.   MEDIATORS OF INFLAMMATION

MiR-146b is a regulator of human visceral preadipocyte proliferation and differentiation and its expression is altered in human obesity

(2014) Ling Chen et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Crosstalk between Adipocytes and Immune Cells in Adipose Tissue Inflammation and Metabolic Dysregulation in Obesity

(2014) Jin Young Huh et al.   MOLECULES AND CELLS

The role of hepatic lipids in hepatic insulin resistance and type 2 diabetes

(2014) Rachel J. Perry et al.   NATURE

Biology of upper-body and lower-body adipose tissue—link to whole-body phenotypes

(2014) Fredrik Karpe et al.   Nature Reviews Endocrinology

The prevalence of metabolically healthy obesity: a systematic review and critical evaluation of the definitions used

(2014) J. P. Rey-López et al.   Obesity Reviews

Metabolically healthy obesity and risk of incident type 2 diabetes: a meta-analysis of prospective cohort studies

(2014) J. A. Bell et al.   Obesity Reviews

Evaluation of Dietary Effects on Hepatic Lipids in High Fat and Placebo Diet Fed Rats by In Vivo MRS and LC-MS Techniques

(2014) Jadegoud Yaligar et al.   PLoS One

Absence of Perilipin 2 Prevents Hepatic Steatosis, Glucose Intolerance and Ceramide Accumulation in Alcohol-Fed Mice

(2014) Rotonya M. Carr et al.   PLoS One

Adipocyte Hypertrophy, Inflammation and Fibrosis Characterize Subcutaneous Adipose Tissue of Healthy, Non-Obese Subjects Predisposed to Type 2 Diabetes

(2014) A. M. Josefin Henninger et al.   PLoS One

Rare variants in PPARG with decreased activity in adipocyte differentiation are associated with increased risk of type 2 diabetes

(2014) A. R. Majithia et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Role of diacylglycerol activation of PKCθ in lipid-induced muscle insulin resistance in humans

(2014) Julia Szendroedi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Adipocytes arise from multiple lineages that are heterogeneously and dynamically distributed

(2014) Joan Sanchez-Gurmaches et al.   Nature Communications

Characterising metabolically healthy obesity in weight-discordant monozygotic twins

(2013) J. Naukkarinen et al.   DIABETOLOGIA

Local proliferation of macrophages in adipose tissue during obesity-induced inflammation

(2013) Julia Haase et al.   DIABETOLOGIA

A comparative perspective on lipid storage in animals

(2013) K. Birsoy et al.   JOURNAL OF CELL SCIENCE

Tracking adipogenesis during white adipose tissue development, expansion and regeneration

(2013) Qiong A Wang et al.   NATURE MEDICINE

Adipose tissue browning and metabolic health

(2013) Alexander Bartelt et al.   Nature Reviews Endocrinology

Subcutaneous adipose cell size and distribution: Relationship to insulin resistance and body fat

(2013) T. McLaughlin et al.   Obesity

Pathophysiology of Human Visceral Obesity: An Update

(2013) André Tchernof et al.   PHYSIOLOGICAL REVIEWS

WISP2 regulates preadipocyte commitment and PPAR  activation by BMP4

(2013) A. Hammarstedt et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mechanisms of insulin resistance in obesity

(2013) Jianping Ye   Frontiers of Medicine

Adipogenesis: From Stem Cell to Adipocyte

(2012) Qi Qun Tang et al.   Annual Review of Biochemistry

Secretory Products From Epicardial Adipose Tissue of Patients With Type 2 Diabetes Mellitus Induce Cardiomyocyte Dysfunction

(2012) Sabrina Greulich et al.   CIRCULATION

The WNT Inhibitor Dickkopf 1 and Bone Morphogenetic Protein 4 Rescue Adipogenesis in Hypertrophic Obesity in Humans

(2012) Birgit Gustafson et al.   DIABETES

The adipose organ at a glance

(2012) S. Cinti   Disease Models & Mechanisms

Secretion of adipokines by human adipose tissue in vivo: partitioning between capillary and lymphatic transport

(2011) Norman E. Miller et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Depot-Specific Differences and Insufficient Subcutaneous Adipose Tissue Angiogenesis in Human Obesity

(2011) Olga Gealekman et al.   CIRCULATION

Ectopic Fat Depots and Cardiovascular Disease

(2011) Kathryn A. Britton et al.   CIRCULATION

Assessing Adiposity

(2011) Marc-Andre Cornier et al.   CIRCULATION

Targeting Curcusomes to Inflammatory Dendritic Cells Inhibits NF-κB and Improves Insulin Resistance in Obese Mice

(2011) Suman Kumar Yekollu et al.   DIABETES

Myocardial, Perivascular, and Epicardial Fat

(2011) P. Iozzo   DIABETES CARE

Randomized comparison of reduced fat and reduced carbohydrate hypocaloric diets on intrahepatic fat in overweight and obese human subjects

(2011) Sven Haufe et al.   HEPATOLOGY

Adipose tissue remodeling and obesity

(2011) Kai Sun et al.   JOURNAL OF CLINICAL INVESTIGATION

Inflammatory links between obesity and metabolic disease

(2011) Carey N. Lumeng et al.   JOURNAL OF CLINICAL INVESTIGATION

Hepatic insulin resistance in mice with hepatic overexpression of diacylglycerol acyltransferase 2

(2011) F. R. Jornayvaz et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Endoplasmic Reticulum Stress and the Inflammatory Basis of Metabolic Disease

(2010) Gökhan S. Hotamisligil   CELL

The distinction of metabolically ‘healthy’ from ‘unhealthy’ obese individuals

(2010) Matthias Blüher   CURRENT OPINION IN LIPIDOLOGY

Transcriptional control of preadipocyte determination by Zfp423

(2010) Rana K. Gupta et al.   NATURE

Adipocyte Turnover: Relevance to Human Adipose Tissue Morphology

(2009) E. Arner et al.   DIABETES

Abdominal Subcutaneous Adipose Tissue: A Protective Fat Depot?

(2009) S. A. Porter et al.   DIABETES CARE

Markers of de novo lipogenesis in adipose tissue: associations with small adipocytes and insulin sensitivity in humans

(2009) R. Roberts et al.   DIABETOLOGIA

BMP signaling pathway is required for commitment of C3H10T1/2 pluripotent stem cells to the adipocyte lineage

(2009) H. Huang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Exercise-induced alterations in intramyocellular lipids and insulin resistance: the athlete's paradox revisited

(2008) John J. Dubé et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

The Obese Without Cardiometabolic Risk Factor Clustering and the Normal Weight With Cardiometabolic Risk Factor Clustering

(2008) Rachel P. Wildman   ARCHIVES OF INTERNAL MEDICINE

Reduced Adipose Tissue Oxygenation in Human Obesity: Evidence for Rarefaction, Macrophage Chemotaxis, and Inflammation Without an Angiogenic Response

(2008) M. Pasarica et al.   DIABETES

Skeletal Muscle-Specific Deletion of Lipoprotein Lipase Enhances Insulin Signaling in Skeletal Muscle but Causes Insulin Resistance in Liver and Other Tissues

(2008) H. Wang et al.   DIABETES

Insulin Resistance and Hyperinsulinemia: You can't have one without the other

(2008) S. H. Kim et al.   DIABETES CARE

Basal lipolysis, not the degree of insulin resistance, differentiates large from small isolated adipocytes in high-fat fed mice

(2008) S. Wueest et al.   DIABETOLOGIA

PPAR  and C/EBP factors orchestrate adipocyte biology via adjacent binding on a genome-wide scale

(2008) M. I. Lefterova et al.   GENES & DEVELOPMENT

Liver lipid metabolism

(2008) P. Nguyen et al.   JOURNAL OF ANIMAL PHYSIOLOGY AND ANIMAL NUTRITION

Dynamics of fat cell turnover in humans

(2008) Kirsty L. Spalding et al.   NATURE

Paradoxical effects of increased expression of PGC-1  on muscle mitochondrial function and insulin-stimulated muscle glucose metabolism

(2008) C. S. Choi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Adipogenesis and WNT signalling

(2008) Constantinos Christodoulides et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM