Muscle cells challenged with saturated fatty acids mount an autonomous inflammatory response that activates macrophages

Combined Influence of Insulin Resistance, Overweight/Obesity, and Fatty Liver as Risk Factors for Type 2 Diabetes

(2012) K.-C. Sung et al.   DIABETES CARE

Skeletal muscle-specific overproduction of constitutively activated c-Jun N-terminal kinase (JNK) induces insulin resistance in mice

(2012) D. C. Henstridge et al.   DIABETOLOGIA

Contractile activity of human skeletal muscle cells prevents insulin resistance by inhibiting pro-inflammatory signalling pathways

(2012) S. Lambernd et al.   DIABETOLOGIA

The Lipid Peroxidation By-Product 4-Hydroxy-2-Nonenal (4-HNE) Induces Insulin Resistance in Skeletal Muscle through Both Carbonyl and Oxidative Stress

(2012) Nicolas J. Pillon et al.   ENDOCRINOLOGY

High Body Mass Index is an Important Risk Factor for the Development of Type 2 Diabetes

(2012) Hironobu Sanada et al.   INTERNAL MEDICINE

Saturated fatty acids activate TLR-mediated proinflammatory signaling pathways

(2012) Shurong Huang et al.   JOURNAL OF LIPID RESEARCH

Inflammatory Mechanisms in Obesity

(2011) Margaret F. Gregor et al.   Annual Review of Immunology

Counter-modulation of fatty acid-induced pro-inflammatory nuclear factor κB signalling in rat skeletal muscle cells by AMP-activated protein kinase

(2011) Charlotte J. Green et al.   BIOCHEMICAL JOURNAL

Impaired Rho GTPase activation abrogates cell polarization and migration in macrophages with defective lipolysis

(2011) Elma Aflaki et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Inflammation Is Necessary for Long-Term but Not Short-Term High-Fat Diet-Induced Insulin Resistance

(2011) Y. S. Lee et al.   DIABETES

Elevated NF-κB Activation Is Conserved in Human Myocytes Cultured From Obese Type 2 Diabetic Patients and Attenuated by AMP-Activated Protein Kinase

(2011) Charlotte J. Green et al.   DIABETES

Inflammatory signaling in macrophages: Transitions from acute to tolerant and alternative activation states

(2011) Lionel B. Ivashkiv   EUROPEAN JOURNAL OF IMMUNOLOGY

ERK-MAPK Drives Lamellipodia Protrusion by Activating the WAVE2 Regulatory Complex

(2011) Michelle C. Mendoza et al.   MOLECULAR CELL

Palmitate-Activated Macrophages Confer Insulin Resistance to Muscle Cells by a Mechanism Involving Protein Kinase C θ and ε

(2011) Girish Kewalramani et al.   PLoS One

Circulating palmitoleic acid and risk of metabolic abnormalities and new-onset diabetes

(2010) Dariush Mozaffarian et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

NF-κB activity in muscle from obese and type 2 diabetic subjects under basal and exercise-stimulated conditions

(2010) Puntip Tantiwong et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Different effects of oleate vs. palmitate on mitochondrial function, apoptosis, and insulin signaling in L6 skeletal muscle cells: role of oxidative stress

(2010) Larysa Yuzefovych et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

NOD2 Activation Induces Muscle Cell-Autonomous Innate Immune Responses and Insulin Resistance

(2010) Akhilesh K. Tamrakar et al.   ENDOCRINOLOGY

Muscle inflammatory response and insulin resistance: synergistic interaction between macrophages and fatty acids leads to impaired insulin action

(2009) Vijayalakshmi Varma et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Macrophage Diversity and Polarization in Atherosclerosis

(2009) Alberto Mantovani et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Muscle resident macrophages control the immune cell reaction in a mouse model of notexin-induced myoinjury

(2009) Madly Brigitte et al.   ARTHRITIS AND RHEUMATISM

Cellular mechanisms of insulin resistance: role of stress-regulated serine kinases and insulin receptor substrates (IRS) serine phosphorylation

(2009) Jean-François Tanti et al.   CURRENT OPINION IN PHARMACOLOGY

Circulating Palmitoleate Strongly and Independently Predicts Insulin Sensitivity in Humans

(2009) N. Stefan et al.   DIABETES CARE

Cyclooxygenase 2 Inhibition Exacerbates Palmitate-Induced Inflammation and Insulin Resistance in Skeletal Muscle Cells

(2009) Teresa Coll et al.   ENDOCRINOLOGY

A CREB-C/EBP  cascade induces M2 macrophage-specific gene expression and promotes muscle injury repair

(2009) D. Ruffell et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Meta-analysis of expression signatures of muscle atrophy: gene interaction networks in early and late stages

(2008) Enrica Calura et al.   BMC GENOMICS

Ablation of CD11c-Positive Cells Normalizes Insulin Sensitivity in Obese Insulin Resistant Animals

(2008) David Patsouris et al.   Cell Metabolism

Dual and Beneficial Roles of Macrophages During Skeletal Muscle Regeneration

(2008) Bénédicte Chazaud et al.   EXERCISE AND SPORT SCIENCES REVIEWS

S6K Directly Phosphorylates IRS-1 on Ser-270 to Promote Insulin Resistance in Response to TNF-α Signaling through IKK2

(2008) Jin Zhang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Tlr-4 Deficiency Selectively Protects Against Obesity Induced by Diets High in Saturated Fat

(2008) Jeremy E. Davis et al.   Obesity