Proteoglycans in Biomedicine: Resurgence of an Underexploited Class of ECM Molecules

Small Leucine Rich Proteoglycans (decorin, biglycan and lumican) in cancer

(2019) Sandeep Appunni et al.   CLINICA CHIMICA ACTA

Biomimetic proteoglycans diffuse throughout articular cartilage and localize within the pericellular matrix

(2019) Evan R. Phillips et al.   JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A

A Synthetic Bottle-Brush Polyelectrolyte Reduces Friction and Wear of Intact and Previously Worn Cartilage

(2019) Benjamin A. Lakin et al.   ACS Biomaterials-Science & Engineering

Aggrecan-like biomimetic proteoglycans (BPGs) composed of natural chondroitin sulfate bristles grafted onto a poly(acrylic acid) core for molecular engineering of the extracellular matrix

(2018) K. Prudnikova et al.   Acta Biomaterialia

Decorin-mediated oncosuppression - a potential future adjuvant therapy for human epithelial cancers

(2018) Annele Orvokki Sainio et al.   BRITISH JOURNAL OF PHARMACOLOGY

Star-like glycosaminoglycans with superior bioactivity assemble with proteins into microfibers

(2018) Ramon Novoa-Carballal et al.   CHEMISTRY-A EUROPEAN JOURNAL

Specific glycosaminoglycan chain length and sulfation patterns are required for cell uptake of tauversusα-synuclein and β-amyloid aggregates

(2018) Barbara E. Stopschinski et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Small Leucine-Rich Proteoglycans in Renal Inflammation: Two Sides of the Coin

(2018) Madalina V. Nastase et al.   JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY

Sweet, yet underappreciated: Proteoglycans and extracellular matrix remodeling in heart disease

(2018) Geir Christensen et al.   MATRIX BIOLOGY

Non-Glycanated Biglycan and LTBP4: Leveraging the extracellular matrix for Duchenne Muscular Dystrophy therapeutics

(2018) Justin R. Fallon et al.   MATRIX BIOLOGY

Flexible Roles for Proteoglycan Sulfation and Receptor Signaling

(2018) Panpan Yu et al.   TRENDS IN NEUROSCIENCES

A synthetic polymeric biolubricant imparts chondroprotection in a rat meniscal tear model

(2018) Michel Wathier et al.   BIOMATERIALS

Proteoglycan Chemical Diversity Drives Multifunctional Cell Regulation and Therapeutics

(2018) Nikos K. Karamanos et al.   CHEMICAL REVIEWS

Perlecan Domain V Inhibits Amyloid-β Induced Brain Endothelial Cell Toxicity and Restores Angiogenic Function

(2018) Christi Parham et al.   JOURNAL OF ALZHEIMERS DISEASE

Tuning carbohydrate density enhances protein binding and inhibition by glycosylated β-sheet peptide nanofibers

(2018) Antonietta Restuccia et al.   Biomaterials Science

Protein-Anchoring Therapy of Biglycan for Mdx Mouse Model of Duchenne Muscular Dystrophy

(2017) Mikako Ito et al.   HUMAN GENE THERAPY

An Oncolytic Adenovirus Encoding Decorin and Granulocyte Macrophage Colony Stimulating Factor Inhibits Tumor Growth in a Colorectal Tumor Model by Targeting Pro-Tumorigenic Signals and via Immune Activation

(2017) Zhao Liu et al.   HUMAN GENE THERAPY

Decorin-evoked paternally expressed gene 3 (PEG3) is an upstream regulator of the transcription factor EB (TFEB) in endothelial cell autophagy

(2017) Thomas Neill et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Proteoglycan 4 and hyaluronan as boundary lubricants for model contact lens hydrogels

(2017) Michael Samsom et al.   JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS

Hyaluronan incorporation into model contact lens hydrogels as a built-in lubricant: Effect of hydrogel composition and proteoglycan 4 as a lubricant in solution

(2017) Michael Samsom et al.   JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS

Reduction of friction by recombinant human proteoglycan 4 in IL-1α stimulated bovine cartilage explants

(2017) Katherine M. Larson et al.   JOURNAL OF ORTHOPAEDIC RESEARCH

Recombinant human lubricin for prevention of postoperative intra-abdominal adhesions in a rat model

(2017) Jaewook Oh et al.   JOURNAL OF SURGICAL RESEARCH

Medical application of glycosaminoglycans: a review

(2017) Alexander Köwitsch et al.   Journal of Tissue Engineering and Regenerative Medicine

Endothelial glycocalyx in health and kidney disease: Rising star or false Dawn?

(2017) Hui Liew et al.   NEPHROLOGY

A Two-Week, Randomized, Double-masked Study to Evaluate Safety and Efficacy of Lubricin (150 μg/mL) Eye Drops Versus Sodium Hyaluronate (HA) 0.18% Eye Drops (Vismed®) in Patients with Moderate Dry Eye Disease

(2017) Alessandro Lambiase et al.   Ocular Surface

Recombinant fibromodulin and decorin effects on NF-κB and TGFβ1 in the 4T1 breast cancer cell line

(2017) Ladan Dawoody Nejad et al.   Oncology Letters

Recombinant Decorin Fusion Protein Attenuates Murine Abdominal Aortic Aneurysm Formation and Rupture

(2017) Yue Shen et al.   Scientific Reports

Lumican Peptides: Rational Design Targeting ALK5/TGFBRI

(2017) Tarsis Ferreira Gesteira et al.   Scientific Reports

Syndecan-4 enhances PDGF-BB activity in diabetic wound healing

(2016) Subhamoy Das et al.   Acta Biomaterialia

Endostatin and endorepellin: A common route of action for similar angiostatic cancer avengers

(2016) Chiara Poluzzi et al.   ADVANCED DRUG DELIVERY REVIEWS

Lumican alleviates hypertrophic scarring by suppressing integrin-FAK signaling

(2016) Yuqian Zhao et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Glypican-1 nanoliposomes for potentiating growth factor activity in therapeutic angiogenesis

(2016) Anthony J. Monteforte et al.   BIOMATERIALS

Fibromodulin reprogrammed cells: A novel cell source for bone regeneration

(2016) Chen-Shuang Li et al.   BIOMATERIALS

Silk biomaterials functionalized with recombinant domain V of human perlecan modulate endothelial cell and platelet interactions for vascular applications

(2016) Jelena Rnjak-Kovacina et al.   COLLOIDS AND SURFACES B-BIOINTERFACES

Perlecan Domain V Inhibits Amyloid-β Induced Activation of the α2β1 Integrin-Mediated Neurotoxic Signaling Cascade

(2016) Christi L. Parham et al.   JOURNAL OF ALZHEIMERS DISEASE

The glycocalyx and its significance in human medicine

(2016) J. M. Tarbell et al.   JOURNAL OF INTERNAL MEDICINE

Decorin interacting network: A comprehensive analysis of decorin-binding partners and their versatile functions

(2016) Maria A. Gubbiotti et al.   MATRIX BIOLOGY

Decorin reduces hypertrophic scarring through inhibition of the TGF-β1/Smad signaling pathway in a rat osteomyelitis model

(2016) Peng Wang et al.   Experimental and Therapeutic Medicine

Oncolytic adenovirus coexpressing interleukin-12 and decorin overcomes Treg-mediated immunosuppression inducing potent antitumor effects in a weakly immunogenic tumor model

(2016) Eonju Oh et al.   Oncotarget

Identification of Glypican-3 as a potential metastasis suppressor gene in gastric cancer

(2016) Shiwei Han et al.   Oncotarget

Syndesome Therapeutics for Enhancing Diabetic Wound Healing

(2016) Subhamoy Das et al.   Advanced Healthcare Materials

Syndecan-4 Enhances Therapeutic Angiogenesis after Hind Limb Ischemia in Mice with Type 2 Diabetes

(2016) Subhamoy Das et al.   Advanced Healthcare Materials

Biomimetic Molecules Lower Catabolic Expression and Prevent Chondroitin Sulfate Degradation in an Osteoarthritic ex Vivo Model

(2016) Shaili Sharma et al.   ACS Biomaterials-Science & Engineering

Biomimetic Molecules Lower Catabolic Expression and Prevent Chondroitin Sulfate Degradation in an Osteoarthritic ex Vivo Model

(2016) Shaili Sharma et al.   ACS Biomaterials Science & Engineering

Lubricin/Proteoglycan 4 binds to and regulates the activity of Toll-Like Receptors In Vitro

(2016) S.M. Iqbal et al.   Scientific Reports

Synthesis and characterization of a lubricin mimic (mLub) to reduce friction and adhesion on the articular cartilage surface

(2015) Alexandra Lawrence et al.   BIOMATERIALS

Self-Assembled Glycopeptide Nanofibers as Modulators of Galectin-1 Bioactivity

(2015) Antonietta Restuccia et al.   Cellular and Molecular Bioengineering

The role of perlecan and endorepellin in the control of tumor angiogenesis and endothelial cell autophagy

(2015) Stephen Douglass et al.   CONNECTIVE TISSUE RESEARCH

Sugar-dependent modulation of neuronal development, regeneration, and plasticity by chondroitin sulfate proteoglycans

(2015) Gregory M. Miller et al.   EXPERIMENTAL NEUROLOGY

Systemic Delivery of an Oncolytic Adenovirus Expressing Decorin for the Treatment of Breast Cancer Bone Metastases

(2015) Yuefeng Yang et al.   HUMAN GENE THERAPY

The small leucine-rich repeat proteoglycans in tissue repair and atherosclerosis

(2015) A. Hultgårdh-Nilsson et al.   JOURNAL OF INTERNAL MEDICINE

Decorin mimic promotes endothelial cell health in endothelial monolayers and endothelial-smooth muscle co-cultures

(2015) Rebecca A. Scott et al.   Journal of Tissue Engineering and Regenerative Medicine

Pivotal role for decorin in angiogenesis

(2015) Hannu Järveläinen et al.   MATRIX BIOLOGY

Proteoglycan form and function: A comprehensive nomenclature of proteoglycans

(2015) Renato V. Iozzo et al.   MATRIX BIOLOGY

Enhanced Achilles tendon healing by fibromodulin gene transfer

(2015) Anthony Delalande et al.   Nanomedicine-Nanotechnology Biology and Medicine

Decorin Mimic Regulates Platelet-Derived Growth Factor and Interferon-γ Stimulation of Vascular Smooth Muscle Cells

(2014) Rebecca A. Scott et al.   BIOMACROMOLECULES

Synthesis and Characterization of Proteoglycan-Mimetic Graft Copolymers with Tunable Glycosaminoglycan Density

(2014) Laura W. Place et al.   BIOMACROMOLECULES

Aggrecan-Mimetic, Glycosaminoglycan-Containing Nanoparticles for Growth Factor Stabilization and Delivery

(2014) Laura W. Place et al.   BIOMACROMOLECULES

Glycocalyx Remodeling with Proteoglycan Mimetics Promotes Neural Specification in Embryonic Stem Cells

(2014) Mia L. Huang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

The potential role of perlecan domain V as novel therapy in vascular dementia

(2014) Aileen Marcelo et al.   METABOLIC BRAIN DISEASE

Decorin blocks scarring and cystic cavitation in acute and induces scar dissolution in chronic spinal cord wounds

(2014) Zubair Ahmed et al.   NEUROBIOLOGY OF DISEASE

Fibromodulin promoted in vitro and in vivo angiogenesis

(2013) Jia Jian et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Glycotherapy: New Advances Inspire a Reemergence of Glycans in Medicine

(2013) Jason E. Hudak et al.   CHEMISTRY & BIOLOGY

Recombinant production of proteoglycans and their bioactive domains

(2013) Megan S. Lord et al.   FEBS Journal

Syndecan-4 signaling at a glance

(2013) A. Elfenbein et al.   JOURNAL OF CELL SCIENCE

A Large-Molecular-Weight Polyanion, Synthesized via Ring-Opening Metathesis Polymerization, as a Lubricant for Human Articular Cartilage

(2013) Michel Wathier et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Biomimetic Aggrecan Reduces Cartilage Extracellular Matrix From Degradation and Lowers Catabolic Activity in Ex Vivo and In Vivo Models

(2013) Shaili Sharma et al.   MACROMOLECULAR BIOSCIENCE

Extracellular Matrix Protein Lumican Promotes Clearance and Resolution of Pseudomonas aeruginosa Keratitis in a Mouse Model

(2013) Hanjuan Shao et al.   PLoS One

Lumican Accelerates Wound Healing by Enhancing α2β1 Integrin-Mediated Fibroblast Contractility

(2013) Xiao-Jin Liu et al.   PLoS One

Lumican Binds ALK5 to Promote Epithelium Wound Healing

(2013) Osamu Yamanaka et al.   PLoS One

Decorin Mimic Inhibits Vascular Smooth Muscle Proliferation and Migration

(2013) Rebecca A. Scott et al.   PLoS One

Lumican – Derived Peptides Inhibit Melanoma Cell Growth and Migration

(2013) Katarzyna Pietraszek et al.   PLoS One

Decorin

(2012) Thomas Neill et al.   AMERICAN JOURNAL OF PATHOLOGY

Diminished cartilage-lubricating ability of human osteoarthritic synovial fluid deficient in proteoglycan 4: Restoration through proteoglycan 4 supplementation

(2012) Taryn E. Ludwig et al.   ARTHRITIS AND RHEUMATISM

Reprogramming of human fibroblasts into multipotent cells with a single ECM proteoglycan, fibromodulin

(2012) Zhong Zheng et al.   BIOMATERIALS

Injectable perlecan domain 1-hyaluronan microgels potentiate the cartilage repair effect of BMP2 in a murine model of early osteoarthritis

(2012) Padma P Srinivasan et al.   Biomedical Materials

Terminal-end functionalization of chondroitin sulfate for the synthesis of biomimetic proteoglycans

(2012) S. Sarkar et al.   CARBOHYDRATE POLYMERS

Biglycan: a promising new therapeutic for neuromuscular and musculoskeletal diseases

(2012) Marian F Young et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

Extracellular Matrix Lumican Promotes Bacterial Phagocytosis, andLum−/−Mice Show IncreasedPseudomonas aeruginosaLung Infection Severity

(2012) HanJuan Shao et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Perlecan Domain V Induces VEGf Secretion in Brain Endothelial Cells through Integrin α5β1 and ERK-Dependent Signaling Pathways

(2012) Douglas N. Clarke et al.   PLoS One

Synthesis and characterization of an aggrecan mimic

(2011) Jonathan C. Bernhard et al.   Acta Biomaterialia

The inhibition of platelet adhesion and activation on collagen during balloon angioplasty by collagen-binding peptidoglycans

(2011) John E. Paderi et al.   BIOMATERIALS

Perlecan domain V is neuroprotective and proangiogenic following ischemic stroke in rodents

(2011) Boyeon Lee et al.   JOURNAL OF CLINICAL INVESTIGATION

Collagen-Binding Peptidoglycans Inhibit MMP Mediated Collagen Degradation and Reduce Dermal Scarring

(2011) Kate Stuart et al.   PLoS One

Fibromodulin regulates collagen fibrillogenesis during peripheral corneal development

(2010) Shoujun Chen et al.   DEVELOPMENTAL DYNAMICS

Fibromodulin Suppresses Nuclear Factor-κB Activity by Inducing the Delayed Degradation of IKBA via a JNK-dependent Pathway Coupled to Fibroblast Apoptosis

(2010) Yong-Hun Lee et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Acidic Polysaccharide Mimics via Ring-Opening Metathesis Polymerization

(2010) Michel Wathier et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

The role of small leucine-rich proteoglycans in collagen fibrillogenesis

(2010) Sebastian Kalamajski et al.   MATRIX BIOLOGY

Biglycan recruits utrophin to the sarcolemma and counters dystrophic pathology in mdx mice

(2010) A. R. Amenta et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

End-functionalized glycopolymers as mimetics of chondroitin sulfate proteoglycans

(2010) Song-Gil Lee et al.   Chemical Science

Perlecan domain I-conjugated, hyaluronic acid-based hydrogel particles for enhanced chondrogenic differentiation via BMP-2 release

(2009) Amit K. Jha et al.   BIOMATERIALS

Lumcorin: A leucine-rich repeat 9-derived peptide from human lumican inhibiting melanoma cell migration

(2009) Cédric Zeltz et al.   FEBS LETTERS

Adenovirus-mediated gene transfer of fibromodulin inhibits neointimal hyperplasia in an organ culture model of human saphenous vein graft disease

(2009) P Ranjzad et al.   GENE THERAPY

Perlecan regulates developmental angiogenesis by modulating the VEGF-VEGFR2 axis

(2009) Jason J. Zoeller et al.   MATRIX BIOLOGY

Decorin Core Protein (Decoron) Shape Complements Collagen Fibril Surface Structure and Mediates Its Binding

(2009) Joseph P. R. O. Orgel et al.   PLoS One

The Basic Science of Articular Cartilage: Structure, Composition, and Function

(2009) Alice J. Sophia Fox et al.   Sports Health-A Multidisciplinary Approach

Design of a Synthetic Collagen-Binding Peptidoglycan that Modulates Collagen Fibrillogenesis

(2008) John E. Paderi et al.   BIOMACROMOLECULES

Biological Functions of the Small Leucine-rich Proteoglycans: From Genetics to Signal Transduction

(2008) Liliana Schaefer et al.   JOURNAL OF BIOLOGICAL CHEMISTRY