Article
Medicine, General & Internal
Tokuko Hosoya, Goshi Oda, Tsuyoshi Nakagawa, Iichiroh Onishi, Tadashi Hosoya, Megumi Ishiguro, Toshiaki Ishikawa, Hiroyuki Uetake
Summary: The study found that the levels of DCN in plasma varied at different pathological stages in breast cancer patients, suggesting it could be a biomarker for advanced-stage patients. The results indicate that DCN plays an important regulatory role in the development of breast cancer.
JOURNAL OF CLINICAL MEDICINE
(2021)
Review
Biochemistry & Molecular Biology
Shingo Saio, Kanna Konishi, Hirofumi Hohjoh, Yuki Tamura, Teruaki Masutani, Arunasiri Iddamalgoda, Masamitsu Ichihashi, Hiroshi Hasegawa, Ken-ichi Mizutani
Summary: Endothelial cells acquire different phenotypes to establish functional vascular networks, with Vascular Endothelial Growth Factor (VEGF) playing a key role in regulating vascular development. The spatiotemporal localization of angiogenic factors and the extracellular matrix are crucial for proper regulation of angiogenesis. Close interactions between the vascular and neural systems involve shared molecular mechanisms to coordinate developmental and regenerative processes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Orthopedics
B. Han, Q. Li, C. Wang, P. Chandrasekaran, Y. Zhou, L. Qin, X. S. Liu, M. Enomoto-Iwamoto, D. Kong, R. V. Iozzo, D. E. Birk, L. Han
Summary: In post-traumatic osteoarthritis (PTOA), decorin plays a more crucial role than biglycan in regulating cartilage degeneration, while biglycan is more important in regulating subchondral bone structure. The two have distinct activities and modest synergy in the pathogenesis of PTOA.
OSTEOARTHRITIS AND CARTILAGE
(2021)
Review
Biochemistry & Molecular Biology
Carolyn G. Chen, Renato Iozzo
Summary: The extracellular matrix (ECM) plays a critical role in maintaining tissue homeostasis and has a significant impact on cancer initiation and progression. The emerging field of matrix biology focuses on the role of proteoglycans in regulating autophagy, a cellular process that has complex and context-dependent functions in cancer.
Article
Multidisciplinary Sciences
Emmanuel Ledoult, Manel Jendoubi, Aurore Collet, Thomas Guerrier, Alexis Largy, Silvia Speca, Solange Vivier, Fabrice Bray, Martin Figeac, Eric Hachulla, Myriam Labalette, Frederic Lepretre, Sheherazade Sebda, Sebastien Sanges, Christian Rolando, Vincent Sobanski, Sylvain Dubucquoi, David Launay
Summary: We provide a novel approach to identify a gene signature for assessing murine fibroblast polarization. Transcriptomic and proteomic profiles were obtained from mouse embryonic fibroblasts (MEFs) subjected to different polarizations. We found a significant number of differentially expressed genes and proteins under different polarization states. By analyzing the differentially expressed genes, we created a gene signature to evaluate fibroblast polarization. This gene signature accurately reflected the polarization states of fibroblasts in an experimental murine model.
SCIENTIFIC REPORTS
(2022)
Article
Chemistry, Multidisciplinary
Jihun Song, Gun-Jae Jeong, Tae-Jin Lee, Sung-Won Kim, Yu-Jin Kim, Suk Ho Bhang
Summary: A new method of delivering ECMs-enriched human adipose derived stem cells using a novel polymer significantly improved therapeutic angiogenesis in ischemic wound sites, enhancing blood flow and blood vessel regeneration in mouse models compared to traditional enzyme-based methods.
JOURNAL OF INDUSTRIAL AND ENGINEERING CHEMISTRY
(2021)
Review
Oncology
Valentina Diehl, Lisa Sophie Huber, Jonel Trebicka, Malgorzata Wygrecka, Renato V. Iozzo, Liliana Schaefer
Summary: Decorin and biglycan play critical roles in tumor biology by influencing key processes that affect tumor growth and progression. Despite their structural homology, these proteoglycans interact with different cell surface receptors, modulating distinct signaling pathways that ultimately impact cancer development.
FRONTIERS IN ONCOLOGY
(2021)
Article
Anatomy & Morphology
Alexandre Veronez, Leticia Albertini Pires, Andrea Aparecida de Aro, Maria Esmeria Corezola do Amaral, Marcelo Augusto Marretto Esquisatto
Summary: The study found that physical exercise in water has a positive effect on the structural organization and chemical composition of fibrocartilage in the tendons of diabetic rats, helping to preserve tendon structure.
Article
Cell Biology
Thomas Neill, Christopher Xie, Renato V. Iozzo
Summary: This study demonstrates that Decorin triggers mitochondrial depolarization in several types of cells, including breast carcinoma, HeLa, and endothelial cells. The bioactivity of Decorin is mediated by the MET receptor and its tyrosine kinase, as well as two mitochondrial proteins, mitostatin and mitofusin 2.
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
(2022)
Article
Cell Biology
Maria Pilar Solis-Hernandez, Carla Martin, Beatriz Garcia, Natalia Perez-Lopez, Yolanda Garcia-Mesa, Sara Gonzalez-Fernandez, Olivia Garcia-Suarez, Jesus Merayo, Ivan Fernandez-Vega, Luis M. Quiros
Summary: The study found that SLRPs exhibit different transcription and protein expression changes in CCs, which are related to patient survival data. There are distinct patterns of SLRP alterations in right- and left-sided colon tumors, with more deregulations observed in LSCCs. The research suggests that SLRPs may impact cell proliferation and serve as new differential markers for RS and LSCCs.
Article
Pharmacology & Pharmacy
Aqsa Iqbal, Ulrike May, Stuart N. Prince, Tero A. H. Jarvinen, Ahlke Heydemann
Summary: Targeted delivery of therapeutic decorin through vascular homing peptide significantly reduces skeletal muscle fibrosis and pathology, while improving functional characteristics of skeletal muscle in mouse models of muscular dystrophy.
Article
Cardiac & Cardiovascular Systems
Toshihiro Tsuruda, Atsushi Yamashita, Misa Otsu, Masanori Koide, Yuko Nakamichi, Yoko Sekita-Hatakeyama, Kinta Hatakeyama, Taro Funamoto, Etsuo Chosa, Yujiro Asada, Nobuyuki Udagawa, Johji Kato, Kazuo Kitamura
Summary: This study found that osteoprotegerin protects against aortic rupture and dissection in Ang II-induced hypertension by inhibiting receptor activator of nuclear factor-kappa B ligand activity and periostin expression.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2022)
Article
Biochemistry & Molecular Biology
Mari E. Strand, Maarten Vanhaverbeke, Michiel T. H. M. Henkens, Maurits A. Sikking, Karoline B. Rypdal, Bjorn Braathen, Vibeke M. Almaas, Theis Tonnessen, Geir Christensen, Stephane Heymans, Ida G. Lunde
Summary: Circulating biomarkers reflecting cardiac inflammation are needed to improve the diagnostics and guide the treatment of heart failure patients. The shedding of syndecan-4 from cardiac myocytes and fibroblasts was attenuated by immunomodulatory therapy. However, the levels of syndecan-4 did not reflect cardiac inflammatory status in patients with heart disease.
Article
Orthopedics
Zakary M. Beach, Kelsey A. Bonilla, Mihir S. Dekhne, Mei Sun, Thomas H. Adams, Sheila M. Adams, Stephanie N. Weiss, Ashley B. Rodriguez, Snehal S. Shetye, David E. Birk, Louis J. Soslowsky
Summary: It was found in mature mice that knockdown of biglycan led to extensive changes in tendon structure and mechanics, while knockdown of decorin had minimal effects. Specifically, biglycan knockdown resulted in reductions in several mechanical parameters and increased collagen fiber realignment during loading. Furthermore, both decorin and biglycan knockdown led to similar alterations in tendon microstructure.
JOURNAL OF ORTHOPAEDIC RESEARCH
(2022)
Article
Dentistry, Oral Surgery & Medicine
Miaomiao Liu, Wei Wang, Songlin Piao, Yuchen Shen, Zhengmiao Li, Wentong Ding, Jichen Li, Wuliji Saiyin
Summary: This study investigated the expression of BGN and DCN in oral squamous cell carcinoma (OSCC) and found that the up-regulation of BGN and down-regulation of DCN were associated with the malignant degree and survival rate of OSCC.
JOURNAL OF ORAL PATHOLOGY & MEDICINE
(2023)
Article
Cell Biology
Marie C. Nyman, Annele O. Sainio, Mirka M. Pennanen, Riikka J. Lund, Sanna Vuorikoski, Jari T. T. Sundstrom, Hannu T. Jarvelainen
JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY
(2015)
Article
Multidisciplinary Sciences
Mikko Konki, Kalyan Pasumarthy, Maia Malonzo, Annele Sainio, Cristina Valensisi, Mirva Soderstrom, Maheswara Reddy Emani, Aki Stubb, Elisa Narva, Bishwa Ghimire, Asta Laiho, Hannu Jarvelainen, Riitta Lahesmaa, Harri Lahdesmaki, R. David Hawkins, Riikka J. Lund
SCIENTIFIC REPORTS
(2016)
Review
Pharmacology & Pharmacy
Annele Orvokki Sainio, Hannu Tapio Jarvelainen
BRITISH JOURNAL OF PHARMACOLOGY
(2019)
Article
Biochemistry & Molecular Biology
Annele Sainio, Tiina Jokela, Markku I. Tammi, Hannu Jarvelainen
Article
Cell Biology
Pia Bostrom, Annele Sainio, Tanja Kakko, Mikko Savontaus, Mirva Soderstrom, Hannu Jarvelainen
HISTOCHEMISTRY AND CELL BIOLOGY
(2013)
Article
Multidisciplinary Sciences
Annele Sainio, Marie Nyman, Riikka Lund, Sanna Vuorikoski, Pia Bostrom, Matti Laato, Peter J. Bostrom, Hannu Jarvelainen
Article
Medicine, Research & Experimental
Mervi Oikonen, Maria Wendelin-Saarenhovi, Niina Siitonen, Annele Sainio, Markus Juonala, Mika Kahonen, Leo-Pekka Lyytikainen, Ilkka Seppala, Terho Lehtimaki, Jorma S. A. Viikari, Hannu Jarvelainen, Olli T. Raitakari
SCANDINAVIAN JOURNAL OF CLINICAL & LABORATORY INVESTIGATION
(2012)
Article
Cell Biology
Marie C. Nyman, Anne B. Jokilammi, Pia C. Bostrom, Samu H. Kurki, Annele O. Sainio, Seija E. Grenman, Katri J. Orte, Sakari H. Hietanen, Klaus Elenius, Hannu T. Jarvelainen
JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY
(2019)
Article
Medicine, General & Internal
Annele Sainio, Piia Takabe, Sanna Oikari, Henriikka Salomaki-Myftari, Markku Koulu, Mirva Soderstrom, Sanna Pasonen-Seppanen, Hannu Jarvelainen
JOURNAL OF INVESTIGATIVE MEDICINE
(2020)
Article
Cell Biology
A. Sainio, H. Jarvelainen
CELLULAR SIGNALLING
(2020)
Article
Medicine, Research & Experimental
Roope Huttunen, Annele Sainio, Anja Hjelt, Anna-Mari Haapanen-Saaristo, Jorma Maatta, Petri Rummukainen, Ilkka Paatero, Hannu Jarvelainen
Summary: The SGLT2 inhibitor canagliflozin increases the risk for lower limb amputations in type 2 diabetics, while empagliflozin and dapagliflozin do not have the same effect. The study using zebrafish and human umbilical vein endothelial cells (HUVECs) found that different SGLT2 inhibitors have varying effects on angiogenesis and cell viability, indicating that the risk for peripheral amputations may differ among SGLT2 inhibitors.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Meeting Abstract
Pathology
A. Sainio, P. Bostrom, N. Eigeliene, I. Koskivuo Section, H. Jarvelainen
INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY
(2017)
Article
Oncology
Pia Bostrom, Annele Sainio, Natalja Eigeliene, Anne Jokilammi, Klaus Elenius, Ilkka Koskivuo, Hannu Jarvelainen
CANCER MICROENVIRONMENT
(2017)
Article
Ophthalmology
Roosa-Maria Mattila, Annele Sainio, Marketta Jarvelainen, Juha Pursiheimo, Hannu Jarvelainen
ACTA OPHTHALMOLOGICA
(2018)