Journal
BRITISH JOURNAL OF PHARMACOLOGY
Volume 176, Issue 1, Pages 5-15Publisher
WILEY
DOI: 10.1111/bph.14180
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Funding
- State Research Funding of the Satakunta Central Hospital
- Cancer Society of Southwestern Finland
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Currently, the multifaceted role of the extracellular matrix (ECM) in tumourigenesis has been realized. One ECM macromolecule exhibiting potent oncosuppressive actions in tumourigenesis is decorin, the prototype of the small leucine-rich proteoglycan gene family. The actions of decorin include its ability to function as an endogenous pan-receptor tyrosine kinase inhibitor, a regulator of both autophagy and mitophagy, as well as a modulator of the immune system. In this review, we will discuss these topics in more detail. We also provide a summary of preclinical studies exploring the value of decorin-mediated oncosuppression, as a potential future adjuvant therapy for epithelial cancers.
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