Biomimetic proteoglycans diffuse throughout articular cartilage and localize within the pericellular matrix

Aggrecan-like biomimetic proteoglycans (BPGs) composed of natural chondroitin sulfate bristles grafted onto a poly(acrylic acid) core for molecular engineering of the extracellular matrix

(2018) K. Prudnikova et al.   Acta Biomaterialia

Biomimetic proteoglycans can molecularly engineer early osteoarthritic cartilage in vivo

(2018) Evan R. Phillips et al.   JOURNAL OF ORTHOPAEDIC RESEARCH

Knockdown of the pericellular matrix molecule perlecan lowers in situ cell and matrix stiffness in developing cartilage

(2016) Xin Xu et al.   DEVELOPMENTAL BIOLOGY

Biomimetic Molecules Lower Catabolic Expression and Prevent Chondroitin Sulfate Degradation in an Osteoarthritic ex Vivo Model

(2016) Shaili Sharma et al.   ACS Biomaterials-Science & Engineering

Biomimetic Molecules Lower Catabolic Expression and Prevent Chondroitin Sulfate Degradation in an Osteoarthritic ex Vivo Model

(2016) Shaili Sharma et al.   ACS Biomaterials Science & Engineering

Type VI Collagen Regulates Pericellular Matrix Properties, Chondrocyte Swelling, and Mechanotransduction in Mouse Articular Cartilage

(2015) Nicole A. Zelenski et al.   Arthritis & Rheumatology

Synthesis and Characterization of Proteoglycan-Mimetic Graft Copolymers with Tunable Glycosaminoglycan Density

(2014) Laura W. Place et al.   BIOMACROMOLECULES

The Mechanobiology of Articular Cartilage: Bearing the Burden of Osteoarthritis

(2014) Johannah Sanchez-Adams et al.   Current Rheumatology Reports

Avidin as a model for charge driven transport into cartilage and drug delivery for treating early stage post-traumatic osteoarthritis

(2013) Ambika G. Bajpayee et al.   BIOMATERIALS

Targeting mechanotransduction pathways in osteoarthritis: a focus on the pericellular matrix

(2013) Tonia L Vincent   CURRENT OPINION IN PHARMACOLOGY

Micromechanical mapping of early osteoarthritic changes in the pericellular matrix of human articular cartilage

(2013) R.E. Wilusz et al.   OSTEOARTHRITIS AND CARTILAGE

Incorporation of an aggrecan mimic prevents proteolytic degradation of anisotropic cartilage analogs

(2012) Shaili Sharma et al.   Acta Biomaterialia

Biomechanical factors in osteoarthritis

(2012) Farshid Guilak   BEST PRACTICE & RESEARCH IN CLINICAL RHEUMATOLOGY

Terminal-end functionalization of chondroitin sulfate for the synthesis of biomimetic proteoglycans

(2012) S. Sarkar et al.   CARBOHYDRATE POLYMERS

Chondrocyte deformation under extreme tissue strain in two regions of the rabbit knee joint

(2012) Ryan Madden et al.   JOURNAL OF BIOMECHANICS

Synthesis and characterization of an aggrecan mimic

(2011) Jonathan C. Bernhard et al.   Acta Biomaterialia

Mechanotransduction and cartilage integrity

(2011) Daniel J. Leong et al.   Annals of the New York Academy of Sciences

Developmental and osteoarthritic changes inCol6a1-knockout mice: Biomechanics of type VI collagen in the cartilage pericellular matrix

(2009) Leonidas G. Alexopoulos et al.   ARTHRITIS AND RHEUMATISM

Effect of Dynamic Loading on the Transport of Solutes into Agarose Hydrogels

(2009) Nadeen O. Chahine et al.   BIOPHYSICAL JOURNAL

Strain-dependent viscoelastic behaviour and rupture force of single chondrocytes and chondrons under compression

(2009) Bac V. Nguyen et al.   BIOTECHNOLOGY LETTERS

Characterization of Gels Composed of Blends of Collagen I, Collagen III, and Chondroitin Sulfate

(2008) Kate Stuart et al.   BIOMACROMOLECULES