Small Leucine-Rich Proteoglycans in Renal Inflammation: Two Sides of the Coin

Biglycan- and Sphingosine Kinase-1 Signaling Crosstalk Regulates the Synthesis of Macrophage Chemoattractants

(2017) Louise Hsieh et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Decorin-evoked paternally expressed gene 3 (PEG3) is an upstream regulator of the transcription factor EB (TFEB) in endothelial cell autophagy

(2017) Thomas Neill et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Decorin-inducible Peg3 Evokes Beclin 1-mediated Autophagy and Thrombospondin 1-mediated Angiostasis

(2017) Annabel Torres et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Progression of chronic kidney disease: too much cellular talk causes damage

(2017) Leslie Gewin et al.   KIDNEY INTERNATIONAL

Proteoglycan neofunctions: regulation of inflammation and autophagy in cancer biology

(2016) Liliana Schaefer et al.   FEBS Journal

A novel biological function of soluble biglycan: Induction of erythropoietin production and polycythemia

(2016) Helena Frey et al.   GLYCOCONJUGATE JOURNAL

Bimodal role of NADPH oxidases in the regulation of biglycan-triggered IL-1β synthesis

(2016) Louise Tzung-Harn Hsieh et al.   MATRIX BIOLOGY

The next generation of therapeutics for chronic kidney disease

(2016) Matthew D. Breyer et al.   NATURE REVIEWS DRUG DISCOVERY

Expression of decorin in intestinal tissues of mice with inflammatory bowel disease and its correlation with autophagy

(2016) Huazhou Zhao et al.   Experimental and Therapeutic Medicine

Decorin-mediated inhibition of the migration of U87MG glioma cells involves activation of autophagy and suppression of TGF-β signaling

(2016) Ting Yao et al.   FEBS Open Bio

Decoding the Matrix: Instructive Roles of Proteoglycan Receptors

(2015) Thomas Neill et al.   BIOCHEMISTRY

Update on Inflammation in Chronic Kidney Disease

(2015) Oleh M. Akchurin et al.   BLOOD PURIFICATION

A Novel Role of Matrix Metalloproteinase-8 in Macrophage Differentiation and Polarization

(2015) Guanmei Wen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

PLAP-1/Asporin Regulates TLR2- and TLR4-induced Inflammatory Responses

(2015) S. Yamaba et al.   JOURNAL OF DENTAL RESEARCH

The small leucine-rich repeat proteoglycans in tissue repair and atherosclerosis

(2015) A. Hultgårdh-Nilsson et al.   JOURNAL OF INTERNAL MEDICINE

Proteoglycans regulate autophagy via outside-in signaling: an emerging new concept

(2015) Maria A. Gubbiotti et al.   MATRIX BIOLOGY

Decorin is an autophagy-inducible proteoglycan and is required for proper in vivo autophagy

(2015) Maria A. Gubbiotti et al.   MATRIX BIOLOGY

Proteoglycan form and function: A comprehensive nomenclature of proteoglycans

(2015) Renato V. Iozzo et al.   MATRIX BIOLOGY

Lumican overexpression exacerbates lipopolysaccharide-induced renal injury in mice

(2015) XIAO-MEI LU et al.   Molecular Medicine Reports

Inflammasomes: mechanism of action, role in disease and therapeutics

(2015) Haitao Guo et al.   NATURE MEDICINE

Instructive Roles of Extracellular Matrix on Autophagy

(2014) Thomas Neill et al.   AMERICAN JOURNAL OF PATHOLOGY

Key roles for the small leucine-rich proteoglycans in renal and pulmonary pathophysiology

(2014) Madalina V. Nastase et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Cell-matrix interactions: focus on proteoglycan-proteinase interplay and pharmacological targeting in cancer

(2014) Achilleas D. Theocharis et al.   FEBS Journal

Soluble biglycan as a biomarker of inflammatory renal diseases

(2014) Louise Tzung-Harn Hsieh et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Complexity of Danger: The Diverse Nature of Damage-associated Molecular Patterns

(2014) Liliana Schaefer   JOURNAL OF BIOLOGICAL CHEMISTRY

Beyond Tissue Injury--Damage-Associated Molecular Patterns, Toll-Like Receptors, and Inflammasomes Also Drive Regeneration and Fibrosis

(2014) H.-J. Anders et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Biglycan-triggered TLR-2- and TLR-4-signaling exacerbates the pathophysiology of ischemic acute kidney injury

(2014) Kristin Moreth et al.   MATRIX BIOLOGY

Reprint of: Decorin activates AMPK, an energy sensor kinase, to induce autophagy in endothelial cells

(2014) Atul Goyal et al.   MATRIX BIOLOGY

Toll-Like Receptor Signaling Pathways

(2014) Takumi Kawasaki et al.   Frontiers in Immunology

Decorin has an appetite for endothelial cell autophagy

(2013) Thomas Neill et al.   Autophagy

The regulatory roles of small leucine-rich proteoglycans in extracellular matrix assembly

(2013) Shoujun Chen et al.   FEBS Journal

Biological interplay between proteoglycans and their innate immune receptors in inflammation

(2013) Helena Frey et al.   FEBS Journal

Processes of Sterile Inflammation

(2013) H. Shen et al.   JOURNAL OF IMMUNOLOGY

De novo expression of circulating biglycan evokes an innate inflammatory tissue response via MyD88/TRIF pathways

(2013) Jinyang Zeng-Brouwers et al.   MATRIX BIOLOGY

The anti-metastatic activity of collagenase-2 in breast cancer cells is mediated by a signaling pathway involving decorin and miR-21

(2013) C Soria-Valles et al.   ONCOGENE

Natural resolution of inflammation

(2013) Marcelo O. Freire et al.   PERIODONTOLOGY 2000

Decorin causes autophagy in endothelial cells via Peg3

(2013) S. Buraschi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Opposing Actions of Heat Shock Protein 90 and 70 Regulate Nicotinamide Adenine Dinucleotide Phosphate Oxidase Stability and Reactive Oxygen Species Production

(2012) Feng Chen et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Extracellular Matrix Remodeling: The Common Denominator in Connective Tissue DiseasesPossibilities for Evaluation and Current Understanding of the Matrix as More Than a Passive Architecture, but a Key Player in Tissue Failure

(2012) Morten A. Karsdal et al.   ASSAY AND DRUG DEVELOPMENT TECHNOLOGIES

Small leucine-rich proteoglycans orchestrate receptor crosstalk during inflammation

(2012) Kristin Moreth et al.   CELL CYCLE

Matrix control of transforming growth factor-  function

(2012) M. Horiguchi et al.   JOURNAL OF BIOCHEMISTRY

Macrophage plasticity and polarization: in vivo veritas

(2012) Antonio Sica et al.   JOURNAL OF CLINICAL INVESTIGATION

Proteoglycan Synthesis and Golgi Organization in Polarized Epithelial Cells

(2012) Gunnar Dick et al.   JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY

Biglycan

(2012) Madalina V. Nastase et al.   JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY

Decorin–TGFβ Axis in Hepatic Fibrosis and Cirrhosis

(2012) Kornélia Baghy et al.   JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY

OTUB1 Overexpression in Mesangial Cells Is a Novel Regulator in the Pathogenesis of Glomerulonephritis through the Decrease of DCN Level

(2012) Yan Zhang et al.   PLoS One

Renal Accumulation of Biglycan and Lipid Retention Accelerates Diabetic Nephropathy

(2011) Joel Thompson et al.   AMERICAN JOURNAL OF PATHOLOGY

Proteoglycan degradation by the ADAMTS family of proteinases

(2011) Heather Stanton et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Extracellular matrix protein lumican regulates inflammation in a mouse model of colitis

(2011) Kristin Lohr et al.   INFLAMMATORY BOWEL DISEASES

Decorin Interacts with Connective Tissue Growth Factor (CTGF)/CCN2 by LRR12 Inhibiting Its Biological Activity

(2011) Cecilia Vial et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Proteoglycan Biglycan Enhances Antigen-Specific T Cell Activation Potentially via MyD88 and TRIF Pathways and Triggers Autoimmune Perimyocarditis

(2011) Z. V. Popovic et al.   JOURNAL OF IMMUNOLOGY

Small Leucine-Rich Proteoglycans in Kidney Disease

(2011) L. Schaefer   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

The pleiotropic effects of erythropoietin in infection and inflammation

(2011) Manfred Nairz et al.   MICROBES AND INFECTION

Mechanical Tension Increases CCN2/CTGF Expression and Proliferation in Gingival Fibroblasts via a TGFβ-Dependent Mechanism

(2011) Fen Guo et al.   PLoS One

Signaling by the Matrix Proteoglycan Decorin Controls Inflammation and Cancer Through PDCD4 and MicroRNA-21

(2011) R. Merline et al.   Science Signaling

The Inflammasomes

(2010) Kate Schroder et al.   CELL

Proteoglycans in health and disease: novel regulatory signaling mechanisms evoked by the small leucine-rich proteoglycans

(2010) Renato V. Iozzo et al.   FEBS Journal

The proteoglycan biglycan regulates expression of the B cell chemoattractant CXCL13 and aggravates murine lupus nephritis

(2010) Kristin Moreth et al.   JOURNAL OF CLINICAL INVESTIGATION

Identification of diabetic nephropathy-selective proteins in human plasma by multi-lectin affinity chromatography and LC-MS/MS

(2010) Jung-Mo Ahn et al.   Proteomics Clinical Applications

Proteoglycans: from structural compounds to signaling molecules

(2009) Liliana Schaefer et al.   CELL AND TISSUE RESEARCH

Biglycan, a Danger Signal That Activates the NLRP3 Inflammasome via Toll-like and P2X Receptors

(2009) Andrea Babelova et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Role of Toll-Like Receptor 2 in Inflammation and Fibrosis during Progressive Renal Injury

(2009) Jaklien C. Leemans et al.   PLoS One

The matricellular functions of small leucine-rich proteoglycans (SLRPs)

(2009) Rosetta Merline et al.   Journal of Cell Communication and Signaling

Alternative Activation of Macrophages: An Immunologic Functional Perspective

(2008) Fernando O. Martinez et al.   Annual Review of Immunology

Biological Functions of the Small Leucine-rich Proteoglycans: From Genetics to Signal Transduction

(2008) Liliana Schaefer et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Novel regulatory mechanisms for the proteoglycans decorin and biglycan during muscle formation and muscular dystrophy

(2008) Enrique Brandan et al.   MATRIX BIOLOGY

Immune system in renal injury and repair: Burning the candle from both ends?

(2008) M GOLIGORSKY   PHARMACOLOGICAL RESEARCH