The Antitumor Efficacy of β-Elemene by Changing Tumor Inflammatory Environment and Tumor Microenvironment

Roles of Pin1 as a Key Molecule for EMT Induction by Activation of STAT3 and NF-κB in Human Gallbladder Cancer

(2019) Shinichiro Nakada et al.   ANNALS OF SURGICAL ONCOLOGY

Immunomodulatory roles of nitric oxide in cancer: tumour microenvironment says “NO” to anti-tumour immune response

(2019) Jon Peñarando et al.   Translational Research

ALK-mediated Tyr95 phosphorylation of Smad4 impairs its transcription activity and the tumor suppressive activity of TGF-β

(2019) Qiaoni Shi et al.   Science China-Life Sciences

MCT-1/miR-34a/IL-6/IL-6R signaling axis promotes EMT progression, cancer stemness and M2 macrophage polarization in triple-negative breast cancer

(2019) Yueh-Shan Weng et al.   Molecular Cancer

Nigella damascena L. essential oil and its main constituents, damascenine and β-elemene modulate inflammatory response of human neutrophils ex vivo

(2019) Elwira Sieniawska et al.   FOOD AND CHEMICAL TOXICOLOGY

Innate immunity to intracellular LPS

(2019) Vijay A. K. Rathinam et al.   NATURE IMMUNOLOGY

β-elemene inhibits radiation and hypoxia-induced macrophages infiltration via Prx-1/NF-κB/HIF-1α signaling pathway

(2019) Xiaomu Yu et al.   OncoTargets and Therapy

Oncogenic potential of truncated RXRα during colitis-associated colorectal tumorigenesis by promoting IL-6-STAT3 signaling

(2019) Xiaohong Ye et al.   Nature Communications

The Nutritional Cytokine Leptin Promotes NSCLC by Activating the PI3K/AKT and MAPK/ERK Pathways in NSCLC Cells in a Paracrine Manner

(2019) Fengzhou Li et al.   Biomed Research International

Helicobacter pylori ‐induced YAP1 nuclear translocation promotes gastric carcinogenesis by enhancing IL‐1β expression

(2019) Yujiao Wu et al.   Cancer Medicine

Suppression of the RAC1/MLK3/p38 Signaling Pathway by β-Elemene Alleviates Sepsis-Associated Encephalopathy in Mice

(2019) Cailong Pan et al.   Frontiers in Neuroscience

Traditional Chinese Medicine (TCM) Astragalus Membranaceus and Curcuma Wenyujin Promote Vascular Normalization in Tumor-derived Endothelial Cells of Human Hepatocellular Carcinoma

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Organization of the Skin Immune System and Compartmentalized Immune Responses in Infectious Diseases

(2019) Juarez Antonio Simões Quaresma   CLINICAL MICROBIOLOGY REVIEWS

CD44 inhibits α-SMA gene expression via a novel G-actin/MRTF mediated pathway that intersects with TGFβR/p38MAPK signaling in murine skin fibroblasts.

(2019) Yan Wang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

β‐Elemene suppresses the proliferation of human airway granulation fibroblasts via attenuation of TGF‐β/Smad signaling pathway

(2019) Cheng Xue et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Tubular GM-CSF Promotes Late MCP-1/CCR2-Mediated Fibrosis and Inflammation after Ischemia/Reperfusion Injury

(2019) Leyuan Xu et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Inducible nitric oxide synthase: Regulation, structure, and inhibition

(2019) Maris A. Cinelli et al.   MEDICINAL RESEARCH REVIEWS

Spliceosome protein Eftud2 promotes colitis-associated tumorigenesis by modulating inflammatory response of macrophage

(2019) Zhonglin Lv et al.   Mucosal Immunology

Immunomodulatory TGF-β Signaling in Hepatocellular Carcinoma

(2019) Jian Chen et al.   TRENDS IN MOLECULAR MEDICINE

IL-33-mediated mast cell activation promotes gastric cancer through macrophage mobilization

(2019) Moritz F. Eissmann et al.   Nature Communications

Diversity, Mechanisms, and Significance of Macrophage Plasticity

(2019) Massimo Locati et al.   Annual Review of Pathology-Mechanisms of Disease

CPAP promotes angiogenesis and metastasis by enhancing STAT3 activity

(2019) Ruo-Yu Chen et al.   CELL DEATH AND DIFFERENTIATION

MANF inhibits liver cancer via SUMO ylation‐related suppression of NF ‐κB/Snail signaling pathway and epithelial‐mesenchymal transition

(2019) Jun Liu et al.   HEPATOLOGY

Helminth‐derived molecules inhibit colitis‐associated colon cancer development through NF‐κB and STAT3 regulation

(2019) Blanca E. Callejas et al.   INTERNATIONAL JOURNAL OF CANCER

Immune and Inflammatory Cells in Thyroid Cancer Microenvironment

(2019) Ferrari et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Resveratrol decreases CD45 + CD206 − subtype macrophages in LPS‐induced murine acute lung injury by SOCS3 signalling pathway

(2019) Lu Hu et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Microglia-Triggered Plasticity of Intrinsic Excitability Modulates Psychomotor Behaviors in Acute Cerebellar Inflammation

(2019) Masamichi Yamamoto et al.   Cell Reports

The Immune Microenvironment and Cancer Metastasis

(2019) Asmaa El-Kenawi et al.   Cold Spring Harbor Perspectives in Medicine

Bacterial RNA Contributes to the Down-Modulation of MHC-II Expression on Monocytes/Macrophages Diminishing CD4+ T Cell Responses

(2019) M. Ayelén Milillo et al.   Frontiers in Immunology

MEK1/2 Inhibitors Unlock the Constrained Interferon Response in Macrophages Through IRF1 Signaling

(2019) Lei Yang et al.   Frontiers in Immunology

PD-L1 expression on tumor-infiltrating immune cells is highly associated with M2 TAM and aggressive malignant potential in patients with resected non-small cell lung cancer

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A mathematical model for the immune-mediated theory of metastasis

(2019) Adam Rhodes et al.   JOURNAL OF THEORETICAL BIOLOGY

Chimeric antigen receptor T cells in solid tumors: a war against the tumor microenvironment

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β-Elemene inhibits the proliferation of primary human airway granulation fibroblasts by down-regulating canonical Wnt/β-catenin pathway

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Nitric oxide-donating aspirin (NO-Aspirin) suppresses lung tumorigenesis in vitro and in vivo and these effects are associated with modulation of the EGFR signaling pathway

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β-elemene attenuates macrophage activation and proinflammatory factor production via crosstalk with Wnt/β-catenin signaling pathway

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Macrophages: Their role, activation and polarization in pulmonary diseases

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Tumor cell-intrinsic Tim-3 promotes liver cancer via NF-κB/IL-6/STAT3 axis

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Angiogenic factor-driven inflammation promotes extravasation of human proangiogenic monocytes to tumours

(2018) Adama Sidibe et al.   Nature Communications

Nitric oxide-mediated fibrinogen deposition prevents platelet adhesion and activation

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The protective effects of a novel synthetic β-elemene derivative on human umbilical vein endothelial cells against oxidative stress-induced injury: Involvement of antioxidation and PI3k/Akt/eNOS/NO signaling pathways

(2018) Khalil Ali Ahmad et al.   BIOMEDICINE & PHARMACOTHERAPY

CCL15 recruits suppressive monocytes to facilitate immune escape and disease progression in hepatocellular carcinoma

(2018) Long-Zi Liu et al.   HEPATOLOGY

Dynamic balance of pro- and anti-inflammatory signals controls disease and limits pathology

(2018) Joseph M. Cicchese et al.   IMMUNOLOGICAL REVIEWS

Interleukin‑17A and heparanase promote angiogenesis and cell proliferation and invasion in cervical cancer

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Anti-inflammatory signaling by mammary tumor cells mediates prometastatic macrophage polarization in an innovative intraductal mouse model for triple-negative breast cancer

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Intracellular NO-Generator Based on Enzyme Trigger for Localized Tumor-Cytoplasm Rapid Drug Release and Synergetic Cancer Therapy

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Evaluation of the efficacy and safety of elemene in treating malignant pleural effusion caused by tumors

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Elemene injection as adjunctive treatment to platinum-based chemotherapy in patients with stage III/IV non-small cell lung cancer: a meta-analysis following the PRISMA guidelines

(2018) Xuewei Wang et al.   PHYTOMEDICINE

Hypothalamic Macrophage Inducible Nitric Oxide Synthase Mediates Obesity-Associated Hypothalamic Inflammation

(2018) Chan Hee Lee et al.   Cell Reports

β-Elemene Synergizes With Gefitinib to Inhibit Stem-Like Phenotypes and Progression of Lung Cancer via Down-Regulating EZH2

(2018) Haibo Cheng et al.   Frontiers in Pharmacology

Neoadjuvant sipuleucel-T induces both Th1 activation and immune regulation in localized prostate cancer

(2018) Katsunobu Hagihara et al.   OncoImmunology

Blockade of TGF-β signaling with novel synthetic antibodies limits immune exclusion and improves chemotherapy response in metastatic ovarian cancer models

(2018) Daniel Newsted et al.   OncoImmunology

ROS and the DNA damage response in cancer

(2018) Upadhyayula Sai Srinivas et al.   Redox Biology

Particulate matter induces inflammatory cytokine production via activation of NFκB by TLR5-NOX4-ROS signaling in human skin keratinocyte and mouse skin

(2018) Yea Seong Ryu et al.   Redox Biology

Constitutive and stimulated macropinocytosis in macrophages: roles in immunity and in the pathogenesis of atherosclerosis

(2018) Sasha A. Doodnauth et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Discovery of novel antitumor nitric oxide-donating β -elemene hybrids through inhibiting the PI3K/Akt pathway

(2017) Jichao Chen et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

TNF-α-induced NF-κB activation promotes myofibroblast differentiation of LR-MSCs and exacerbates bleomycin-induced pulmonary fibrosis

(2017) Jiwei Hou et al.   JOURNAL OF CELLULAR PHYSIOLOGY

TNF-α and cancer cachexia: Molecular insights and clinical implications

(2017) Hetal J. Patel et al.   LIFE SCIENCES

Evidence of elemene injection combined radiotherapy in lung cancer treatment among patients with brain metastases

(2017) Xutao Jiang et al.   MEDICINE

Interleukin-22 drives nitric oxide-dependent DNA damage and dysplasia in a murine model of colitis-associated cancer

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A muscle-specific protein ‘myoferlin’ modulates IL-6/STAT3 signaling by chaperoning activated STAT3 to nucleus

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WITHDRAWN: Elemene Increases Autophagic Apoptosis and Drug Sensitivity in Human Cisplatin (DDP)-Resistant Lung Cancer Cell Line SPC-A-1/DDP By Inducing Beclin-1 Expression

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Antioxidant Properties of Novel Dimers Derived from Natural β-Elemene through Inhibiting H2O2-Induced Apoptosis

(2017) Jichao Chen et al.   ACS Medicinal Chemistry Letters

Acyloxyacyl hydrolase promotes the resolution of lipopolysaccharide-induced acute lung injury

(2017) Benkun Zou et al.   PLoS Pathogens

Early IL-6 signalling promotes IL-27 dependent maturation of regulatory T cells in the lungs and resolution of viral immunopathology

(2017) Chloe J. Pyle et al.   PLoS Pathogens

Effects of elemene on inhibiting proliferation of vascular smooth muscle cells and promoting reendothelialization at the stent implantation site

(2017) Wenjie Sun et al.   Biomaterials Science

β-Elemene: Mechanistic Studies on Cancer Cell Interaction and Its Chemosensitization Effect

(2017) Ziyu Jiang et al.   Frontiers in Pharmacology

Growth-induced stress enhances epithelial-mesenchymal transition induced by IL-6 in clear cell renal cell carcinoma via the Akt/GSK-3β/β-catenin signaling pathway

(2017) Q Chen et al.   Oncogenesis

Myeloid protein tyrosine phosphatase 1B (PTP1B) deficiency protects against atherosclerotic plaque formation in the ApoE −/− mouse model of atherosclerosis with alterations in IL10/AMPKα pathway

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Nitric oxide mediates apoptosis and mitochondrial dysfunction and plays a role in growth hormone deficiency by nivalenol in GH3 cells

(2017) Deyu Huang et al.   Scientific Reports

TGF-β Tumor Suppression through a Lethal EMT

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Two Traditional Chinese MedicinesCurcumae RadixandCurcumae Rhizoma: An Ethnopharmacology, Phytochemistry, and Pharmacology Review

(2016) Yang Zhou et al.   Evidence-based Complementary and Alternative Medicine

Anti-inflammatory effects of royal poinciana through inhibition of toll-like receptor 4 signaling pathway

(2016) Satyajit Patra et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Inverse role of distinct subsets and distribution of macrophage in lung cancer prognosis: a meta-analysis

(2016) Pin Wu et al.   Oncotarget

β-Elemene Selectively Inhibits the Proliferation of Glioma Stem-Like Cells Through the Downregulation of Notch1

(2016) Hai-bin Feng et al.   Stem Cells Translational Medicine

Serum Amyloid A Induces Toll-Like Receptor 2-Dependent Inflammatory Cytokine Expression and Atrophy in C2C12 Skeletal Muscle Myotubes

(2016) Samantha L. Passey et al.   PLoS One

The Evolution of T-cell Therapies for Solid Malignancies

(2015) K. Fousek et al.   CLINICAL CANCER RESEARCH

Tadalafil Integrates Nitric Oxide-Hydrogen Sulfide Signaling to Inhibit High Glucose-induced Matrix Protein Synthesis in Podocytes

(2015) Hak Joo Lee et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Reversion of malignant phenotypes of human glioblastoma cells by β-elemene through β-catenin-mediated regulation of stemness-, differentiation- and epithelial-to-mesenchymal transition-related molecules

(2015) Tingzhun Zhu et al.   Journal of Translational Medicine

β-elemene enhances the radiosensitivity of gastric cancer cells by inhibiting Pak1 activation

(2015) Jun-Song Liu   WORLD JOURNAL OF GASTROENTEROLOGY

The dual role of iNOS in cancer

(2015) Federica Vannini et al.   Redox Biology

TGFβ responsive tyrosine phosphatase promotes rheumatoid synovial fibroblast invasiveness

(2014) Stephanie M Stanford et al.   ANNALS OF THE RHEUMATIC DISEASES

Design, synthesis and antioxidant activity evaluation of novel β-elemene derivatives

(2014) Jichao Chen et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

The influence of astragalus polysaccharide and β-elemene on LX-2 cell growth, apoptosis and activation

(2014) Jin Zheng et al.   BMC GASTROENTEROLOGY

�-Elemene Reverses Chemoresistance of Breast Cancer via Regulating MDR-Related MicroRNA Expression

(2014) Jun Zhang et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

A time course of NADPH-oxidase up-regulation and endothelial nitric oxide synthase activation in the hippocampus following neurotrauma

(2014) Mubeen A. Ansari et al.   FREE RADICAL BIOLOGY AND MEDICINE

Essential oil from Pterodon emarginatus seeds ameliorates experimental autoimmune encephalomyelitis by modulating Th1/Treg cell balance

(2014) Thaís B. Alberti et al.   JOURNAL OF ETHNOPHARMACOLOGY

iNOS Inhibitory Activity of Sesquiterpenoids and a Monoterpenoid from the Rhizomes of Curcuma wenyujin

(2014) Guo-Ping Yin et al.   JOURNAL OF NATURAL PRODUCTS

Th17-type cytokines, IL-6 and TNF-α synergistically activate STAT3 and NF-kB to promote colorectal cancer cell growth

(2014) V De Simone et al.   ONCOGENE

Functional subsets of mesenchymal cell types in the tumor microenvironment

(2014) Eliane Cortez et al.   SEMINARS IN CANCER BIOLOGY

A novel androstenedione derivative induces ROS-mediated autophagy and attenuates drug resistance in osteosarcoma by inhibiting macrophage migration inhibitory factor (MIF)

(2014) Y Liu et al.   Cell Death & Disease

β-elemene reverses the drug resistance of A549/DDP lung cancer cells by activating intracellular redox system, decreasing mitochondrial membrane potential and P-glycoprotein expression, and inducing apoptosis

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Elemene, One Ingredient of a Chinese Herb, Against Malignant Tumors: A Literature-based Meta-analysis

(2013) Hong-Bin Xu et al.   CANCER INVESTIGATION

Molecular mechanisms underlying chronic inflammation-associated cancers

(2013) Yongzhong Wu et al.   CANCER LETTERS

Eugenia unifloraL. Essential Oil as a Potential Anti-LeishmaniaAgent: Effects onLeishmania amazonensisand Possible Mechanisms of Action

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Human CD14+CTLA-4+regulatory dendritic cells suppress T-cell response by cytotoxic T-lymphocyte antigen-4-dependent IL-10 and indoleamine-2,3-dioxygenase production in hepatocellular carcinoma

(2013) Yanmei Han et al.   HEPATOLOGY

β-Elemene enhances susceptibility to cisplatin in resistant ovarian carcinoma cells via downregulation of ERCC-1 and XIAP and inactivation of JNK

(2013) QUENTIN Q. LI et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

DNA Damage in Inflammation-Related Carcinogenesis and Cancer Stem Cells

(2013) Shiho Ohnishi et al.   Oxidative Medicine and Cellular Longevity

Beta-Elemene Blocks Epithelial-Mesenchymal Transition in Human Breast Cancer Cell Line MCF-7 through Smad3-Mediated Down-Regulation of Nuclear Transcription Factors

(2013) Xian Zhang et al.   PLoS One

Toll-like receptor 4 signaling promotes epithelial-mesenchymal transition in human hepatocellular carcinoma induced by lipopolysaccharide

(2012) Ying-Ying Jing et al.   BMC Medicine

Role of Chemokines and Chemokine Receptors in Shaping the Effector Phase of the Antitumor Immune Response

(2012) K. Franciszkiewicz et al.   CANCER RESEARCH

Systematic review of β-Elemene injection as adjunctive treatment for lung cancer

(2012) Bin Wang et al.   Chinese Journal of Integrative Medicine

Colocalization of Inflammatory Response with B7-H1 Expression in Human Melanocytic Lesions Supports an Adaptive Resistance Mechanism of Immune Escape

(2012) J. M. Taube et al.   Science Translational Medicine

B-Cell Lymphoma-2 Over-Expression Protects δ-Elemene-Induced Apoptosis in Human Lung Carcinoma Mucoepidermoid Cells via a Nuclear Factor Kappa B-Related Pathway

(2011) Chun Ying Xie et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

Amelioration of Experimental Autoimmune Encephalomyelitis by β-elemene Treatment is Associated with Th17 and Treg Cell Balance

(2011) Rongwei Zhang et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

β-Elemene Radiosensitizes Lung Cancer A549 Cells by Enhancing DNA Damage and Inhibiting DNA Repair

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Anti-cancer natural products isolated from chinese medicinal herbs

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Downregulation effects of beta-elemene on the levels of plasma endotoxin, serum TNF-alpha, and hepatic CD14 expression in rats with liver fibrosis

(2011) Jianguo Liu et al.   Frontiers of Medicine

Potential Therapeutic Targets for Cardiac Fibrosis

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Downregulation of IL-17 and IFN-γ in the optic nerve by β-elemene in experimental autoimmune encephalomyelitis

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Immune Regulation of Cancer

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An investigation of the ability of elemene to pass through the blood-brain barrier and its effect on brain carcinomas

(2010) Xue Shen Wu et al.   JOURNAL OF PHARMACY AND PHARMACOLOGY

Helicobacter pylori Immune Escape Is Mediated by Dendritic Cell–Induced Treg Skewing and Th17 Suppression in Mice

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β-Elemene, a novel plant-derived antineoplastic agent, increases cisplatin chemosensitivity of lung tumor cells by triggering apoptosis

(2009) Li   ONCOLOGY REPORTS

Epigenetic Enhancement of Antigen Processing and Presentation Promotes Immune Recognition of Tumors

(2008) A. F. Setiadi et al.   CANCER RESEARCH

A pro-inflammatory signature mediates FGF2-induced angiogenesis

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Demonstration of cooperative contribution of MET- and EGFR-mediated STAT3 phosphorylation to liver regeneration by exogenous suppressor of cytokine signalings

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