Constitutive and stimulated macropinocytosis in macrophages: roles in immunity and in the pathogenesis of atherosclerosis

Differential ability of proinflammatory and anti-inflammatory macrophages to perform macropinocytosis

(2018) Dar’ya S. Redka et al.   MOLECULAR BIOLOGY OF THE CELL

PI3K-AKT-mTOR inhibition in cancer immunotherapy, redux

(2018) Jake S. O’Donnell et al.   SEMINARS IN CANCER BIOLOGY

Small GTPase Rab8a-recruited Phosphatidylinositol 3-Kinase γ Regulates Signaling and Cytokine Outputs from Endosomal Toll-like Receptors

(2017) Adam A. Wall et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Macropinocytosis: A Metabolic Adaptation to Nutrient Stress in Cancer

(2017) Maria Victoria Recouvreux et al.   Frontiers in Endocrinology

A phagocytosis assay for oxidized low-density lipoprotein versus immunoglobulin G-coated microbeads in human U937 macrophages

(2016) David T. Vance et al.   ANALYTICAL BIOCHEMISTRY

mTORC2 mediates CXCL12-induced angiogenesis

(2016) Mary E. Ziegler et al.   ANGIOGENESIS

Enzymatically Modified Low-Density Lipoprotein Promotes Foam Cell Formation in Smooth Muscle Cells via Macropinocytosis and Enhances Receptor-Mediated Uptake of Oxidized Low-Density LipoproteinHighlights

(2016) Bijoy Chellan et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

CXCL12-induced macropinocytosis modulates two distinct pathways to activate mTORC1 in macrophages

(2016) Regina Pacitto et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Coincident signals from GPCRs and receptor tyrosine kinases are uniquely transduced by PI3Kβ in myeloid cells

(2016) Daniel M. Houslay et al.   Science Signaling

Calcium-sensing receptors signal constitutive macropinocytosis and facilitate the uptake of NOD2 ligands in macrophages

(2016) Johnathan Canton et al.   Nature Communications

Bone marrow-derived and peritoneal macrophages have different inflammatory response to oxLDL and M1/M2 marker expression – implications for atherosclerosis research

(2016) Line S. Bisgaard et al.   Scientific Reports

Chemokine Signaling Enhances CD36 Responsiveness toward Oxidized Low-Density Lipoproteins and Accelerates Foam Cell Formation

(2016) Harikesh S. Wong et al.   Cell Reports

Coincident signals from GPCRs and receptor tyrosine kinases are uniquely transduced by PI3Kβ in myeloid cells

(2016) Daniel M. Houslay et al.   Science Signaling

Phosphoinositides in phagocytosis and macropinocytosis

(2015) Roni Levin et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Human Pancreatic Cancer Tumors Are Nutrient Poor and Tumor Cells Actively Scavenge Extracellular Protein

(2015) J. J. Kamphorst et al.   CANCER RESEARCH

A critical role of Src family kinase in SDF-1/CXCR4-mediated bone-marrow progenitor cell recruitment to the ischemic heart

(2015) Min Cheng et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Catabolic pathways regulated by mTORC1 are pivotal for survival and growth of cancer cells expressing mutant Ras

(2015) Suhyun Sung et al.   Oncotarget

Active macropinocytosis induction by stimulation of epidermal growth factor receptor and oncogenic Ras expression potentiates cellular uptake efficacy of exosomes

(2015) Ikuhiko Nakase et al.   Scientific Reports

Differential signaling during macropinocytosis in response to M-CSF and PMA in macrophages

(2015) Sei Yoshida et al.   Frontiers in Physiology

Regulation of Macropinocytosis by Diacylglycerol Kinase ζ

(2015) Ryan Ard et al.   PLoS One

Stromal Cell-Derived Factor 1α Mediates Resistance to mTOR-Directed Therapy in Pancreatic Cancer

(2015) Colin D. Weekes et al.   NEOPLASIA

Macrophage Activation and Polarization: Nomenclature and Experimental Guidelines

(2014) Peter J. Murray et al.   IMMUNITY

Delivery of CSF-1R to the lumen of macropinosomes promotes its destruction in macrophages

(2014) J. Lou et al.   JOURNAL OF CELL SCIENCE

Cell-intrinsic lysosomal lipolysis is essential for alternative activation of macrophages

(2014) Stanley Ching-Cheng Huang et al.   NATURE IMMUNOLOGY

The Cellular and Physiological Functions of the Lowe Syndrome Protein OCRL1

(2014) Zenobia B. Mehta et al.   TRAFFIC

CXCR4 and CXCR7 transduce through mTOR in human renal cancer cells

(2014) C Ieranò et al.   Cell Death & Disease

Vav Guanine Nucleotide Exchange Factors Regulate Atherosclerotic Lesion Development in Mice

(2013) Shaik O. Rahaman et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Multimolecular Signaling Complexes Enable Syk-Mediated Signaling of CD36 Internalization

(2013) Bryan Heit et al.   DEVELOPMENTAL CELL

Specific inhibition of PI3K p110δ inhibits CSF-1-induced macrophage spreading and invasive capacity

(2013) Kellie A. Mouchemore et al.   FEBS Journal

Phosphatidic acid is required for the constitutive ruffling and macropinocytosis of phagocytes

(2013) Michal Bohdanowicz et al.   MOLECULAR BIOLOGY OF THE CELL

Macropinocytosis of protein is an amino acid supply route in Ras-transformed cells

(2013) Cosimo Commisso et al.   NATURE

Fluid-Phase Pinocytosis of Native Low Density Lipoprotein Promotes Murine M-CSF Differentiated Macrophage Foam Cell Formation

(2013) Manoj K. Barthwal et al.   PLoS One

CSF-1 receptor signalling from endosomes mediates the sustained activation of Erk1/2 and Akt in macrophages

(2012) Jennifer Huynh et al.   CELLULAR SIGNALLING

CXCR4 Stimulates Macropinocytosis: Implications for Cellular Uptake of Arginine-Rich Cell-Penetrating Peptides and HIV

(2012) Gen Tanaka et al.   CHEMISTRY & BIOLOGY

Inhibition of Chemokine (CXC Motif) Ligand 12/Chemokine (CXC Motif) Receptor 4 Axis (CXCL12/CXCR4)-mediated Cell Migration by Targeting Mammalian Target of Rapamycin (mTOR) Pathway in Human Gastric Carcinoma Cells

(2012) Guang Chen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Macropinocytosis of the PDGF β-receptor promotes fibroblast transformation by H-RasG12V

(2012) C. Schmees et al.   MOLECULAR BIOLOGY OF THE CELL

A growth factor signaling cascade confined to circular ruffles in macrophages

(2012) T. P. Welliver et al.   Biology Open

Reversal of Hyperlipidemia With a Genetic Switch Favorably Affects the Content and Inflammatory State of Macrophages in Atherosclerotic Plaques

(2011) Jonathan E. Feig et al.   CIRCULATION

NR4A1 (Nur77) Deletion Polarizes Macrophages Toward an Inflammatory Phenotype and Increases Atherosclerosis

(2011) Richard N. Hanna et al.   CIRCULATION RESEARCH

Vav Family Rho Guanine Nucleotide Exchange Factors Regulate CD36-mediated Macrophage Foam Cell Formation

(2011) S. Ohidar Rahaman et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Chemokine CXCL12 Uses CXCR4 and a Signaling Core Formed by Bifunctional Akt, Extracellular Signal-regulated Kinase (ERK)1/2, and Mammalian Target of Rapamycin Complex 1 (mTORC1) Proteins to Control Chemotaxis and Survival Simultaneously in Mature Dendritic Cells

(2011) Cristina Delgado-Martín et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Murine bone marrow-derived macrophages differentiated with GM-CSF become foam cells by PI3Kγ-dependent fluid-phase pinocytosis of native LDL

(2011) Joshua J. Anzinger et al.   JOURNAL OF LIPID RESEARCH

Recruitment of OCRL and Inpp5B to phagosomes by Rab5 and APPL1 depletes phosphoinositides and attenuates Akt signaling

(2011) Michal Bohdanowicz et al.   MOLECULAR BIOLOGY OF THE CELL

Effects of Disturbed Flow on Vascular Endothelium: Pathophysiological Basis and Clinical Perspectives

(2011) Jeng-Jiann Chiu et al.   PHYSIOLOGICAL REVIEWS

Native Low-Density Lipoprotein Uptake by Macrophage Colony-Stimulating Factor–Differentiated Human Macrophages Is Mediated by Macropinocytosis and Micropinocytosis

(2010) Joshua J. Anzinger et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Oxidized LDL enhances pro-inflammatory responses of alternatively activated M2 macrophages: A crucial role for Krüppel-like factor 2

(2010) L.J.H. van Tits et al.   ATHEROSCLEROSIS

Dorsal Ruffle Microdomains Potentiate Met Receptor Tyrosine Kinase Signaling and Down-regulation

(2010) Jasmine V. Abella et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Amiloride inhibits macropinocytosis by lowering submembranous pH and preventing Rac1 and Cdc42 signaling

(2010) Mirkka Koivusalo et al.   JOURNAL OF CELL BIOLOGY

Macrophage Plasticity in Experimental Atherosclerosis

(2010) Jamila Khallou-Laschet et al.   PLoS One

Role of Cordycepin and Adenosine on the Phenotypic Switch of Macrophages via Induced Anti-inflammatory Cytokines

(2010) Seulmee Shin et al.   Immune Network

Macropinocytosis contributes to the macrophage foam cell formation in RAW264.7 cells

(2009) W. Yao et al.   ACTA BIOCHIMICA ET BIOPHYSICA SINICA

Lipoprotein Accumulation in Macrophages via Toll-Like Receptor-4–Dependent Fluid Phase Uptake

(2009) Soo-Ho Choi et al.   CIRCULATION RESEARCH

Uptake of Oxidized Low Density Lipoprotein by CD36 Occurs by an Actin-dependent Pathway Distinct from Macropinocytosis

(2009) Richard F. Collins et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Fluorescent pegylated nanoparticles demonstrate fluid-phase pinocytosis by macrophages in mouse atherosclerotic lesions

(2009) Chiara Buono et al.   JOURNAL OF CLINICAL INVESTIGATION

Loss of SR-A and CD36 Activity Reduces Atherosclerotic Lesion Complexity Without Abrogating Foam Cell Formation in Hyperlipidemic Mice

(2008) Jennifer J. Manning-Tobin et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

A role for SNX5 in the regulation of macropinocytosis

(2008) Jet Lim et al.   BMC CELL BIOLOGY

Blocking on the CXCR4/mTOR signalling pathway induces the anti-metastatic properties and autophagic cell death in peritoneal disseminated gastric cancer cells

(2008) Isaya Hashimoto et al.   EUROPEAN JOURNAL OF CANCER

Atherosclerosis: evidence for impairment of resolution of vascular inflammation governed by specific lipid mediators

(2008) Aksam J. Merched et al.   FASEB JOURNAL