Tadalafil Integrates Nitric Oxide-Hydrogen Sulfide Signaling to Inhibit High Glucose-induced Matrix Protein Synthesis in Podocytes

Endogenous Hydrogen Sulfide Production Is Essential for Dietary Restriction Benefits

(2015) Christopher Hine et al.   CELL

Wnt/β-catenin signaling induces the transcription of cystathionine-γ-lyase, a stimulator of tumor in colon cancer

(2014) Kun Fan et al.   CELLULAR SIGNALLING

Hydrogen sulfide to the rescue in obstructive kidney injury

(2014) Balakuntalam S. Kasinath   KIDNEY INTERNATIONAL

HIF-1α Signaling Activation by Post-Ischemia Treatment with Astragaloside IV Attenuates Myocardial Ischemia-Reperfusion Injury

(2014) Jingwen Si et al.   PLoS One

The coordination of S-sulfhydration, S-nitrosylation, and phosphorylation of endothelial nitric oxide synthase by hydrogen sulfide

(2014) Z. Altaany et al.   Science Signaling

The ever-evolving role of mTOR in translation

(2014) Bruno D. Fonseca et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Leptospira Interrogans Induces Fibrosis in the Mouse Kidney through Inos-Dependent, TLR- and NLR-Independent Signaling Pathways

(2014) Martine Fanton d'Andon et al.   PLoS Neglected Tropical Diseases

H 2 S Protects Against Pressure Overload–Induced Heart Failure via Upregulation of Endothelial Nitric Oxide Synthase

(2013) Kazuhisa Kondo et al.   CIRCULATION

Effectiveness and Safety of Phosphodiesterase 5 Inhibitors in Patients with Cardiovascular Disease and Hypertension

(2013) Steven G. Chrysant   CURRENT HYPERTENSION REPORTS

Renal improvement by zinc in diabetic mice is associated with glucose metabolism signaling mediated by metallothionein and Akt, but not Akt2

(2013) Weixia Sun et al.   FREE RADICAL BIOLOGY AND MEDICINE

AMPK dysregulation promotes diabetes-related reduction of superoxide and mitochondrial function

(2013) Laura L. Dugan et al.   JOURNAL OF CLINICAL INVESTIGATION

Antenatal maternally-administered phosphodiesterase type 5 inhibitors normalize eNOS expression in the fetal lamb model of congenital diaphragmatic hernia

(2013) Eveline H. Shue et al.   JOURNAL OF PEDIATRIC SURGERY

Hydrogen Sulfide Attenuates sFlt1-Induced Hypertension and Renal Damage by Upregulating Vascular Endothelial Growth Factor

(2013) K. M. Holwerda et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Cystathionine  -Lyase Protects against Renal Ischemia/Reperfusion by Modulating Oxidative Stress

(2013) E. M. Bos et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Hydrogen sulfide inhibits the renal fibrosis of obstructive nephropathy

(2013) Kai Song et al.   KIDNEY INTERNATIONAL

Tumor-derived hydrogen sulfide, produced by cystathionine- -synthase, stimulates bioenergetics, cell proliferation, and angiogenesis in colon cancer

(2013) C. Szabo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Molecular events in matrix protein metabolism in the aging kidney

(2012) Kavithalakshmi Sataranatarajan et al.   AGING CELL

Sildenafil stimulates the expression of gaseous monoxide-generating enzymes in vascular smooth muscle cells via distinct signaling pathways

(2012) Xiao-ming Liu et al.   BIOCHEMICAL PHARMACOLOGY

Distribution of hydrogen sulfide (H2S)-producing enzymes and the roles of the H2S donor sodium hydrosulfide in diabetic nephropathy

(2012) Junichiro Yamamoto et al.   Clinical and Experimental Nephrology

Signaling Mechanisms in the Regulation of Renal Matrix Metabolism in Diabetes

(2012) Meenalakshmi M. Mariappan   Experimental Diabetes Research

A unifying model for mTORC1-mediated regulation of mRNA translation

(2012) Carson C. Thoreen et al.   NATURE

Selective phosphodiesterase-5 (PDE-5) inhibitor vardenafil ameliorates renal damage in type 1 diabetic rats by restoring cyclic 3′,5′ guanosine monophosphate (cGMP) level in podocytes

(2012) Lilla Fang et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

Shared signaling pathways among gasotransmitters

(2012) R. Wang   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Hydrogen sulfide and nitric oxide are mutually dependent in the regulation of angiogenesis and endothelium-dependent vasorelaxation

(2012) C. Coletta et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Pathogenic Role of Cystathionine γ-Lyase/Hydrogen Sulfide in Streptozotocin-Induced Diabetes in Mice

(2011) Guangdong Yang et al.   AMERICAN JOURNAL OF PATHOLOGY

A Glimpse of Various Pathogenetic Mechanisms of Diabetic Nephropathy

(2011) Yashpal S. Kanwar et al.   Annual Review of Pathology-Mechanisms of Disease

Sildenafil attenuates LPS-induced pro-inflammatory responses through down-regulation of intracellular ROS-related MAPK/NF-κB signaling pathways in N9 microglia

(2011) Siqi Zhao et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Hydrogen Sulfide Inhibits High Glucose-induced Matrix Protein Synthesis by Activating AMP-activated Protein Kinase in Renal Epithelial Cells

(2011) Hak Joo Lee et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Specificity Protein-1 as a Critical Regulator of Human Cystathionine γ-Lyase in Smooth Muscle Cells

(2011) Guangdong Yang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

MicroRNA-21 represses human cystathionine gamma-lyase expression by targeting at specificity protein-1 in smooth muscle cells

(2011) Guangdong Yang et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Hydrogen Sulfide Upregulates Cyclooxygenase-2 and Prostaglandin E Metabolite in Sepsis-Evoked Acute Lung Injury via Transient Receptor Potential Vanilloid Type 1 Channel Activation

(2011) S.-F. Ang et al.   JOURNAL OF IMMUNOLOGY

Rescue of mesangial cells from high glucose-induced over-proliferation and extracellular matrix secretion by hydrogen sulfide

(2011) P. Yuan et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

Hydrogen sulfide replacement therapy protects the vascular endothelium in hyperglycemia by preserving mitochondrial function

(2011) K. Suzuki et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Sildenafil, a phosphodiesterase type 5 inhibitor, attenuates diabetic nephropathy in non-insulin-dependent Otsuka Long-Evans Tokushima Fatty rats

(2010) Yoshihiro Kuno et al.   BRITISH JOURNAL OF PHARMACOLOGY

AMP-activated Protein Kinase (AMPK) Negatively Regulates Nox4-dependent Activation of p53 and Epithelial Cell Apoptosis in Diabetes

(2010) Assaad A. Eid et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Hydrogen Sulfide Inhibits Plasma Renin Activity

(2010) M. Lu et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Inhibition of hydrogen sulphide formation reduces cisplatin-induced renal damage

(2010) H. D. C. Francescato et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

Resveratrol ameliorates high glucose-induced protein synthesis in glomerular epithelial cells

(2009) Myung-Ja Lee et al.   CELLULAR SIGNALLING

Phosphodiesterase-5 Inhibitor, Tadalafil, Protects Against Myocardial Ischemia/Reperfusion Through Protein-Kinase G-Dependent Generation of Hydrogen Sulfide

(2009) F. N. Salloum et al.   CIRCULATION

Transcription factors in the pathogenesis of diabetic nephropathy

(2009) Amber Paratore Sanchez et al.   EXPERT REVIEWS IN MOLECULAR MEDICINE

Effects of Sildenafil on Oxidative and Inflammatory Injuries of the Kidney in Streptozotocin-Induced Diabetic Rats

(2008) Kyung-Hwan Jeong et al.   AMERICAN JOURNAL OF NEPHROLOGY

Effect of sildenafil citrate on interleukin-1β-induced nitric oxide synthesis and iNOS expression in SW982 cells

(2008) Kyung-Ok Kim et al.   EXPERIMENTAL AND MOLECULAR MEDICINE

Glycogen Synthase Kinase 3β Is a Novel Regulator of High Glucose- and High Insulin-induced Extracellular Matrix Protein Synthesis in Renal Proximal Tubular Epithelial Cells

(2008) Meenalakshmi M. Mariappan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Generation of endogenous hydrogen sulfide by cystathionine γ-lyase limits renal ischemia/reperfusion injury and dysfunction

(2008) Pinpat Tripatara et al.   LABORATORY INVESTIGATION

PDE-5 inhibition impedes TSP-1 expression, TGF-  activation and matrix accumulation in experimental glomerulonephritis

(2008) B. Hohenstein et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

H2S as a Physiologic Vasorelaxant: Hypertension in Mice with Deletion of Cystathionine  -Lyase

(2008) G. Yang et al.   SCIENCE