Spliceosome protein Eftud2 promotes colitis-associated tumorigenesis by modulating inflammatory response of macrophage

Transcriptome-Wide Analysis Reveals Modulation of Human Macrophage Inflammatory Phenotype Through Alternative SplicingHighlights

(2016) Jennie Lin et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Quaking promotes monocyte differentiation into pro-atherogenic macrophages by controlling pre-mRNA splicing and gene expression

(2016) Ruben G. de Bruin et al.   Nature Communications

Novel de novo mutations inEFTUD2detected by exome sequencing in mandibulofacial dysostosis with Microcephaly syndrome

(2015) Arindam Sarkar et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART A

Cytokines, IBD, and Colitis-associated Cancer

(2015) Ralph Francescone et al.   INFLAMMATORY BOWEL DISEASES

EFTUD2 Is a Novel Innate Immune Regulator Restricting Hepatitis C Virus Infection through the RIG-I/MDA5 Pathway

(2015) Chuanlong Zhu et al.   JOURNAL OF VIROLOGY

Macrophages and cancer: from mechanisms to therapeutic implications

(2015) Renato Ostuni et al.   TRENDS IN IMMUNOLOGY

Regulation of Toll-like Receptor Signaling by the SF3a mRNA Splicing Complex

(2015) Brian P. O’Connor et al.   PLoS Genetics

Neutrophil infiltration favors colitis-associated tumorigenesis by activating the interleukin-1 (IL-1)/IL-6 axis

(2014) Y Wang et al.   Mucosal Immunology

Tumor-Derived GM-CSF Promotes Inflammatory Colon Carcinogenesis via Stimulating Epithelial Release of VEGF

(2013) Y. Wang et al.   CANCER RESEARCH

Comparative Genomics RNAi Screen Identifies Eftud2 as a Novel Regulator of Innate Immunity

(2013) Lesly De Arras et al.   GENETICS

Conditioned media from macrophages of M1, but not M2 phenotype, inhibit the proliferation of the colon cancer cell lines HT-29 and CACO-2

(2013) ALEXANDER ENGSTRÖM et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Splicing kinetics and transcript release from the chromatin compartment limit the rate of Lipid A-induced gene expression

(2013) A. Pandya-Jones et al.   RNA

microRNA Regulation of Inflammatory Responses

(2012) Ryan M. O'Connell et al.   Annual Review of Immunology

EFTUD2haploinsufficiency leads to syndromic oesophageal atresia

(2012) Christopher T Gordon et al.   JOURNAL OF MEDICAL GENETICS

Opposite Role of Tumor Necrosis Factor Receptors in Dextran Sulfate Sodium-Induced Colitis in Mice

(2012) Ke Wang et al.   PLoS One

IL-10 regulation of macrophage VEGF production is dependent on macrophage polarisation and hypoxia

(2010) Wei-Kang Wu et al.   IMMUNOBIOLOGY

ERK activation drives intestinal tumorigenesis in Apcmin/+ mice

(2010) Sung Hee Lee et al.   NATURE MEDICINE

Inflammation: cytokines and RNA-based regulation

(2010) Deborah J. Stumpo et al.   Wiley Interdisciplinary Reviews-RNA

IL-6 and Stat3 Are Required for Survival of Intestinal Epithelial Cells and Development of Colitis-Associated Cancer

(2009) Sergei Grivennikov et al.   CANCER CELL

Essential Roles of IL-6 Trans-Signaling in Colonic Epithelial Cells, Induced by the IL-6/Soluble-IL-6 Receptor Derived from Lamina Propria Macrophages, on the Development of Colitis-Associated Premalignant Cancer in a Murine Model

(2009) S. Matsumoto et al.   JOURNAL OF IMMUNOLOGY

Macrophage-derived IL-1β stimulates Wnt signaling and growth of colon cancer cells: a crosstalk interrupted by vitamin D3

(2009) P Kaler et al.   ONCOGENE

Cytokines: From Gut Inflammation to Colorectal Cancer

(2008) Massimo Fantini et al.   CURRENT DRUG TARGETS

Retinoblastoma Protein (pRb), but Not p107 or p130, Is Required for Maintenance of Enterocyte Quiescence and Differentiation in Small Intestine

(2008) Jun Guo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Role of cytokines in inflammatory bowel disease

(2008) Fausto Sanchez-Muñoz et al.   WORLD JOURNAL OF GASTROENTEROLOGY