Impact of the Co-Administration of N-3 Fatty Acids and Olive Oil Components in Preclinical Nonalcoholic Fatty Liver Disease Models: A Mechanistic View

Targeting n-3 Polyunsaturated Fatty Acids in Non-Alcoholic Fatty Liver Disease

(2020) Rodrigo Valenzuela et al.   CURRENT MEDICINAL CHEMISTRY

Involvement of G-Protein-Coupled Receptor 40 in the Inhibitory Effects of Docosahexaenoic Acid on SREBP1-Mediated Lipogenic Enzyme Expression in Primary Hepatocytes

(2019) Seungtae On et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Combined docosahexaenoic acid and thyroid hormone supplementation as a protocol supporting energy supply to precondition and afford protection against metabolic stress situations

(2019) Luis A. Videla   IUBMB LIFE

Hydroxytyrosol, Tyrosol and Derivatives and Their Potential Effects on Human Health

(2019) Karković Marković et al.   MOLECULES

Industrial Trans Fatty Acids Stimulate SREBP2‐mediated Cholesterogenesis and Promote non‐alcoholic Fatty Liver Disease

(2019) Antwi‐Boasiako Oteng et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Docosahexaenoic acid and hydroxytyrosol co‐administration fully prevents liver steatosis and related parameters in mice subjected to high‐fat diet: A molecular approach

(2019) Sandra A. Soto‐Alarcón et al.   BIOFACTORS

Therapeutic Potential of ω-3 Polyunsaturated Fatty Acids in Human Autoimmune Diseases

(2019) Xiaoxi Li et al.   Frontiers in Immunology

Lipid Related Genes Altered in NASH Connect Inflammation in Liver Pathogenesis Progression to HCC: A Canonical Pathway

(2019) Desterke et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Hydroxytyrosol Supplementation Modifies Plasma Levels of Tissue Inhibitor of Metallopeptidase 1 in Women with Breast Cancer

(2019) Cesar Ramirez-Tortosa et al.   Antioxidants

Dietary fatty acid oxidation is decreased in non‐alcoholic fatty liver disease: A palmitate breath test study

(2019) Gihan Naguib et al.   LIVER INTERNATIONAL

High Oleic Acid Peanut Oil and Extra Virgin Olive Oil Supplementation Attenuate Metabolic Syndrome in Rats by Modulating the Gut Microbiota

(2019) Zhihao Zhao et al.   Nutrients

Omega-3 fatty acids as a treatment for non-alcoholic fatty liver disease in children: A systematic review and meta-analysis of randomized controlled trials

(2018) Lian-hui Chen et al.   CLINICAL NUTRITION

Fatty acid and non-alcoholic fatty liver disease: Meta-analyses of case-control and randomized controlled trials

(2018) Xiao-fei Guo et al.   CLINICAL NUTRITION

The Transplantation of ω3 PUFA–Altered Gut Microbiota of fat-1 Mice to Wild-Type Littermates Prevents Obesity and Associated Metabolic Disorders

(2018) Célia Bidu et al.   DIABETES

Saturated Fat Is More Metabolically Harmful for the Human Liver Than Unsaturated Fat or Simple Sugars

(2018) Panu K. Luukkonen et al.   DIABETES CARE

Systematic review and meta-analysis of controlled intervention studies on the effectiveness of long-chain omega-3 fatty acids in patients with nonalcoholic fatty liver disease

(2018) Kathy Musa-Veloso et al.   NUTRITION REVIEWS

Hypoxic Signaling and Cholesterol Lipotoxicity in Fatty Liver Disease Progression

(2018) Oren Tirosh   Oxidative Medicine and Cellular Longevity

Attenuation of High-Fat Diet-Induced Rat Liver Oxidative Stress and Steatosis by Combined Hydroxytyrosol- (HT-) Eicosapentaenoic Acid Supplementation Mainly Relies on HT

(2018) Francisca Echeverría et al.   Oxidative Medicine and Cellular Longevity

Molecular mechanisms related to the hepatoprotective effects of antioxidant-rich extra virgin olive oil supplementation in rats subjected to short-term iron administration

(2018) Cynthia Barrera et al.   FREE RADICAL BIOLOGY AND MEDICINE

Reduction of high-fat diet-induced liver pro-inflammatory state by eicosapentaenoic acid plus hydroxytyrosol supplementation: Involvement of resolvins RvE1/2 and RvD1/2

(2018) F. Echeverría et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Current guidelines for the management of non-alcoholic fatty liver disease: A systematic review with comparative analysis

(2018) Simona Leoni et al.   WORLD JOURNAL OF GASTROENTEROLOGY

The antioxidant effects of Hydroxytyrosol and Vitamin E on pediatric NAFLD, in a clinical trial: a new treatment?

(2018) Valerio Nobili et al.   ANTIOXIDANTS & REDOX SIGNALING

Combined administration of docosahexaenoic acid and thyroid hormone synergistically enhances rat liver levels of resolvins RvD1 and RvD2

(2018) Luis A. Videla et al.   PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS

Impact of Omega-3 Fatty Acids on the Gut Microbiota

(2017) Lara Costantini et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Hydroxytyrosol and Cytoprotection: A Projection for Clinical Interventions

(2017) Francisca Echeverría et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Evidence of a DHA Signature in the Lipidome and Metabolome of Human Hepatocytes

(2017) Veronica Ghini et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Thyroid hormones and changes in body weight and metabolic parameters in response to weight loss diets: the POUNDS LOST trial

(2017) G Liu et al.   INTERNATIONAL JOURNAL OF OBESITY

Acute dietary fat intake initiates alterations in energy metabolism and insulin resistance

(2017) Elisa Álvarez Hernández et al.   JOURNAL OF CLINICAL INVESTIGATION

Supplementation with Docosahexaenoic Acid and Extra Virgin Olive Oil Prevents Liver Steatosis Induced by a High-Fat Diet in Mice through PPAR-α and Nrf2 Upregulation with Concomitant SREBP-1c and NF-kB Downregulation

(2017) María C. Hernández-Rodas et al.   MOLECULAR NUTRITION & FOOD RESEARCH

DHA increases adiponectin expression more effectively than EPA at relative low concentrations by regulating PPARγ and its phosphorylation at Ser273 in 3T3-L1 adipocytes

(2017) Jia Song et al.   Nutrition & Metabolism

Antioxidant Effects of a Hydroxytyrosol-Based Pharmaceutical Formulation on Body Composition, Metabolic State, and Gene Expression: A Randomized Double-Blinded, Placebo-Controlled Crossover Trial

(2017) Carmela Colica et al.   Oxidative Medicine and Cellular Longevity

Effects of Resveratrol and ACE Inhibitor Enalapril on Glucose and Lipid Profiles in Mice

(2017) Thaisa de Almeida Pinheiro et al.   PROTEIN AND PEPTIDE LETTERS

Effect of metabolites of hydroxytyrosol on protection against oxidative stress and inflammation in human endothelial cells

(2017) Sergio Lopez et al.   Journal of Functional Foods

Fructose Consumption, Lipogenesis, and Non-Alcoholic Fatty Liver Disease

(2017) et al.   Nutrients

Fructose and NAFLD: The Multifaceted Aspects of  Fructose Metabolism

(2017) Prasanthi Jegatheesan et al.   Nutrients

Liver Protective Effects of Extra Virgin Olive Oil: Interaction between Its Chemical Composition and the Cell-signaling Pathways Involved in Protection

(2017) Sandra A. Soto-Alarcon et al.   Endocrine Metabolic & Immune Disorders-Drug Targets

Docosahexaenoic Acid

(2016) Philip C. Calder   ANNALS OF NUTRITION AND METABOLISM

Genes and miRNA expression signatures in peripheral blood mononuclear cells in healthy subjects and patients with metabolic syndrome after acute intake of extra virgin olive oil

(2016) Simona D'Amore et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Global epidemiology of nonalcoholic fatty liver disease-Meta-analytic assessment of prevalence, incidence, and outcomes

(2016) Zobair M. Younossi et al.   HEPATOLOGY

Hydroxytyrosol prevents metabolic impairment reducing hepatic inflammation and restoring duodenal integrity in a rat model of NAFLD

(2016) Claudio Pirozzi et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Animal models of non-alcoholic fatty liver disease: current perspectives and recent advances

(2016) Jennie Ka Ching Lau et al.   JOURNAL OF PATHOLOGY

Treatment of Nonalcoholic Fatty Liver Disease with Long-Chain n-3 Polyunsaturated Fatty Acids in Humans

(2016) Nirvair S. Kelley   Metabolic Syndrome and Related Disorders

Dietary saturated fatty acid and polyunsaturated fatty acid oppositely affect hepatic NOD-like receptor protein 3 inflammasome through regulating nuclear factor-kappa B activation

(2016) Yong-Heng Sui   WORLD JOURNAL OF GASTROENTEROLOGY

Effects of Omega-3 Fatty Acid in Nonalcoholic Fatty Liver Disease: A Meta-Analysis

(2016) Wenxia Lu et al.   Gastroenterology Research and Practice

Docosahexaenoic acid inhibits proteolytic processing of sterol regulatory element-binding protein-1c (SREBP-1c) via activation of AMP-activated kinase

(2015) Xiong Deng et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Hydroxytyrosol improves mitochondrial function and reduces oxidative stress in the brain of db/db mice: role of AMP-activated protein kinase activation

(2015) Adi Zheng et al.   BRITISH JOURNAL OF NUTRITION

Relevant Aspects of Nutritional and Dietary Interventions in Non-Alcoholic Fatty Liver Disease

(2015) Maria Hernandez-Rodas et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Eicosapentaenoic and docosahexaenoic acid-enriched high fat diet delays the development of fatty liver in mice

(2015) Nikul K Soni et al.   Lipids in Health and Disease

Comparative study of the modulation of fructose/sucrose-induced hepatic steatosis by mixed lipid formulations varying in unsaturated fatty acid content

(2015) Rafat A. Siddiqui et al.   Nutrition & Metabolism

Membrane composition and dynamics: A target of bioactive virgin olive oil constituents

(2014) Sergio Lopez et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Unsaturated Fatty Acids, Desaturases, and Human Health

(2014) Hyungjae Lee et al.   JOURNAL OF MEDICINAL FOOD

Reversal of high-fat diet-induced hepatic steatosis by n-3 LCPUFA: role of PPAR-α and SREBP-1c

(2014) Camila G. Dossi et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

N-3long-chain PUFA supplementation prevents high fat diet induced mouse liver steatosis and inflammation in relation to PPAR-α upregulation and NF-κB DNA binding abrogation

(2014) Gladys Tapia et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Omega-3 Free Fatty Acids Suppress Macrophage Inflammasome Activation by Inhibiting NF-κB Activation and Enhancing Autophagy

(2014) Yolanda Williams-Bey et al.   PLoS One

Hydroxytyrosol attenuates tunicamycin-induced endoplasmic reticulum stress in human hepatocarcinoma cells

(2013) Elena Giordano et al.   MOLECULAR NUTRITION & FOOD RESEARCH

A Metabolomic Analysis of Omega-3 Fatty Acid-Mediated Attenuation of Western Diet-Induced Nonalcoholic Steatohepatitis in LDLR-/- Mice

(2013) Christopher M. Depner et al.   PLoS One

The innate immune response during liver inflammation and metabolic disease

(2013) Veerle Bieghs et al.   TRENDS IN IMMUNOLOGY

Hepatic Steatosis and Thyroid Function Tests in Overweight and Obese Children

(2013) L. Pacifico et al.   International Journal of Endocrinology

N-3 Long-Chain Polyunsaturated Fatty Acid Supplementation Significantly Reduces Liver Oxidative Stress in High Fat Induced Steatosis

(2012) Rodrigo Valenzuela et al.   PLoS One

Inverse Association Between Serum Free Thyroxine Levels and Hepatic Steatosis: Results from the Study of Health in Pomerania

(2012) Till Ittermann et al.   THYROID

Misregulation of PPAR Functioning and Its Pathogenic Consequences Associated with Nonalcoholic Fatty Liver Disease in Human Obesity

(2012) Luis A. Videla et al.   PPAR Research

Frequency and Outcomes of Liver Transplantation for Nonalcoholic Steatohepatitis in the United States

(2011) Michael R. Charlton et al.   GASTROENTEROLOGY

Effects of eicosapentaenoic acid and docosahexaenoic acid on low-density lipoprotein cholesterol and other lipids: A review

(2011) Terry A. Jacobson et al.   Journal of Clinical Lipidology

Omega-3 supplementation and non-alcoholic fatty liver disease: A systematic review and meta-analysis

(2011) Helen M. Parker et al.   JOURNAL OF HEPATOLOGY

Prevention of liver ischemia reperfusion injury by a combined thyroid hormone and fish oil protocol

(2011) Marcelo Mardones et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

The importance of the long-chain polyunsaturated fatty acid n-6/n-3 ratio in development of non-alcoholic fatty liver associated with obesity

(2011) Rodrigo Valenzuela et al.   Food & Function

A Role for Low Hepatic Copper Concentrations in Nonalcoholic Fatty Liver Disease

(2010) Elmar Aigner et al.   AMERICAN JOURNAL OF GASTROENTEROLOGY

GPR120 Is an Omega-3 Fatty Acid Receptor Mediating Potent Anti-inflammatory and Insulin-Sensitizing Effects

(2010) Da Young Oh et al.   CELL

Liver NF-κB and AP-1 activation and PPAR-α expression are negatively correlated in obese patients: Pro-inflammatory implications

(2010) Luis A. Videla   CLINICAL NUTRITION

Hydroxytyrosol protects against oxidative damage by simultaneous activation of mitochondrial biogenesis and phase II detoxifying enzyme systems in retinal pigment epithelial cells

(2010) Lu Zhu et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Enhancement in liver SREBP-1c/PPAR-α ratio and steatosis in obese patients: Correlations with insulin resistance and n-3 long-chain polyunsaturated fatty acid depletion

(2009) Paulina Pettinelli et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Long-chain n-3 polyunsaturated fatty acids: new insights into mechanisms relating to inflammation and coronary heart disease

(2009) Baukje de Roos et al.   BRITISH JOURNAL OF PHARMACOLOGY

Copper Availability Contributes to Iron Perturbations in Human Nonalcoholic Fatty Liver Disease

(2008) Elmar Aigner et al.   GASTROENTEROLOGY

Fructose consumption as a risk factor for non-alcoholic fatty liver disease

(2008) Xiaosen Ouyang et al.   JOURNAL OF HEPATOLOGY

Hormesis in aging

(2007) Suresh I.S. Rattan   AGEING RESEARCH REVIEWS