Animal models of non-alcoholic fatty liver disease: current perspectives and recent advances

Iron overload results in hepatic oxidative stress, immune cell activation, and hepatocellular ballooning injury, leading to nonalcoholic steatohepatitis in genetically obese mice

(2016) Priya Handa et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Carboxylesterase 2 prevents liver steatosis by modulating lipolysis, endoplasmic reticulum stress, and lipogenesis and is regulated by hepatocyte nuclear factor 4 alpha in mice

(2016) Yuanyuan Li et al.   HEPATOLOGY

CXC chemokine receptor 3 promotes steatohepatitis in mice through mediating inflammatory cytokines, macrophages and autophagy

(2016) Xiang Zhang et al.   JOURNAL OF HEPATOLOGY

A diet-induced animal model of non-alcoholic fatty liver disease and hepatocellular cancer

(2016) Amon Asgharpour et al.   JOURNAL OF HEPATOLOGY

Gd-EOB-DTPA-enhanced-MR imaging in the inflammation stage of nonalcoholic steatohepatitis (NASH) in mice

(2016) Tomomi Yamada et al.   MAGNETIC RESONANCE IMAGING

Oncogenic mutations and dysregulated pathways in obesity-associated hepatocellular carcinoma

(2016) J Shen et al.   ONCOGENE

Glucagon-like peptide-1 analogue prevents nonalcoholic steatohepatitis in non-obese mice

(2016) Takaya Yamamoto   WORLD JOURNAL OF GASTROENTEROLOGY

Activation of CDK4 Triggers Development of Non-alcoholic Fatty Liver Disease

(2016) Jingling Jin et al.   Cell Reports

Characteristics of nonalcoholic fatty liver disease induced in wistar rats following four different diets

(2015) Nicole Fakhoury-Sayegh et al.   Nutrition Research and Practice

Adipokines and proinflammatory cytokines, the key mediators in the pathogenesis of nonalcoholic fatty liver disease

(2015) Sanja Stojsavljević   WORLD JOURNAL OF GASTROENTEROLOGY

Metabolic Activation of Intrahepatic CD8+ T Cells and NKT Cells Causes Nonalcoholic Steatohepatitis and Liver Cancer via Cross-Talk with Hepatocytes

(2014) Monika Julia Wolf et al.   CANCER CELL

HCC Development Is Associated to Peripheral Insulin Resistance in a Mouse Model of NASH

(2014) Samuele De Minicis et al.   PLoS One

Immune and inflammatory pathways in NASH

(2013) Michal Ganz et al.   Hepatology International

In Vitro and in Vivo Models of Non-Alcoholic Fatty Liver Disease (NAFLD)

(2013) Giridhar Kanuri et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Strain dependence of diet-induced NASH and liver fibrosis in obese mice is linked to diabetes and inflammatory phenotype

(2013) Geoffrey C. Farrell et al.   LIVER INTERNATIONAL

A murine model for non-alcoholic steatohepatitis showing evidence of association between diabetes and hepatocellular carcinoma

(2013) Masato Fujii et al.   Medical Molecular Morphology

From NAFLD to NASH to cirrhosis—new insights into disease mechanisms

(2013) Alexander Wree et al.   Nature Reviews Gastroenterology & Hepatology

Non-Alcoholic Fatty Liver Disease (NAFLD) and Its Connection with Insulin Resistance, Dyslipidemia, Atherosclerosis and Coronary Heart Disease

(2013) Melania Gaggini et al.   Nutrients

Review article: is non-alcoholic fatty liver disease a spectrum, or are steatosis and non-alcoholic steatohepatitis distinct conditions?

(2012) Y. Yilmaz   ALIMENTARY PHARMACOLOGY & THERAPEUTICS

Synergistic interaction of dietary cholesterol and dietary fat in inducing experimental steatohepatitis

(2012) Christopher Savard et al.   HEPATOLOGY

Animal models of nonalcoholic fatty liver disease/nonalcoholic steatohepatitis

(2012) Yoshihisa Takahashi   WORLD JOURNAL OF GASTROENTEROLOGY

Congenital leptin deficiency: diagnosis and effects of leptin replacement therapy

(2011) Gilberto Paz-Filho et al.   Arquivos Brasileiros de Endocrinologia e Metabologia

Choline metabolism provides novel insights into nonalcoholic fatty liver disease and its progression

(2011) Karen D. Corbin et al.   CURRENT OPINION IN GASTROENTEROLOGY

Pathology of the liver in obese and diabetic ob/ob and db/db mice fed a standard or high-calorie diet

(2011) Viviane Trak-Smayra et al.   INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY

Coordinated improvement in glucose tolerance, liver steatosis and obesity-associated inflammation by cannabinoid 1 receptor antagonism in fat Aussie mice

(2011) K S Bell-Anderson et al.   INTERNATIONAL JOURNAL OF OBESITY

Dietary cholesterol exacerbates hepatic steatosis and inflammation in obese LDL receptor-deficient mice

(2011) Savitha Subramanian et al.   JOURNAL OF LIPID RESEARCH

Chronic Exposure to a High-Fat Diet Induces Hepatic Steatosis, Impairs Nitric Oxide Bioavailability, and Modifies the Mitochondrial Proteome in Mice

(2010) Heather B. Eccleston et al.   ANTIOXIDANTS & REDOX SIGNALING

The Role of Cytokines in Non-Alcoholic Fatty Liver Disease

(2010) Herbert Tilg   DIGESTIVE DISEASES

Nonalcoholic fatty liver disease and hepatocellular carcinoma: A weighty connection

(2010) Brad Q. Starley et al.   HEPATOLOGY

High-fructose, medium chain trans fat diet induces liver fibrosis and elevates plasma coenzyme Q9 in a novel murine model of obesity and nonalcoholic steatohepatitis

(2010) Rohit Kohli et al.   HEPATOLOGY

Evolution of inflammation in nonalcoholic fatty liver disease: The multiple parallel hits hypothesis

(2010) Herbert Tilg et al.   HEPATOLOGY

Presence and significance of microvesicular steatosis in nonalcoholic fatty liver disease

(2010) Sweta Tandra et al.   JOURNAL OF HEPATOLOGY

Histopathology of nonalcoholic fatty liver disease

(2010) Elizabeth M Brunt   WORLD JOURNAL OF GASTROENTEROLOGY

Non-alcoholic fatty liver disease pathogenesis: The present and the future

(2009) S. Petta et al.   DIGESTIVE AND LIVER DISEASE

Experimental mouse models for hepatocellular carcinoma research

(2009) Femke Heindryckx et al.   INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY

Pathogenesis of non-alcoholic fatty liver disease

(2009) J. K. Dowman et al.   QJM-AN INTERNATIONAL JOURNAL OF MEDICINE

Long-Term Follow-Up of Patients With Nonalcoholic Fatty Liver

(2008) Nila Rafiq et al.   Clinical Gastroenterology and Hepatology

Ezetimibe improves high fat and cholesterol diet-induced non-alcoholic fatty liver disease in mice

(2008) Shuqin Zheng et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Portal chronic inflammation in nonalcoholic fatty liver disease (NAFLD): A histologic marker of advanced NAFLD-Clinicopathologic correlations from the nonalcoholic steatohepatitis clinical research network

(2008) Elizabeth M. Brunt et al.   HEPATOLOGY

Increased overall mortality and liver-related mortality in non-alcoholic fatty liver disease

(2008) Janus P. Ong et al.   JOURNAL OF HEPATOLOGY

MCD-induced steatohepatitis is associated with hepatic adiponectin resistance and adipogenic transformation of hepatocytes

(2008) Claire Z. Larter et al.   JOURNAL OF HEPATOLOGY

Insulin resistance associated to obesity: the link TNF-alpha

(2008) Iria Nieto-Vazquez et al.   ARCHIVES OF PHYSIOLOGY AND BIOCHEMISTRY