Article
Biochemistry & Molecular Biology
Tomomi Yamazaki, Megumi Ihato
Summary: PPAR-alpha prevents fatty liver caused by excessive sucrose intake through regulating SREBP-1c target gene expression and liver TG accumulation. Gender differences may be related to the expression level of PPAR-gamma.
Article
Agriculture, Multidisciplinary
Huazhen Liu, Yonger Chen, Yifan Wen, Shumin Zhu, Song Huang, Lian He, Shaozhen Hou, Xiaoping Lai, Shuxian Chen, Zhenhua Dai, Jian Liang
Summary: The study demonstrated that phloridzin can effectively alleviate nonalcoholic fatty liver disease by regulating lipid metabolism and insulin resistance through inhibiting the mTORC1/SREBP-1c pathway.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Hong Lu, Xiaohong Lei, Rebecca Winkler, Savio John, Devendra Kumar, Wenkuan Li, Yazen Alnouti
Summary: The down-regulation of HNF4 alpha and GR plays an important role in fatty liver and hyperlipidemia. They regulate hepatic gene expression, suppress lipogenesis, and induce lipid catabolism to protect the liver from fat accumulation.
LIPIDS IN HEALTH AND DISEASE
(2022)
Article
Endocrinology & Metabolism
Christopher L. Axelrod, Ingeborg Langohr, Wagner S. Dantas, Elizabeth C. Heintz, Bolormaa Vandanmagsar, Shengping Yang, Elizabeth R. M. Zunica, R. Leigh Townsend, Vance L. Albaugh, Hans-Rudolf Berthoud, John P. Kirwan
Summary: Obesity is a driver of non-alcoholic fatty liver disease, and interventions that decrease body weight, such as bariatric surgery and/or calorie restriction, may serve as effective therapies. This study compared the effects of Roux-en-Y gastric bypass surgery and calorie restriction on hepatic function in mice with obesity and NAFLD. The results showed that gastric bypass surgery reduced hepatic lipid content and adiposity while increasing energy expenditure and lean body mass. Gastric bypass surgery also activated enterohepatic signaling and genes regulating hepatic lipid homeostasis.
Article
Multidisciplinary Sciences
Simara Larissa Fanalli, Bruna Pereira Martins da Silva, Julia Dezen Gomes, Fernanda Nery Ciconello, Vivian Vezzoni de Almeida, Felipe Andre Oliveira Freitas, Gabriel Costa Monteiro Moreira, Barbara Silva-Vignato, Juliana Afonso, James Reecy, James Koltes, Dawn Koltes, Luciana Correia Almeida Regitano, Julio Cesar de Carvalho Baileiro, Luciana Freitas, Luiz Lehmann Coutinho, Heidge Fukumasu, Severino Matias de Alencar, Albino Luchiari Filho, Aline Silva Mello Cesar
Summary: A study was conducted to identify key transcription factors involved in lipid metabolism and inflammatory response through transcriptome analysis from liver samples of animal models. The findings demonstrated that the key transcription factors related to lipid metabolism could be modulated by dietary inclusion of soybean oil.
SCIENTIFIC REPORTS
(2022)
Article
Nutrition & Dietetics
Danijela Ristic-Medic, Marijana Kovacic, Marija Takic, Aleksandra Arsic, Snjezana Petrovic, Marija Paunovic, Maja Jovicic, Vesna Vucic
Summary: This study evaluated the effects of calorie-restricted Mediterranean and low-fat diets on patients with NAFLD. Both diets resulted in significant weight loss and improvements in liver status and cardiometabolic markers. The Mediterranean diet may have additional benefits compared to the low-fat diet by improving fatty acid profiles and FLI in NAFLD patients.
Article
Pharmacology & Pharmacy
Mahdis Rahimi Naiini, Beydolah Shahouzehi, Shahrzad Azizi, Bentolhoda Shafiei, Mahdieh Nazari-Robati
Summary: Aging leads to impaired liver metabolic function, increasing the risk of liver and systemic diseases. Trehalose, a natural disaccharide, has shown potential in reducing dyslipidemia, hepatic steatosis, and glucose intolerance. This study aimed to investigate the effects of trehalose on lipid metabolism in aged liver.
NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY
(2023)
Editorial Material
Cell Biology
Thuy T. P. Nguyen, Do-Young Kim, Seung-Soon Im, Tae-Il Jeon
Summary: Nonalcoholic fatty liver disease affects a quarter of the global population with its pathogenesis not completely understood. A recent study has shown that SREBF1/SREBP-1c contributes to hepatic lipid accumulation through increased lipid synthesis and decreased lipid degradation mediated by autophagic dysregulation.
Article
Food Science & Technology
Eunjeong Hong, Hyuno Kang, Garam Yang, Sejong Oh, Eungseok Kim
Summary: The study aimed to evaluate the protective effect of Lactobacillus johnsonii JNU3402 (LJ3402) against diet-induced non-alcoholic fatty liver disease (NAFLD) and investigate the underlying mechanism. The results show that LJ3402 supplementation alleviates liver steatosis, diet-induced obesity, and insulin resistance by reducing the expression of lipogenic genes and increasing SREBP-1c phosphorylation. Mechanistic study reveals that LJ3402 inhibits SREBP-1c transcriptional activity through the lactate-PKA pathway.
MOLECULAR NUTRITION & FOOD RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Sheng Qiu, Zerong Liang, Qinan Wu, Miao Wang, Mengliu Yang, Chen Chen, Hongting Zheng, Zhiming Zhu, Ling Li, Gangyi Yang
Summary: The study reveals that Nrf2 deficiency promotes hepatic lipid accumulation by enhancing SREBP-1c activity and attenuating autophagy. Additionally, the Nrf2-LAMP1 interaction plays a crucial role in regulating Nrf2-mediated hepatosteatosis.
Article
Biology
Sahar Khateeb, Aishah Albalawi, Adel Alkhedaide
Summary: The study found that DG significantly reduced body weight gain, adjusted liver enzymes, and improved lipid levels in mice. Additionally, DG improved histopathological changes by reducing lipid vacuoles and hepatosteatosis, as well as downregulated SREBP-1c and FASN gene expression involved in fatty acid synthesis.
SAUDI JOURNAL OF BIOLOGICAL SCIENCES
(2021)
Article
Food Science & Technology
Dianzhi Hou, Jian Tang, Meili Huan, Fang Liu, Sumei Zhou, Qun Shen
Summary: Mung bean coat (MBC) can improve hepatic steatosis by manipulating the crosstalk between gut microbiota and its metabolites.
FOOD SCIENCE AND HUMAN WELLNESS
(2022)
Article
Environmental Sciences
Yifan Zhang, Heping Feng, Ao Tian, Cuili Zhang, Fuyong Song, Tao Zeng, Xiulan Zhao
Summary: This study aimed to investigate the combined effects of low-dose DEHP and a high-fat diet on obesity in female mice and explore the underlying mechanisms. It was found that chronic low-dose DEHP exposure increased fat accumulation and accelerated weight gain in HFD-fed mice. DEHP exposure reduced energy metabolism, down-regulated UCP1 and oxidative phosphorylation proteins expression in brown adipose tissue, and up-regulated PPAR gamma expression and phosphorylation at Ser273 in white adipose tissue. Additionally, DEHP and HFD co-treatment resulted in gut microbiota remodeling and a decrease in SCFAs levels. Sodium butyrate inhibited adipogenesis and lipid accumulation induced by DEHP or MEHP. These findings demonstrate that chronic low-dose DEHP exposure promotes fat accumulation by affecting PPAR gamma phosphorylation and thermogenesis, which may be associated with SCFAs reduction.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2023)
Article
Medicine, Research & Experimental
Poliana C. Marinello, Paola S. Cella, Mayra T. J. Testa, Phillipe B. Guirro, Walison Augusto da Silva Brito, Camila S. Padilha, Alessandra L. Cecchini, Robin P. da Silva, Jose Alberto R. Duarte, Rafael Deminice
Summary: This study investigated the effects of creatine supplementation on the pathogenesis of non-alcoholic fatty liver disease and alcoholic liver disease. The results showed that creatine supplementation prevented high-fat diet-induced non-alcoholic fatty liver disease but exacerbated ethanol-induced alcoholic liver disease. The exacerbating effects may be related to oxidative stress and inflammation-mediated upregulation of ethanol metabolism.
Article
Immunology
Min Jin, Yuedong Shen, Tingting Pan, Tingting Zhu, Xuejiao Li, Fangmin Xu, Monica B. Betancor, Lefei Jiao, Douglas R. Tocher, Qicun Zhou
Summary: The study found that betaine, as a lipid-lowering substance, has significant effects on lipid metabolism and inflammation regulation in juvenile black seabream, reducing hepatic steatosis and attenuating inflammatory responses by modulating multiple signaling pathways.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Xinyu Wang, Jun Huang, Huan Li, Yanlong Li, Shuang Cai, Bangxin Xue, Zhekun Zhu, Xiangzhou Zeng, Xiangfang Zeng
Summary: Embryo development plays a crucial role in pregnancy outcome and lifelong health. A high throughput screening cell model was established to select nutrients that can enhance embryonic development. Resveratrol was identified as a potential candidate for promoting embryo development.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Ren Yoshitomi, Motofumi Kumazoe, Kwan-Woo Lee, Yuki Marugame, Yoshinori Fujimura, Hirofumi Tachibana
Summary: This study investigated the connection between food components and circular RNA (circRNA), as well as the regulatory effect of (-)-Epigallocatechin-3-O-gallate (EGCG) on circRNA expression in the liver. The results showed that EGCG treatment altered the expression of circRNAs in mice livers, and one upregulated circRNA (mmu_circRNA_011775) affected the expression of genes related to liver fibrosis and the cardiovascular system.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
ViVi Tang Kang Wee, Hitoshi Shirakawa, Sung-Ling Yeh, Chiu-Li Yeh
Summary: This study investigated the effects of fermented rice bran (FRB) on modulating intestinal aryl hydrocarbon receptor (AhR) expression, innate lymphoid cell (ILC)3 populations, the fecal microbiota distribution, and their associations with dextran sodium sulfate (DSS)-induced acute colitis. The results showed that FRB supplementation can improve gut health, alleviate colitis symptoms, and have anti-colitis effects by enhancing ILC3 and AhR functions.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Xinzhuang Ma, Xijuan Ren, Xuemin Zhang, Guangyin Wang, Hui Liu, Li Wang
Summary: The study demonstrates that rutin can ameliorate kidney damage caused by PFOA exposure by improving oxidative stress and regulating lipid metabolism.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Ya-Jie Ding, Xue-Ning Li, Zhe Xiao, Chen-Yang Li, Li-Hong Jia
Summary: This study investigates the impact of maternal vitamin D levels during pregnancy on infantile eczema. The findings suggest that lower prenatal maternal vitamin D levels increase the risk of eczema in infants aged 0-1 year. Furthermore, the study indicates that infants with eczema have lower expression of the Foxp3 gene in cord blood and decreased placental FOXP3 protein expression. These results suggest that vitamin D may affect the development of infantile eczema through the regulation of gene and protein expression in cord blood and placenta.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Shujing Liu, Shiyu Song, Shuan Wang, Tonghui Cai, Lian Qin, Xinzhuang Wang, Guangming Zhu, Haibo Wang, Wenqi Yang, Chunlu Fang, Yuan Wei, Fu Zhou, Yang Yu, Shaozhang Lin, Shuang Peng, Liangming Li
Summary: Long-term consumption of a high-fat diet disrupts energy balance and leads to weight gain. The fat mass and obesity-associated (FTO) gene is involved in high-fat diet-induced obesity. The hypothalamus plays a crucial role in regulating energy balance, and high-fat diet-induced hypothalamic leptin resistance contributes to obesity. The study reveals that FTO is associated with hypothalamic leptin resistance and provides new insight into its role in obesity.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Shuang Liu, Xiaoling Chen, Jun He, Yuheng Luo, Ping Zheng, Bing Yu, Daiwen Chen, Zhiqing Huang
Summary: This study found that oleanolic acid promotes the transformation of fast muscle fibers to slow muscle fibers through the TGR5-mediated CaN/NFATc1 signaling pathway.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Huijuan Hu, Fan Li, Shaoli Cheng, Tingting Qu, Fanqi Shen, Jie Cheng, Lina Chen, Zhenghang Zhao, Hao Hu
Summary: Long-term alternate-day fasting can ameliorate obesity-induced anxiety-like behavior and hippocampal damage, but it can cause anxiety in normal-weight mice. Short-term alternate-day fasting does not produce adverse emotional reactions in normal-weight mice.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Jannis Ulke, Christian Schwedler, Janine Krueger, Vanessa Stein, Peter Geserick, Andre Kleinridders, Kai Kappert
Summary: This study characterized the glycosylation pattern of PTPRJ in the liver and found that high-fat diet-induced obesity altered the glycosylation pattern of PTPRJ. These findings provide new insights into the role of glycosylation in metabolic disorders.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Shuang Liu, Marii Mochizuki, Yasuyuki Suzuki, Erika Takemasa, Akiko Yano, Matome Imai, Masaki Mogi
Summary: This study evaluated the feasibility and efficacy of leucine supplementation in offsetting immune dysfunction in sarcopenia. The results showed that leucine supplementation not only improved muscle mass and restored mitochondrial respiratory function, but also reduced inflammation levels. These findings are important for the rational design and optimization of leucine supplementation in patients with sarcopenia and autoimmune diseases.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Review
Biochemistry & Molecular Biology
Zhan Su, Jun Fang, Bin Yao, Gang Liu
Summary: Osteoporosis is a serious skeletal disorder that can be prevented and treated by polyphenols, which have antioxidant and anti-allergy properties. Polyphenols affect bone metabolism and density by inhibiting oxidative stress and exhibiting antibacterial effects. This article provides an overview of the preventive and therapeutic effects of polyphenols on osteoporosis and discusses the mechanisms involved.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Qian Zhang, Xinhua Xiao, Jia Zheng, Ming Li, Miao Yu, Fan Ping, Tong Wang, Xiaojing Wang
Summary: Maternal high-fat diet can affect the structure and function of offspring's pancreas, leading to weight gain, glucose metabolism disorders, and insulin secretion defects. The study found that this may be related to DNA methylation of specific genes in the pancreas.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Hanaa Mousa, Aisha Al Saei, Rozaimi Mohamad Razali, Susu M. Zughaier
Summary: Vitamin D deficiency and dyslipidemia have significant implications for human health. This study investigates the proteomic profiles of individuals with and without these conditions, revealing decreased HDL-associated apolipoproteins and increased acute-phase proteins. Pathway analysis highlights inflammatory and cancer pathways associated with vitamin D deficiency and dyslipidemia.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Qi-Lan Jiang, Tao Li, Qin Xu, Yang Zeng, Wei Wang, Bo-Tao Zhang, Qing-Ping Yao, Rui Jiang, Jun Jiang
Summary: Environmental factors, especially dietary habits, play a significant role in the susceptibility and progression of cardiovascular diseases through epigenetic modification. This study found that a methyl donor diet can attenuate balloon injury-induced intimal hyperplasia in rat carotid arteries, potentially by influencing the composition and function of the extracellular matrix.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Review
Biochemistry & Molecular Biology
Jiayi Cai, Yajie Qiao, Lingbin Chen, Youguang Lu, Dali Zheng
Summary: The Notch signaling pathway plays a regulatory role in normal biological processes such as cellular differentiation, apoptosis, and stem cell self-renewal. Dysregulation of this pathway is associated with various types of cancer. Natural products targeting the Notch pathway have shown potential as chemopreventive and anti-cancer agents, providing a feasible solution to fight against cancer by either alone or in combination with current therapeutic agents.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)