Metabolic Regulation of Glial Phenotypes: Implications in Neuron–Glia Interactions and Neurological Disorders

Iron accumulation in microglia triggers a cascade of events that leads to altered metabolism and compromised function in APP/PS1 mice

(2019) Allison McIntosh et al.   BRAIN PATHOLOGY

Lipopolysaccharide-induced alteration of mitochondrial morphology induces a metabolic shift in microglia modulating the inflammatory response in vitro and in vivo

(2019) Syam Nair et al.   GLIA

Glucose transporter 1 critically controls microglial activation through facilitating glycolysis

(2019) Luxi Wang et al.   Molecular Neurodegeneration

Beyond the neuron–cellular interactions early in Alzheimer disease pathogenesis

(2019) Christopher M. Henstridge et al.   NATURE REVIEWS NEUROSCIENCE

Sodium rutin ameliorates Alzheimer’s disease–like pathology by enhancing microglial amyloid-β clearance

(2019) Rui-Yuan Pan et al.   Science Advances

Mitochondrial Dysfunction in Astrocytes Impairs the Generation of Reactive Astrocytes and Enhances Neuronal Cell Death in the Cortex Upon Photothrombotic Lesion

(2019) Christian Fiebig et al.   Frontiers in Molecular Neuroscience

Metabolic Reprogramming in Astrocytes Distinguishes Region-Specific Neuronal Susceptibility in Huntington Mice

(2019) Aris A. Polyzos et al.   Cell Metabolism

Neuron-Astrocyte Metabolic Coupling Protects against Activity-Induced Fatty Acid Toxicity

(2019) Maria S. Ioannou et al.   CELL

Nerve Growth Factor modulates LPS - induced microglial glycolysis and inflammatory responses

(2019) Georgia Fodelianaki et al.   EXPERIMENTAL CELL RESEARCH

Alpha-synuclein induces microglial migration via PKM2-dependent glycolysis

(2019) Hongfei Qiao et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Dual PPARα/γ agonist aleglitazar confers stroke protection in a model of mild focal brain ischemia in mice

(2019) Valérie Boujon et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

LncRNA-1810034E14Rik reduces microglia activation in experimental ischemic stroke

(2019) Xi Zhang et al.   Journal of Neuroinflammation

The Effects of Sodium Dichloroacetate on Mitochondrial Dysfunction and Neuronal Death Following Hypoglycemia-Induced Injury

(2019) Kho et al.   Cells

A Breakdown in Metabolic Reprogramming Causes Microglia Dysfunction in Alzheimer's Disease

(2019) Sung Hoon Baik et al.   Cell Metabolism

Enhanced glycolytic metabolism supports transmigration of brain-infiltrating macrophages in multiple sclerosis

(2019) Deepak Kumar Kaushik et al.   JOURNAL OF CLINICAL INVESTIGATION

Methylglyoxal-Derived Advanced Glycation Endproducts Accumulate in Multiple Sclerosis Lesions

(2019) Suzan Wetzels et al.   Frontiers in Immunology

Fragmented mitochondria released from microglia trigger A1 astrocytic response and propagate inflammatory neurodegeneration

(2019) Amit U. Joshi et al.   NATURE NEUROSCIENCE

Fractalkine Modulates Microglia Metabolism in Brain Ischemia

(2019) Clotilde Lauro et al.   Frontiers in Cellular Neuroscience

Inhibitors of Oxidative Phosphorylation Modulate Astrocyte Inflammatory Responses through AMPK-Dependent Ptgs2 mRNA Stabilization

(2019) Alina Astakhova et al.   Cells

Cholesterol sulfate alters astrocyte metabolism and provides protection against oxidative stress

(2019) Jude Prah et al.   BRAIN RESEARCH

TET2 Regulates the Neuroinflammatory Response in Microglia

(2019) Alejandro Carrillo-Jimenez et al.   Cell Reports

Dimethyl fumarate: targeting glycolysis to treat MS

(2018) Stefano Angiari et al.   CELL RESEARCH

Neuron-glia Interaction as a Possible Pathophysiological Mechanism of Bipolar Disorder

(2018) Jairo Vinicius Pinto et al.   Current Neuropharmacology

Hexokinase 2-dependent hyperglycolysis driving microglial activation contributes to ischemic brain injury

(2018) Yuan Li et al.   JOURNAL OF NEUROCHEMISTRY

CrossTalk proposal: an important astrocyte-to-neuron lactate shuttle couples neuronal activity to glucose utilisation in the brain

(2018) L. F. Barros et al.   JOURNAL OF PHYSIOLOGY-LONDON

Fingolimod anti-inflammatory and neuroprotective effects modulation of RAGE axis in multiple sclerosis patients

(2018) Zohara Sternberg et al.   NEUROPHARMACOLOGY

Do ketone bodies mediate the anti-seizure effects of the ketogenic diet?

(2018) Timothy A. Simeone et al.   NEUROPHARMACOLOGY

The Evolving Dialogue of Microglia and Neurons in Alzheimer’s Disease: Microglia as Necessary Transducers of Pathology

(2018) E. Simon et al.   NEUROSCIENCE

The multi-dimensional roles of astrocytes in ALS

(2018) Koji Yamanaka et al.   NEUROSCIENCE RESEARCH

Microglia-Astrocyte Crosstalk: An Intimate Molecular Conversation

(2018) Mithilesh Kumar Jha et al.   NEUROSCIENTIST

Attenuation of reactive gliosis in stroke-injured mouse brain does not affect neurogenesis from grafted human iPSC-derived neural progenitors

(2018) Cecilia Laterza et al.   PLoS One

Gliotransmitters and cytokines in the control of blood-brain barrier permeability

(2018) Elena D. Osipova et al.   REVIEWS IN THE NEUROSCIENCES

Dimethyl fumarate targets GAPDH and aerobic glycolysis to modulate immunity

(2018) Michael D. Kornberg et al.   SCIENCE

An Inflammation-Centric View of Neurological Disease: Beyond the Neuron

(2018) Stephen D. Skaper et al.   Frontiers in Cellular Neuroscience

The Aging Astrocyte Transcriptome from Multiple Regions of the Mouse Brain

(2018) Matthew M. Boisvert et al.   Cell Reports

Netrin-1 attenuates brain injury after middle cerebral artery occlusion via downregulation of astrocyte activation in mice

(2018) Xiaosong He et al.   Journal of Neuroinflammation

Anti-TLR2 antibody triggers oxidative phosphorylation in microglia and increases phagocytosis of β-amyloid

(2018) Ana Rubio-Araiz et al.   Journal of Neuroinflammation

Mitochondrial Modulation by Dichloroacetate Reduces Toxicity of Aberrant Glial Cells and Gliosis in the SOD1G93A Rat Model of Amyotrophic Lateral Sclerosis

(2018) Laura Martínez-Palma et al.   Neurotherapeutics

Basal fatty acid oxidation increases after recurrent low glucose in human primary astrocytes

(2018) Paul G. Weightman Potter et al.   DIABETOLOGIA

Rapidly progressive amyotrophic lateral sclerosis is associated with microglial reactivity and small heat shock protein expression in reactive astrocytes

(2018) R. P. Gorter et al.   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY

Microglia in Neurological Diseases: A Road Map to Brain-Disease Dependent-Inflammatory Response

(2018) Sara Bachiller et al.   Frontiers in Cellular Neuroscience

Tet2 restrains inflammatory gene expression in macrophages

(2017) Alyssa H. Cull et al.   EXPERIMENTAL HEMATOLOGY

The ketone body metabolite β-hydroxybutyrate induces an antidepression-associated ramification of microglia via HDACs inhibition-triggered Akt-small RhoGTPase activation

(2017) Chao Huang et al.   GLIA

Astrocyte lipid metabolism is critical for synapse development and function in vivo

(2017) Anne-Lieke F. van Deijk et al.   GLIA

Wildtype motoneurons, ALS-Linked SOD1 mutation and glutamate profoundly modify astrocyte metabolism and lactate shuttling

(2017) Blandine Madji Hounoum et al.   GLIA

Nanomolar nitric oxide concentrations quickly and reversibly modulate astrocytic energy metabolism

(2017) Alejandro San Martín et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Oligodendroglia: metabolic supporters of neurons

(2017) Thomas Philips et al.   JOURNAL OF CLINICAL INVESTIGATION

Proteomic analysis of aged microglia: shifts in transcription, bioenergetics, and nutrient response

(2017) Antwoine Flowers et al.   Journal of Neuroinflammation

Creatine Enhances Mitochondrial-Mediated Oligodendrocyte Survival After Demyelinating Injury

(2017) Kelly A. Chamberlain et al.   JOURNAL OF NEUROSCIENCE

Impairments in Motor Neurons, Interneurons and Astrocytes Contribute to Hyperexcitability in ALS: Underlying Mechanisms and Paths to Therapy

(2017) Dzung Do-Ha et al.   MOLECULAR NEUROBIOLOGY

Neurotoxic reactive astrocytes are induced by activated microglia

(2017) Shane A. Liddelow et al.   NATURE

Reactive astrogliosis in stroke: Contributions of astrocytes to recovery of neurological function

(2017) Neil R. Sims et al.   NEUROCHEMISTRY INTERNATIONAL

Brain energy metabolism spurns fatty acids as fuel due to their inherent mitotoxicity and potential capacity to unleash neurodegeneration

(2017) Peter Schönfeld et al.   NEUROCHEMISTRY INTERNATIONAL

Glial phenotype modulators

(2017) Kyoungho Suk   Oncotarget

Sirt3 Mediates the Inhibitory Effect of Adjudin on Astrocyte Activation and Glial Scar Formation following Ischemic Stroke

(2017) Xiao Yang et al.   Frontiers in Pharmacology

PSEN1 Mutant iPSC-Derived Model Reveals Severe Astrocyte Pathology in Alzheimer's Disease

(2017) Minna Oksanen et al.   Stem Cell Reports

Succinate supplementation improves metabolic performance of mixed glial cell cultures with mitochondrial dysfunction

(2017) Susan Giorgi-Coll et al.   Scientific Reports

Demyelination and neurodegeneration in multiple sclerosis: The role of hypoxia

(2016) Hans Lassmann   ANNALS OF NEUROLOGY

Functional polarization of neuroglia: Implications in neuroinflammation and neurological disorders

(2016) Mithilesh Kumar Jha et al.   BIOCHEMICAL PHARMACOLOGY

Targeting fatty acid metabolism in cancer and endothelial cells

(2016) Ulrike Harjes et al.   CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY

Microglial brain region−dependent diversity and selective regional sensitivities to aging

(2016) Kathleen Grabert et al.   NATURE NEUROSCIENCE

NMDA Receptors: Power Switches for Oligodendrocytes

(2016) Anna M. Krasnow et al.   NEURON

Astrocyte-derived interleukin-15 exacerbates ischemic brain injury via propagation of cellular immunity

(2016) Minshu Li et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Connecting Malfunctioning Glial Cells and Brain Degenerative Disorders

(2016) Natalie Kaminsky et al.   GENOMICS PROTEOMICS & BIOINFORMATICS

High expression of neutrophil gelatinase-associated lipocalin (NGAL) in the kidney proximal tubules of diabetic rats

(2015) Fenghua Liu et al.   Advances in Medical Sciences

Metabolic gene expression changes in astrocytes in Multiple Sclerosis cerebral cortex are indicative of immune-mediated signaling

(2015) T. Zeis et al.   BRAIN BEHAVIOR AND IMMUNITY

MicroRNA let-7c-5p protects against cerebral ischemia injury via mechanisms involving the inhibition of microglia activation

(2015) Jingshu Ni et al.   BRAIN BEHAVIOR AND IMMUNITY

Metabolic reprogramming in macrophages and dendritic cells in innate immunity

(2015) Beth Kelly et al.   CELL RESEARCH

Bioenergetic Mechanisms in Astrocytes May Contribute to Amyloid Plaque Deposition and Toxicity

(2015) Wen Fu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The degree of astrocyte activation in multiple system atrophy is inversely proportional to the distance to α-synuclein inclusions

(2015) Rowan Radford et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Tet2 is required to resolve inflammation by recruiting Hdac2 to specifically repress IL-6

(2015) Qian Zhang et al.   NATURE

Do glia drive synaptic and cognitive impairment in disease?

(2015) Won-Suk Chung et al.   NATURE NEUROSCIENCE

Up-regulation of glutamine synthesis in microglia activated with endotoxin

(2015) Kazuyuki Nakajima et al.   NEUROSCIENCE LETTERS

PD-1 alters T-cell metabolic reprogramming by inhibiting glycolysis and promoting lipolysis and fatty acid oxidation

(2015) Nikolaos Patsoukis et al.   Nature Communications

Astrocyte-Derived TGF-β1 Accelerates Disease Progression in ALS Mice by Interfering with the Neuroprotective Functions of Microglia and T Cells

(2015) Fumito Endo et al.   Cell Reports

Induction of a common microglia gene expression signature by aging and neurodegenerative conditions: a co-expression meta-analysis

(2015) Inge R Holtman et al.   Acta Neuropathologica Communications

Neuroprotective Effect of 6-Paradol in Focal Cerebral Ischemia Involves the Attenuation of Neuroinflammatory Responses in Activated Microglia

(2015) Bhakta Prasad Gaire et al.   PLoS One

Interaction of neurons and astrocytes underlies the mechanism of Aβ-induced neurotoxicity

(2014) Plamena R. Angelova et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Microglial regulation of immunological and neuroprotective functions of astroglia

(2014) Shih-Heng Chen et al.   GLIA

Lactate Storm Marks Cerebral Metabolism following Brain Trauma

(2014) Sanju Lama et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Neuroinflammation and M2 microglia: the good, the bad, and the inflamed

(2014) Jonathan D Cherry et al.   Journal of Neuroinflammation

An RNA-Sequencing Transcriptome and Splicing Database of Glia, Neurons, and Vascular Cells of the Cerebral Cortex

(2014) Y. Zhang et al.   JOURNAL OF NEUROSCIENCE

Glucose pathways adaptation supports acquisition of activated microglia phenotype

(2014) J. Gimeno-Bayón et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Can lactate serve as an energy substrate for axons in good times and in bad, in sickness and in health?

(2014) Selva Baltan   METABOLIC BRAIN DISEASE

Microglia Induce Motor Neuron Death via the Classical NF-κB Pathway in Amyotrophic Lateral Sclerosis

(2014) Ashley E. Frakes et al.   NEURON

Mitochondrial Dysfunctions in Neurodegenerative Diseases: Relevance to Alzheimer’s Disease

(2014) Jana Hroudová et al.   Biomed Research International

Inflammation-Induced Alteration of Astrocyte Mitochondrial Dynamics Requires Autophagy for Mitochondrial Network Maintenance

(2013) Elisa Motori et al.   Cell Metabolism

Inflammatory response of microglial BV-2 cells includes a glycolytic shift and is modulated by mitochondrial glucose-regulated protein 75/mortalin

(2013) Ludmila A. Voloboueva et al.   FEBS LETTERS

Reversible reactivity by optic nerve astrocytes

(2013) Daniel Sun et al.   GLIA

Amyloid beta deregulates astroglial mGluR5-mediated calcium signaling via calcineurin and Nf-kB

(2013) Dmitry Lim et al.   GLIA

Metabolic Pathways in Immune Cell Activation and Quiescence

(2013) Erika L. Pearce et al.   IMMUNITY

Microglia: Multiple roles in surveillance, circuit shaping, and response to injury

(2013) E. E. Benarroch   NEUROLOGY

Microglia, Amyloid and Glucose Metabolism in Parkinson’s Disease with and without Dementia

(2013) Paul Edison et al.   NEUROPSYCHOPHARMACOLOGY

Astrocytic therapies for neuronal repair in stroke

(2013) Amy J. Gleichman et al.   NEUROSCIENCE LETTERS

A  induces astrocytic glutamate release, extrasynaptic NMDA receptor activation, and synaptic loss

(2013) M. Talantova et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

mTOR and metabolic pathways in T cell quiescence and functional activation

(2013) Kai Yang et al.   SEMINARS IN IMMUNOLOGY

Oligodendroglia: metabolic supporters of axons

(2013) Brett M. Morrison et al.   TRENDS IN CELL BIOLOGY

Sugar for the brain: the role of glucose in physiological and pathological brain function

(2013) Philipp Mergenthaler et al.   TRENDS IN NEUROSCIENCES

The TSC-mTOR pathway regulates macrophage polarization

(2013) Vanessa Byles et al.   Nature Communications

NADPH oxidase expression in active multiple sclerosis lesions in relation to oxidative tissue damage and mitochondrial injury

(2012) Marie T. Fischer et al.   BRAIN

Extracellular aggregated Cu/Zn superoxide dismutase activates microglia to give a cytotoxic phenotype

(2012) Kate Roberts et al.   GLIA

Microglia and neurodegeneration: The role of systemic inflammation

(2012) Colm Cunningham   GLIA

Molecular mechanisms of metabolic reprogramming in proliferating cells: implications for T-cell-mediated immunity

(2012) Federica M. Marelli-Berg et al.   IMMUNOLOGY

Carbon Monoxide Modulates Apoptosis by Reinforcing Oxidative Metabolism in Astrocytes

(2012) Ana S. Almeida et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Energetics of CNS White Matter

(2012) J. J. Harris et al.   JOURNAL OF NEUROSCIENCE

Endothelial Cell-Derived Nitric Oxide Enhances Aerobic Glycolysis in Astrocytes via HIF-1 -Mediated Target Gene Activation

(2012) B. Brix et al.   JOURNAL OF NEUROSCIENCE

Genomic Analysis of Reactive Astrogliosis

(2012) J. L. Zamanian et al.   JOURNAL OF NEUROSCIENCE

The effects of Foxp3 on gene expression profiles in activated microglial cells

(2012) Sung-Hwa Sohn et al.   Molecular & Cellular Toxicology

Oligodendroglia metabolically support axons and contribute to neurodegeneration

(2012) Youngjin Lee et al.   NATURE

Review: Activation patterns of microglia and their identification in the human brain

(2012) D. Boche et al.   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY

Metabolic regulation by SIRT3: implications for tumorigenesis

(2012) Lydia W.S. Finley et al.   TRENDS IN MOLECULAR MEDICINE

Assessing mitochondrial dysfunction in cells

(2011) Martin D. Brand et al.   BIOCHEMICAL JOURNAL

Astrocyte - neuron lactate shuttle may boost more ATP supply to the neuron under hypoxic conditions - in silico study supported by in vitro expression data

(2011) Seda Genc et al.   BMC Systems Biology

Astrocyte-Neuron Lactate Transport Is Required for Long-Term Memory Formation

(2011) Akinobu Suzuki et al.   CELL

Brain Energy Metabolism: Focus on Astrocyte-Neuron Metabolic Cooperation

(2011) Mireille Bélanger et al.   Cell Metabolism

CX3CR1 Protein Signaling Modulates Microglial Activation and Protects against Plaque-independent Cognitive Deficits in a Mouse Model of Alzheimer Disease

(2011) Seo-Hyun Cho et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

ATP and glutamate released via astroglial connexin 43 hemichannels mediate neuronal death through activation of pannexin 1 hemichannels

(2011) Juan A. Orellana et al.   JOURNAL OF NEUROCHEMISTRY

Amyloid  -Induced Death in Neurons Involves Glial and Neuronal Hemichannels

(2011) J. A. Orellana et al.   JOURNAL OF NEUROSCIENCE

Myelination and Axonal Electrical Activity Modulate the Distribution and Motility of Mitochondria at CNS Nodes of Ranvier

(2011) N. Ohno et al.   JOURNAL OF NEUROSCIENCE

Astrocytes from familial and sporadic ALS patients are toxic to motor neurons

(2011) Amanda M Haidet-Phillips et al.   NATURE BIOTECHNOLOGY

Activated microglia decrease histone acetylation and Nrf2-inducible anti-oxidant defence in astrocytes: Restoring effects of inhibitors of HDACs, p38 MAPK and GSK3β

(2011) Fernando Correa et al.   NEUROBIOLOGY OF DISEASE

Microglia-Derived Macrophage Colony Stimulating Factor Promotes Generation of Proinflammatory Cytokines by Astrocytes in the Periventricular White Matter in the Hypoxic Neonatal Brain

(2010) Yi Yu Deng et al.   BRAIN PATHOLOGY

Mechanisms Underlying Inflammation in Neurodegeneration

(2010) Christopher K. Glass et al.   CELL

Adhesion and signaling between neurons and glial cells in Drosophila

(2010) Marion Silies et al.   CURRENT OPINION IN NEUROBIOLOGY

Foxp3 is a novel repressor of microglia activation

(2010) Hwan-Suck Chung et al.   GLIA

Concomitant astroglial atrophy and astrogliosis in a triple transgenic animal model of Alzheimer's disease

(2010) Markel Olabarria et al.   GLIA

The perivascular astroglial sheath provides a complete covering of the brain microvessels: An electron microscopic 3D reconstruction

(2010) Thomas Misje Mathiisen et al.   GLIA

Astrocyte loss of mutant SOD1 delays ALS disease onset and progression in G85R transgenic mice

(2010) L. Wang et al.   HUMAN MOLECULAR GENETICS

Amyloid-β Protein Oligomer at Low Nanomolar Concentrations Activates Microglia and Induces Microglial Neurotoxicity

(2010) Izumi Maezawa et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Amyloid-  Aggregates Cause Alterations of Astrocytic Metabolic Phenotype: Impact on Neuronal Viability

(2010) I. Allaman et al.   JOURNAL OF NEUROSCIENCE

Preconditioning and tolerance against cerebral ischaemia: from experimental strategies to clinical use

(2009) Ulrich Dirnagl et al.   LANCET NEUROLOGY

Evidence of Multisystem Disorder in Whole-Brain Map of Pathological TDP-43 in Amyotrophic Lateral Sclerosis

(2008) Felix Geser et al.   ARCHIVES OF NEUROLOGY

Advances in measuring cellular bioenergetics using extracellular flux

(2008) David A. Ferrick et al.   DRUG DISCOVERY TODAY

Mitochondrial Dysfunction in SOD1G93A-Bearing Astrocytes Promotes Motor Neuron Degeneration: Prevention by Mitochondrial-Targeted Antioxidants

(2008) P. Cassina et al.   JOURNAL OF NEUROSCIENCE

Astrocytes as determinants of disease progression in inherited amyotrophic lateral sclerosis

(2008) Koji Yamanaka et al.   NATURE NEUROSCIENCE

Astrocyte phenotype in relation to Alzheimer-type pathology in the ageing brain

(2008) J.E. Simpson et al.   NEUROBIOLOGY OF AGING