Mitochondrial Modulation by Dichloroacetate Reduces Toxicity of Aberrant Glial Cells and Gliosis in the SOD1G93A Rat Model of Amyotrophic Lateral Sclerosis

The regulation of tumor cell physiology by mitochondrial dynamics

(2018) David F. Kashatus   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Personalized Dosing of Dichloroacetate Using GSTZ1 Clinical Genotyping Assay

(2018) Taimour Langaee et al.   Genetic Testing and Molecular Biomarkers

Glia in brain energy metabolism: A perspective

(2018) L. Felipe Barros et al.   GLIA

Mitochondrial fission promotes cell migration by Ca2+ /CaMKII/ERK/FAK pathway in hepatocellular carcinoma

(2018) Xiacheng Sun et al.   LIVER INTERNATIONAL

Mitochondrial Dynamics at the Interface of Immune Cell Metabolism and Function

(2018) Angelika S. Rambold et al.   TRENDS IN IMMUNOLOGY

Lack of appropriate stoichiometry: Strong evidence against an energetically important astrocyte-neuron lactate shuttle in brain

(2017) Gerald A. Dienel   JOURNAL OF NEUROSCIENCE RESEARCH

Therapeutic Targeting of the Pyruvate Dehydrogenase Complex/Pyruvate Dehydrogenase Kinase (PDC/PDK) Axis in Cancer

(2017) Peter W Stacpoole   JNCI-Journal of the National Cancer Institute

Focal Transplantation of Aberrant Glial Cells Carrying the SOD1G93A Mutation into Rat Spinal Cord Induces Extensive Gliosis

(2017) Sofía Ibarburu et al.   NEUROIMMUNOMODULATION

The role of mitochondria in amyotrophic lateral sclerosis

(2017) Emma F. Smith et al.   NEUROSCIENCE LETTERS

Amyotrophic Lateral Sclerosis

(2017) Robert H. Brown et al.   NEW ENGLAND JOURNAL OF MEDICINE

Therapeutic applications of dichloroacetate and the role of glutathione transferase zeta-1

(2017) Margaret O. James et al.   PHARMACOLOGY & THERAPEUTICS

Therapeutic Targeting of the Pyruvate Dehydrogenase Complex/Pyruvate Dehydrogenase Kinase (PDC/PDK) Axis in Cancer

(2017) Peter W Stacpoole   JNCI-Journal of the National Cancer Institute

Molecular Mechanisms Modulating the Phenotype of Macrophages and Microglia

(2017) Stephanie A. Amici et al.   Frontiers in Immunology

Additive amelioration of ALS by co-targeting independent pathogenic mechanisms

(2017) Ashley E. Frakes et al.   Annals of Clinical and Translational Neurology

Altered Metabolic Profiles Associate with Toxicity in SOD1G93A Astrocyte-Neuron Co-Cultures

(2017) Gabriel N. Valbuena et al.   Scientific Reports

Post-paralysis tyrosine kinase inhibition with masitinib abrogates neuroinflammation and slows disease progression in inherited amyotrophic lateral sclerosis

(2016) Emiliano Trias et al.   Journal of Neuroinflammation

Metabolic reprogramming by the pyruvate dehydrogenase kinase–lactic acid axis: Linking metabolism and diverse neuropathophysiologies

(2016) Mithilesh Kumar Jha et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

Pharmacogenetic considerations with dichloroacetate dosing

(2016) Margaret O James et al.   PHARMACOGENOMICS

Defective Human Sperm Cells Are Associated with Mitochondrial Dysfunction and Oxidant Production1

(2015) Adriana Cassina et al.   BIOLOGY OF REPRODUCTION

Microglial M1/M2 polarization and metabolic states

(2015) Ruben Orihuela et al.   BRITISH JOURNAL OF PHARMACOLOGY

Redox Homeostasis and Mitochondrial Dynamics

(2015) Peter H.G.M. Willems et al.   Cell Metabolism

A metabolic switch toward lipid use in glycolytic muscle is an early pathologic event in a mouse model of amyotrophic lateral sclerosis

(2015) L. Palamiuc et al.   EMBO Molecular Medicine

Protective and Toxic Neuroinflammation in Amyotrophic Lateral Sclerosis

(2015) Kristopher G. Hooten et al.   Neurotherapeutics

Dichloroacetate affects proliferation but not survival of human colorectal cancer cells

(2014) L. M. Delaney et al.   APOPTOSIS

Necroptosis Drives Motor Neuron Death in Models of Both Sporadic and Familial ALS

(2014) Diane B. Re et al.   NEURON

Long-term safety of dichloroacetate in congenital lactic acidosis

(2013) Monica Abdelmalak et al.   MOLECULAR GENETICS AND METABOLISM

Phenotypic transition of microglia into astrocyte-like cells associated with disease onset in a model of inherited ALS

(2013) Emiliano Trias et al.   Frontiers in Cellular Neuroscience

Pyruvate Dehydrogenase Kinases in the Nervous System: Their Principal Functions in Neuronal-glial Metabolic Interaction and Neuro-metabolic Disorders

(2012) Mithilesh Kumar Jha et al.   Current Neuropharmacology

Mitochondrial morphology—emerging role in bioenergetics

(2012) Chad A. Galloway et al.   FREE RADICAL BIOLOGY AND MEDICINE

Modulation of Astrocytic Mitochondrial Function by Dichloroacetate Improves Survival and Motor Performance in Inherited Amyotrophic Lateral Sclerosis

(2012) Ernesto Miquel et al.   PLoS One

Assessing mitochondrial dysfunction in cells

(2011) Martin D. Brand et al.   BIOCHEMICAL JOURNAL

Astrocytes from familial and sporadic ALS patients are toxic to motor neurons

(2011) Amanda M Haidet-Phillips et al.   NATURE BIOTECHNOLOGY

Phenotypically aberrant astrocytes that promote motoneuron damage in a model of inherited amyotrophic lateral sclerosis

(2011) P. Diaz-Amarilla et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Sodium dichloroacetate selectively targets cells with defects in the mitochondrial ETC

(2010) Luke H. Stockwin et al.   INTERNATIONAL JOURNAL OF CANCER

Energy metabolism in amyotrophic lateral sclerosis

(2010) Luc Dupuis et al.   LANCET NEUROLOGY

Metabolic Modulation of Glioblastoma with Dichloroacetate

(2010) E. D. Michelakis et al.   Science Translational Medicine

Peripheral Neuropathy in Rats Exposed to Dichloroacetate

(2009) Nigel A. Calcutt et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Modulation of astrocytic metabolic phenotype by proinflammatory cytokines

(2008) Mathilde Gavillet et al.   GLIA

Mitochondrial Dysfunction in SOD1G93A-Bearing Astrocytes Promotes Motor Neuron Degeneration: Prevention by Mitochondrial-Targeted Antioxidants

(2008) P. Cassina et al.   JOURNAL OF NEUROSCIENCE

Evaluation of Long-term Treatment of Children With Congenital Lactic Acidosis With Dichloroacetate

(2008) P. W. Stacpoole et al.   PEDIATRICS