Rapidly progressive amyotrophic lateral sclerosis is associated with microglial reactivity and small heat shock protein expression in reactive astrocytes

Microglia-mediated recovery from ALS-relevant motor neuron degeneration in a mouse model of TDP-43 proteinopathy

(2018) Krista J. Spiller et al.   NATURE NEUROSCIENCE

Modeling Protein Aggregation and the Heat Shock Response in ALS iPSC-Derived Motor Neurons

(2018) Emily R. Seminary et al.   Frontiers in Neuroscience

Frequent genes in rare diseases: panel-based next generation sequencing to disclose causal mutations in hereditary neuropathies

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Clinical Significance of TDP-43 Neuropathology in Amyotrophic Lateral Sclerosis

(2017) Matthew D. Cykowski et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Amyotrophic lateral sclerosis

(2017) Michael A van Es et al.   LANCET

The heat shock response in neurons and astroglia and its role in neurodegenerative diseases

(2017) Rebecca San Gil et al.   Molecular Neurodegeneration

SOD1 Mutations Causing Familial Amyotrophic Lateral Sclerosis Induce Toxicity in Astrocytes: Evidence for Bystander Effects in a Continuum of Astrogliosis

(2017) Nicole Wallis et al.   NEUROCHEMICAL RESEARCH

Heat shock protein expression in cerebral X-linked adrenoleukodystrophy reveals astrocyte stress prior to myelin loss

(2017) A. L. Görtz et al.   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY

Phosphorylation of αB-crystallin supports reactive astrogliosis in demyelination

(2017) Hedwich F. Kuipers et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Correlation of Peripheral Immunity With Rapid Amyotrophic Lateral Sclerosis Progression

(2017) Benjamin J. Murdock et al.   JAMA Neurology

Characterization of Gene Expression Phenotype in Amyotrophic Lateral Sclerosis Monocytes

(2017) Weihua Zhao et al.   JAMA Neurology

Decreased Levels of Foldase and Chaperone Proteins Are Associated with an Early-Onset Amyotrophic Lateral Sclerosis

(2017) Melania Filareti et al.   Frontiers in Molecular Neuroscience

Protein Homeostasis in Amyotrophic Lateral Sclerosis: Therapeutic Opportunities?

(2017) Christopher P. Webster et al.   Frontiers in Molecular Neuroscience

Cellular Chaperones As Therapeutic Targets in ALS to Restore Protein Homeostasis and Improve Cellular Function

(2017) Bernadett Kalmar et al.   Frontiers in Molecular Neuroscience

Sporadic ALS Astrocytes Induce Neuronal Degeneration In Vivo

(2017) Kun Qian et al.   Stem Cell Reports

A data-driven approach links microglia to pathology and prognosis in amyotrophic lateral sclerosis

(2017) Johnathan Cooper-Knock et al.   Acta Neuropathologica Communications

αB-Crystallin overexpression in astrocytes modulates the phenotype of the BACHD mouse model of Huntington's disease

(2016) Ana Osório Oliveira et al.   HUMAN MOLECULAR GENETICS

Heat shock proteins as potential targets for protective strategies in neurodegeneration

(2016) Harm H Kampinga et al.   LANCET NEUROLOGY

Elevation of serum heat-shock protein levels in amyotrophic lateral sclerosis

(2016) Daigo Miyazaki et al.   NEUROLOGICAL SCIENCES

CSF1R blockade slows the progression of amyotrophic lateral sclerosis by reducing microgliosis and invasion of macrophages into peripheral nerves

(2016) Anna Martínez-Muriana et al.   Scientific Reports

Small heat shock proteins: Role in cellular functions and pathology

(2015) Raman Bakthisaran et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Identifying who will benefit from non-invasive ventilation in amyotrophic lateral sclerosis/motor neurone disease in a clinical cohort

(2015) David J Berlowitz et al.   JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY

Small heat shock proteins are induced during multiple sclerosis lesion development in white but not grey matter

(2015) Laura A. N. Peferoen et al.   Acta Neuropathologica Communications

Demyelination during multiple sclerosis is associated with combined activation of microglia/macrophages by IFN-γ and alpha B-crystallin

(2014) Malika Bsibsi et al.   ACTA NEUROPATHOLOGICA

Modulation of the Maladaptive Stress Response to Manage Diseases of Protein Folding

(2014) Daniela Martino Roth et al.   PLOS BIOLOGY

Expression of ALS-linked TDP-43 mutant in astrocytes causes non-cell-autonomous motor neuron death in rats

(2013) Jianbin Tong et al.   EMBO JOURNAL

The small heat shock proteins αB-crystallin and Hsp27 suppress SOD1 aggregation in vitro

(2012) Justin J. Yerbury et al.   CELL STRESS & CHAPERONES

HSPBs: Small proteins with big implications in human disease

(2012) Harm H. Kampinga et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Small heat shock proteins and the cytoskeleton: An essential interplay for cell integrity?

(2012) G. Wettstein et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Fiji: an open-source platform for biological-image analysis

(2012) Johannes Schindelin et al.   NATURE METHODS

The Aggregation and Neurotoxicity of TDP-43 and Its ALS-Associated 25 kDa Fragment Are Differentially Affected by Molecular Chaperones in Drosophila

(2012) Jenna M. Gregory et al.   PLoS One

Small Heat Shock Proteins Induce a Cerebral Inflammatory Reaction

(2011) I. B. Bruinsma et al.   JOURNAL OF NEUROSCIENCE

Amyotrophic lateral sclerosis

(2011) Matthew C Kiernan et al.   LANCET

The small heat shock protein B8 (HspB8) promotes autophagic removal of misfolded proteins involved in amyotrophic lateral sclerosis (ALS)

(2010) Valeria Crippa et al.   HUMAN MOLECULAR GENETICS

A Systematic Review of the Incidence and Prevalence of Long-Term Neurological Conditions in the UK

(2010) Thomas Hoppitt et al.   NEUROEPIDEMIOLOGY

Why proteins without an α-crystallin domain should not be included in the human small heat shock protein family HSPB

(2009) Guido Kappé et al.   CELL STRESS & CHAPERONES

Suppression of GFAP toxicity by αB-crystallin in mouse models of Alexander disease

(2009) Tracy L. Hagemann et al.   HUMAN MOLECULAR GENETICS

Astrocytes in amyotrophic lateral sclerosis: direct effects on motor neuron survival

(2009) K. A. Staats et al.   JOURNAL OF BIOLOGICAL PHYSICS

Proteome analysis reveals candidate markers of disease progression in amyotrophic lateral sclerosis (ALS)

(2009) Johannes Brettschneider et al.   NEUROSCIENCE LETTERS

Guidelines for the nomenclature of the human heat shock proteins

(2008) Harm H. Kampinga et al.   CELL STRESS & CHAPERONES

Vesicle associated membrane protein B (VAPB) is decreased in ALS spinal cord

(2008) Georgia Anagnostou et al.   NEUROBIOLOGY OF AGING

Stress proteins in CNS inflammation

(2007) JM van Noort   JOURNAL OF PATHOLOGY