Enhanced glycolytic metabolism supports transmigration of brain-infiltrating macrophages in multiple sclerosis

Lactate secreted by cervical cancer cells modulates macrophage phenotype

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Chondroitin sulfate proteoglycans as novel drivers of leucocyte infiltration in multiple sclerosis

(2018) Erin L Stephenson et al.   BRAIN

Dimethyl fumarate targets GAPDH and aerobic glycolysis to modulate immunity

(2018) Michael D. Kornberg et al.   SCIENCE

Advances in Meningeal Immunity

(2018) Rejane Rua et al.   TRENDS IN MOLECULAR MEDICINE

CNS inflammation and neurodegeneration

(2017) Tanuja Chitnis et al.   JOURNAL OF CLINICAL INVESTIGATION

Lineage-Specific Metabolic Properties and Vulnerabilities of T Cells in the Demyelinating Central Nervous System

(2017) Scott M. Seki et al.   JOURNAL OF IMMUNOLOGY

Extracellular Lactate: A Novel Measure of T Cell Proliferation

(2017) James T. Grist et al.   JOURNAL OF IMMUNOLOGY

Metabolic regulation of inflammation

(2017) Timo Gaber et al.   Nature Reviews Rheumatology

Hyperpolarized13C MR metabolic imaging can detect neuroinflammation in vivo in a multiple sclerosis murine model

(2017) Caroline Guglielmetti et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Anti-inflammatory effect of IL-10 mediated by metabolic reprogramming of macrophages

(2017) W. K. Eddie Ip et al.   SCIENCE

FX11 inhibits aerobic glycolysis and growth of neuroblastoma cells

(2017) Eric J. Rellinger et al.   SURGERY

Disruption of the monocarboxylate transporter-4-basigin interaction inhibits the hypoxic response, proliferation, and tumor progression

(2017) Dillon M. Voss et al.   Scientific Reports

LDHA-Associated Lactic Acid Production Blunts Tumor Immunosurveillance by T and NK Cells

(2016) Almut Brand et al.   Cell Metabolism

HIF1α and metabolic reprogramming in inflammation

(2016) Sarah E. Corcoran et al.   JOURNAL OF CLINICAL INVESTIGATION

Impact of Minocycline on Extracellular Matrix Metalloproteinase Inducer, a Factor Implicated in Multiple Sclerosis Immunopathogenesis

(2016) Jennifer N. Hahn et al.   JOURNAL OF IMMUNOLOGY

Proinflammatory signal suppresses proliferation and shifts macrophage metabolism from Myc-dependent to HIF1α-dependent

(2016) Lingling Liu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Aerobic glycolysis promotes T helper 1 cell differentiation through an epigenetic mechanism

(2016) M. Peng et al.   SCIENCE

HIF-1α-PDK1 axis-induced active glycolysis plays an essential role in macrophage migratory capacity

(2016) Hiroaki Semba et al.   Nature Communications

A Diet Mimicking Fasting Promotes Regeneration and Reduces Autoimmunity and Multiple Sclerosis Symptoms

(2016) In Young Choi et al.   Cell Reports

Lactate Inhibits the Pro-Inflammatory Response and Metabolic Reprogramming in Murine Macrophages in a GPR81-Independent Manner

(2016) Agustina Errea et al.   PLoS One

Gray Matter Hypoxia in the Brain of the Experimental Autoimmune Encephalomyelitis Model of Multiple Sclerosis

(2016) Thomas W. Johnson et al.   PLoS One

Metabolic reprogramming in macrophages and dendritic cells in innate immunity

(2015) Beth Kelly et al.   CELL RESEARCH

Postharvest Processing and Benefits of Black Pepper, Coriander, Cinnamon, Fenugreek, and Turmeric Spices

(2015) S. Balasubramanian et al.   CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION

Stimulation of Monocytes, Macrophages, and Microglia by Amphotericin B and Macrophage Colony-Stimulating Factor Promotes Remyelination

(2015) A. Doring et al.   JOURNAL OF NEUROSCIENCE

Focal MMP-2 and MMP-9 Activity at the Blood-Brain Barrier Promotes Chemokine-Induced Leukocyte Migration

(2015) Jian Song et al.   Cell Reports

Lactate Regulates Metabolic and Pro-inflammatory Circuits in Control of T Cell Migration and Effector Functions

(2015) Robert Haas et al.   PLOS BIOLOGY

Functional Relevance of Protein Glycosylation to the Pro-Inflammatory Effects of Extracellular Matrix Metalloproteinase Inducer (EMMPRIN) on Monocytes/Macrophages

(2015) Heng Ge et al.   PLoS One

Cinnamon Ameliorates Experimental Allergic Encephalomyelitis in Mice via Regulatory T Cells: Implications for Multiple Sclerosis Therapy

(2015) Susanta Mondal et al.   PLoS One

Inhibition of lactate dehydrogenase activity as an approach to cancer therapy

(2014) Luigi Fiume et al.   Future Medicinal Chemistry

Cellular distribution of glucose and monocarboxylate transporters in human brain white matter and multiple sclerosis lesions

(2014) Philip G. Nijland et al.   GLIA

Upregulation of CD147 protects hepatocellular carcinoma cell from apoptosis through glycolytic switch via HIF-1 and MCT-4 under hypoxia

(2014) Xia Ke et al.   Hepatology International

Importance of N-Glycosylation on CD147 for Its Biological Functions

(2014) Yang Bai et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

The Monocarboxylate Transporter 4 Is Required for Glycolytic Reprogramming and Inflammatory Response in Macrophages

(2014) Zheng Tan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Functional polarization of tumour-associated macrophages by tumour-derived lactic acid

(2014) Oscar R. Colegio et al.   NATURE

Extracellular matrix metalloproteinase inducer shows active perivascular cuffs in multiple sclerosis

(2013) Smriti M. Agrawal et al.   BRAIN

Succinate is an inflammatory signal that induces IL-1β through HIF-1α

(2013) G. M. Tannahill et al.   NATURE

Hypoxia upregulates CD147 through a combined effect of HIF-1α and Sp1 to promote glycolysis and tumor progression in epithelial solid tumors

(2012) Xia Ke et al.   CARCINOGENESIS

Acute feedback control of astrocytic glycolysis by lactate

(2012) T. Sotelo-Hitschfeld et al.   GLIA

Oligodendroglia metabolically support axons and contribute to neurodegeneration

(2012) Youngjin Lee et al.   NATURE

Control of TH17/Treg Balance by Hypoxia-Inducible Factor 1

(2011) Eric V. Dang et al.   CELL

Myelin ingestion alters macrophage antigen-presenting function in vitro and in vivo

(2011) M. van Zwam et al.   JOURNAL OF LEUKOCYTE BIOLOGY

EMMPRIN: A Novel Regulator of Leukocyte Transmigration into the CNS in Multiple Sclerosis and Experimental Autoimmune Encephalomyelitis

(2011) S. M. Agrawal et al.   JOURNAL OF NEUROSCIENCE

Neuroprotection by Spice-Derived Nutraceuticals: You Are What You Eat!

(2011) Ramaswamy Kannappan et al.   MOLECULAR NEUROBIOLOGY

CD147 subunit of lactate/H+ symporters MCT1 and hypoxia-inducible MCT4 is critical for energetics and growth of glycolytic tumors

(2011) R. Le Floch et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Inhibition of lactate dehydrogenase A induces oxidative stress and inhibits tumor progression

(2010) A. Le et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Lactate Boosts TLR4 Signaling and NF- B Pathway-Mediated Gene Transcription in Macrophages via Monocarboxylate Transporters and MD-2 Up-Regulation

(2009) D. J. Samuvel et al.   JOURNAL OF IMMUNOLOGY