Wildtype motoneurons, ALS-Linked SOD1 mutation and glutamate profoundly modify astrocyte metabolism and lactate shuttling

Metabolomics in amyotrophic lateral sclerosis: how far can it take us?

(2016) H. Blasco et al.   EUROPEAN JOURNAL OF NEUROLOGY

Connexin 43 in astrocytes contributes to motor neuron toxicity in amyotrophic lateral sclerosis

(2016) Akshata A. Almad et al.   GLIA

Enhancing NAD+Salvage Pathway Reverts the Toxicity of Primary Astrocytes Expressing Amyotrophic Lateral Sclerosis-linked Mutant Superoxide Dismutase 1 (SOD1)

(2016) Benjamin A. Harlan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Multi-platform mass spectrometry analysis of the CSF and plasma metabolomes of rigorously matched amyotrophic lateral sclerosis, Parkinson's disease and control subjects

(2016) Anna Wuolikainen et al.   Molecular BioSystems

Purinergic contribution to amyotrophic lateral sclerosis

(2016) Cinzia Volonté et al.   NEUROPHARMACOLOGY

Combined Metabolomics and Transcriptomics Approaches to Assess the IL-6 Blockade as a Therapeutic of ALS: Deleterious Alteration of Lipid Metabolism

(2016) Franck Patin et al.   Neurotherapeutics

Liquid chromatography–high-resolution mass spectrometry-based cell metabolomics: Experimental design, recommendations, and applications

(2016) Blandine Madji Hounoum et al.   TRAC-TRENDS IN ANALYTICAL CHEMISTRY

NSC-34 Motor Neuron-Like Cells Are Unsuitable as Experimental Model for Glutamate-Mediated Excitotoxicity

(2016) Blandine Madji Hounoum et al.   Frontiers in Cellular Neuroscience

Analytical methodology for metabolomics study of adherent mammalian cells using NMR, GC-MS and LC-HRMS

(2015) Blandine Madji Hounoum et al.   ANALYTICAL AND BIOANALYTICAL CHEMISTRY

Tweak regulates astrogliosis, microgliosis and skeletal muscle atrophy in a mouse model of amyotrophic lateral sclerosis

(2015) M. Bowerman et al.   HUMAN MOLECULAR GENETICS

A Cellular Perspective on Brain Energy Metabolism and Functional Imaging

(2015) Pierre J. Magistretti et al.   NEURON

Reductions of docosahexaenoic acid-containing phosphatidylcholine levels in the anterior horn of an ALS mouse model

(2015) H. Arima et al.   NEUROSCIENCE

MetaboAnalyst 3.0—making metabolomics more meaningful

(2015) Jianguo Xia et al.   NUCLEIC ACIDS RESEARCH

Astrocyte physiopathology: At the crossroads of intercellular networking, inflammation and cell death

(2015) Daniela Rossi   PROGRESS IN NEUROBIOLOGY

The Glutamate Hypothesis in ALS: Pathophysiology and Drug Development

(2014) H. Blasco et al.   CURRENT MEDICINAL CHEMISTRY

A Local Glutamate-Glutamine Cycle Sustains Synaptic Excitatory Transmitter Release

(2014) Hiroaki Tani et al.   NEURON

Astrocytes expressing mutant SOD1 and TDP43 trigger motoneuron death that is mediated via sodium channels and nitroxidative stress

(2014) Fabiola Rojas et al.   Frontiers in Cellular Neuroscience

Lactate oxidation at the mitochondria: a lactate-malate-aspartate shuttle at work

(2014) Daniel A. Kane   Frontiers in Neuroscience

Energy metabolism and glutamate-glutamine cycle in the brain: a stoichiometric modeling perspective

(2013) Francesco A Massucci et al.   BMC Systems Biology

1H–13C NMR-based urine metabolic profiling in autism spectrum disorders

(2013) Sylvie Mavel et al.   TALANTA

Unraveling the complex metabolic nature of astrocytes

(2013) Anne-Karine Bouzier-Sore et al.   Frontiers in Cellular Neuroscience

Lactate-starved neurons in ALS

(2012) B. A. Martinez   Disease Models & Mechanisms

Phosphatidylethanolamine Deficiency in Mammalian Mitochondria Impairs Oxidative Phosphorylation and Alters Mitochondrial Morphology

(2012) Guergana Tasseva et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Oligodendroglia metabolically support axons and contribute to neurodegeneration

(2012) Youngjin Lee et al.   NATURE

Global metabolic profiling of animal and human tissues via UPLC-MS

(2012) Elizabeth J Want et al.   Nature Protocols

Substrate Competition Studies Demonstrate Oxidative Metabolism of Glucose, Glutamate, Glutamine, Lactate and 3-Hydroxybutyrate in Cortical Astrocytes from Rat Brain

(2012) Mary C. McKenna   NEUROCHEMICAL RESEARCH

Dysregulation of astrocyte–motoneuron cross-talk in mutant superoxide dismutase 1-related amyotrophic lateral sclerosis

(2011) Laura Ferraiuolo et al.   BRAIN

Glutamate and glutathione interplay in a motor neuronal model of amyotrophic lateral sclerosis reveals altered energy metabolism

(2011) Giuseppina D'Alessandro et al.   NEUROBIOLOGY OF DISEASE

Astrocytes carrying the superoxide dismutase 1 (SOD1G93A) mutation induce wild-type motor neuron degeneration in vivo

(2011) S. T. Papadeas et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

IFNγ triggers a LIGHT-dependent selective death of motoneurons contributing to the non-cell-autonomous effects of mutant SOD1

(2010) J Aebischer et al.   CELL DEATH AND DIFFERENTIATION

Systems level studies of mammalian metabolomes: the roles of mass spectrometry and nuclear magnetic resonance spectroscopy

(2010) Warwick B. Dunn et al.   CHEMICAL SOCIETY REVIEWS

Energy metabolism in amyotrophic lateral sclerosis

(2010) Luc Dupuis et al.   LANCET NEUROLOGY

Astrocytes in amyotrophic lateral sclerosis: direct effects on motor neuron survival

(2009) K. A. Staats et al.   JOURNAL OF BIOLOGICAL PHYSICS

Non–cell autonomous toxicity in neurodegenerative disorders: ALS and beyond

(2009) Hristelina Ilieva et al.   JOURNAL OF CELL BIOLOGY

A metabolic switch in brain: glucose and lactate metabolism modulation by ascorbic acid

(2009) Maite A. Castro et al.   JOURNAL OF NEUROCHEMISTRY

Multivariate paired data analysis: multilevel PLSDA versus OPLSDA

(2009) Johan A. Westerhuis et al.   Metabolomics

Evidence of Multisystem Disorder in Whole-Brain Map of Pathological TDP-43 in Amyotrophic Lateral Sclerosis

(2008) Felix Geser et al.   ARCHIVES OF NEUROLOGY

Crosstalk between astrocytes and motor neurons: What is the message?

(2008) L. Van Den Bosch et al.   EXPERIMENTAL NEUROLOGY

Excitotoxic damage, disrupted energy metabolism, and oxidative stress in the rat brain: antioxidant and neuroprotective effects of l-carnitine

(2008) Daniela Silva-Adaya et al.   JOURNAL OF NEUROCHEMISTRY