Dual PPARα/γ agonist aleglitazar confers stroke protection in a model of mild focal brain ischemia in mice

Partial loss of VE-cadherin improves long-term outcome and cerebral blood flow after transient brain ischemia in mice

(2016) Karen Gertz et al.   BMC Neurology

Actin dynamics shape microglia effector functions

(2015) Ria Uhlemann et al.   Brain Structure & Function

The dual PPARα/γ agonist aleglitazar increases the number and function of endothelial progenitor cells: implications for vascular function and atherogenesis

(2014) C M Werner et al.   BRITISH JOURNAL OF PHARMACOLOGY

Of mice and men: modelling post-stroke depression experimentally

(2014) G Kronenberg et al.   BRITISH JOURNAL OF PHARMACOLOGY

The dual peroxisome proliferator-activated receptor alpha/delta agonist GFT505 exerts anti-diabetic effects in db/db mice without peroxisome proliferator-activated receptor gamma–associated adverse cardiac effects

(2014) Rémy Hanf et al.   Diabetes & Vascular Disease Research

Effect of Aleglitazar on Cardiovascular Outcomes After Acute Coronary Syndrome in Patients With Type 2 Diabetes Mellitus

(2014) A. Michael Lincoff et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Histone Acetylation and CREB Binding Protein Are Required for Neuronal Resistance against Ischemic Injury

(2014) Ferah Yildirim et al.   PLoS One

Catabolic Signaling and Muscle Wasting After Acute Ischemic Stroke in Mice

(2014) Jochen Springer et al.   STROKE

Evaluation of the dual peroxisome proliferator–activated receptor α/γ agonist aleglitazar to reduce cardiovascular events in patients with acute coronary syndrome and type 2 diabetes mellitus: Rationale and design of the AleCardio trial

(2013) A. Michael Lincoff et al.   AMERICAN HEART JOURNAL

Central and haematopoietic interleukin-1 both contribute to ischaemic brain injury in mice

(2013) A. Denes et al.   Disease Models & Mechanisms

Accelerated degradation of retinoic acid by activated microglia

(2013) Julian Hellmann-Regen et al.   JOURNAL OF NEUROIMMUNOLOGY

Characterization of long-term functional outcome in a murine model of mild brain ischemia

(2013) Mustafa Balkaya et al.   JOURNAL OF NEUROSCIENCE METHODS

Phagocytosis executes delayed neuronal death after focal brain ischemia

(2013) J. J. Neher et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Exofocal Dopaminergic Degeneration as Antidepressant Target in Mouse Model of Poststroke Depression

(2012) Golo Kronenberg et al.   BIOLOGICAL PSYCHIATRY

Essential role of interleukin-6 in post-stroke angiogenesis

(2012) Karen Gertz et al.   BRAIN

Comparative Molecular Profiling of the PPARα/γ Activator Aleglitazar: PPAR Selectivity, Activity and Interaction with Cofactors

(2012) Michel Dietz et al.   ChemMedChem

Imaging blood-brain barrier dysfunction in animal disease models

(2012) Andreas Wunder et al.   EPILEPSIA

Assessing Post-Stroke Behavior in Mouse Models of Focal Ischemia

(2012) Mustafa Balkaya et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Eaten alive! Cell death by primary phagocytosis: ‘phagoptosis’

(2012) Guy C. Brown et al.   TRENDS IN BIOCHEMICAL SCIENCES

Peroxisome proliferator-activated receptor γ promotes neuroprotection by modulating cyclic D1 expression after focal cerebral ischemia

(2010) Lichun Pei et al.   CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY

Improving Bioscience Research Reporting: The ARRIVE Guidelines for Reporting Animal Research

(2010) Carol Kilkenny et al.   PLOS BIOLOGY

Aleglitazar, a new, potent, and balanced dual PPARα/γ agonist for the treatment of type II diabetes

(2009) Agnes Bénardeau et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Design and Biological Evaluation of Novel, Balanced Dual PPARα/γ Agonists

(2009) Uwe Grether et al.   ChemMedChem

Fenofibrate Improves Cerebral Blood Flow after Middle Cerebral Artery Occlusion in Mice

(2009) Qingmin Guo et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Neuronal PPAR  Deficiency Increases Susceptibility to Brain Damage after Cerebral Ischemia

(2009) X. Zhao et al.   JOURNAL OF NEUROSCIENCE

Acute neuroprotection by pioglitazone after mild brain ischemia without effect on long-term outcome

(2008) Shengbo Ji et al.   EXPERIMENTAL NEUROLOGY