Role of inflammasomes in the pathogenesis of periodontal disease and therapeutics

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The Gasdermin-D pore acts as a conduit for IL-1β secretion in mice

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Effects of colchicine on gingival inflammation, apoptosis, and alveolar bone loss in experimental periodontitis

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In search of appropriate measures of periodontal status: The Periodontal Profile Phenotype (P3 ) system

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Periodontal profile classes predict periodontal disease progression and tooth loss

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OLT1177, a β-sulfonyl nitrile compound, safe in humans, inhibits the NLRP3 inflammasome and reverses the metabolic cost of inflammation

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The pyrin inflammasome: from sensing RhoA GTPases-inhibiting toxins to triggering autoinflammatory syndromes

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Anti-inflammatory therapy with canakinumab for atherosclerotic disease: lessons from the CANTOS trial

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Inhibition of AIM2 inflammasome activation by a novel transcript isoform of IFI16

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Sixteen diverse laboratory mouse reference genomes define strain-specific haplotypes and novel functional loci

(2018) Jingtao Lilue et al.   NATURE GENETICS

An experimental murine model to study periodontitis

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Targeting the NLRP3 inflammasome in inflammatory diseases

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Periodontal complications with obesity

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Chloride regulates dynamic NLRP3-dependent ASC oligomerization and inflammasome priming

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GWAS for Interleukin-1β levels in gingival crevicular fluid identifies IL37 variants in periodontal inflammation

(2018) Steven Offenbacher et al.   Nature Communications

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R202Q/M694V as novel MEFV gene mutations in chronic periodontitis and familial Mediterranean fever

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Salivary Levels of NLRP3 Inflammasome-Related Proteins as Potential Biomarkers of Periodontal Clinical Status

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Derivation and Validation of the Periodontal and Tooth Profile Classification System for Patient Stratification

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Common Polymorphisms in IFI16 and AIM2 Genes Are Associated With Periodontal Disease

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Pro-resolving mediators in the regulation of periodontal disease

(2017) Thomas E. Van Dyke   MOLECULAR ASPECTS OF MEDICINE

Dense genotyping of immune-related loci implicates host responses to microbial exposure in Behçet's disease susceptibility

(2017) Masaki Takeuchi et al.   NATURE GENETICS

Inflammation in gout: mechanisms and therapeutic targets

(2017) Alexander K. So et al.   Nature Reviews Rheumatology

Antiinflammatory Therapy with Canakinumab for Atherosclerotic Disease

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Anakinra for Colchicine-Resistant Familial Mediterranean Fever: A Randomized, Double-Blind, Placebo-Controlled Trial

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Familial Mediterranean Fever: Recent Developments in Pathogenesis and New Recommendations for Management

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Bone matrix components activate the NLRP3 inflammasome and promote osteoclast differentiation

(2017) Yael Alippe et al.   Scientific Reports

Inflammasome Complexes: Emerging Mechanisms and Effector Functions

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Genome-wide association study of biologically informed periodontal complex traits offers novel insights into the genetic basis of periodontal disease

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The AIM2-like Receptors Are Dispensable for the Interferon Response to Intracellular DNA

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Role of NOD2 and RIP2 in host–microbe interactions with Gram-negative bacteria: insights from the periodontal disease model

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NEK7 is an essential mediator of NLRP3 activation downstream of potassium efflux

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A Study to Investigate the Efficacy and Safety of an Anti-Interleukin-18 Monoclonal Antibody in the Treatment of Type 2 Diabetes Mellitus

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Familial Mediterranean fever mutations lift the obligatory requirement for microtubules in Pyrin inflammasome activation

(2016) Hanne Van Gorp et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Functional and Evolutionary Analyses Identify Proteolysis as a General Mechanism for NLRP1 Inflammasome Activation

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Canakinumab for the treatment of active systemic juvenile idiopathic arthritis

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Interleukin-1 Gene Cluster Polymorphisms and Their Association with Coronary Artery Disease: Separate Evidences from the Largest Case-Control Study amongst North Indians and an Updated Meta-Analysis

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Adhesion of monocytes to periodontal fibroblasts requires activation of NOD1/2- and TLR4-mediated LFA-1 and VLA-4

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The expression of NLRP3, NLRP1 and AIM2 in the gingival tissue of periodontitis patients: RT-PCR study and immunohistochemistry

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Relationship between periodontal destruction and gene mutations in patients with familial Mediterranean fever

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The NLRP1 inflammasomes

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Strong Upregulation of AIM2 and IFI16 Inflammasomes in the Mucosa of Patients with Active Inflammatory Bowel Disease

(2015) Wiebe Vanhove et al.   INFLAMMATORY BOWEL DISEASES

A Genome-wide CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) Screen Identifies NEK7 as an Essential Component of NLRP3 Inflammasome Activation

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Nicotinamide Riboside Ameliorates Hepatic Metaflammation by Modulating NLRP3 Inflammasome in a Rodent Model of Type 2 Diabetes

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Variants of the IFI16 Gene Affecting the Levels of Expression of mRNA Are Associated with Susceptibility to Behcet Disease

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NLRP3 activation and mitosis are mutually exclusive events coordinated by NEK7, a new inflammasome component

(2015) Hexin Shi et al.   NATURE IMMUNOLOGY

Inflammasomes: mechanism of action, role in disease and therapeutics

(2015) Haitao Guo et al.   NATURE MEDICINE

Inflammasome-independent role of AIM2 in suppressing colon tumorigenesis via DNA-PK and Akt

(2015) Justin E Wilson et al.   NATURE MEDICINE

Molecular aspects of the pathogenesis of periodontitis

(2015) Joerg Meyle et al.   PERIODONTOLOGY 2000

Colchicine—Update on mechanisms of action and therapeutic uses

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Enhanced activity of NLRP3 inflammasome in peripheral blood cells of patients with active rheumatoid arthritis

(2015) Christianna Choulaki et al.   ARTHRITIS RESEARCH & THERAPY

Bruton’s tyrosine kinase is essential for NLRP3 inflammasome activation and contributes to ischaemic brain injury

(2015) Minako Ito et al.   Nature Communications

BRCA1 Regulates IFI16 Mediated Nuclear Innate Sensing of Herpes Viral DNA and Subsequent Induction of the Innate Inflammasome and Interferon-β Responses

(2015) Dipanjan Dutta et al.   PLoS Pathogens

IL-1 Blockade in Autoinflammatory Syndromes

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Free fatty acids as modulators of the NLRP3 inflammasome in obesity/type 2 diabetes

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Cytosolic Double-Stranded RNA Activates the NLRP3 Inflammasome via MAVS-Induced Membrane Permeabilization and K+Efflux

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Association of interleukin-1 gene variations with moderate to severe chronic periodontitis in multiple ethnicities

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The pan-caspase inhibitor Emricasan (IDN-6556) decreases liver injury and fibrosis in a murine model of non-alcoholic steatohepatitis

(2014) Fernando J. Barreyro et al.   LIVER INTERNATIONAL

Transcriptome analysis of human adipocytes implicates the NOD-like receptor pathway in obesity-induced adipose inflammation

(2014) Zheng Yin et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Negative regulation of the NLRP3 inflammasome by A20 protects against arthritis

(2014) Lieselotte Vande Walle et al.   NATURE

Omega-3 Free Fatty Acids Suppress Macrophage Inflammasome Activation by Inhibiting NF-κB Activation and Enhancing Autophagy

(2014) Yolanda Williams-Bey et al.   PLoS One

The structural basis for receptor recognition of human interleukin-18

(2014) Naotaka Tsutsumi et al.   Nature Communications

Increased NLRP3-dependent interleukin 1β secretion in patients with familial Mediterranean fever: correlation withMEFVgenotype

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First-in-class cardiolipin-protective compound as a therapeutic agent to restore mitochondrial bioenergetics

(2013) Hazel H Szeto   BRITISH JOURNAL OF PHARMACOLOGY

The Adaptor MAVS Promotes NLRP3 Mitochondrial Localization and Inflammasome Activation

(2013) Naeha Subramanian et al.   CELL

Induction of Bone Loss by Pathobiont-Mediated Nod1 Signaling in the Oral Cavity

(2013) Yizu Jiao et al.   Cell Host & Microbe

Diabetes and gout: efficacy and safety of febuxostat and allopurinol

(2013) M. A. Becker et al.   DIABETES OBESITY & METABOLISM

Divergence of IL-1, IL-18, and cell death in NLRP3 inflammasomopathies

(2013) Susannah D. Brydges et al.   JOURNAL OF CLINICAL INVESTIGATION

The Mitochondrial Antiviral Protein MAVS Associates with NLRP3 and Regulates Its Inflammasome Activity

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Effect of Chronic Periodontitis on Serum and Gingival Crevicular Fluid Oxidant and Antioxidant Status in Patients With Familial Mediterranean Fever Before and After Periodontal Treatment

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Interleukin-1 antagonism in type 1 diabetes of recent onset: two multicentre, randomised, double-blind, placebo-controlled trials

(2013) Antoinette Moran et al.   LANCET

Phosphorylation of the adaptor ASC acts as a molecular switch that controls the formation of speck-like aggregates and inflammasome activity

(2013) Hideki Hara et al.   NATURE IMMUNOLOGY

Microtubule-driven spatial arrangement of mitochondria promotes activation of the NLRP3 inflammasome

(2013) Takuma Misawa et al.   NATURE IMMUNOLOGY

CD36 coordinates NLRP3 inflammasome activation by facilitating intracellular nucleation of soluble ligands into particulate ligands in sterile inflammation

(2013) Frederick J Sheedy et al.   NATURE IMMUNOLOGY

Activation of the Nlrp3 inflammasome in infiltrating macrophages by endocannabinoids mediates beta cell loss in type 2 diabetes

(2013) Tony Jourdan et al.   NATURE MEDICINE

Genetic Associations with Diabetes: Meta-Analyses of 10 Candidate Polymorphisms

(2013) Linlin Tang et al.   PLoS One

Mitochondrial protein mitofusin 2 is required for NLRP3 inflammasome activation after RNA virus infection

(2013) T. Ichinohe et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Autoinflammation and autoimmunity: Bridging the divide

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Preferential binding of IFI16 protein to cruciform structure and superhelical DNA

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Strong induction of AIM2 expression in human epidermis in acute and chronic inflammatory skin conditions

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Interleukin-1 Gene Polymorphisms and Chronic Periodontitis in Adult Whites: A Systematic Review and Meta-Analysis

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The Innate Immune Protein Nod2 Binds Directly to MDP, a Bacterial Cell Wall Fragment

(2012) Catherine Leimkuhler Grimes et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Resistance to HSV-1 infection in the epithelium resides with the novel innate sensor, IFI-16

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Inflammasomes in health and disease

(2012) Till Strowig et al.   NATURE

Regulation of inflammasome signaling

(2012) Vijay A K Rathinam et al.   NATURE IMMUNOLOGY

IFI16 Acts as a Nuclear Pathogen Sensor to Induce the Inflammasome in Response to Kaposi Sarcoma-Associated Herpesvirus Infection

(2011) Nagaraj Kerur et al.   Cell Host & Microbe

Biological approaches to the development of novel periodontal therapies - Consensus of the Seventh European Workshop on Periodontology

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The Multifaceted Interferon-Inducible p200 Family Proteins: From Cell Biology to Human Pathology

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Interleukin-17 and interleukin-18 levels in saliva and plasma of patients with chronic periodontitis

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Differential Roles for the Interferon-Inducible IFI16 and AIM2 Innate Immune Sensors for Cytosolic DNA in Cellular Senescence of Human Fibroblasts

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Interferon-inducible p200-family protein IFI16, an innate immune sensor for cytosolic and nuclear double-stranded DNA: Regulation of subcellular localization

(2011) Sudhakar Veeranki et al.   MOLECULAR IMMUNOLOGY

Fatty acid–induced NLRP3-ASC inflammasome activation interferes with insulin signaling

(2011) Haitao Wen et al.   NATURE IMMUNOLOGY

Atherosclerosis: current pathogenesis and therapeutic options

(2011) Christian Weber et al.   NATURE MEDICINE

The NLRP3 inflammasome instigates obesity-induced inflammation and insulin resistance

(2011) Bolormaa Vandanmagsar et al.   NATURE MEDICINE

IL-12 and IL-18 levels in serum and gingival tissue in aggressive and chronic periodontitis

(2011) PE Sánchez-Hernández et al.   ORAL DISEASES

IFI16 Protein Mediates the Anti-inflammatory Actions of the Type-I Interferons through Suppression of Activation of Caspase-1 by Inflammasomes

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Cytosolic DNA Triggers Inflammasome Activation in Keratinocytes in Psoriatic Lesions

(2011) Y. Dombrowski et al.   Science Translational Medicine

High versus low dosing of oral colchicine for early acute gout flare: Twenty-four-hour outcome of the first multicenter, randomized, double-blind, placebo-controlled, parallel-group, dose-comparison colchicine study

(2010) Robert A. Terkeltaub et al.   ARTHRITIS AND RHEUMATISM

NALP1 Influences Susceptibility to Human Congenital Toxoplasmosis, Proinflammatory Cytokine Response, and Fate ofToxoplasma gondii-Infected Monocytic Cells

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Proinflammatory effects of muramyldipeptide on human gingival fibroblasts

(2010) I. Hosokawa et al.   JOURNAL OF PERIODONTAL RESEARCH

NLRP3 inflammasomes are required for atherogenesis and activated by cholesterol crystals

(2010) Peter Duewell et al.   NATURE

IFI16 is an innate immune sensor for intracellular DNA

(2010) Leonie Unterholzner et al.   NATURE IMMUNOLOGY

Incentives for Drug Development — The Curious Case of Colchicine

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Familial Mediterranean fever gene mutations in the Southeastern region of Turkey and their phenotypical features

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Familial mediterranean fever with a singleMEFVmutation: Where is the second hit?

(2009) Matthew G. Booty et al.   ARTHRITIS AND RHEUMATISM

Expression and regulation of the NALP3 inflammasome complex in periodontal diseases

(2009) N. Bostanci et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Rilonacept for the treatment of cryopyrin-associated periodic syndromes (CAPS)

(2009) Hal M Hoffman   EXPERT OPINION ON BIOLOGICAL THERAPY

Biological Therapies for Inflammatory Bowel Diseases

(2009) Paul Rutgeerts et al.   GASTROENTEROLOGY

Restoration of absent in melanoma 2 (AIM2) induces G2/M cell cycle arrest and promotes invasion of colorectal cancer cells

(2009) Georgios Patsos et al.   INTERNATIONAL JOURNAL OF CANCER

Unresponsiveness to Colchicine Therapy in Patients with Familial Mediterranean Fever Homozygous for the M694V Mutation

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Thioredoxin-interacting protein links oxidative stress to inflammasome activation

(2009) Rongbin Zhou et al.   NATURE IMMUNOLOGY

The infevers autoinflammatory mutation online registry: update with new genes and functions

(2008) Florian Milhavet et al.   HUMAN MUTATION

The NLR Gene Family: A Standard Nomenclature

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Cytokine gene polymorphisms in periodontal disease: a meta-analysis of 53 studies including 4178 cases and 4590 controls

(2008) Georgios K. Nikolopoulos et al.   JOURNAL OF CLINICAL PERIODONTOLOGY

Relationship between periodontal parameters and Behçet’s disease and evaluation of different treatments for oral recurrent aphthous stomatitis

(2008) T. Arabaci et al.   JOURNAL OF PERIODONTAL RESEARCH

Common variants in the NLRP3 region contribute to Crohn's disease susceptibility

(2008) Alexandra-Chloé Villani et al.   NATURE GENETICS

A NOD2-NALP1 complex mediates caspase-1-dependent IL-1  secretion in response to Bacillus anthracis infection and muramyl dipeptide

(2008) L.-C. Hsu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA