Familial Mediterranean Fever: Recent Developments in Pathogenesis and New Recommendations for Management

Development of the autoinflammatory disease damage index (ADDI)

(2016) Nienke M ter Haar et al.   ANNALS OF THE RHEUMATIC DISEASES

EULAR recommendations for the management of familial Mediterranean fever: Table 1

(2016) Seza Ozen et al.   ANNALS OF THE RHEUMATIC DISEASES

Discontinuing colchicine in symptomatic carriers for MEFV (Mediterranean FeVer) variants

(2016) Hafize Emine Sönmez et al.   CLINICAL RHEUMATOLOGY

Familial Mediterranean fever patients homozygous for E148Q variant

(2016) Rezan Topaloglu et al.   International Journal of Rheumatic Diseases

Pyrin inflammasome activation and RhoA signaling in the autoinflammatory diseases FMF and HIDS

(2016) Yong Hwan Park et al.   NATURE IMMUNOLOGY

Anakinra induce la remisión completa del síndrome nefrótico en un paciente con fiebre mediterránea familiar y amiloidosis

(2016) Ángel M. Sevillano et al.   NEFROLOGIA

Familial Mediterranean fever mutations lift the obligatory requirement for microtubules in Pyrin inflammasome activation

(2016) Hanne Van Gorp et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Autosomal dominant familial Mediterranean fever in Northern European Caucasians associated with deletion of p.M694 residue—a case series and genetic exploration

(2016) Dorota M. Rowczenio et al.   RHEUMATOLOGY

Correlation of Secretory Activity of Neutrophils With Genotype in Patients With Familial Mediterranean Fever

(2016) Faekah Gohar et al.   Arthritis & Rheumatology

TRIM-mediated precision autophagy targets cytoplasmic regulators of innate immunity

(2015) Tomonori Kimura et al.   JOURNAL OF CELL BIOLOGY

Anti-interleukin 1 treatment in secondary amyloidosis associated with autoinflammatory diseases

(2015) Rezan Topaloglu et al.   PEDIATRIC NEPHROLOGY

Treatment of colchicine-resistant Familial Mediterranean fever in children and adolescents

(2015) Fehime Kara Eroglu et al.   RHEUMATOLOGY INTERNATIONAL

The myths we believed in familial Mediterranean fever: what have we learned in the past years?

(2015) Seza Ozen et al.   Seminars in Immunopathology

Efficacy and safety of canakinumab in adolescents and adults with colchicine-resistant familial Mediterranean fever

(2015) Ahmet Gül et al.   ARTHRITIS RESEARCH & THERAPY

Canakinumab as rescue therapy in familial Mediterranean fever refractory to conventional treatment

(2015) Dario Roccatello et al.   Drug Design Development and Therapy

Current therapeutic options for managing familial Mediterranean fever

(2015) Ezgi Deniz Batu et al.   Expert Opinion on Orphan Drugs

Accelerated Apoptosis of Neutrophils in Familial Mediterranean Fever

(2015) Gayane Manukyan et al.   Frontiers in Immunology

FMF50: a score for assessing outcome in familial Mediterranean fever

(2014) Seza Ozen et al.   ANNALS OF THE RHEUMATIC DISEASES

Neutrophil extracellular traps regulate IL-1β-mediated inflammation in familial Mediterranean fever

(2014) Eirini Apostolidou et al.   ANNALS OF THE RHEUMATIC DISEASES

Anti-IL-1 treatment in familial Mediterranean fever and related amyloidosis

(2014) Z. Birsin Özçakar et al.   CLINICAL RHEUMATOLOGY

Efficacy of Interleukin-1 Targeting Treatments in Patients with Familial Mediterranean Fever

(2014) Pinar Cetin et al.   INFLAMMATION

Rapid resolution of protracted febrile myalgia syndrome with anakinra: Report of two cases

(2014) Rıdvan Mercan et al.   Modern Rheumatology

Innate immune sensing of bacterial modifications of Rho GTPases by the Pyrin inflammasome

(2014) Hao Xu et al.   NATURE

Colchicine-free remission in familial Mediterranean fever: featuring a unique subset of the disease-a case control study

(2014) Ilan Ben-Zvi et al.   Orphanet Journal of Rare Diseases

Evidence based recommendations for genetic diagnosis of Familial Mediterranean Fever

(2014) Gabriella Giancane et al.   Pediatric Rheumatology

Genotype-phenotype correlation in Japanese patients with familial Mediterranean fever: differences in genotype and clinical features between Japanese and Mediterranean populations

(2014) Dai Kishida et al.   ARTHRITIS RESEARCH & THERAPY

Canakinumab for the Treatment of Children With Colchicine-Resistant Familial Mediterranean Fever: A 6-Month Open-Label, Single-Arm Pilot Study

(2014) Riva Brik et al.   Arthritis & Rheumatology

Rilonacept for Colchicine-Resistant or -Intolerant Familial Mediterranean Fever

(2013) Philip J. Hashkes et al.   ANNALS OF INTERNAL MEDICINE

MEFVmutations affecting pyrin amino acid 577 cause autosomal dominant autoinflammatory disease

(2013) Monique Stoffels et al.   ANNALS OF THE RHEUMATIC DISEASES

Mortality risk factors associated with familial Mediterranean fever among a cohort of 1.25 million adolescents

(2013) Gilad Twig et al.   ANNALS OF THE RHEUMATIC DISEASES

Validation of the Auto-Inflammatory Diseases Activity Index (AIDAI) for hereditary recurrent fever syndromes

(2013) Maryam Piram et al.   ANNALS OF THE RHEUMATIC DISEASES

Results from a multicentre international registry of familial Mediterranean fever: impact of environment on the expression of a monogenic disease in children

(2013) Seza Ozen et al.   ANNALS OF THE RHEUMATIC DISEASES

Three Japanese patients (Mother and Two Children) with familial Mediterranean fever associated with compound heterozygosity for L110P/E148Q/M694I and an autosomal true dominant inheritance pattern

(2013) Yasutsugu Fukushima   ASIAN PACIFIC JOURNAL OF ALLERGY AND IMMUNOLOGY

IL-1β Biological Treatment of Familial Mediterranean Fever

(2013) Alessandra Soriano et al.   CLINICAL REVIEWS IN ALLERGY & IMMUNOLOGY

Myositis in a patient with familial Mediterranean fever and spondyloarthritis successfully treated with anakinra

(2013) Charline Estublier et al.   JOINT BONE SPINE

The Contribution of SAA1 Polymorphisms to Familial Mediterranean Fever Susceptibility in the Japanese Population

(2013) Kiyoshi Migita et al.   PLoS One

Evidence-based recommendations for the practical management of Familial Mediterranean Fever

(2013) Véronique Hentgen et al.   SEMINARS IN ARTHRITIS AND RHEUMATISM

Clinical impact ofMEFVmutations in children with periodic fever in a prevalent western European Caucasian population

(2012) Silvia Federici et al.   ANNALS OF THE RHEUMATIC DISEASES

Guidelines for the genetic diagnosis of hereditary recurrent fevers

(2012) Y Shinar et al.   ANNALS OF THE RHEUMATIC DISEASES

Effects of Anti-Tumor Necrosis Factor Agents for Familial Mediterranean Fever Patients With Chronic Arthritis and/or Sacroiliitis Who Were Resistant to Colchicine Treatment

(2012) Sule Apras Bilgen et al.   JCR-JOURNAL OF CLINICAL RHEUMATOLOGY

The effect of colchicine on pyrin and pyrin interacting proteins

(2012) Ekim Z. Taskiran et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Colchicine is a Safe Drug in Children with Familial Mediterranean Fever

(2012) Shai Padeh et al.   JOURNAL OF PEDIATRICS

Treating inflammation by blocking interleukin-1 in a broad spectrum of diseases

(2012) Charles A. Dinarello et al.   NATURE REVIEWS DRUG DISCOVERY

Two Randomized Trials of Canakinumab in Systemic Juvenile Idiopathic Arthritis

(2012) Nicolino Ruperto et al.   NEW ENGLAND JOURNAL OF MEDICINE

Genetic Loss of Murine Pyrin, the Familial Mediterranean Fever Protein, Increases Interleukin-1β Levels

(2012) Pamela R. Hesker et al.   PLoS One

The efficacy of canakinumab in the treatment of a patient with familial Mediterranean fever and longstanding destructive arthritis

(2011) I. Mitroulis et al.   ANNALS OF THE RHEUMATIC DISEASES

On-demand anakinra treatment is effective in mevalonate kinase deficiency

(2011) E. J. Bodar et al.   ANNALS OF THE RHEUMATIC DISEASES

Gain-of-Function Pyrin Mutations Induce NLRP3 Protein-Independent Interleukin-1β Activation and Severe Autoinflammation in Mice

(2011) Jae Jin Chae et al.   IMMUNITY

Serum Amyloid A Activates the NLRP3 Inflammasome via P2X7 Receptor and a Cathepsin B-Sensitive Pathway

(2011) K. Niemi et al.   JOURNAL OF IMMUNOLOGY

Non-canonical inflammasome activation targets caspase-11

(2011) Nobuhiko Kayagaki et al.   NATURE

Dramatic beneficial effect of interleukin-1 inhibitor treatment in patients with familial Mediterranean fever complicated with amyloidosis and renal failure

(2011) K. Stankovic Stojanovic et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

Interleukin-1 Targeting Drugs in Familial Mediterranean Fever: A Case Series and a Review of the Literature

(2011) Ulrich Meinzer et al.   SEMINARS IN ARTHRITIS AND RHEUMATISM

Pregnancy outcome after in utero exposure to colchicine

(2010) Orna Diav-Citrin et al.   AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY

Colchicine poisoning: the dark side of an ancient drug

(2010) Yaron Finkelstein et al.   CLINICAL TOXICOLOGY

Clostridium difficile Toxin–Induced Inflammation and Intestinal Injury Are Mediated by the Inflammasome

(2010) Jeffrey Ng et al.   GASTROENTEROLOGY

Genotype–phenotype studies in a large cohort of Armenian patients with familial Mediterranean fever suggest clinical disease with heterozygous MEFV mutations

(2010) Mike M Moradian et al.   JOURNAL OF HUMAN GENETICS

Anti-Interleukin 1 Treatment for Patients with Familial Mediterranean Fever Resistant to Colchicine: Table 1.

(2010) SEZA ÖZEN et al.   JOURNAL OF RHEUMATOLOGY

The role of toxin A and toxin B in Clostridium difficile infection

(2010) Sarah A. Kuehne et al.   NATURE

Pneumonia in a patient with familial Mediterranean fever successfully treated with anakinra—case report and review

(2010) Stefanie Hennig et al.   RHEUMATOLOGY INTERNATIONAL

Efficacy of anakinra treatment in a patient with colchicine-resistant familial Mediterranean fever

(2010) Nilüfer Alpay et al.   RHEUMATOLOGY INTERNATIONAL

Transmission of Familial Mediterranean Fever Mutation After Bone Marrow Transplantation and Successful Treatment With Anakinra

(2010) Anna D. Petropoulou et al.   TRANSPLANTATION

Pregnancy outcomes in women with Familial Mediterranean Fever receiving colchicine: Is amniocentesis justified?

(2010) Eli Ben-Chetrit et al.   ARTHRITIS CARE & RESEARCH

Clinical disease among patients heterozygous for familial mediterranean fever

(2009) Dina Marek-Yagel et al.   ARTHRITIS AND RHEUMATISM

Changing concepts in familial mediterranean fever: Is it possible to have an autosomal-recessive disease with only one mutation?

(2009) Seza Özen   ARTHRITIS AND RHEUMATISM

Familial mediterranean fever with a singleMEFVmutation: Where is the second hit?

(2009) Matthew G. Booty et al.   ARTHRITIS AND RHEUMATISM

Toxin B is essential for virulence of Clostridium difficile

(2009) Dena Lyras et al.   NATURE

Anakinra: New therapeutic approach in children with Familial Mediterranean Fever resistant to colchicine

(2008) Rosa Roldan et al.   JOINT BONE SPINE

Successful treatment of familial Mediterranean fever with Anakinra and outcome after renal transplantation

(2008) C. Moser et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

Predominant Role of Host Genetics in Controlling the Composition of Gut Microbiota

(2008) Zaruhi A. Khachatryan et al.   PLoS One