AMPA receptor structure and auxiliary subunits

Cryo-EM structures of the ionotropic glutamate receptor GluD1 reveal a non-swapped architecture

(2020) Ananth Prasad Burada et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Noncompetitive antagonists induce cooperative AMPA receptor channel gating

(2019) Edward Y. Shi et al.   JOURNAL OF GENERAL PHYSIOLOGY

Morphologic determinant of tight junctions revealed by claudin-3 structures

(2019) Shun Nakamura et al.   Nature Communications

Architecture of the heteromeric GluA1/2 AMPA receptor in complex with the auxiliary subunit TARP γ8

(2019) Beatriz Herguedas et al.   SCIENCE

Structure and mechanism of AMPA receptor — auxiliary protein complexes

(2019) Shanshuang Chen et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Nanoscale Mobility of the Apo State and TARP Stoichiometry Dictate the Gating Behavior of Alternatively Spliced AMPA Receptors

(2019) G. Brent Dawe et al.   NEURON

Architecture and subunit arrangement of native AMPA receptors elucidated by cryo-EM

(2019) Yan Zhao et al.   SCIENCE

AMPA receptor GluA2 subunit defects are a cause of neurodevelopmental disorders

(2019) Vincenzo Salpietro et al.   Nature Communications

Phase Separation-Mediated TARP/MAGUK Complex Condensation and AMPA Receptor Synaptic Transmission

(2019) Menglong Zeng et al.   NEURON

Structural and functional insights into transmembrane AMPA receptor regulatory protein complexes

(2019) Edward C. Twomey et al.   JOURNAL OF GENERAL PHYSIOLOGY

Mechanism of modulation of AMPA receptors by TARP-γ8

(2019) Elisa Carrillo et al.   JOURNAL OF GENERAL PHYSIOLOGY

An ER Assembly Line of AMPA-Receptors Controls Excitatory Neurotransmission and Its Plasticity

(2019) Jochen Schwenk et al.   NEURON

Shisa7 is a GABAA receptor auxiliary subunit controlling benzodiazepine actions

(2019) Wenyan Han et al.   SCIENCE

Structures of the AMPA receptor in complex with its auxiliary subunit cornichon

(2019) Terunaga Nakagawa   SCIENCE

Folding unpredicted

(2019) Jochen Schwenk et al.   SCIENCE

LTP requires postsynaptic PDZ-domain interactions with glutamate receptor/auxiliary protein complexes

(2018) Nengyin Sheng et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

CORNICHON sorting and regulation of GLR channels underlie pollen tube Ca2+homeostasis

(2018) Michael M. Wudick et al.   SCIENCE

CKAMP44 modulates integration of visual inputs in the lateral geniculate nucleus

(2018) Xufeng Chen et al.   Nature Communications

SynDIG4/Prrt1 Is Required for Excitatory Synapse Development and Plasticity Underlying Cognitive Function

(2018) Lucas Matt et al.   Cell Reports

Mechanisms of Channel Block in Calcium-Permeable AMPA Receptors

(2018) Edward C. Twomey et al.   NEURON

Structural Basis for Cholesterol Transport-like Activity of the Hedgehog Receptor Patched

(2018) Yunxiao Zhang et al.   CELL

Optimizing genomic medicine in epilepsy through a gene-customized approach to missense variant interpretation

(2017) Joshua Traynelis et al.   GENOME RESEARCH

A point mutation in the ion conduction pore of AMPA receptor GRIA3 causes dramatically perturbed sleep patterns as well as intellectual disability

(2017) Benjamin Davies et al.   HUMAN MOLECULAR GENETICS

Divergent roles of a peripheral transmembrane segment in AMPA and NMDA receptors

(2017) Johansen B. Amin et al.   JOURNAL OF GENERAL PHYSIOLOGY

Stargazin and cornichon-3 relieve polyamine block of AMPA receptors by enhancing blocker permeation

(2017) Patricia M.G.E. Brown et al.   JOURNAL OF GENERAL PHYSIOLOGY

Engineering defined membrane-embedded elements of AMPA receptor induces opposing gating modulation by cornichon 3 and stargazin

(2017) Natalie M. Hawken et al.   JOURNAL OF PHYSIOLOGY-LONDON

Channel opening and gating mechanism in AMPA-subtype glutamate receptors

(2017) Edward C. Twomey et al.   NATURE

Opening of the human epithelial calcium channel TRPV6

(2017) Luke L. McGoldrick et al.   NATURE

Structural and Functional Architecture of AMPA-Type Glutamate Receptors and Their Auxiliary Proteins

(2017) Ingo H. Greger et al.   NEURON

Molecular Mechanism of AMPA Receptor Modulation by TARP/Stargazin

(2017) Anat Ben-Yaacov et al.   NEURON

Structural Bases of Desensitization in AMPA Receptor-Auxiliary Subunit Complexes

(2017) Edward C. Twomey et al.   NEURON

Getting a Handle on Neuropharmacology by Targeting Receptor-Associated Proteins

(2017) Michael P. Maher et al.   NEURON

Subunit-specific role for the amino-terminal domain of AMPA receptors in synaptic targeting

(2017) Javier Díaz-Alonso et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Molecular Mechanism of Disease-Associated Mutations in the Pre-M1 Helix of NMDA Receptors and Potential Rescue Pharmacology

(2017) Kevin K. Ogden et al.   PLoS Genetics

Control of AMPA receptor activity by the extracellular loops of auxiliary proteins

(2017) Irene Riva et al.   eLife

Synaptic transmission and plasticity require AMPA receptor anchoring via its N-terminal domain

(2017) Jake F Watson et al.   eLife

The AMPA receptor-associated protein Shisa7 regulates hippocampal synaptic function and contextual memory

(2017) Leanne J M Schmitz et al.   eLife

Screening for AMPA receptor auxiliary subunit specific modulators

(2017) Caleigh M. Azumaya et al.   PLoS One

Discovery of the First α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid (AMPA) Receptor Antagonist Dependent upon Transmembrane AMPA Receptor Regulatory Protein (TARP) γ-8

(2016) Kevin M. Gardinier et al.   JOURNAL OF MEDICINAL CHEMISTRY

The dynamic AMPA receptor extracellular region: a platform for synaptic protein interactions

(2016) J. García-Nafría et al.   JOURNAL OF PHYSIOLOGY-LONDON

Architecture of fully occupied GluA2 AMPA receptor–TARP complex elucidated by cryo-EM

(2016) Yan Zhao et al.   NATURE

Structural basis for inhibition of a voltage-gated Ca2+ channel by Ca2+ antagonist drugs

(2016) Lin Tang et al.   NATURE

Activation of NMDA receptors and the mechanism of inhibition by ifenprodil

(2016) Nami Tajima et al.   NATURE

Forebrain-selective AMPA-receptor antagonism guided by TARP γ-8 as an antiepileptic mechanism

(2016) Akihiko S Kato et al.   NATURE MEDICINE

Distinct Structural Pathways Coordinate the Activation of AMPA Receptor-Auxiliary Subunit Complexes

(2016) G. Brent Dawe et al.   NEURON

CaMKII Phosphorylation of TARPγ-8 Is a Mediator of LTP and Learning and Memory

(2016) Joongkyu Park et al.   NEURON

Structure and organization of heteromeric AMPA-type glutamate receptors

(2016) Beatriz Herguedas et al.   SCIENCE

Elucidation of AMPA receptor-stargazin complexes by cryo-electron microscopy

(2016) E. C. Twomey et al.   SCIENCE

GSG1L suppresses AMPA receptor-mediated synaptic transmission and uniquely modulates AMPA receptor kinetics in hippocampal neurons

(2016) Xinglong Gu et al.   Nature Communications

Shisa6 traps AMPA receptors at postsynaptic sites and prevents their desensitization during synaptic activity

(2016) Remco V. Klaassen et al.   Nature Communications

Porcupine Controls Hippocampal AMPAR Levels, Composition, and Synaptic Transmission

(2016) Nadine Erlenhardt et al.   Cell Reports

Cholesterol modulates open probability and desensitization of NMDA receptors

(2015) Miloslav Korinek et al.   JOURNAL OF PHYSIOLOGY-LONDON

Structural insight into tight junction disassembly by Clostridium perfringens enterotoxin

(2015) Y. Saitoh et al.   SCIENCE

Structure and Dynamics of AMPA Receptor GluA2 in Resting, Pre-Open, and Desensitized States

(2014) Katharina L. Dürr et al.   CELL

Auxiliary proteins promote modal gating of AMPA- and kainate-type glutamate receptors

(2014) Wei Zhang et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Molecular Dissection of the Interaction between the AMPA Receptor and Cornichon Homolog-3

(2014) N. F. Shanks et al.   JOURNAL OF NEUROSCIENCE

Structural mechanism of glutamate receptor activation and desensitization

(2014) Joel R. Meyerson et al.   NATURE

Regional Diversity and Developmental Dynamics of the AMPA-Receptor Proteome in the Mammalian Brain

(2014) Jochen Schwenk et al.   NEURON

Coexpressed Auxiliary Subunits Exhibit Distinct Modulatory Profiles on AMPA Receptor Function

(2014) Konstantin Khodosevich et al.   NEURON

Cornichon2 Dictates the Time Course of Excitatory Transmission at Individual Hippocampal Synapses

(2014) Sami Boudkkazi et al.   NEURON

Structure of an agonist-bound ionotropic glutamate receptor

(2014) M. V. Yelshanskaya et al.   SCIENCE

X-ray structures of AMPA receptor-cone snail toxin complexes illuminate activation mechanism

(2014) L. Chen et al.   SCIENCE

Crystal Structure of a Claudin Provides Insight into the Architecture of Tight Junctions

(2014) H. Suzuki et al.   SCIENCE

Mapping the Interaction Sites between AMPA Receptors and TARPs Reveals a Role for the Receptor N-Terminal Domain in Channel Gating

(2014) Ondrej Cais et al.   Cell Reports

Xq25 duplications encompassingGRIA3andSTAG2genes in two families convey recognizable X-linked intellectual disability with distinctive facial appearance

(2013) Anne Philippe et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART A

Cornichon Proteins Determine the Subunit Composition of Synaptic AMPA Receptors

(2013) Bruce E. Herring et al.   NEURON

Cornichons Control ER Export of AMPA Receptors to Regulate Synaptic Excitability

(2013) Penelope J. Brockie et al.   NEURON

AMPARs and Synaptic Plasticity: The Last 25 Years

(2013) Richard L. Huganir et al.   NEURON

Partial deletion of GLRB and GRIA2 in a patient with intellectual disability

(2012) Karl Hackmann et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

A 1 Mb de novo deletion within 11q13.1q13.2 in a boy with mild intellectual disability and minor dysmorphic features

(2012) Karijn Floor et al.   European Journal of Medical Genetics

AMPA receptors as drug targets in neurological disease - advantages, caveats, and future outlook

(2012) Philip K.-Y. Chang et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Proteomic Analysis of α-Amino-3-hydroxy-5-methyl-4-isoxazole Propionate Receptor Complexes

(2012) Myoung-Goo Kang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cornichons Modify Channel Properties of Recombinant and Glial AMPA Receptors

(2012) I. D. Coombs et al.   JOURNAL OF NEUROSCIENCE

TARP-associated AMPA receptors display an increased maximum channel conductance and multiple kinetically distinct open states

(2012) Chris Shelley et al.   JOURNAL OF PHYSIOLOGY-LONDON

High-Resolution Proteomics Unravel Architecture and Molecular Diversity of Native AMPA Receptor Complexes

(2012) Jochen Schwenk et al.   NEURON

Differences in AMPA and Kainate Receptor Interactomes Facilitate Identification of AMPA Receptor Auxiliary Subunit GSG1L

(2012) Natalie F. Shanks et al.   Cell Reports

Excess of De Novo Deleterious Mutations in Genes Associated with Glutamatergic Systems in Nonsyndromic Intellectual Disability

(2011) Fadi F. Hamdan et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Subunit-selective N-terminal domain associations organize the formation of AMPA receptor heteromers

(2011) Maxim Rossmann et al.   EMBO JOURNAL

Cornichon-2 Modulates AMPA Receptor-Transmembrane AMPA Receptor Regulatory Protein Assembly to Dictate Gating and Pharmacology

(2011) M. B. Gill et al.   JOURNAL OF NEUROSCIENCE

PDZ binding of TARPγ-8 controls synaptic transmission but not synaptic plasticity

(2011) Akio Sumioka et al.   NATURE NEUROSCIENCE

The Expanding Social Network of Ionotropic Glutamate Receptors: TARPs and Other Transmembrane Auxiliary Subunits

(2011) Alexander C. Jackson et al.   NEURON

Revisiting AMPA Receptors as an Antiepileptic Drug Target

(2011) Michael A. Rogawski   Epilepsy Currents

Characterization of an interstitial 4q32 deletion in a patient with mental retardation and a complex chromosome rearrangement

(2010) Andreas Tzschach et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART A

Contribution of the Global Subunit Structure and Stargazin on the Maturation of AMPA Receptors

(2010) N. F. Shanks et al.   JOURNAL OF NEUROSCIENCE

The Biochemistry, Ultrastructure, and Subunit Assembly Mechanism of AMPA Receptors

(2010) Terunaga Nakagawa   MOLECULAR NEUROBIOLOGY

Control of Assembly and Function of Glutamate Receptors by the Amino-Terminal Domain

(2010) K. B. Hansen et al.   MOLECULAR PHARMACOLOGY

Hippocampal AMPA Receptor Gating Controlled by Both TARP and Cornichon Proteins

(2010) Akihiko S. Kato et al.   NEURON

SynDIG1: An Activity-Regulated, AMPA- Receptor-Interacting Transmembrane Protein that Regulates Excitatory Synapse Development

(2010) Evgenia Kalashnikova et al.   NEURON

Glutamate Receptor Ion Channels: Structure, Regulation, and Function

(2010) S. F. Traynelis et al.   PHARMACOLOGICAL REVIEWS

Functional comparison of the effects of TARPs and cornichons on AMPA receptor trafficking and gating

(2010) Y. Shi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

CKAMP44: A Brain-Specific Protein Attenuating Short-Term Synaptic Plasticity in the Dentate Gyrus

(2010) J. von Engelhardt et al.   SCIENCE

AberrantGRIA3transcripts with multi-exon duplications in a family with X-linked mental retardation

(2009) C. Bonnet et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART A

Crystal structure and association behaviour of the GluR2 amino-terminal domain

(2009) Rongsheng Jin et al.   EMBO JOURNAL

X-ray structure, symmetry and mechanism of an AMPA-subtype glutamate receptor

(2009) Alexander I. Sobolevsky et al.   NATURE

The Stoichiometry of AMPA Receptors and TARPs Varies by Neuronal Cell Type

(2009) Yun Shi et al.   NEURON

TARP modulation of synaptic AMPA receptor trafficking and gating depends on multiple intracellular domains

(2009) A. D. Milstein et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Functional Proteomics Identify Cornichon Proteins as Auxiliary Subunits of AMPA Receptors

(2009) J. Schwenk et al.   SCIENCE

RASD2, MYH9, and CACNG2 Genes at Chromosome 22q12 Associated with the Subgroup of Schizophrenia with Non-Deficit in Sustained Attention and Executive Function

(2008) Yu-Li Liu et al.   BIOLOGICAL PSYCHIATRY

AMPA Receptor Subunit-Specific Regulation by a Distinct Family of Type II TARPs

(2008) Akihiko S. Kato et al.   NEURON

A nomenclature for ligand-gated ion channels

(2008) Graham L. Collingridge et al.   NEUROPHARMACOLOGY