Molecular Mechanism of Disease-Associated Mutations in the Pre-M1 Helix of NMDA Receptors and Potential Rescue Pharmacology

Mechanistic Insight into NMDA Receptor Dysregulation by Rare Variants in the GluN2A and GluN2B Agonist Binding Domains

(2016) Sharon A. Swanger et al.   AMERICAN JOURNAL OF HUMAN GENETICS

A Molecular Determinant of Subtype-Specific Desensitization in Ionotropic Glutamate Receptors

(2016) Matthew Alsaloum et al.   JOURNAL OF NEUROSCIENCE

Genetically Targeted All-Optical Electrophysiology with a Transgenic Cre-Dependent Optopatch Mouse

(2016) S. Lou et al.   JOURNAL OF NEUROSCIENCE

Human GRIN2B variants in neurodevelopmental disorders

(2016) Chun Hu et al.   JOURNAL OF PHARMACOLOGICAL SCIENCES

Activation of NMDA receptors and the mechanism of inhibition by ifenprodil

(2016) Nami Tajima et al.   NATURE

Analysis of protein-coding genetic variation in 60,706 humans

(2016) Monkol Lek et al.   NATURE

NMDA receptor subunit mutations in neurodevelopmental disorders

(2015) Nail Burnashev et al.   CURRENT OPINION IN PHARMACOLOGY

GRIN1mutations cause encephalopathy with infantile-onset epilepsy, and hyperkinetic and stereotyped movement disorders

(2015) Chihiro Ohba et al.   EPILEPSIA

Efficient strategy for the molecular diagnosis of intellectual disability using targeted high-throughput sequencing

(2014) Claire Redin et al.   JOURNAL OF MEDICAL GENETICS

NMDA receptor structures reveal subunit arrangement and pore architecture

(2014) Chia-Hsueh Lee et al.   NATURE

Mechanical coupling maintains the fidelity of NMDA receptor–mediated currents

(2014) Rashek Kazi et al.   NATURE NEUROSCIENCE

Distinct Functional and Pharmacological Properties of Triheteromeric GluN1/GluN2A/GluN2B NMDA Receptors

(2014) Kasper B. Hansen et al.   NEURON

Crystal structure of a heterotetrameric NMDA receptor ion channel

(2014) E. Karakas et al.   SCIENCE

Functional analysis of a de novo GRIN2A missense mutation associated with early-onset epileptic encephalopathy

(2014) Hongjie Yuan et al.   Nature Communications

Dendritic GluN2A Synthesis Mediates Activity-Induced NMDA Receptor Insertion

(2013) S. A. Swanger et al.   JOURNAL OF NEUROSCIENCE

Asynchronous Movements Prior to Pore Opening in NMDA Receptors

(2013) R. Kazi et al.   JOURNAL OF NEUROSCIENCE

De novo mutations in epileptic encephalopathies

(2013) et al.   NATURE

GRIN2A mutations in acquired epileptic aphasia and related childhood focal epilepsies and encephalopathies with speech and language dysfunction

(2013) Gaetan Lesca et al.   NATURE GENETICS

Genic Intolerance to Functional Variation and the Interpretation of Personal Genomes

(2013) Slavé Petrovski et al.   PLoS Genetics

Functional Insights from Glutamate Receptor Ion Channel Structures

(2012) Janesh Kumar et al.   Annual Review of Physiology

Subunit-Selective Allosteric Inhibition of Glycine Binding to NMDA Receptors

(2012) K. B. Hansen et al.   JOURNAL OF NEUROSCIENCE

Short-term field stimulation mimics synaptic maturation of hippocampal synapses

(2012) Elena E. Bagley et al.   JOURNAL OF PHYSIOLOGY-LONDON

Sporadic autism exomes reveal a highly interconnected protein network of de novo mutations

(2012) Brian J. O’Roak et al.   NATURE

Diagnostic Exome Sequencing in Persons with Severe Intellectual Disability

(2012) Joep de Ligt et al.   NEW ENGLAND JOURNAL OF MEDICINE

Multiplex Targeted Sequencing Identifies Recurrently Mutated Genes in Autism Spectrum Disorders

(2012) B. J. O'Roak et al.   SCIENCE

GluN1-Specific Redox Effects on the Kinetic Mechanism of NMDA Receptor Activation

(2011) Iehab Talukder et al.   BIOPHYSICAL JOURNAL

Molecular pharmacology of human NMDA receptors

(2011) Maiken Hedegaard et al.   NEUROCHEMISTRY INTERNATIONAL

Emerging Models of Glutamate Receptor Ion Channel Structure and Function

(2011) Mark L. Mayer   STRUCTURE

Ligand-specific deactivation time course of GluN1/GluN2D NMDA receptors

(2011) Katie M. Vance et al.   Nature Communications

Specific Sites within the Ligand-Binding Domain and Ion Channel Linkers Modulate NMDA Receptor Gating

(2010) I. Talukder et al.   JOURNAL OF NEUROSCIENCE

A method and server for predicting damaging missense mutations

(2010) Ivan A Adzhubei et al.   NATURE METHODS

Glutamate Receptor Ion Channels: Structure, Regulation, and Function

(2010) S. F. Traynelis et al.   PHARMACOLOGICAL REVIEWS

A subunit-selective potentiator of NR2C- and NR2D-containing NMDA receptors

(2010) Praseeda Mullasseril et al.   Nature Communications

Zn2+ regulates Kv2.1 voltage-dependent gating and localization following ischemia

(2009) Mandar A. Aras et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Protein kinase C regulation of neuronal zinc signaling mediates survival during preconditioning

(2009) Mandar A. Aras et al.   JOURNAL OF NEUROCHEMISTRY

Control of NMDA Receptor Function by the NR2 Subunit Amino-Terminal Domain

(2009) H. Yuan et al.   JOURNAL OF NEUROSCIENCE

Mg2+ Imparts NMDA Receptor Subtype Selectivity to the Alzheimer's Drug Memantine

(2009) S. E. Kotermanski et al.   JOURNAL OF NEUROSCIENCE

X-ray structure, symmetry and mechanism of an AMPA-subtype glutamate receptor

(2009) Alexander I. Sobolevsky et al.   NATURE

Kinetic basis of partial agonism at NMDA receptors

(2009) Cassandra L Kussius et al.   NATURE NEUROSCIENCE

The Activation Gate and Gating Mechanism of the NMDA Receptor

(2008) H.-R. Chang et al.   JOURNAL OF NEUROSCIENCE

Zinc inhibition of rat NR1/NR2AN-methyl-d-aspartate receptors

(2007) Kevin Erreger et al.   JOURNAL OF PHYSIOLOGY-LONDON