Inhibition of metabotropic glutamate receptor 5 induces cellular stress through pertussis toxin-sensitive Gi-proteins in murine BV-2 microglia cells

The suitability of BV2 cells as alternative model system for primary microglia cultures or for animal experiments examining brain inflammation

(2016) Anja Henn   ALTEX-Alternatives to Animal Experimentation

ER stress-induced cell death mechanisms

(2013) Renata Sano et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Ca 2+ spiking activity caused by the activation of store-operated Ca 2+ channels mediates TNF-α release from microglial cells under chronic purinergic stimulation

(2013) Masayuki Ikeda et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Microglial calcium signaling in the adult, aged and diseased brain

(2013) Bianca Brawek et al.   CELL CALCIUM

Oleate prevents saturated-fatty-acid-induced ER stress, inflammation and insulin resistance in skeletal muscle cells through an AMPK-dependent mechanism

(2013) L. Salvadó et al.   DIABETOLOGIA

Phenformin Activates the Unfolded Protein Response in an AMP-activated Protein Kinase (AMPK)-dependent Manner

(2013) Liu Yang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Activation of AMP-Activated Protein Kinase Alleviates Homocysteine-Mediated Neurotoxicity in SH-SY5Y Cells

(2013) Youn-Jin Park et al.   NEUROCHEMICAL RESEARCH

Chronological changes and effects of AMP-activated kinase in the hippocampal CA1 region after transient forebrain ischemia in gerbils

(2013) Han Ga Wi Nam et al.   NEUROLOGICAL RESEARCH

Activation of metabotropic glutamate receptor 5 reduces the secondary brain injury after traumatic brain injury in rats

(2012) Jia-Wei Wang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Expression and cell distribution of metabotropic glutamate receptor 5 in the rat cortex following traumatic brain injury

(2012) Jia-Wei Wang et al.   BRAIN RESEARCH

ATP-P2X7 receptor signaling controls basal and TNFα-stimulated glial cell proliferation

(2012) Jian Zou et al.   GLIA

Oxidized lipids and lysophosphatidylcholine induce the chemotaxis and intracellular calcium influx in natural killer cells

(2012) Johannes Rolin et al.   IMMUNOBIOLOGY

A novel proteasome inhibitor acting in mitochondrial dysfunction, ER stress and ROS production

(2012) Durvanei Augusto Maria et al.   INVESTIGATIONAL NEW DRUGS

Redox implications of AMPK-mediated signal transduction beyond energetic clues

(2012) S. Cardaci et al.   JOURNAL OF CELL SCIENCE

Microglial neurotransmitter receptors trigger superoxide production in microglia; consequences for microglial-neuronal interactions

(2012) Emma L. Mead et al.   JOURNAL OF NEUROCHEMISTRY

Delayed mGluR5 activation limits neuroinflammation and neurodegeneration after traumatic brain injury

(2012) Kimberly R Byrnes et al.   Journal of Neuroinflammation

Activation of mGluR5 and Inhibition of NADPH Oxidase Improves Functional Recovery after Traumatic Brain Injury

(2012) David J. Loane et al.   JOURNAL OF NEUROTRAUMA

Mitochondria, oxidative stress and neurodegeneration

(2012) Antonio Federico et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES

Oxidative Stress and Microglial Cells in Parkinson's Disease

(2012) Lynda J. Peterson et al.   MEDIATORS OF INFLAMMATION

Naloxone in ultralow concentration restores endomorphin-1–evoked Ca2+ signaling in lipopolysaccharide pretreated astrocytes

(2012) L. Block et al.   NEUROSCIENCE

Neurotoxic Effects of Bisphenol AF on Calcium-Induced ROS and MAPKs

(2012) Soyoung Lee et al.   NEUROTOXICITY RESEARCH

Retinal Microglial Activation and Inflammation Induced by Amadori-Glycated Albumin in a Rat Model of Diabetes

(2011) A. S. Ibrahim et al.   DIABETES

AMP-activated protein kinase--an energy sensor that regulates all aspects of cell function

(2011) D. G. Hardie   GENES & DEVELOPMENT

Suppressed microglial E prostanoid receptor 1 signaling selectively reduces tumor necrosis factor alpha and interleukin 6 secretion from toll-like receptor 3 activation

(2011) Xianwu Li et al.   GLIA

Endotoxin-activated microglia injure brain derived endothelial cells via NF-κB, JAK-STAT and JNK stress kinase pathways

(2011) Rachid Kacimi et al.   Journal of Inflammation-London

Reactive oxygen species drive herpes simplex virus (HSV)-1-induced proinflammatory cytokine production by murine microglia

(2011) Shuxian Hu et al.   Journal of Neuroinflammation

The role of mitochondria in neurodegenerative diseases

(2011) Massimiliano Filosto et al.   JOURNAL OF NEUROLOGY

AMPK and Akt Determine Apoptotic Cell Death following Perturbations of One-Carbon Metabolism by Regulating ER Stress in Acute Lymphoblastic Leukemia

(2011) J. N. Kuznetsov et al.   MOLECULAR CANCER THERAPEUTICS

A prolonged pharmacological blockade of type-5 metabotropic glutamate receptors protects cultured spinal cord motor neurons against excitotoxic death

(2011) Simona D'Antoni et al.   NEUROBIOLOGY OF DISEASE

Novel Neuroinflammatory Targets in the Chronically Injured Spinal Cord

(2011) Ahdeah Pajoohesh-Ganji et al.   Neurotherapeutics

Microglial calcium signal acts as a rapid sensor of single neuron damage in vivo

(2010) Gerhard Eichhoff et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Intracellular Ca2+ storage in health and disease: A dynamic equilibrium

(2010) Eva Sammels et al.   CELL CALCIUM

Berberine suppresses neuroinflammatory responses through AMP-activated protein kinase activation in BV-2 microglia

(2010) Dah-Yuu Lu et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Effects of mitochondrial dysfunction on the immunological properties of microglia

(2010) Annette I Ferger et al.   Journal of Neuroinflammation

Activation of metabotropic glutamate receptor 5 improves recovery after spinal cord injury in rodents

(2009) Kimberly R. Byrnes et al.   ANNALS OF NEUROLOGY

Activation of Metabotropic Glutamate Receptor 5 Modulates Microglial Reactivity and Neurotoxicity by Inhibiting NADPH Oxidase

(2009) David J. Loane et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

AMPK in the brain: its roles in energy balance and neuroprotection

(2009) Gabriele V. Ronnett et al.   JOURNAL OF NEUROCHEMISTRY

AICAR (5-aminoimidazole-4-carboxamide-1-β-4-ribofuranoside) increases the production of toxic molecules and affects the profile of cytokines release in LPS-stimulated rat primary microglial cultures

(2009) Krzysztof Łabuzek et al.   NEUROTOXICOLOGY

Metabotropic glutamate receptor 5 activation inhibits microglial associated inflammation and neurotoxicity

(2008) Kimberly R. Byrnes et al.   GLIA

Identification of Nitric Oxide as an Endogenous Activator of the AMP-activated Protein Kinase in Vascular Endothelial Cells

(2008) Junhua Zhang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Inhibition of MMP-3 or -9 suppresses lipopolysaccharide-induced expression of proinflammatory cytokines and iNOS in microglia

(2008) Moon-Sook Woo et al.   JOURNAL OF NEUROCHEMISTRY

Dantrolene: Mechanisms of Neuroprotection and Possible Clinical Applications in the Neurointensive Care Unit

(2008) Susanne Muehlschlegel et al.   Neurocritical Care

Metabotropic glutamate receptors as targets for multipotential treatment of neurological disorders

(2008) Kimberly R. Byrnes et al.   Neurotherapeutics