Microglial activatory (immunoreceptor tyrosine-based activation motif)- and inhibitory (immunoreceptor tyrosine-based inhibition motif)-signaling receptors for recognition of the neuronal glycocalyx

Complement component C3 and complement receptor type 3 contribute to the phagocytosis and clearance of fibrillar Aβ by microglia

(2012) Hongjun Fu et al.   GLIA

Sialic Acid on the Neuronal Glycocalyx Prevents Complement C1 Binding and Complement Receptor-3-Mediated Removal by Microglia

(2012) B. Linnartz et al.   JOURNAL OF NEUROSCIENCE

The Cell Biology of Phagocytosis

(2011) Ronald S. Flannagan et al.   Annual Review of Pathology-Mechanisms of Disease

Targeting Siglecs—A novel pharmacological strategy for immuno- and glycotherapy

(2011) Camilla Jandus et al.   BIOCHEMICAL PHARMACOLOGY

Epitope mapping, expression and post-translational modifications of two isoforms of CD33 (CD33M and CD33m) on lymphoid and myeloid human cells

(2011) A. B. Perez-Oliva et al.   GLYCOBIOLOGY

Letter to the Glyco-Forum: Since there are PAMPs and DAMPs, there must be SAMPs? Glycan "self-associated molecular patterns" dampen innate immunity, but pathogens can mimic them

(2011) A. Varki   GLYCOBIOLOGY

Monophosphorylation of CD79a and CD79b ITAM Motifs Initiates a SHIP-1 Phosphatase-Mediated Inhibitory Signaling Cascade Required for B Cell Anergy

(2011) Shannon K. O'Neill et al.   IMMUNITY

Complement receptor 1 (CR1) and Alzheimer's disease

(2011) Helen Crehan et al.   IMMUNOBIOLOGY

Systemic Inflammation Modulates Fc Receptor Expression on Microglia during Chronic Neurodegeneration

(2011) K. Lunnon et al.   JOURNAL OF IMMUNOLOGY

Myelin down-regulates myelin phagocytosis by microglia and macrophages through interactions between CD47 on myelin and SIRPα (signal regulatory protein-α) on phagocytes

(2011) Miri Gitik et al.   Journal of Neuroinflammation

Alzheimer risk associated with a copy number variation in the complement receptor 1 increasing C3b/C4b binding sites

(2011) N Brouwers et al.   MOLECULAR PSYCHIATRY

Dual Induction of TREM2 and Tolerance-Related Transcript, Tmem176b, in Amyloid Transgenic Mice: Implications for Vaccine-Based Therapies for Alzheimer's Disease

(2010) Benoit Melchior et al.   ASN Neuro

Decrease of sialic acid residues as an eat-me signal on the surface of apoptotic lymphocytes

(2010) H. M. Meesmann et al.   JOURNAL OF CELL SCIENCE

Alleviation of Neurotoxicity by Microglial Human Siglec-11

(2010) Y. Wang et al.   JOURNAL OF NEUROSCIENCE

Fate Mapping Analysis Reveals That Adult Microglia Derive from Primitive Macrophages

(2010) F. Ginhoux et al.   SCIENCE

Signal Regulatory Protein-β1

(2009) Sadanand Gaikwad et al.   AMERICAN JOURNAL OF PATHOLOGY

Microglial Physiology: Unique Stimuli, Specialized Responses

(2009) Richard M. Ransohoff et al.   Annual Review of Immunology

Lectins as pattern recognition molecules: The effects of epitope density in innate immunity

(2009) T. K Dam et al.   GLYCOBIOLOGY

Natural ligands for CD33-related Siglecs?

(2009) A. Varki   GLYCOBIOLOGY

Comparative genomics indicates the mammalian CD33rSiglec locus evolved by an ancient large-scale inverse duplication and suggests all Siglecs share a common ancestral region

(2009) Huan Cao et al.   IMMUNOGENETICS

TREM-2 (triggering receptor expressed on myeloid cells 2) is a phagocytic receptor for bacteria

(2009) Elsa-Noah N'Diaye et al.   JOURNAL OF CELL BIOLOGY

Siglec-E Is Up-Regulated and Phosphorylated Following Lipopolysaccharide Stimulation in Order to Limit TLR-Driven Cytokine Production

(2009) C. R. Boyd et al.   JOURNAL OF IMMUNOLOGY

Siglec receptors and hiding plaques in Alzheimer's disease

(2009) Antero Salminen et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Microarrays with Varying Carbohydrate Density Reveal Distinct Subpopulations of Serum Antibodies

(2009) Oyindasola Oyelaran et al.   JOURNAL OF PROTEOME RESEARCH

Genome-wide association study identifies variants at CLU and CR1 associated with Alzheimer's disease

(2009) Jean-Charles Lambert et al.   NATURE GENETICS

Cross-regulation of signaling by ITAM-associated receptors

(2009) Lionel B Ivashkiv   NATURE IMMUNOLOGY

Directing an Appropriate Immune Response: The Role of Defense Collagens and other Soluble Pattern Recognition Molecules

(2008) D. Fraser et al.   CURRENT DRUG TARGETS

SIGLEC16encodes a DAP12-associated receptor expressed in macrophages that evolved from its inhibitory counterpartSIGLEC11and has functional and non-functional alleles in humans

(2008) Huan Cao et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Mutations inTREM2lead to pure early-onset dementia without bone cysts

(2008) Eliane Chouery et al.   HUMAN MUTATION

Developmental Neuronal Death in Hippocampus Requires the Microglial CD11b Integrin and DAP12 Immunoreceptor

(2008) S. Wakselman et al.   JOURNAL OF NEUROSCIENCE

Draper-dependent glial phagocytic activity is mediated by Src and Syk family kinase signalling

(2008) Jennifer S. Ziegenfuss et al.   NATURE