β‐Catenin Preserves the Stem State of Murine Bone Marrow Stromal Cells Through Activation of EZH2

Wnt signaling in development and tissue homeostasis

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Enhancer of zeste homolog 2 (Ezh2) controls bone formation and cell cycle progression during osteogenesis in mice

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Constitutive β-catenin activation in osteoblasts impairs terminal osteoblast differentiation and bone quality

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Intranuclear Actin Structure Modulates Mesenchymal Stem Cell Differentiation

(2017) Buer Sen et al.   STEM CELLS

Osteogenic Stimulation of Human Adipose-Derived Mesenchymal Stem Cells Using a Fungal Metabolite That Suppresses the Polycomb Group Protein EZH2

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Emerging roles for Polycomb proteins in cancer

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Enhancer of Zeste Homolog 2 Inhibition Stimulates Bone Formation and Mitigates Bone Loss Caused by Ovariectomy in Skeletally Mature Mice

(2016) Amel Dudakovic et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Epigenetic Plasticity Drives Adipogenic and Osteogenic Differentiation of Marrow-derived Mesenchymal Stem Cells

(2016) Mark B. Meyer et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Suppression of EZH2 Prevents the Shift of Osteoporotic MSC Fate to Adipocyte and Enhances Bone Formation During Osteoporosis

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Ki-67 acts as a biological surfactant to disperse mitotic chromosomes

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Mechanical regulation of transcription controls Polycomb-mediated gene silencing during lineage commitment

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Targeting EZH2 in cancer

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BMP signalling in skeletal development, disease and repair

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Identification of Novel EZH2 Targets Regulating Osteogenic Differentiation in Mesenchymal Stem Cells

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Downregulation of Enhancer of Zeste Homolog 2 (EZH2) is essential for the Induction of Autophagy and Apoptosis in Colorectal Cancer Cells

(2016) Yizhou Yao et al.   Genes

InteractiVenn: a web-based tool for the analysis of sets through Venn diagrams

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In vivo mechanical loading rapidly activates β-catenin signaling in osteocytes through a prostaglandin mediated mechanism

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Epigenetic Control of Skeletal Development by the Histone Methyltransferase Ezh2

(2015) Amel Dudakovic et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Intranuclear Actin Regulates Osteogenesis

(2015) Buer Sen et al.   STEM CELLS

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HiChIP: a high-throughput pipeline for integrative analysis of ChIP-Seq data

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MAP-RSeq: Mayo Analysis Pipeline for RNA sequencing

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YAP/TAZ Incorporation in the β-Catenin Destruction Complex Orchestrates the Wnt Response

(2014) Luca Azzolin et al.   CELL

Wnt-induced transcriptional activation is exclusively mediated by TCF/LEF

(2014) Jurian Schuijers et al.   EMBO JOURNAL

Wnt and the Wnt signaling pathway in bone development and disease

(2014) Yiping Wang   Frontiers in Bioscience-Landmark

The RUNX2 Cistrome in Osteoblasts

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High-Resolution Molecular Validation of Self-Renewal and Spontaneous Differentiation in Clinical-Grade Adipose-Tissue Derived Human Mesenchymal Stem Cells

(2014) Amel Dudakovic et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Regulation of MKL1 via actin cytoskeleton dynamics drives adipocyte differentiation

(2014) Hiroyuki Nobusue et al.   Nature Communications

WNT-LRP5 Signaling Induces Warburg Effect through mTORC2 Activation during Osteoblast Differentiation

(2013) Emel Esen et al.   Cell Metabolism

mTORC2 Regulates Mechanically Induced Cytoskeletal Reorganization and Lineage Selection in Marrow-Derived Mesenchymal Stem Cells

(2013) Buer Sen et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Mechanically activated fyn utilizes mTORC2 to regulate RhoA and adipogenesis in mesenchymal stem cells

(2013) William R. Thompson et al.   STEM CELLS

EZH2andKDM6AAct as an Epigenetic Switch to Regulate Mesenchymal Stem Cell Lineage Specification

(2013) Sarah Hemming et al.   STEM CELLS

TopHat2: accurate alignment of transcriptomes in the presence of insertions, deletions and gene fusions

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Mechanical input restrains PPARγ2 expression and action to preserve mesenchymal stem cell multipotentiality

(2012) Natasha Case et al.   BONE

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β-catenin promotes bone formation and suppresses bone resorption in postnatal growing mice

(2012) Jianquan Chen et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Genomic occupancy of HLH, AP1 and Runx2 motifs within a nuclease sensitive site of the Runx2 gene

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Transduction of mechanical and cytoskeletal cues by YAP and TAZ

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Spontaneous osteogenesis of MSCs cultured on 3D microcarriers through alteration of cytoskeletal tension

(2011) Pei-Chi Tseng et al.   BIOMATERIALS

EZH2-Mediated Concordant Repression of Wnt Antagonists Promotes  -Catenin-Dependent Hepatocarcinogenesis

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Mechanical Regulation of Glycogen Synthase Kinase 3β (GSK3β) in Mesenchymal Stem Cells Is Dependent on Akt Protein Serine 473 Phosphorylation via mTORC2 Protein

(2011) Natasha Case et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

High levels of β-catenin signaling reduce osteogenic differentiation of stem cells in inflammatory microenvironments through inhibition of the noncanonical Wnt pathway

(2011) Na Liu et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Forced Activation of  -Catenin Signaling Supports the Transformation of hTERT-Immortalized Human Fetal Hepatocytes

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VDR/RXR and TCF4/β-Catenin Cistromes in Colonic Cells of Colorectal Tumor Origin: Impact onc-FOSandc-MYCGene Expression

(2011) Mark B. Meyer et al.   MOLECULAR ENDOCRINOLOGY

Role of YAP/TAZ in mechanotransduction

(2011) Sirio Dupont et al.   NATURE

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Mechanically Induced Focal Adhesion Assembly Amplifies Anti-Adipogenic Pathways in Mesenchymal Stem Cells

(2011) Buer Sen et al.   STEM CELLS

Disruption of PCP signaling causes limb morphogenesis and skeletal defects and may underlie Robinow syndrome and brachydactyly type B

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Mechanical signal influence on mesenchymal stem cell fate is enhanced by incorporation of refractory periods into the loading regimen

(2010) Buer Sen et al.   JOURNAL OF BIOMECHANICS

Mechanical activation of β-catenin regulates phenotype in adult murine marrow-derived mesenchymal stem cells

(2010) Natasha Case et al.   JOURNAL OF ORTHOPAEDIC RESEARCH

CDK1-dependent phosphorylation of EZH2 suppresses methylation of H3K27 and promotes osteogenic differentiation of human mesenchymal stem cells

(2010) Yongkun Wei et al.   NATURE CELL BIOLOGY

Histone H3K27 methyltransferase Ezh2 represses Wnt genes to facilitate adipogenesis

(2010) L. Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Balance of WNT and FGF Signaling Influences Mesenchymal Stem Cell Fate During Skeletal Development

(2010) T. Maruyama et al.   Science Signaling

Targeted Overexpression of EZH2 in the Mammary Gland Disrupts Ductal Morphogenesis and Causes Epithelial Hyperplasia

(2009) Xin Li et al.   AMERICAN JOURNAL OF PATHOLOGY

A clustering approach for identification of enriched domains from histone modification ChIP-Seq data

(2009) Chongzhi Zang et al.   BIOINFORMATICS

Mechanical Loading Regulates NFATc1 and β-Catenin Signaling through a GSK3β Control Node

(2009) Buer Sen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Canonical Wnts function as potent regulators of osteogenesis by human mesenchymal stem cells

(2009) Guizhong Liu et al.   JOURNAL OF CELL BIOLOGY

The notch-responsive transcription factor Hes-1 attenuates osteocalcin promoter activity in osteoblastic cells

(2009) Ying Zhang et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Evidence that Fold-Change, and Not Absolute Level, of β-Catenin Dictates Wnt Signaling

(2009) Lea Goentoro et al.   MOLECULAR CELL

Wnt and PPARγ signaling in osteoblastogenesis and adipogenesis

(2009) Ichiro Takada et al.   Nature Reviews Rheumatology

Mechanical Strain Inhibits Adipogenesis in Mesenchymal Stem Cells by Stimulating a Durable β-Catenin Signal

(2008) Buer Sen et al.   ENDOCRINOLOGY

Intricate gene regulatory networks of helix-loop-helix (HLH) proteins support regulation of bone-tissue related genes during osteoblast differentiation

(2008) Ying Zhang et al.   JOURNAL OF CELLULAR BIOCHEMISTRY