Epigenetic Control of Skeletal Development by the Histone Methyltransferase Ezh2

Germline mutations in the oncogene EZH2 cause Weaver syndrome and increased human height

(2015) Katrina Tatton-Brown et al.   Oncotarget

Bookmarking Target Genes in Mitosis: A Shared Epigenetic Trait of Phenotypic Transcription Factors and Oncogenes?

(2014) Sayyed K. Zaidi et al.   CANCER RESEARCH

Roles of enhancer of zeste homolog 2: From skeletal muscle differentiation to rhabdomyosarcoma carcinogenesis

(2014) Irene Marchesi et al.   CELL CYCLE

Ezh2 is required for neural crest-derived cartilage and bone formation

(2014) D. Schwarz et al.   DEVELOPMENT

High-Resolution Molecular Validation of Self-Renewal and Spontaneous Differentiation in Clinical-Grade Adipose-Tissue Derived Human Mesenchymal Stem Cells

(2014) Amel Dudakovic et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Histone Deacetylase Inhibition Destabilizes the Multi-Potent State of Uncommitted Adipose-Derived Mesenchymal Stromal Cells

(2014) Amel Dudakovic et al.   JOURNAL OF CELLULAR PHYSIOLOGY

EZH2, a Potential Regulator of Dental Pulp Inflammation and Regeneration

(2014) Tianqian Hui et al.   JOURNAL OF ENDODONTICS

Genomic occupancy of Runx2 with global expression profiling identifies a novel dimension to control of osteoblastogenesis

(2014) Hai Wu et al.   GENOME BIOLOGY

Downregulated LncRNA-ANCR promotes osteoblast differentiation by targeting EZH2 and regulating Runx2 expression

(2013) Lin Zhu et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Histone Deacetylase Inhibition Promotes Osteoblast Maturation by Altering the Histone H4 Epigenome and Reduces Akt Phosphorylation

(2013) Amel Dudakovic et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Optimizing patient derived mesenchymal stem cells as virus carriers for a Phase I clinical trial in ovarian cancer

(2013) Emily K Mader et al.   Journal of Translational Medicine

EZH2andKDM6AAct as an Epigenetic Switch to Regulate Mesenchymal Stem Cell Lineage Specification

(2013) Sarah Hemming et al.   STEM CELLS

ChromoHub: a data hub for navigators of chromatin-mediated signalling

(2012) L. Liu et al.   BIOINFORMATICS

A decade of 3C technologies: insights into nuclear organization

(2012) E. de Wit et al.   GENES & DEVELOPMENT

Twist-1 Induces Ezh2 Recruitment Regulating Histone Methylation along the Ink4A/Arf Locus in Mesenchymal Stem Cells

(2012) D. Cakouros et al.   MOLECULAR AND CELLULAR BIOLOGY

MicroRNA control of bone formation and homeostasis

(2012) Jane B. Lian et al.   Nature Reviews Endocrinology

Mutations in EZH2 Cause Weaver Syndrome

(2011) William T. Gibson et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Ezh2 regulates anteroposterior axis specification and proximodistal axis elongation in the developing limb

(2011) L. A. Wyngaarden et al.   DEVELOPMENT

HDAC inhibitors in cancer biology: emerging mechanisms and clinical applications

(2011) Omar Khan et al.   IMMUNOLOGY AND CELL BIOLOGY

Novel actions of bisphosphonates in bone: Preservation of osteoblast and osteocyte viability

(2010) Teresita Bellido et al.   BONE

Platelet Lysate Consisting of a Natural Repair Proteome Supports Human Mesenchymal Stem Cell Proliferation and Chromosomal Stability

(2010) Ruben Crespo-Diaz et al.   CELL TRANSPLANTATION

Histone deacetylases in skeletal development and bone mass maintenance

(2010) Meghan E. McGee-Lawrence et al.   GENE

Epigenetics and gene expression

(2010) E R Gibney et al.   HEREDITY

Guidelines for assessment of bone microstructure in rodents using micro-computed tomography

(2010) Mary L Bouxsein et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Genome-scale techniques highlight the epigenome and redefine fundamental principles of gene regulation

(2010) J Wesley Pike   JOURNAL OF BONE AND MINERAL RESEARCH

Update in New Anabolic Therapies for Osteoporosis

(2010) Ernesto Canalis   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

CDK1-dependent phosphorylation of EZH2 suppresses methylation of H3K27 and promotes osteogenic differentiation of human mesenchymal stem cells

(2010) Yongkun Wei et al.   NATURE CELL BIOLOGY

Principles and challenges of genome-wide DNA methylation analysis

(2010) Peter W. Laird   NATURE REVIEWS GENETICS

Epigenetic regulation in the pathophysiology of Alzheimer's disease

(2010) Leonidas Chouliaras et al.   PROGRESS IN NEUROBIOLOGY

Genome-Wide Views of Chromatin Structure

(2009) Oliver J. Rando et al.   Annual Review of Biochemistry

Histone deacetylase inhibitors decrease proliferation potential and multilineage differentiation capability of human mesenchymal stem cells

(2009) S. Lee et al.   CELL PROLIFERATION

Targeting DNA Methylation

(2009) J.-P. J. Issa et al.   CLINICAL CANCER RESEARCH

The genetics and epigenetics of autoimmune diseases

(2009) Anura Hewagama et al.   JOURNAL OF AUTOIMMUNITY

Epigenetic Modulation of mGlu2 Receptors by Histone Deacetylase Inhibitors in the Treatment of Inflammatory Pain

(2009) S. Chiechio et al.   MOLECULAR PHARMACOLOGY

Denosumab for Prevention of Fractures in Postmenopausal Women with Osteoporosis

(2009) Steven R. Cummings et al.   NEW ENGLAND JOURNAL OF MEDICINE

CDKN1C (p57KIP2) Is a Direct Target of EZH2 and Suppressed by Multiple Epigenetic Mechanisms in Breast Cancer Cells

(2009) Xiaojing Yang et al.   PLoS One

An Abundance of Ubiquitously Expressed Genes Revealed by Tissue Transcriptome Sequence Data

(2009) Daniel Ramsköld et al.   PLoS Computational Biology

Efficacy of Bazedoxifene in Reducing New Vertebral Fracture Risk in Postmenopausal Women With Osteoporosis: Results From a 3-Year, Randomized, Placebo-, and Active-Controlled Clinical Trial*

(2008) Stuart L Silverman et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Ezh1 and Ezh2 Maintain Repressive Chromatin through Different Mechanisms

(2008) Raphael Margueron et al.   MOLECULAR CELL

Histone Deacetylase Inhibitors Promote Apoptosis and Senescence in Human Mesenchymal Stem Cells

(2008) Giovanni Di Bernardo et al.   STEM CELLS AND DEVELOPMENT