Enhancer of Zeste Homolog 2 Inhibition Stimulates Bone Formation and Mitigates Bone Loss Caused by Ovariectomy in Skeletally Mature Mice

Suppression of EZH2 Prevents the Shift of Osteoporotic MSC Fate to Adipocyte and Enhances Bone Formation During Osteoporosis

(2016) Huan Jing et al.   MOLECULAR THERAPY

Targeting EZH2 in cancer

(2016) Kimberly H Kim et al.   NATURE MEDICINE

Postmenopausal Osteoporosis

(2016) Dennis M. Black et al.   NEW ENGLAND JOURNAL OF MEDICINE

Replicative senescence of mesenchymal stem cells causes DNA-methylation changes which correlate with repressive histone marks

(2016) Anne Schellenberg et al.   Aging-US

Bone morphogenetic protein signaling in bone homeostasis

(2015) Gonzalo Sánchez-Duffhues et al.   BONE

Chromatin modifiers and histone modifications in bone formation, regeneration, and therapeutic intervention for bone-related disease

(2015) Jonathan A.R. Gordon et al.   BONE

The Potential Roles of EZH2 in Regenerative Medicine

(2015) Ruey-Hwang Chou et al.   CELL TRANSPLANTATION

Epigenetic Control of Skeletal Development by the Histone Methyltransferase Ezh2

(2015) Amel Dudakovic et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The promise and peril of chemical probes

(2015) Cheryl H Arrowsmith et al.   Nature Chemical Biology

Reciprocal negative feedback loop between EZH2 and miR-101-1 contributes to miR-101 deregulation in hepatocellular carcinoma

(2015) DA HUANG et al.   ONCOLOGY REPORTS

HiChIP: a high-throughput pipeline for integrative analysis of ChIP-Seq data

(2014) Huihuang Yan et al.   BMC BIOINFORMATICS

ngs.plot: Quick mining and visualization of next-generation sequencing data by integrating genomic databases

(2014) Li Shen et al.   BMC GENOMICS

Roles of enhancer of zeste homolog 2: From skeletal muscle differentiation to rhabdomyosarcoma carcinogenesis

(2014) Irene Marchesi et al.   CELL CYCLE

High-Resolution Molecular Validation of Self-Renewal and Spontaneous Differentiation in Clinical-Grade Adipose-Tissue Derived Human Mesenchymal Stem Cells

(2014) Amel Dudakovic et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

EZH2, a Potential Regulator of Dental Pulp Inflammation and Regeneration

(2014) Tianqian Hui et al.   JOURNAL OF ENDODONTICS

Genomic occupancy of Runx2 with global expression profiling identifies a novel dimension to control of osteoblastogenesis

(2014) Hai Wu et al.   GENOME BIOLOGY

Systematic Review: Comparative Effectiveness of Treatments to Prevent Fractures in Men and Women with Low Bone Density or Osteoporosis

(2013) Catherine MacLean et al.   ANNALS OF INTERNAL MEDICINE

Downregulated LncRNA-ANCR promotes osteoblast differentiation by targeting EZH2 and regulating Runx2 expression

(2013) Lin Zhu et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Histone Deacetylase Inhibition Promotes Osteoblast Maturation by Altering the Histone H4 Epigenome and Reduces Akt Phosphorylation

(2013) Amel Dudakovic et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Wnt signalling in osteoporosis: mechanisms and novel therapeutic approaches

(2013) Ernesto Canalis   Nature Reviews Endocrinology

EZH2andKDM6AAct as an Epigenetic Switch to Regulate Mesenchymal Stem Cell Lineage Specification

(2013) Sarah Hemming et al.   STEM CELLS

MicroRNA Functions in Osteogenesis and Dysfunctions in Osteoporosis

(2013) Andre J. van Wijnen et al.   Current Osteoporosis Reports

Epigenetic regulation of adipogenesis by histone methylation

(2012) Kai Ge   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

Effects of PTH on osteocyte function

(2012) Teresita Bellido et al.   BONE

Twist-1 Induces Ezh2 Recruitment Regulating Histone Methylation along the Ink4A/Arf Locus in Mesenchymal Stem Cells

(2012) D. Cakouros et al.   MOLECULAR AND CELLULAR BIOLOGY

EZH2 inhibition as a therapeutic strategy for lymphoma with EZH2-activating mutations

(2012) Michael T. McCabe et al.   NATURE

NIH Image to ImageJ: 25 years of image analysis

(2012) Caroline A Schneider et al.   NATURE METHODS

MicroRNA control of bone formation and homeostasis

(2012) Jane B. Lian et al.   Nature Reviews Endocrinology

Suberoylanilide hydroxamic acid (SAHA; vorinostat) causes bone loss by inhibiting immature osteoblasts

(2011) Meghan E. McGee-Lawrence et al.   BONE

The Polycomb complex PRC2 and its mark in life

(2011) Raphaël Margueron et al.   NATURE

The Language of Histone Crosstalk

(2010) Jung-Shin Lee et al.   CELL

Genome-scale techniques highlight the epigenome and redefine fundamental principles of gene regulation

(2010) J Wesley Pike   JOURNAL OF BONE AND MINERAL RESEARCH

CDK1-dependent phosphorylation of EZH2 suppresses methylation of H3K27 and promotes osteogenic differentiation of human mesenchymal stem cells

(2010) Yongkun Wei et al.   NATURE CELL BIOLOGY

Ezh2, the histone methyltransferase of PRC2, regulates the balance between self-renewal and differentiation in the cerebral cortex

(2010) J. D. Pereira et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Histone H3K27 methyltransferase Ezh2 represses Wnt genes to facilitate adipogenesis

(2010) L. Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A clustering approach for identification of enriched domains from histone modification ChIP-Seq data

(2009) Chongzhi Zang et al.   BIOINFORMATICS

The Sequence Alignment/Map format and SAMtools

(2009) H. Li et al.   BIOINFORMATICS

BMP2 signaling in bone development and repair

(2009) Vicki Rosen   CYTOKINE & GROWTH FACTOR REVIEWS

DZNep is a global histone methylation inhibitor that reactivates developmental genes not silenced by DNA methylation

(2009) T. B. Miranda et al.   MOLECULAR CANCER THERAPEUTICS

Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources

(2009) Da Wei Huang et al.   Nature Protocols

Ezh1 and Ezh2 Maintain Repressive Chromatin through Different Mechanisms

(2008) Raphael Margueron et al.   MOLECULAR CELL

Genomic Loss of microRNA-101 Leads to Overexpression of Histone Methyltransferase EZH2 in Cancer

(2008) S. Varambally et al.   SCIENCE