BMP signalling in skeletal development, disease and repair

Myhre syndrome: Clinical features and restrictive cardiopulmonary complications

(2015) Lois J. Starr et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART A

Nosology and classification of genetic skeletal disorders: 2015 revision

(2015) Luisa Bonafe et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART A

A Novel Missense Mutation of NOG Interferes With the Dimerization of NOG and Causes Proximal Symphalangism Syndrome in a Chinese Family

(2015) Xiuhong Pang et al.   ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY

GDF-5 can act as a context-dependent BMP-2 antagonist

(2015) Uwe Klammert et al.   BMC BIOLOGY

Bone morphogenetic protein signaling in bone homeostasis

(2015) Gonzalo Sánchez-Duffhues et al.   BONE

Bmp2 conditional knockout in osteoblasts and endothelial cells does not impair bone formation after injury or mechanical loading in adult mice

(2015) Sarah Howe McBride-Gagyi et al.   BONE

GDF11 Increases with Age and Inhibits Skeletal Muscle Regeneration

(2015) Marc A. Egerman et al.   Cell Metabolism

GDF11 Does Not Rescue Aging-Related Pathological HypertrophyNovelty and Significance

(2015) Shavonn C. Smith et al.   CIRCULATION RESEARCH

On the development of the patella

(2015) S. Eyal et al.   DEVELOPMENT

Precise spatial restriction of BMP signaling is essential for articular cartilage differentiation

(2015) A. Ray et al.   DEVELOPMENT

BMP–Smad4 signaling is required for precartilaginous mesenchymal condensation independent of Sox9 in the mouse

(2015) Joohyun Lim et al.   DEVELOPMENTAL BIOLOGY

Gdf5 progenitors give rise to fibrocartilage cells that mineralize via hedgehog signaling to form the zonal enthesis

(2015) Nathaniel A. Dyment et al.   DEVELOPMENTAL BIOLOGY

Elimination of BMP7 from the developing limb mesenchyme leads to articular cartilage degeneration and synovial inflammation with increased age

(2015) Kahaer Abula et al.   FEBS LETTERS

The Type I BMP Receptor ACVR1/ALK2 is Required for Chondrogenesis During Development

(2015) Diana Rigueur et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Fibrillin-1 Regulates Skeletal Stem Cell Differentiation by Modulating TGFβ Activity Within the Marrow Niche

(2015) Silvia Smaldone et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Loss of BMPR2 leads to high bone mass due to increased osteoblast activity

(2015) J. W. Lowery et al.   JOURNAL OF CELL SCIENCE

Bmp2 Deletion Causes an Amelogenesis Imperfecta Phenotype Via Regulating Enamel Gene Expression

(2015) Feng Guo et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Routine use of recombinant human bone morphogenetic protein–2 in posterior fusions of the pediatric spine and incidence of cancer

(2015) Christina Sayama et al.   Journal of Neurosurgery-Pediatrics

A comprehensive assessment of the risk of bone morphogenetic protein use in spinal fusion surgery and postoperative cancer diagnosis

(2015) Kevin S. Cahill et al.   JOURNAL OF NEUROSURGERY-SPINE

Generation of articular chondrocytes from human pluripotent stem cells

(2015) April M Craft et al.   NATURE BIOTECHNOLOGY

Excess TGF-β mediates muscle weakness associated with bone metastases in mice

(2015) David L Waning et al.   NATURE MEDICINE

ACVR1 R206H receptor mutation causes fibrodysplasia ossificans progressiva by imparting responsiveness to activin A

(2015) Sarah J. Hatsell et al.   Science Translational Medicine

Temporally coordinated signals progressively pattern the anteroposterior and dorsoventral body axes

(2015) Francesca B. Tuazon et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

BMP signalling: agony and antagony in the family

(2015) Derek P. Brazil et al.   TRENDS IN CELL BIOLOGY

A mutation in the heparin-binding site of noggin as a novel mechanism of proximal symphalangism and conductive hearing loss

(2014) Sawako Masuda et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Bone morphogenetic proteins and their antagonists: current and emerging clinical uses

(2014) Imran H A Ali et al.   BRITISH JOURNAL OF PHARMACOLOGY

Osteogenic fate of hypertrophic chondrocytes

(2014) Guan Yang et al.   CELL RESEARCH

Myhre syndrome

(2014) C. Le Goff et al.   CLINICAL GENETICS

Dynamics of BMP signaling in limb bud mesenchyme and polydactyly

(2014) Jacqueline L. Norrie et al.   DEVELOPMENTAL BIOLOGY

Loeys–Dietz syndrome: a primer for diagnosis and management

(2014) Gretchen MacCarrick et al.   GENETICS IN MEDICINE

Synchrotron imaging reveals bone healing and remodelling strategies in extinct and extant vertebrates

(2014) J. Anne et al.   Journal of the Royal Society Interface

A subset of chondrogenic cells provides early mesenchymal progenitors in growing bones

(2014) Noriaki Ono et al.   NATURE CELL BIOLOGY

Excessive transforming growth factor-β signaling is a common mechanism in osteogenesis imperfecta

(2014) Ingo Grafe et al.   NATURE MEDICINE

Long Bone Structure and Strength Depend on BMP2 from Osteoblasts and Osteocytes, but Not Vascular Endothelial Cells

(2014) Sarah H. McBride et al.   PLoS One

Hypertrophic chondrocytes can become osteoblasts and osteocytes in endochondral bone formation

(2014) L. Yang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Restoring Systemic GDF11 Levels Reverses Age-Related Dysfunction in Mouse Skeletal Muscle

(2014) M. Sinha et al.   SCIENCE

To BMP or not to BMP during vertebrate limb bud development

(2014) Emanuele Pignatti et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Smad9 is a new type of transcriptional regulator in bone morphogenetic protein signaling

(2014) S. Tsukamoto et al.   Scientific Reports

Chondrocytes Transdifferentiate into Osteoblasts in Endochondral Bone during Development, Postnatal Growth and Fracture Healing in Mice

(2014) Xin Zhou et al.   PLoS Genetics

Growth Differentiation Factor 11 Is a Circulating Factor that Reverses Age-Related Cardiac Hypertrophy

(2013) Francesco S. Loffredo et al.   CELL

Specification of chondrocytes and cartilage tissues from embryonic stem cells

(2013) A. M. Craft et al.   DEVELOPMENT

Homozygous missense and nonsense mutations in BMPR1B cause acromesomelic chondrodysplasia-type Grebe

(2013) Luitgard M Graul-Neumann et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

Elevated expression of activins promotes muscle wasting and cachexia

(2013) Justin L. Chen et al.   FASEB JOURNAL

BMP Receptor 1A Determines the Cell Fate of the Postnatal Growth Plate

(2013) Junjun Jing et al.   International Journal of Biological Sciences

Embryonic ablation of osteoblast Smad4 interrupts matrix synthesis in response to canonical Wnt signaling and causes an osteogenesis-imperfecta-like phenotype

(2013) V. S. Salazar et al.   JOURNAL OF CELL SCIENCE

Bmp2 in osteoblasts of periosteum and trabecular bone links bone formation to vascularization and mesenchymal stem cells

(2013) W. Yang et al.   JOURNAL OF CELL SCIENCE

Multiple phases of chondrocyte enlargement underlie differences in skeletal proportions

(2013) Kimberly L. Cooper et al.   NATURE

BMP signaling controls muscle mass

(2013) Roberta Sartori et al.   NATURE GENETICS

Development of the Endochondral Skeleton

(2013) F. Long et al.   Cold Spring Harbor Perspectives in Biology

Human Developmental Chondrogenesis as a Basis for Engineering Chondrocytes from Pluripotent Stem Cells

(2013) Ling Wu et al.   Stem Cell Reports

Studies of bone morphogenetic protein-based surgical repair

(2012) Kevin W.-H. Lo et al.   ADVANCED DRUG DELIVERY REVIEWS

Periosteal BMP2 activity drives bone graft healing

(2012) Vivianne Chappuis et al.   BONE

Smad4 is required to induce digit ray primordia and to initiate the aggregation and differentiation of chondrogenic progenitors in mouse limb buds

(2012) J.-D. Benazet et al.   DEVELOPMENT

TGF-β Type II Receptor/MCP-5 Axis: At the Crossroad between Joint and Growth Plate Development

(2012) Lara Longobardi et al.   DEVELOPMENTAL CELL

Molecular profiling of synovial joints: Use of microarray analysis to identify factors that direct the development of the knee and elbow

(2012) Dorothy E. Pazin et al.   DEVELOPMENTAL DYNAMICS

Structural studies of the TGF-βs and their receptors - insights into evolution of the TGF-β superfamily

(2012) Andrew P. Hinck   FEBS LETTERS

Chondrocyte BMP2 signaling plays an essential role in bone fracture healing

(2012) Meng Mi et al.   GENE

TGFβ signalling in context

(2012) Joan Massagué   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Bmp2, Bmp4 and Bmp7 Are Co-Required in the Mouse AER for Normal Digit Patterning but Not Limb Outgrowth

(2012) Kyung-Suk Choi et al.   PLoS One

Joint TGF-β Type II Receptor-Expressing Cells: Ontogeny and Characterization as Joint Progenitors

(2012) Tieshi Li et al.   STEM CELLS AND DEVELOPMENT

Master Transcription Factors Determine Cell-Type-Specific Responses to TGF-β Signaling

(2011) Alan C. Mullen et al.   CELL

A Poised Chromatin Platform for TGF-β Access to Master Regulators

(2011) Qiaoran Xi et al.   CELL

Lineage Regulators Direct BMP and Wnt Pathways to Cell-Specific Programs during Differentiation and Regeneration

(2011) Eirini Trompouki et al.   CELL

Non-Smad signaling pathways

(2011) Yabing Mu et al.   CELL AND TISSUE RESEARCH

Abnormalities in the Enamel in Bmp2-Deficient Mice

(2011) Junsheng Feng et al.   CELLS TISSUES ORGANS

Exome Sequencing Identifies SMAD3 Mutations as a Cause of Familial Thoracic Aortic Aneurysm and Dissection With Intracranial and Other Arterial Aneurysms

(2011) Ellen S. Regalado et al.   CIRCULATION RESEARCH

Cooperative activity of noggin and gremlin 1 in axial skeleton development

(2011) D. A. Stafford et al.   DEVELOPMENT

Expression of the osteoarthritis-associated gene GDF5 is modulated epigenetically by DNA methylation

(2011) Louise N. Reynard et al.   HUMAN MOLECULAR GENETICS

BMP2, but not BMP4, is crucial for chondrocyte proliferation and maturation during endochondral bone development

(2011) B. Shu et al.   JOURNAL OF CELL SCIENCE

Genetics and epigenetics of osteoarthritis

(2011) Louise N. Reynard et al.   MATURITAS

BMP3 Suppresses Osteoblast Differentiation of Bone Marrow Stromal Cells via Interaction with Acvr2b

(2011) Shoichiro Kokabu et al.   MOLECULAR ENDOCRINOLOGY

Mutations at a single codon in Mad homology 2 domain of SMAD4 cause Myhre syndrome

(2011) Carine Le Goff et al.   NATURE GENETICS

Expression of endogenous BMP-2 in periosteal progenitor cells is essential for bone healing

(2010) Qun Wang et al.   BONE

Reversal of Cancer Cachexia and Muscle Wasting by ActRIIB Antagonism Leads to Prolonged Survival

(2010) Xiaolan Zhou et al.   CELL

Early Mortality and Cardiorespiratory Failure in Patients with Fibrodysplasia Ossificans Progressiva

(2010) Frederick S Kaplan et al.   JOURNAL OF BONE AND JOINT SURGERY-AMERICAN VOLUME

Responsiveness of clonal limb bud cell lines to bone morphogenetic protein 2 reveals a sequential relationship between cartilage and bone cell phenotypes

(2010) Vicki Rosen et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Hypertrophic chondrocytes undergo further differentiation to osteoblast-like cells and participate in the initial bone formation in developing chick embryo

(2010) Maria Galotto et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Bone Morphogenetic Proteins and articular cartilage

(2010) P.M. van der Kraan et al.   OSTEOARTHRITIS AND CARTILAGE

Osteoarthritis and a high-fat diet: the full 'OA syndrome' in a small animal model

(2010) Peter M van der Kraan   ARTHRITIS RESEARCH & THERAPY

Purification, crystallization and preliminary data analysis of ligand–receptor complexes of growth and differentiation factor 5 (GDF5) and BMP receptor IB (BRIB)

(2009) Alexander Kotzsch et al.   Acta Crystallographica Section F-Structural Biology and Crystallization Communications

Duplications Involving a Conserved Regulatory Element Downstream of BMP2 Are Associated with Brachydactyly Type A2

(2009) Katarina Dathe et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Emergence, development and diversification of the TGF-β signalling pathway within the animal kingdom

(2009) Lukasz Huminiecki et al.   BMC EVOLUTIONARY BIOLOGY

BMP2 signaling in bone development and repair

(2009) Vicki Rosen   CYTOKINE & GROWTH FACTOR REVIEWS

Informatics approaches to understanding TGF  pathway regulation

(2009) P. Kahlem et al.   DEVELOPMENT

The regulation of TGF  signal transduction

(2009) A. Moustakas et al.   DEVELOPMENT

BMP canonical Smad signaling through Smad1 and Smad5 is required for endochondral bone formation

(2009) K. N. Retting et al.   DEVELOPMENT

Mutation of the bone morphogenetic protein GDF3 causes ocular and skeletal anomalies

(2009) M. Ye et al.   HUMAN MOLECULAR GENETICS

Vertebrate limb bud development: moving towards integrative analysis of organogenesis

(2009) Rolf Zeller et al.   NATURE REVIEWS GENETICS

Mutations in GDF5 Reveal a Key Residue Mediating BMP Inhibition by NOGGIN

(2009) Petra Seemann et al.   PLoS Genetics

Compound heterozygosity for GDF5 in Du Pan type chondrodysplasia

(2008) Sofia Douzgou et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART A

Lifetime risk of symptomatic knee osteoarthritis

(2008) Louise Murphy et al.   ARTHRITIS AND RHEUMATISM

Regulation of TGF-β family signaling by E3 ubiquitin ligases

(2008) Yasumichi Inoue et al.   CANCER SCIENCE

Bone Morphogenetic Protein-9 Is a Circulating Vascular Quiescence Factor

(2008) Laurent David et al.   CIRCULATION RESEARCH

A Perspective: Engineering Periosteum for Structural Bone Graft Healing

(2008) Xinping Zhang et al.   CLINICAL ORTHOPAEDICS AND RELATED RESEARCH

A distinct cohort of progenitor cells participates in synovial joint and articular cartilage formation during mouse limb skeletogenesis

(2008) Eiki Koyama et al.   DEVELOPMENTAL BIOLOGY

GDF3 is a BMP inhibitor that can activate Nodal signaling only at very high doses

(2008) Ariel J. Levine et al.   DEVELOPMENTAL BIOLOGY

BMP4 Is Dispensable for Skeletogenesis and Fracture-Healing in the Limb

(2008) Kunikazu Tsuji et al.   JOURNAL OF BONE AND JOINT SURGERY-AMERICAN VOLUME

Skeletal Cell Fate Decisions Within Periosteum and Bone Marrow During Bone Regeneration

(2008) Céline Colnot   JOURNAL OF BONE AND MINERAL RESEARCH

Cooperative Assembly of TGF-β Superfamily Signaling Complexes Is Mediated by Two Disparate Mechanisms and Distinct Modes of Receptor Binding

(2008) Jay Groppe et al.   MOLECULAR CELL

Common variants in the GDF5-UQCC region are associated with variation in human height

(2008) Serena Sanna et al.   NATURE GENETICS

Phylogeny.fr: robust phylogenetic analysis for the non-specialist

(2008) A. Dereeper et al.   NUCLEIC ACIDS RESEARCH