Mechanically activated fyn utilizes mTORC2 to regulate RhoA and adipogenesis in mesenchymal stem cells

Fyn Deficiency Promotes a Preferential Increase in Subcutaneous Adipose Tissue Mass and Decreased Visceral Adipose Tissue Inflammation

(2013) T.-W. A. Lee et al.   DIABETES

Integrin-dependent force transmission to the extracellular matrix by  -actinin triggers adhesion maturation

(2013) P. Roca-Cusachs et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mechanical regulation of signaling pathways in bone

(2012) William R. Thompson et al.   GENE

c-Src Links a RANK/ v 3 Integrin Complex to the Osteoclast Cytoskeleton

(2012) T. Izawa et al.   MOLECULAR AND CELLULAR BIOLOGY

Wnt6, Wnt10a and Wnt10b inhibit adipogenesis and stimulate osteoblastogenesis through a β-catenin-dependent mechanism

(2011) William P. Cawthorn et al.   BONE

Lysophosphatidic acid induces a migratory phenotype through a crosstalk between RhoA–Rock and Src–FAK signalling in colon cancer cells

(2011) Fernanda Leve et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Evidence for Direct Activation of mTORC2 Kinase Activity by Phosphatidylinositol 3,4,5-Trisphosphate

(2011) Xiaoqing Gan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mechanical Regulation of Glycogen Synthase Kinase 3β (GSK3β) in Mesenchymal Stem Cells Is Dependent on Akt Protein Serine 473 Phosphorylation via mTORC2 Protein

(2011) Natasha Case et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Rho GEFs LARG and GEF-H1 regulate the mechanical response to force on integrins

(2011) Christophe Guilluy et al.   NATURE CELL BIOLOGY

The 'invisible hand': regulation of RHO GTPases by RHOGDIs

(2011) Rafael Garcia-Mata et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Mechanically Induced Focal Adhesion Assembly Amplifies Anti-Adipogenic Pathways in Mesenchymal Stem Cells

(2011) Buer Sen et al.   STEM CELLS

mTORC2 Regulates Neutrophil Chemotaxis in a cAMP- and RhoA-Dependent Fashion

(2010) Lunhua Liu et al.   DEVELOPMENTAL CELL

Mammalian Target of Rapamycin (mTOR): Conducting the Cellular Signaling Symphony

(2010) Kathryn G. Foster et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Rapamycin Inhibits Cytoskeleton Reorganization and Cell Motility by Suppressing RhoA Expression and Activity

(2010) Lei Liu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Phosphorylation of Ser 21 in Fyn regulates its kinase activity, focal adhesion targeting, and is required for cell migration

(2010) Myeong Gu Yeo et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Mechanical activation of β-catenin regulates phenotype in adult murine marrow-derived mesenchymal stem cells

(2010) Natasha Case et al.   JOURNAL OF ORTHOPAEDIC RESEARCH

Mechanical signals as anabolic agents in bone

(2010) Engin Ozcivici et al.   Nature Reviews Rheumatology

Mechanical stretch-induced RhoA activation is mediated by the RhoGEF Vav2 in mesangial cells

(2009) Fangfang Peng et al.   CELLULAR SIGNALLING

Bone marrow fat accumulation after 60 days of bed rest persisted 1 year after activities were resumed along with hemopoietic stimulation: the Women International Space Simulation for Exploration study

(2009) Guy Trudel et al.   JOURNAL OF APPLIED PHYSIOLOGY

Mechanical Loading Regulates NFATc1 and β-Catenin Signaling through a GSK3β Control Node

(2009) Buer Sen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Growth Factors, Matrices, and Forces Combine and Control Stem Cells

(2009) D. E. Discher et al.   SCIENCE

Repetitive deformation activates Src-independent FAK-dependent ERK motogenic signals in human Caco-2 intestinal epithelial cells

(2008) Lakshmi S. Chaturvedi et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Climbing exercise enhances osteoblast differentiation and inhibits adipogenic differentiation with high expression of PTH/PTHrP receptor in bone marrow cells

(2008) Kunitaka Menuki et al.   BONE

The Tyrosine Kinase Activity of c-Src Regulates Actin Dynamics and Organization of Podosomes in Osteoclasts

(2007) Olivier Destaing et al.   MOLECULAR BIOLOGY OF THE CELL