Molecular Mechanisms: Connections between Nonalcoholic Fatty Liver Disease, Steatohepatitis and Hepatocellular Carcinoma

Correlation Between Adiponectin Gene rs1501299 Polymorphism and Nonalcoholic Fatty Liver Disease Susceptibility: A Systematic Review and Meta-Analysis

(2019) Jiaxing Liu et al.   MEDICAL SCIENCE MONITOR

Exosomes and Hepatocellular Carcinoma: From Bench to Bedside

(2019) Reina Sasaki et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Molecular Mechanisms Driving Progression of Liver Cirrhosis towards Hepatocellular Carcinoma in Chronic Hepatitis B and C Infections: A Review

(2019) Tatsuo Kanda et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

A HSD 17B13 variant protects from hepatocellular carcinoma development in alcoholic liver disease

(2019) Jie Yang et al.   HEPATOLOGY

MyD88-dependent signaling in non-parenchymal cells promotes liver carcinogenesis

(2019) Antje Mohs et al.   CARCINOGENESIS

Interaction of TM6SF2 E167K and PNPLA3 I148M variants in NAFLD in northeast China

(2019) Min Xu et al.   Annals of Hepatology

Risks and clinical predictors of cirrhosis and hepatocellular carcinoma diagnoses in adults with diagnosed NAFLD: real-world study of 18 million patients in four European cohorts

(2019) Myriam Alexander et al.   BMC Medicine

From NASH to HCC: current concepts and future challenges

(2019) Quentin M. Anstee et al.   Nature Reviews Gastroenterology & Hepatology

eNOS Deletion Impairs Mitochondrial Quality Control and Exacerbates Western Diet Induced NASH

(2019) Ryan D Sheldon et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

GWAS and enrichment analyses of non-alcoholic fatty liver disease identify new trait-associated genes and pathways across eMERGE Network

(2019) Bahram Namjou et al.   BMC Medicine

Microbiome Signatures Associated with Steatohepatitis and Moderate to Severe Fibrosis in Children With Nonalcoholic Fatty Liver Disease

(2019) Jeffrey B. Schwimmer et al.   GASTROENTEROLOGY

Nonalcoholic Fatty Liver Disease and Obesity Treatment

(2019) Katherine T. Brunner et al.   Current Obesity Reports

KLB gene polymorphism is associated with obesity and non-alcoholic fatty liver disease in the Han Chinese

(2019) Fang Ji et al.   Aging-US

Indole-3-propionic acid inhibits gut dysbiosis and endotoxin leakage to attenuate steatohepatitis in rats

(2019) Ze-Hua Zhao et al.   EXPERIMENTAL AND MOLECULAR MEDICINE

Microbiota-driven gut vascular barrier disruption is a prerequisite for non-alcoholic steatohepatitis development

(2019) Juliette Mouries et al.   JOURNAL OF HEPATOLOGY

Report of the 20th Nationwide Follow‐up Survey of Primary Liver Cancer in Japan

(2019) Masatoshi Kudo et al.   HEPATOLOGY RESEARCH

Lipid Related Genes Altered in NASH Connect Inflammation in Liver Pathogenesis Progression to HCC: A Canonical Pathway

(2019) Desterke et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Transition in the etiology of liver cirrhosis in Japan: a nationwide survey

(2019) Hirayuki Enomoto et al.   JOURNAL OF GASTROENTEROLOGY

Improving NASH with a little help from thyromimetics

(2019) Vlad Ratziu   LANCET

Increased Tim-3 expression alleviates liver injury by regulating macrophage activation in MCD-induced NASH mice

(2018) Xianhong Du et al.   Cellular & Molecular Immunology

Deletion of both p62 and Nrf2 spontaneously results in the development of nonalcoholic steatohepatitis

(2018) Kentaro Akiyama et al.   EXPERIMENTAL ANIMALS

17-beta-hydroxysteroid dehydrogenase 13 inhibits the progression and recurrence of hepatocellular carcinoma

(2018) Jun Chen et al.   Hepatobiliary & Pancreatic Diseases International

Restoration of a healthy intestinal microbiota normalizes portal hypertension in a rat model of nonalcoholic steatohepatitis

(2018) Teresa García-Lezana et al.   HEPATOLOGY

A Protein-Truncating HSD17B13 Variant and Protection from Chronic Liver Disease

(2018) Noura S. Abul-Husn et al.   NEW ENGLAND JOURNAL OF MEDICINE

Risk estimation model for nonalcoholic fatty liver disease in the Japanese using multiple genetic markers

(2018) Takahisa Kawaguchi et al.   PLoS One

Apoptosis and non-alcoholic fatty liver diseases

(2018) Tatsuo Kanda et al.   WORLD JOURNAL OF GASTROENTEROLOGY

Association of mRNA expression of iron metabolism-associated genes and progression of non-alcoholic steatohepatitis in rats

(2018) Teruhisa Higuchi et al.   Oncotarget

Nonalcoholic fatty liver disease is associated with dysbiosis independent of body mass index and insulin resistance

(2018) Hannah E. Da Silva et al.   Scientific Reports

ER Stress Drives Lipogenesis and Steatohepatitis via Caspase-2 Activation of S1P

(2018) Ju Youn Kim et al.   CELL

Investigating Pathogenic and Hepatocarcinogenic Mechanisms from Normal Liver to HCC by Constructing Genetic and Epigenetic Networks via Big Genetic and Epigenetic Data Mining and Genome-Wide NGS Data Identification

(2018) Cheng-Wei Li et al.   DISEASE MARKERS

Targeting Metabolism, Insulin Resistance, and Diabetes to Treat Nonalcoholic Steatohepatitis

(2018) Brian N. Finck   DIABETES

HSD17B13 is a Hepatic Retinol Dehydrogenase Associated with Histological Features of Non-Alcoholic Fatty Liver Disease

(2018) Yanling Ma et al.   HEPATOLOGY

Splice variant rs72613567 prevents worst histologic outcomes in patients with nonalcoholic fatty liver disease

(2018) Carlos J. Pirola et al.   JOURNAL OF LIPID RESEARCH

Obesity and nonalcoholic fatty liver disease: From pathophysiology to therapeutics

(2018) Stergios A. Polyzos et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

The role of macrophages in nonalcoholic fatty liver disease and nonalcoholic steatohepatitis

(2018) Konstantin Kazankov et al.   Nature Reviews Gastroenterology & Hepatology

An inflammatory-CCRK circuitry drives mTORC1-dependent metabolic and immunosuppressive reprogramming in obesity-associated hepatocellular carcinoma

(2018) Hanyong Sun et al.   Nature Communications

OX40 Regulates Both Innate and Adaptive Immunity and Promotes Nonalcoholic Steatohepatitis

(2018) Guangyong Sun et al.   Cell Reports

The diagnosis and management of nonalcoholic fatty liver disease: Practice guidance from the American Association for the Study of Liver Diseases

(2017) Naga Chalasani et al.   HEPATOLOGY

Effect of miglitol on the suppression of nonalcoholic steatohepatitis development and improvement of the gut environment in a rodent model

(2017) Yumi Kishida et al.   JOURNAL OF GASTROENTEROLOGY

Asia-Pacific Working Party on Non-alcoholic Fatty Liver Disease guidelines 2017-Part 1: Definition, risk factors and assessment

(2017) Vincent Wai-Sun Wong et al.   JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY

Nonalcoholic Fatty Liver Disease and Insulin Resistance: New Insights and Potential New Treatments

(2017) Hironori Kitade et al.   Nutrients

Total fecal microbiota transplantation alleviates high-fat diet-induced steatohepatitis in mice via beneficial regulation of gut microbiota

(2017) Da Zhou et al.   Scientific Reports

Iron overload results in hepatic oxidative stress, immune cell activation, and hepatocellular ballooning injury, leading to nonalcoholic steatohepatitis in genetically obese mice

(2016) Priya Handa et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Hepatocellular Carcinoma in the Absence of Cirrhosis in United States Veterans Is Associated With Nonalcoholic Fatty Liver Disease

(2016) Sahil Mittal et al.   Clinical Gastroenterology and Hepatology

Loss of Junctional Adhesion Molecule A Promotes Severe Steatohepatitis in Mice on a Diet High in Saturated Fat, Fructose, and Cholesterol

(2016) Khalidur Rahman et al.   GASTROENTEROLOGY

Hepatocyte MyD88 affects bile acids, gut microbiota and metabolome contributing to regulate glucose and lipid metabolism

(2016) Thibaut Duparc et al.   GUT

Global epidemiology of nonalcoholic fatty liver disease-Meta-analytic assessment of prevalence, incidence, and outcomes

(2016) Zobair M. Younossi et al.   HEPATOLOGY

Serum-inducible protein (IP)-10 is a disease progression-related marker for non-alcoholic fatty liver disease

(2016) Nozomu Wada et al.   Hepatology International

Dysregulated hepatic bile acids collaboratively promote liver carcinogenesis

(2016) Guoxiang Xie et al.   INTERNATIONAL JOURNAL OF CANCER

A micro-RNA expression signature for human NAFLD progression

(2016) Yan Guo et al.   JOURNAL OF GASTROENTEROLOGY

EASL–EASD–EASO Clinical Practice Guidelines for the management of non-alcoholic fatty liver disease

(2016)   JOURNAL OF HEPATOLOGY

Effect of Lipopolysaccharide on the Progression of Non-Alcoholic Fatty Liver Disease in High Caloric Diet-Fed Mice

(2016) N. Matsushita et al.   SCANDINAVIAN JOURNAL OF IMMUNOLOGY

Role of NLRP3 Inflammasome in the Progression of NAFLD to NASH

(2016) Xingyong Wan et al.   Canadian Journal of Gastroenterology and Hepatology

Bile Acids and Dysbiosis in Non-Alcoholic Fatty Liver Disease

(2016) Marialena Mouzaki et al.   PLoS One

Kupffer Cells Undergo Fundamental Changes during the Development of Experimental NASH and Are Critical in Initiating Liver Damage and Inflammation

(2016) D. T. Reid et al.   PLoS One

Calcium Reduces Liver Injury in Mice on a High-Fat Diet: Alterations in Microbial and Bile Acid Profiles

(2016) Muhammad Nadeem Aslam et al.   PLoS One

Bacterial endotoxin and non-alcoholic fatty liver disease in the general population: a prospective cohort study

(2015) V. W.-S. Wong et al.   ALIMENTARY PHARMACOLOGY & THERAPEUTICS

Mosapride citrate improves nonalcoholic steatohepatitis with increased fecal lactic acid bacteria and plasma glucagon-like peptide-1 level in a rodent model

(2015) Hirofumi Okubo et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Lactobacillus paracasei Induces M2-Dominant Kupffer Cell Polarization in a Mouse Model of Nonalcoholic Steatohepatitis

(2015) Won Sohn et al.   DIGESTIVE DISEASES AND SCIENCES

Association of nonalcoholic fatty liver disease (NAFLD) with hepatocellular carcinoma (HCC) in the United States from 2004 to 2009

(2015) Zobair M. Younossi et al.   HEPATOLOGY

Oxidative stress promotes pathologic polyploidization in nonalcoholic fatty liver disease

(2015) Géraldine Gentric et al.   JOURNAL OF CLINICAL INVESTIGATION

The impact of PNPLA3 and JAZF1 on hepatocellular carcinoma in non-viral hepatitis patients with type 2 diabetes mellitus

(2015) Misuzu Ueyama et al.   JOURNAL OF GASTROENTEROLOGY

Small intestinal bacterial overgrowth and toll-like receptor signaling in patients with non-alcoholic fatty liver disease

(2015) Shweta Kapil et al.   JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY

The Effect of PNPLA3 on Fibrosis Progression and Development of Hepatocellular Carcinoma: A Meta-analysis

(2014) Amit G Singal et al.   AMERICAN JOURNAL OF GASTROENTEROLOGY

Carriage of the PNPLA3 rs738409 C >G polymorphism confers an increased risk of non-alcoholic fatty liver disease associated hepatocellular carcinoma

(2014) Y.-L. Liu et al.   JOURNAL OF HEPATOLOGY

Comparative proteomic study reveals 17 -HSD13 as a pathogenic protein in nonalcoholic fatty liver disease

(2014) W. Su et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Clinical features and outcome of cryptogenic hepatocellular carcinoma compared to those of viral and alcoholic hepatocellular carcinoma

(2013) Sang Soo Lee et al.   BMC CANCER

CYP2E1 potentiates binge alcohol-induced gut leakiness, steatohepatitis, and apoptosis

(2013) Mohamed A. Abdelmegeed et al.   FREE RADICAL BIOLOGY AND MEDICINE

Intestinal microbiota in patients with nonalcoholic fatty liver disease

(2013) Marialena Mouzaki et al.   HEPATOLOGY

Immune and inflammatory pathways in NASH

(2013) Michal Ganz et al.   Hepatology International

Characteristics and diagnosis of NAFLD/NASH

(2013) Etsuko Hashimoto et al.   JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY

Endotoxemia unrequired in the pathogenesis of pediatric nonalcoholic steatohepatitis

(2013) Jianye Yuan et al.   JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY

Hepatocellular cancer: The impact of obesity, type 2 diabetes and a multidisciplinary team

(2013) Jessica Dyson et al.   JOURNAL OF HEPATOLOGY

Effects of probiotics on nonalcoholic fatty liver disease: A meta-analysis

(2013) Yan-Yan Ma   WORLD JOURNAL OF GASTROENTEROLOGY

Innate Immune Reactivity of the Ileum–Liver Axis in Nonalcoholic Steatohepatitis

(2012) Tatsuhiro Tsujimoto et al.   DIGESTIVE DISEASES AND SCIENCES

Intestinal microbiota determines development of non-alcoholic fatty liver disease in mice

(2012) Tiphaine Le Roy et al.   GUT

Inhibition of natural killer cells protects the liver against acute injury in the absence of glycine N-methyltransferase

(2012) Laura Gomez-Santos et al.   HEPATOLOGY

The diagnosis and management of non-alcoholic fatty liver disease: Practice Guideline by the American Association for the Study of Liver Diseases, American College of Gastroenterology, and the American Gastroenterological Association

(2012) Naga Chalasani et al.   HEPATOLOGY

Inflammasome-mediated dysbiosis regulates progression of NAFLD and obesity

(2012) Jorge Henao-Mejia et al.   NATURE

Genetic Polymorphisms of the Human PNPLA3 Gene Are Strongly Associated with Severity of Non-Alcoholic Fatty Liver Disease in Japanese

(2012) Takahisa Kawaguchi et al.   PLoS One

Microvesicular fat, inter cellular adhesion molecule-1 and regulatory T-lymphocytes are of importance for the inflammatory process in livers with non-alcoholic steatohepatitis

(2011) CECILIA SÖDERBERG et al.   APMIS

NLRP6 Inflammasome Regulates Colonic Microbial Ecology and Risk for Colitis

(2011) Eran Elinav et al.   CELL

Characteristics of Patients With Nonalcoholic Steatohepatitis Who Develop Hepatocellular Carcinoma

(2011) Kohichiroh Yasui et al.   Clinical Gastroenterology and Hepatology

Inflammatory links between obesity and metabolic disease

(2011) Carey N. Lumeng et al.   JOURNAL OF CLINICAL INVESTIGATION

Small Intestinal Bacterial Overgrowth in Nonalcoholic Steatohepatitis: Association with Toll-Like Receptor 4 Expression and Plasma Levels of Interleukin 8

(2010) Ahmed Abu Shanab et al.   DIGESTIVE DISEASES AND SCIENCES

Increased intestinal permeability and tight junction alterations in nonalcoholic fatty liver disease

(2009) Luca Miele et al.   HEPATOLOGY

Morbid obesity exposes the association between PNPLA3 I148M (rs738409) and indices of hepatic injury in individuals of European descent

(2009) S Romeo et al.   INTERNATIONAL JOURNAL OF OBESITY

Population-Based Genome-wide Association Studies Reveal Six Loci Influencing Plasma Levels of Liver Enzymes

(2008) Xin Yuan et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Clinical features and outcomes of cirrhosis due to non-alcoholic steatohepatitis compared with cirrhosis caused by chronic hepatitis C

(2008) Satoru Yatsuji et al.   JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY

Hepatitis C Virus Core Protein Augments Androgen Receptor-Mediated Signaling

(2008) T. Kanda et al.   JOURNAL OF VIROLOGY

Genetic variation in PNPLA3 confers susceptibility to nonalcoholic fatty liver disease

(2008) Stefano Romeo et al.   NATURE GENETICS

Change of intestinal mucosa barrier function in the progress of non-alcoholic steatohepatitis in rats

(2008) Sheng Li et al.   WORLD JOURNAL OF GASTROENTEROLOGY

Small intestinal bacteria overgrowth decreases small intestinal motility in the NASH rats

(2008) Wan-Chun Wu et al.   WORLD JOURNAL OF GASTROENTEROLOGY