Nonalcoholic Fatty Liver Disease and Insulin Resistance: New Insights and Potential New Treatments

Pathophysiology and Mechanisms of Nonalcoholic Fatty Liver Disease

(2016) Joel T. Haas et al.   Annual Review of Physiology

Metabolic Impact of Nonalcoholic Steatohepatitis in Obese Patients With Type 2 Diabetes

(2016) Romina Lomonaco et al.   DIABETES CARE

Liver innate immune cells and insulin resistance: the multiple facets of Kupffer cells

(2016) J. Jager et al.   JOURNAL OF INTERNAL MEDICINE

Astaxanthin prevents and reverses the activation of mouse primary hepatic stellate cells

(2016) Yue Yang et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Liraglutide safety and efficacy in patients with non-alcoholic steatohepatitis (LEAN): a multicentre, double-blind, randomised, placebo-controlled phase 2 study

(2016) Matthew James Armstrong et al.   LANCET

Metabolic aspects of adult patients with nonalcoholic fatty liver disease

(2016) Ludovico Abenavoli et al.   WORLD JOURNAL OF GASTROENTEROLOGY

A concise review of non-alcoholic fatty liver disease

(2015) Nwe Ni Than et al.   ATHEROSCLEROSIS

Astaxanthin prevents TGFβ1-induced pro-fibrogenic gene expression by inhibiting Smad3 activation in hepatic stellate cells

(2015) Yue Yang et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Nonalcoholic Fatty Liver Disease Review: Diagnosis, Treatment, and Outcomes

(2015) Aijaz Ahmed et al.   Clinical Gastroenterology and Hepatology

Prevention and Reversal of Lipotoxicity-Induced Hepatic Insulin Resistance and Steatohepatitis in Mice by an Antioxidant Carotenoid, β-Cryptoxanthin

(2015) Yinhua Ni et al.   ENDOCRINOLOGY

Bariatric Surgery Reduces Features of Nonalcoholic Steatohepatitis in Morbidly Obese Patients

(2015) Guillaume Lassailly et al.   GASTROENTEROLOGY

Current efforts and trends in the treatment of NASH

(2015) Vlad Ratziu et al.   JOURNAL OF HEPATOLOGY

Vitamin B12 and omega-3 fatty acids together regulate lipid metabolism in Wistar rats

(2015) Amrita Khaire et al.   PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS

Astaxanthin prevents and reverses diet-induced insulin resistance and steatohepatitis in mice: A comparison with vitamin E

(2015) Yinhua Ni et al.   Scientific Reports

Low Serum Concentrations of Carotenoids and Vitamin E Are Associated with High Adiposity in Mexican-American Children

(2014) Inong R. Gunanti et al.   JOURNAL OF NUTRITION

Astaxanthin: Sources, Extraction, Stability, Biological Activities and Its Commercial Applications—A Review

(2014) Ranga Ambati et al.   Marine Drugs

Carotenoids, inflammation, and oxidative stress—implications of cellular signaling pathways and relation to chronic disease prevention

(2014) Anouk Kaulmann et al.   NUTRITION RESEARCH

β-Cryptoxanthin Alleviates Diet-Induced Nonalcoholic Steatohepatitis by Suppressing Inflammatory Gene Expression in Mice

(2014) Masuko Kobori et al.   PLoS One

Management of nonalcoholic fatty liver disease: An evidence-based clinical practice review

(2014) Juan P Arab   WORLD JOURNAL OF GASTROENTEROLOGY

Mediterranean diet and health

(2013) Francesco Sofi et al.   BIOFACTORS

Impact of Divergent Effects of Astaxanthin on Insulin Signaling in L6 Cells

(2013) Manabu Ishiki et al.   ENDOCRINOLOGY

M2 Kupffer cells promote M1 Kupffer cell apoptosis: A protective mechanism against alcoholic and nonalcoholic fatty liver disease

(2013) Jinghong Wan et al.   HEPATOLOGY

Macrophage plasticity and polarization in liver homeostasis and pathology

(2013) Antonio Sica et al.   HEPATOLOGY

Distinct development and functions of resident and recruited liver Kupffer cells/macrophages

(2013) Masami Ikarashi et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Hepatic recruitment of macrophages promotes nonalcoholic steatohepatitis through CCR2

(2012) Kouichi Miura et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

CCR5 Plays a Critical Role in Obesity-Induced Adipose Tissue Inflammation and Insulin Resistance by Regulating Both Macrophage Recruitment and M1/M2 Status

(2012) H. Kitade et al.   DIABETES

Association between diabetes, family history of diabetes, and risk of nonalcoholic steatohepatitis and fibrosis

(2012) Rohit Loomba et al.   HEPATOLOGY

Macrophage plasticity and polarization: in vivo veritas

(2012) Antonio Sica et al.   JOURNAL OF CLINICAL INVESTIGATION

Role of cytokines and chemokines in non-alcoholic fatty liver disease

(2012) Vincent Braunersreuther   WORLD JOURNAL OF GASTROENTEROLOGY

Cannabinoid CB2 receptors protect against alcoholic liver disease by regulating Kupffer cell polarization in mice

(2011) Alexandre Louvet et al.   HEPATOLOGY

Effect of Vitamin E or Metformin for Treatment of Nonalcoholic Fatty Liver Disease in Children and Adolescents

(2011) Joel E. Lavine   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Mechanism of Visceral Fat Reduction in Tsumura Suzuki Obese, Diabetes (TSOD) Mice Orally Administered β-Cryptoxanthin from Satsuma Mandarin Oranges (Citrus unshiu Marc)

(2011) Katsuhiko Takayanagi et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Review article: current management of non-alcoholic fatty liver disease and non-alcoholic steatohepatitis

(2010) Z. M. YOUNOSSI   ALIMENTARY PHARMACOLOGY & THERAPEUTICS

A high-fat, ketogenic diet causes hepatic insulin resistance in mice, despite increasing energy expenditure and preventing weight gain

(2010) François R. Jornayvaz et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

C-C Chemokine Receptor 2 (CCR2) Regulates the Hepatic Recruitment of Myeloid Cells That Promote Obesity-Induced Hepatic Steatosis

(2010) A. E. Obstfeld et al.   DIABETES

Prevalence of Nonalcoholic Fatty Liver Disease and Nonalcoholic Steatohepatitis Among a Largely Middle-Aged Population Utilizing Ultrasound and Liver Biopsy: A Prospective Study

(2010) Christopher D. Williams et al.   GASTROENTEROLOGY

A meta-analysis of randomized trials for the treatment of nonalcoholic fatty liver disease

(2010) Giovanni Musso et al.   HEPATOLOGY

Evolution of inflammation in nonalcoholic fatty liver disease: The multiple parallel hits hypothesis

(2010) Herbert Tilg et al.   HEPATOLOGY

Alternative Activation of Macrophages: Mechanism and Functions

(2010) Siamon Gordon et al.   IMMUNITY

Macrophage plasticity and interaction with lymphocyte subsets: cancer as a paradigm

(2010) Subhra K Biswas et al.   NATURE IMMUNOLOGY

Pioglitazone, Vitamin E, or Placebo for Nonalcoholic Steatohepatitis

(2010) Arun J. Sanyal et al.   NEW ENGLAND JOURNAL OF MEDICINE

Synergistic interaction of cigarette smoking and alcohol drinking with serum carotenoid concentrations: findings from a middle-aged Japanese population

(2009) Minoru Sugiura et al.   BRITISH JOURNAL OF NUTRITION

Antifibrotic Effects of CXCL9 and Its Receptor CXCR3 in Livers of Mice and Humans

(2009) Hermann E. Wasmuth et al.   GASTROENTEROLOGY

CCR2 promotes hepatic fibrosis in mice

(2009) Ekihiro Seki et al.   HEPATOLOGY

Dietary lycopene and tomato extract supplementations inhibit nonalcoholic steatohepatitis-promoted hepatocarcinogenesis in rats

(2009) Yan Wang et al.   INTERNATIONAL JOURNAL OF CANCER

CCR1 and CCR5 promote hepatic fibrosis in mice

(2009) Ekihiro Seki et al.   JOURNAL OF CLINICAL INVESTIGATION

Adherence to the Mediterranean Diet Is Associated with Lower Abdominal Adiposity in European Men and Women

(2009) Dora Romaguera et al.   JOURNAL OF NUTRITION

β-Carotene and β-cryptoxanthin but not lutein evoke redox and immune changes in RAW264 murine macrophages

(2009) Sakurako Katsuura et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Impact of micronutrient deficiencies on obesity

(2009) Olga P García et al.   NUTRITION REVIEWS

Inhibition of CCR2 Ameliorates Insulin Resistance and Hepatic Steatosis in db/db Mice

(2008) Yukinori Tamura et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Alternative M2 Activation of Kupffer Cells by PPARδ Ameliorates Obesity-Induced Insulin Resistance

(2008) Justin I. Odegaard et al.   Cell Metabolism

Monocyte Chemoattractant Protein-1 Deficiency Fails to Restrain Macrophage Infiltration Into Adipose Tissue

(2008) E. A. Kirk et al.   DIABETES

Clinical features and outcomes of cirrhosis due to non-alcoholic steatohepatitis compared with cirrhosis caused by chronic hepatitis C

(2008) Satoru Yatsuji et al.   JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY

Adherence to Mediterranean diet and risk of developing diabetes: prospective cohort study

(2008) M Á Martínez-González et al.   BMJ-British Medical Journal