Increased Tim-3 expression alleviates liver injury by regulating macrophage activation in MCD-induced NASH mice

Negative regulation of Nod-like receptor protein 3 inflammasome activation by T cell Ig mucin-3 protects against peritonitis

(2017) Wei Wang et al.   IMMUNOLOGY

Frontline Science: Tim-3-mediated dysfunctional engulfment of apoptotic cells in SLE

(2017) Di Zhao et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Innate Immunity and Inflammation in NAFLD/NASH

(2016) Marco Arrese et al.   DIGESTIVE DISEASES AND SCIENCES

NKp46+ natural killer cells attenuate metabolism-induced hepatic fibrosis by regulating macrophage activation in mice

(2016) Annie-Carole Tosello-Trampont et al.   HEPATOLOGY

Multispectral Imaging of T and B Cells in Murine Spleen and Tumor

(2016) Zipei Feng et al.   JOURNAL OF IMMUNOLOGY

TNF and ROS Crosstalk in Inflammation

(2016) Heiko Blaser et al.   TRENDS IN CELL BIOLOGY

Role of Tim-3 in hepatitis B virus infection: An overview

(2016) Yuan Liu et al.   WORLD JOURNAL OF GASTROENTEROLOGY

TIM-3 Regulates Distinct Functions in Macrophages

(2016) Ranferi Ocaña-Guzman et al.   Frontiers in Immunology

Reactive Oxygen Species-Induced TXNIP Drives Fructose-Mediated Hepatic Inflammation and Lipid Accumulation Through NLRP3 Inflammasome Activation

(2015) Xian Zhang et al.   ANTIOXIDANTS & REDOX SIGNALING

Blockade of PD1 and TIM3 Restores Innate and Adaptive Immunity in Patients With Acute Alcoholic Hepatitis

(2015) Lee J.L. Markwick et al.   GASTROENTEROLOGY

Tim-3 fosters HCC development by enhancing TGF-β-mediated alternative activation of macrophages

(2015) Wenjiang Yan et al.   GUT

How Inflammation Impinges on NAFLD: A Role for Kupffer Cells

(2015) Nádia Duarte et al.   Biomed Research International

Helicobacter pylori induces IL-1β and IL-18 production in human monocytic cell line through activation of NLRP3 inflammasome via ROS signaling pathway

(2015) Xiang Li et al.   Pathogens and Disease

Inflammasome Activation Is Reactive Oxygen Species Dependent and Mediates Irinotecan-Induced Mucositis through IL-1β and IL-18 in Mice

(2014) Raquel D.N. Arifa et al.   AMERICAN JOURNAL OF PATHOLOGY

NOX2-generated oxidative stress is associated with severity of ultrasound liver steatosis in patients with non-alcoholic fatty liver disease

(2014) Maria Del Ben et al.   BMC GASTROENTEROLOGY

Anti-oxidant and anti-apoptotic effects of luteolin on mice peritoneal macrophages stimulated by angiotensin II

(2014) Tian Zhang et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Macrophage-specific NOX2 contributes to the development of lung emphysema through modulation of SIRT1/MMP-9 pathways

(2014) Candice Trocme et al.   JOURNAL OF PATHOLOGY

CEACAM1 regulates TIM-3-mediated tolerance and exhaustion

(2014) Yu-Hwa Huang et al.   NATURE

Tim-3 expression on peripheral monocytes and CD3+CD16/CD56+natural killer-like T cells in patients with chronic hepatitis B

(2014) Y.-H. Rong et al.   TISSUE ANTIGENS

Oxidative stress, cardiolipin and mitochondrial dysfunction in nonalcoholic fatty liver disease

(2014) Giuseppe Paradies   WORLD JOURNAL OF GASTROENTEROLOGY

From NAFLD to NASH to fibrosis to HCC: Role of dendritic cell populations in the liver

(2013) Frank Tacke et al.   HEPATOLOGY

The portal inflammatory infiltrate and ductular reaction in human nonalcoholic fatty liver disease

(2013) Victoria L. Gadd et al.   HEPATOLOGY

Tim-3/Galectin-9 Regulate the Homeostasis of Hepatic NKT Cells in a Murine Model of Nonalcoholic Fatty Liver Disease

(2013) Z.-H. Tang et al.   JOURNAL OF IMMUNOLOGY

Tissue-resident macrophages

(2013) Luke C Davies et al.   NATURE IMMUNOLOGY

The global NAFLD epidemic

(2013) Rohit Loomba et al.   Nature Reviews Gastroenterology & Hepatology

Galectin-9 suppresses Th17 cell development in an IL-2-dependent but Tim-3-independent manner

(2012) Souichi Oomizu et al.   CLINICAL IMMUNOLOGY

Toll-like receptor-4 mediates obesity-induced non-alcoholic steatohepatitis through activation of X-box binding protein-1 in mice

(2012) Dewei Ye et al.   GUT

Toll-like receptor 2 and palmitic acid cooperatively contribute to the development of nonalcoholic steatohepatitis through inflammasome activation in mice

(2012) Kouichi Miura et al.   HEPATOLOGY

Galectin-9 signaling prolongs survival in murine lung-cancer by inducing macrophages to differentiate into plasmacytoid dendritic cell-like macrophages

(2011) Takeshi Kadowaki et al.   CLINICAL IMMUNOLOGY

Pharmacological inhibition of the chemokine CCL2 (MCP-1) diminishes liver macrophage infiltration and steatohepatitis in chronic hepatic injury

(2011) Christer Baeck et al.   GUT

Tim-3 Negatively Regulates IL-12 Expression by Monocytes in HCV Infection

(2011) Ying Zhang et al.   PLoS One

Evolution of inflammation in nonalcoholic fatty liver disease: The multiple parallel hits hypothesis

(2010) Herbert Tilg et al.   HEPATOLOGY

T cell immunoglobulin- and mucin-domain-containing molecule-3 (Tim-3) mediates natural killer cell suppression in chronic hepatitis B

(2010) Ying Ju et al.   JOURNAL OF HEPATOLOGY

Cooperation of Tim-3 and PD-1 in CD8 T-cell exhaustion during chronic viral infection

(2010) H.-T. Jin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Kupffer cells in non-alcoholic fatty liver disease: The emerging view

(2009) György Baffy   JOURNAL OF HEPATOLOGY