Neutrophil Adaptations upon Recruitment to the Lung: New Concepts and Implications for Homeostasis and Disease

Activated PMN Exosomes: Pathogenic Entities Causing Matrix Destruction and Disease in the Lung

(2019) Kristopher R. Genschmer et al.   CELL

Untangling “NETosis” from NETs

(2019) Shida Yousefi et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Excessive neutrophil levels in the lung underlie the age-associated increase in influenza mortality

(2019) Upasana Kulkarni et al.   Mucosal Immunology

Novel reprogramming of neutrophils modulates inflammation resolution during atherosclerosis

(2019) Shuo Geng et al.   Science Advances

Cathepsin G Activity as a New Marker for Detecting Airway Inflammation by Microscopy and Flow Cytometry

(2019) Matteo Guerra et al.   ACS Central Science

Neutrophil Dysfunction in the Airways of Children with Acute Respiratory Failure Due to Lower Respiratory Tract Viral and Bacterial Coinfections

(2019) Jocelyn R. Grunwell et al.   Scientific Reports

Neutrophils promote the development of reparative macrophages mediated by ROS to orchestrate liver repair

(2019) Wenting Yang et al.   Nature Communications

Osteopontin Mediates Murine Transfusion-Related Acute Lung Injury Via Stimulation of Pulmonary Neutrophil Accumulation

(2019) Rick Kapur et al.   BLOOD

BCL6 modulates tissue neutrophil survival and exacerbates pulmonary inflammation following influenza virus infection

(2019) Bibo Zhu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Assessment of Induced Sputum Cellularity in COPD Patients Belonging to Two Different Classes of Air Pollution Exposure

(2019) Silvano Dragonieri et al.   ARCHIVOS DE BRONCONEUMOLOGIA

Tissue Tropism in Streptococcal Infection: Wild-Type M1T1 Group A Streptococcus is Efficiently Cleared by Neutrophils Using an NADPH Oxidase-Dependent Mechanism in the Lung but not in the Skin

(2019) Benfang Lei et al.   INFECTION AND IMMUNITY

Neutrophil recruitment and activation are differentially dependent on MyD88/TRIF and MAVS signaling during RSV infection

(2019) Freja C. M. Kirsebom et al.   Mucosal Immunology

Airway inflammatory profile is correlated with symptoms in stable COPD: A longitudinal proof-of-concept cohort study

(2019) Marco Contoli et al.   RESPIROLOGY

Prix Nobel et histoire de la transfusion sanguine

(2019) J.-Y. Muller   TRANSFUSION CLINIQUE ET BIOLOGIQUE

Neutrophil Diversity in Health and Disease

(2019) Carlos Silvestre-Roig et al.   TRENDS IN IMMUNOLOGY

CD200R deletion promotes a neutrophil niche for Francisella tularensis and increases infectious burden and mortality

(2019) J. Casulli et al.   Nature Communications

LAIR-1 Limits Neutrophilic Airway Inflammation

(2019) Kuldeep Kumawat et al.   Frontiers in Immunology

Hyperactivation of the NLRP3 inflammasome protects mice against influenza A virus infection via IL-1β mediated neutrophil recruitment

(2019) Junling Niu et al.   CYTOKINE

Detrimental Effect of Type I IFNs During Acute Lung Infection With Pseudomonas aeruginosa Is Mediated Through the Stimulation of Neutrophil NETosis

(2019) Ekaterina Pylaeva et al.   Frontiers in Immunology

Targeting Proteases in Cystic Fibrosis Lung Disease: Paradigms, Progress, and Potential

(2019) Michael C McKelvey et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Mucus obstruction and inflammation in early cystic fibrosis lung disease: Emerging role of the IL‐1 signaling pathway

(2019) Anita Balázs et al.   PEDIATRIC PULMONOLOGY

The Role of Complement in Transfusion-Related Acute Lung Injury

(2019) Ilse Jongerius et al.   TRANSFUSION MEDICINE REVIEWS

E-Cigarette Use Causes a Unique Innate Immune Response in the Lung, Involving Increased Neutrophilic Activation and Altered Mucin Secretion

(2018) Boris Reidel et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Neutrophils in viral infection

(2018) Victor Naumenko et al.   CELL AND TISSUE RESEARCH

Differential susceptibility of Dectin-1 isoforms to functional inactivation by neutrophil and fungal proteases

(2018) James S. Griffiths et al.   FASEB JOURNAL

Aspergillus fumigatus -sensitive IgE is associated with bronchial hypersensitivity in a murine model of neutrophilic airway inflammation

(2018) G. Morán et al.   JOURNAL DE MYCOLOGIE MEDICALE

Resistin is elevated in cystic fibrosis sputum and correlates negatively with lung function

(2018) Osric A. Forrest et al.   Journal of Cystic Fibrosis

Role of Peptidylarginine Deiminase 4 in Neutrophil Extracellular Trap Formation and Host Defense duringKlebsiella pneumoniae–Induced Pneumonia-Derived Sepsis

(2018) Theodora A. M. Claushuis et al.   JOURNAL OF IMMUNOLOGY

High Level of Neutrophil Extracellular Traps Correlates With Poor Prognosis of Severe Influenza A Infection

(2018) Liuluan Zhu et al.   JOURNAL OF INFECTIOUS DISEASES

Frontline Science: Pathological conditioning of human neutrophils recruited to the airway milieu in cystic fibrosis

(2018) Osric A. Forrest et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Aged polymorphonuclear leukocytes cause fibrotic interstitial lung disease in the absence of regulation by B cells

(2018) Jung Hwan Kim et al.   NATURE IMMUNOLOGY

Respiratory Viruses and Treatment Failure in Children With Asthma Exacerbation

(2018) Joanna Merckx et al.   PEDIATRICS

Neutrophil Elastase Subverts the Immune Response by Cleaving Toll-Like Receptors and Cytokines in Pneumococcal Pneumonia

(2018) Hisanori Domon et al.   Frontiers in Immunology

Candida albicans-Induced NETosis Is Independent of Peptidylarginine Deiminase 4

(2018) Eva Guiducci et al.   Frontiers in Immunology

The Neutrophil Chemoattractant Peptide Proline-Glycine-Proline Is Associated With Acute Respiratory Distress Syndrome (ARDS)

(2018) Nirmal S Sharma et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Neutrophilic Inflammation in the Pathogenesis of Chronic Obstructive Pulmonary Disease

(2018) Aidan Butler et al.   COPD-Journal of Chronic Obstructive Pulmonary Disease

Myeloperoxidase oxidation of methionine associates with early cystic fibrosis lung disease

(2018) Joshua D. Chandler et al.   EUROPEAN RESPIRATORY JOURNAL

Influenza A Virus Infection Causes Chronic Lung Disease Linked to Sites of Active Viral RNA Remnants

(2018) Shamus P. Keeler et al.   JOURNAL OF IMMUNOLOGY

A GRIM fate for human neutrophils in airway disease

(2018) Thomas C. Mitchell   JOURNAL OF LEUKOCYTE BIOLOGY

The Pathogenic Involvement of Neutrophils in Acute Respiratory Distress Syndrome and Transfusion-Related Acute Lung Injury

(2018) Johan Rebetz et al.   TRANSFUSION MEDICINE AND HEMOTHERAPY

The Lung Microvasculature Is a Functional Immune Niche

(2018) Elise Granton et al.   TRENDS IN IMMUNOLOGY

Respiratory Syncytial Virus induces the classical ROS-dependent NETosis through PAD-4 and necroptosis pathways activation

(2018) Stéfanie P. Muraro et al.   Scientific Reports

Systematic analysis of transcriptomic profiles of COPD airway epithelium using next-generation sequencing and bioinformatics

(2018) Wei-An Chang et al.   International Journal of Chronic Obstructive Pulmonary Disease

Elastase Exocytosis by Airway Neutrophils Associates with Early Lung Damage in Cystic Fibrosis Children

(2018) Camilla Margaroli et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

The state of art of neutrophil extracellular traps in protozoan and helminthic infections

(2018) César Díaz-Godínez et al.   BIOSCIENCE REPORTS

Nitrosative stress and cytokines are linked with the severity of sepsis and organ dysfunction

(2018) S Kumar et al.   BRITISH JOURNAL OF BIOMEDICAL SCIENCE

New insights in neutrophilic asthma

(2018) Sven F. Seys et al.   CURRENT OPINION IN PULMONARY MEDICINE

Prevalence and diversity of filamentous fungi in the airways of cystic fibrosis patients – A Dutch, multicentre study

(2018) Tobias G.P. Engel et al.   Journal of Cystic Fibrosis

Suppression of Neutrophil Antimicrobial Functions by Total Particulate Matter From Cigarette Smoke

(2018) Yao Zhang et al.   Frontiers in Immunology

Respiratory Chlamydia Infection Induce Release of Hepoxilin A3 and Histamine Production by Airway Neutrophils

(2018) Katir K. Patel et al.   Frontiers in Immunology

Oxidative stress in early cystic fibrosis lung disease is exacerbated by airway glutathione deficiency

(2017) Nina Dickerhof et al.   FREE RADICAL BIOLOGY AND MEDICINE

Interferon-λ Mediates Non-redundant Front-Line Antiviral Protection against Influenza Virus Infection without Compromising Host Fitness

(2017) Ioanna E. Galani et al.   IMMUNITY

Host DNA released by NETosis promotes rhinovirus-induced type-2 allergic asthma exacerbation

(2017) Marie Toussaint et al.   NATURE MEDICINE

Neutrophilic Inflammation in Asthma and Association with Disease Severity

(2017) Anuradha Ray et al.   TRENDS IN IMMUNOLOGY

Linking resistin, inflammation, and cardiometabolic diseases

(2017) Hyeong Kyu Park et al.   KOREAN JOURNAL OF INTERNAL MEDICINE

Global, regional, and national deaths, prevalence, disability-adjusted life years, and years lived with disability for chronic obstructive pulmonary disease and asthma, 1990–2015: a systematic analysis for the Global Burden of Disease Study 2015

(2017) Joan B Soriano et al.   Lancet Respiratory Medicine

Mechanical deformation induces depolarization of neutrophils

(2017) Andrew E. Ekpenyong et al.   Science Advances

Transcriptional firing helps to drive NETosis

(2017) Meraj A. Khan et al.   Scientific Reports

ADAMTS-13 regulates neutrophil recruitment in a mouse model of invasive pulmonary aspergillosis

(2017) Astrid Alflen et al.   Scientific Reports

Alpha-1 Antitrypsin Mitigates the Inhibition of Airway Epithelial Cell Repair by Neutrophil Elastase

(2016) Luke W. Garratt et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Neutrophils in cystic fibrosis

(2016) Julie Laval et al.   BIOLOGICAL CHEMISTRY

Matters of life and death. How neutrophils die or survive along NET release and is “NETosis” = necroptosis?

(2016) Jyaysi Desai et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Neutrophil Dysfunction in Sepsis

(2016) Shu-Bin Guo et al.   CHINESE MEDICAL JOURNAL

Transfusion of 35-Day Stored RBCs in the Presence of Endotoxemia Does Not Result in Lung Injury in Humans*

(2016) Anna L. Peters et al.   CRITICAL CARE MEDICINE

Disease phenotyping in chronic obstructive pulmonary disease

(2016) Derek W. Russell et al.   CURRENT OPINION IN PULMONARY MEDICINE

How neutrophils kill fungi

(2016) Roel P. Gazendam et al.   IMMUNOLOGICAL REVIEWS

Eosinophilic Endotype of Asthma

(2016) Fernando Aleman et al.   IMMUNOLOGY AND ALLERGY CLINICS OF NORTH AMERICA

The Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3)

(2016) Mervyn Singer et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Neutrophil extracellular traps — the dark side of neutrophils

(2016) Ole E. Sørensen et al.   JOURNAL OF CLINICAL INVESTIGATION

Electronic cigarette inhalation alters innate immunity and airway cytokines while increasing the virulence of colonizing bacteria

(2016) John H. Hwang et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Aspergillosis and the role of mucins in cystic fibrosis

(2016) Abigail C. Cowley et al.   PEDIATRIC PULMONOLOGY

Donor-variation effect on red blood cell storage lesion: A close relationship emerges

(2016) Vassilis L. Tzounakas et al.   Proteomics Clinical Applications

Effect of Blood Donor Characteristics on Transfusion Outcomes: A Systematic Review and Meta-Analysis

(2016) Michaël Chassé et al.   TRANSFUSION MEDICINE REVIEWS

Neutrophil Extracellular Traps Go Viral

(2016) Günther Schönrich et al.   Frontiers in Immunology

Transfusion of fresher vs older red blood cells in hospitalized patients: a systematic review and meta-analysis

(2015) P. E. Alexander et al.   BLOOD

Pathogenesis of non-antibody mediated transfusion-related acute lung injury from bench to bedside

(2015) Anna L. Peters et al.   BLOOD REVIEWS

Antibody-mediated transfusion-related acute lung injury; from discovery to prevention

(2015) Anna L. Peters et al.   BRITISH JOURNAL OF HAEMATOLOGY

Matrix metalloproteinase activation by free neutrophil elastase contributes to bronchiectasis progression in early cystic fibrosis

(2015) Luke W. Garratt et al.   EUROPEAN RESPIRATORY JOURNAL

Reactive nitrogen species in cellular signaling

(2015) Levi Adams et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

Neutrophil elastase inhibitors: a patent review and potential applications for inflammatory lung diseases (2010 – 2014)

(2015) Yung-Fong Tsai et al.   EXPERT OPINION ON THERAPEUTIC PATENTS

Changing the Paradigm – Treating the Basic Defect in Cystic Fibrosis

(2015) Lokesh Guglani   INDIAN JOURNAL OF PEDIATRICS

Mature Cystic Fibrosis Airway Neutrophils Suppress T Cell Function: Evidence for a Role of Arginase 1 but Not Programmed Death-Ligand 1

(2015) Sarah A. Ingersoll et al.   JOURNAL OF IMMUNOLOGY

Human Neutrophils Use Different Mechanisms To KillAspergillus fumigatusConidia and Hyphae: Evidence from Phagocyte Defects

(2015) Roel P. Gazendam et al.   JOURNAL OF IMMUNOLOGY

Neutrophils in viral infections: Current concepts and caveats

(2015) I. E. Galani et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Differential neutrophil activation in viral infections: Enhanced TLR-7/8-mediated CXCL8 release in asthma

(2015) Francesca S.M. Tang et al.   RESPIROLOGY

Neutrophil trails guide influenza-specific CD8+ T cells in the airways

(2015) K. Lim et al.   SCIENCE

Transfusion-related acute lung injury: three decades of progress but miles to go before we sleep

(2015) Mark A. Popovsky   TRANSFUSION

Lack of Neutrophil Elastase Reduces Inflammation, Mucus Hypersecretion, and Emphysema, but Not Mucus Obstruction, in Mice with Cystic Fibrosis–like Lung Disease

(2014) Stefanie Gehrig et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

CFTR: cystic fibrosis and beyond

(2014) M. A. Mall et al.   EUROPEAN RESPIRATORY JOURNAL

Neutrophil extracellular traps promote differentiation and function of fibroblasts

(2014) Akrivi Chrysanthopoulou et al.   JOURNAL OF PATHOLOGY

Pulmonary retention of primed neutrophils: a novel protective host response, which is impaired in the acute respiratory distress syndrome

(2014) Charlotte Summers et al.   THORAX

The Neutrophil in Chronic Obstructive Pulmonary Disease. Too Little, Too Late or Too Much, Too Soon?

(2013) Kim Hoenderdos et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Anti–Human Neutrophil Antigen-3a Induced Transfusion-Related Acute Lung Injury in Mice by Direct Disturbance of Lung Endothelial Cells

(2013) Behnaz Bayat et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Neutrophils Recruited to Sites of Infection Protect from Virus Challenge by Releasing Neutrophil Extracellular Traps

(2013) Craig N. Jenne et al.   Cell Host & Microbe

Neutrophil interactions with the vascular endothelium

(2013) David Dimasi et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Neutrophil mobilization via plerixafor-mediated CXCR4 inhibition arises from lung demargination and blockade of neutrophil homing to the bone marrow

(2013) Sapna Devi et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Metabolic Adaptation of Neutrophils in Cystic Fibrosis Airways Involves Distinct Shifts in Nutrient Transporter Expression

(2013) J. Laval et al.   JOURNAL OF IMMUNOLOGY

Protecting Against Post-influenza Bacterial Pneumonia by Increasing Phagocyte Recruitment and ROS Production

(2013) R. Subramaniam et al.   JOURNAL OF INFECTIOUS DISEASES

Risk Factors for Bronchiectasis in Children with Cystic Fibrosis

(2013) Peter D. Sly et al.   NEW ENGLAND JOURNAL OF MEDICINE

Molecular mechanisms regulating NETosis in infection and disease

(2013) Nora Branzk et al.   Seminars in Immunopathology

Strain-specific red blood cell storage, metabolism, and eicosanoid generation in a mouse model

(2013) James C. Zimring et al.   TRANSFUSION

A Large Subgroup of Mild-to-Moderate Asthma Is Persistently Noneosinophilic

(2012) Kelly Wong McGrath et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Neutrophil Function: From Mechanisms to Disease

(2012) Borko Amulic et al.   Annual Review of Immunology

Neutrophil Extracellular Traps Mediate a Host Defense Response to Human Immunodeficiency Virus-1

(2012) Tatsuya Saitoh et al.   Cell Host & Microbe

Acute lung injury results from failure of neutrophil de-priming: a new hypothesis

(2012) Nanak R. P. Singh et al.   EUROPEAN JOURNAL OF CLINICAL INVESTIGATION

Neutrophils Mediate Maturation and Efflux of Lung Dendritic Cells in Response to Aspergillus fumigatus Germ Tubes

(2012) Stacy J. Park et al.   INFECTION AND IMMUNITY

Infection-induced NETosis is a dynamic process involving neutrophil multitasking in vivo

(2012) Bryan G Yipp et al.   NATURE MEDICINE

Excessive Neutrophils and Neutrophil Extracellular Traps Contribute to Acute Lung Injury of Influenza Pneumonitis

(2011) Teluguakula Narasaraju et al.   AMERICAN JOURNAL OF PATHOLOGY

Lysophosphatidylcholines: Bioactive Lipids Generated During Storage of Blood Components

(2011) Krystyna Maślanka et al.   ARCHIVUM IMMUNOLOGIAE ET THERAPIAE EXPERIMENTALIS

The incidence, risk factors, and outcome of transfusion-related acute lung injury in a cohort of cardiac surgery patients: a prospective nested case-control study

(2011) A. P. J. Vlaar et al.   BLOOD

Transfusion-related acute lung injury: incidence and risk factors

(2011) P. Toy et al.   BLOOD

Neutrophil Degranulation and Immunosuppression in Patients with GBM: Restoration of Cellular Immune Function by Targeting Arginase I

(2011) T. R. Sippel et al.   CLINICAL CANCER RESEARCH

Transfusion-related acute lung injury in a neutropenic patient

(2011) J. Finlayson et al.   INTERNAL MEDICINE JOURNAL

ROS-induced ATF3 causes susceptibility to secondary infections during sepsis-associated immunosuppression

(2011) Wolfram Hoetzenecker et al.   NATURE MEDICINE

Suppressing production of reactive oxygen species (ROS) for influenza A virus therapy

(2011) Ross Vlahos et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Mechanism of transfusion-related acute lung injury induced by HLA class II antibodies

(2010) U. J. H. Sachs et al.   BLOOD

Pulmonary Proteases in the Cystic Fibrosis Lung Induce Interleukin 8 Expression from Bronchial Epithelial Cells via a Heme/Meprin/Epidermal Growth Factor Receptor/Toll-like Receptor Pathway

(2010) Sonya Cosgrove et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Infectious Chlamydia pneumoniae is Associated With Elevated Interleukin-8 and Airway Neutrophilia in Children With Refractory Asthma

(2010) Katir K. Patel et al.   PEDIATRIC INFECTIOUS DISEASE JOURNAL

Lung Disease at Diagnosis in Infants with Cystic Fibrosis Detected by Newborn Screening

(2009) Peter D. Sly et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

IL-8 induces exocytosis of arginase 1 by neutrophil polymorphonuclears in nonsmall cell lung cancer

(2009) Rita Rotondo et al.   INTERNATIONAL JOURNAL OF CANCER

Platelet depletion and aspirin treatment protect mice in a two-event model of transfusion-related acute lung injury

(2009) Mark R. Looney et al.   JOURNAL OF CLINICAL INVESTIGATION

Activation of critical, host-induced, metabolic and stress pathways marks neutrophil entry into cystic fibrosis lungs

(2009) M. Makam et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A GSK-3/TSC2/mTOR pathway regulates glucose uptake and GLUT1 glucose transporter expression

(2008) Carolyn L. Buller et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

A critical function for CD200 in lung immune homeostasis and the severity of influenza infection

(2008) Robert J Snelgrove et al.   NATURE IMMUNOLOGY

Profound functional and signaling changes in viable inflammatory neutrophils homing to cystic fibrosis airways

(2008) R. Tirouvanziam et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Pulmonary pathology of rapidly fatal transfusion-related acute lung injury reveals minimal evidence of diffuse alveolar damage or alveolar granulocyte infiltration

(2008) Constance Danielson et al.   TRANSFUSION

Clarithromycin Targets Neutrophilic Airway Inflammation in Refractory Asthma

(2007) Jodie L. Simpson et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE