Lack of Neutrophil Elastase Reduces Inflammation, Mucus Hypersecretion, and Emphysema, but Not Mucus Obstruction, in Mice with Cystic Fibrosis–like Lung Disease

Roles for proteinases in the pathogenesis of chronic obstructive pulmonary disease

(2016) Caroline Owen   International Journal of Chronic Obstructive Pulmonary Disease

Magnetic Resonance Imaging Detects Changes in Structure and Perfusion, and Response to Therapy in Early Cystic Fibrosis Lung Disease

(2014) Mark O. Wielpütz et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

FRET-based and other fluorescent proteinase probes

(2014) Hai-Yu Hu et al.   Biotechnology Journal

Neutrophil Elastase Mediates Innate Host Protection against Pseudomonas aeruginosa

(2014) T. O. Hirche et al.   JOURNAL OF IMMUNOLOGY

Hypertonic Saline Is Effective in the Prevention and Treatment of Mucus Obstruction, but Not Airway Inflammation, in Mice with Chronic Obstructive Lung Disease

(2013) Simon Y. Graeber et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Risk Factors for Bronchiectasis in Children with Cystic Fibrosis

(2013) Peter D. Sly et al.   NEW ENGLAND JOURNAL OF MEDICINE

Early lung disease in cystic fibrosis

(2013) Hartmut Grasemann et al.   Lancet Respiratory Medicine

Sputum Biomarkers of Inflammation and Lung Function Decline in Children with Cystic Fibrosis

(2012) Scott D. Sagel et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Neutrophil Elastase Degrades Cystic Fibrosis Transmembrane Conductance Regulator via Calpains and Disables Channel FunctionIn VitroandIn Vivo

(2012) Mathieu Le Gars et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Spatially Resolved Monitoring of Neutrophil Elastase Activity with Ratiometric Fluorescent Reporters

(2012) Stefanie Gehrig et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Efficacy, safety and effect on biomarkers of AZD9668 in cystic fibrosis

(2012) J. Stuart Elborn et al.   EUROPEAN RESPIRATORY JOURNAL

SLC26A9-mediated chloride secretion prevents mucus obstruction in airway inflammation

(2012) Pinelopi Anagnostopoulou et al.   JOURNAL OF CLINICAL INVESTIGATION

Mucus clearance, MyD88-dependent and MyD88-independent immunity modulate lung susceptibility to spontaneous bacterial infection and inflammation

(2012) A Livraghi-Butrico et al.   Mucosal Immunology

CFTR Regulates Early Pathogenesis of Chronic Obstructive Lung Disease in βENaC-Overexpressing Mice

(2012) Bjarki Johannesson et al.   PLoS One

A Periciliary Brush Promotes the Lung Health by Separating the Mucus Layer from Airway Epithelia

(2012) B. Button et al.   SCIENCE

In vivo monitoring of cystic fibrosis-like lung disease in mice by volumetric computed tomography

(2011) M. O. Wielputz et al.   EUROPEAN RESPIRATORY JOURNAL

Neutrophil elastase inhibitors

(2011) William C Groutas et al.   EXPERT OPINION ON THERAPEUTIC PATENTS

Pharmacological therapy for cystic fibrosis: From bench to bedside

(2011) Frédéric Becq et al.   Journal of Cystic Fibrosis

The ENaC-overexpressing mouse as a model of cystic fibrosis lung disease

(2011) Zhe Zhou et al.   Journal of Cystic Fibrosis

Allergic airway inflammation induces a pro-secretory epithelial ion transport phenotype in mice

(2010) P. Anagnostopoulou et al.   EUROPEAN RESPIRATORY JOURNAL

Airway Surface Liquid Volume Regulation Determines Different Airway Phenotypes in Liddle Compared with βENaC-overexpressing Mice

(2010) Marcus A. Mall et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Airway Mucus Function and Dysfunction

(2010) John V. Fahy et al.   NEW ENGLAND JOURNAL OF MEDICINE

Lung Disease at Diagnosis in Infants with Cystic Fibrosis Detected by Newborn Screening

(2009) Peter D. Sly et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Membrane-bound FRET probe visualizes MMP12 activity in pulmonary inflammation

(2009) Amanda Cobos-Correa et al.   Nature Chemical Biology

Novel Method to Process Cystic Fibrosis Sputum for Determination of Oxidative State

(2009) A. Hector et al.   RESPIRATION

Preventive but Not Late Amiloride Therapy Reduces Morbidity and Mortality of Lung Disease in βENaC-overexpressing Mice

(2008) Zhe Zhou et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Detection of Anaerobic Bacteria in High Numbers in Sputum from Patients with Cystic Fibrosis

(2008) Michael M. Tunney et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Inhibition of airway proteases in cystic fibrosis lung disease

(2008) M. Griese et al.   EUROPEAN RESPIRATORY JOURNAL

Role of the amiloride-sensitive epithelial Na+channel in the pathogenesis and as a therapeutic target for cystic fibrosis lung disease

(2008) Marcus A. Mall   EXPERIMENTAL PHYSIOLOGY

Proteases and cystic fibrosis

(2008) J VOYNOW et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Role of Cilia, Mucus, and Airway Surface Liquid in Mucociliary Dysfunction: Lessons from Mouse Models

(2008) Marcus A. Mall   Journal of Aerosol Medicine and Pulmonary Drug Delivery

Cleavage in the γ-subunit of the epithelial sodium channel (ENaC) plays an important role in the proteolytic activation of near-silent channels

(2008) Alexei Diakov et al.   JOURNAL OF PHYSIOLOGY-LONDON

Development of Chronic Bronchitis and Emphysema in β-Epithelial Na+Channel–Overexpressing Mice

(2007) Marcus A. Mall et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE