Neutrophil elastase inhibitors: a patent review and potential applications for inflammatory lung diseases (2010 – 2014)

Synthesis and pharmacological characterization of 2-aminobenzaldehyde oxime analogs as dual inhibitors of neutrophil elastase and proteinase 3

(2015) Tsong-Long Hwang et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Ezrin/Exocyst Complex Regulates Mucin 5AC Secretion Induced by Neutrophil Elastase in Human Airway Epithelial Cells

(2015) Qi Li et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Sirtinol Inhibits Neutrophil Elastase Activity and Attenuates Lipopolysaccharide-Mediated Acute Lung Injury in Mice

(2015) Yung-Fong Tsai et al.   Scientific Reports

Increased Neutrophil Elastase and Proteinase 3 and Augmented NETosis Are Closely Associated With  -Cell Autoimmunity in Patients With Type 1 Diabetes

(2014) Y. Wang et al.   DIABETES

Phosphodiesterase Inhibitors for Chronic Obstructive Pulmonary Disease: What Does the Future Hold?

(2014) Maria Gabriella Matera et al.   DRUGS

NET formation induced by Pseudomonas aeruginosa cystic fibrosis isolates measured as release of myeloperoxidase–DNA and neutrophil elastase–DNA complexes

(2014) Dae-goon Yoo et al.   IMMUNOLOGY LETTERS

Interplay of Infections, Autoimmunity, and Immunosuppression in Systemic Lupus Erythematosus

(2014) Tiffany Caza et al.   INTERNATIONAL REVIEWS OF IMMUNOLOGY

Neutrophils sense microbe size and selectively release neutrophil extracellular traps in response to large pathogens

(2014) Nora Branzk et al.   NATURE IMMUNOLOGY

New Aspects on the Structure of Neutrophil Extracellular Traps from Chronic Obstructive Pulmonary Disease and In Vitro Generation

(2014) Astrid Obermayer et al.   PLoS One

The Neutrophil in Chronic Obstructive Pulmonary Disease. Too Little, Too Late or Too Much, Too Soon?

(2013) Kim Hoenderdos et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

The potential of neutrophil elastase inhibitors as anti-inflammatory therapies

(2013) Peter A. Henriksen   CURRENT OPINION IN HEMATOLOGY

Neutrophil Elastase and Proteinase-3 Trigger G Protein-biased Signaling through Proteinase-activated Receptor-1 (PAR1)

(2013) Koichiro Mihara et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Neutrophil elastase induces MUC5AC secretion via protease-activated receptor 2

(2013) Jia Zhou et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Modulation of neutrophil NETosis: interplay between infectious agents and underlying host physiology

(2013) Sinuhe Hahn et al.   Seminars in Immunopathology

Molecular mechanisms regulating NETosis in infection and disease

(2013) Nora Branzk et al.   Seminars in Immunopathology

NETosis and NADPH oxidase: at the intersection of host defense, inflammation, and injury

(2013) Nikolaos G. Almyroudis et al.   Frontiers in Immunology

NSP4, an elastase-related protease in human neutrophils with arginine specificity

(2012) N. C. Perera et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Neutrophil extracellular traps

(2011) Borko Amulic et al.   CURRENT BIOLOGY

Unexpected Active-Site Flexibility in the Structure of Human Neutrophil Elastase in Complex with a New Dihydropyrimidone Inhibitor

(2011) Guido Hansen et al.   JOURNAL OF MOLECULAR BIOLOGY

Epidemiology of invasive candidiasis

(2010) Maiken C Arendrup   Current Opinion in Critical Care

Synthesis and evaluation of benzoxazinone derivatives on activity of human neutrophil elastase and on hemorrhagic shock-induced lung injury in rats

(2010) Pei-Wen Hsieh et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Acute Lung Injury with Alveolar Hemorrhage Due to a Novel Swine-Origin Influenza A (H1N1) Virus

(2010) Toshiki Yokoyama et al.   INTERNAL MEDICINE

Neutrophil elastase and myeloperoxidase regulate the formation of neutrophil extracellular traps

(2010) Venizelos Papayannopoulos et al.   JOURNAL OF CELL BIOLOGY

Neutrophil Elastase, Proteinase 3, and Cathepsin G as Therapeutic Targets in Human Diseases

(2010) B. Korkmaz et al.   PHARMACOLOGICAL REVIEWS

Structural basis of substrate specificity in the serine proteases

(2010) John J. Perona et al.   PROTEIN SCIENCE

Leukocyte Elastase Induces Lung Epithelial Apoptosis via a PAR-1–, NF-κB–, and p53-Dependent Pathway

(2009) Tomoko Suzuki et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Synthesis and optimization of 2-pyridin-3-yl-benzo[d][1,3]oxazin-4-one based inhibitors of human neutrophil elastase

(2009) Kevin R. Shreder et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Potent Inhibitors of β-Tryptase and Human Leukocyte Elastase Based on the MCoTI-II Scaffold

(2009) Panumart Thongyoo et al.   JOURNAL OF MEDICINAL CHEMISTRY