Review
Respiratory System
Pearl Toy, Mark R. Looney, Mark Popovsky, Miodrag Palfi, Gosta Berlin, Catherine E. Chapman, Paula Bolton-Maggs, Michael A. Matthay
Summary: Transfusion-related acute lung injury (TRALI) is a condition characterized by acute respiratory distress syndrome (ARDS) after blood transfusion, often associated with donor leukocyte antibodies or plasma from multiparous donors. While there have been successful measures to reduce TRALI, there are still unanswered questions regarding non-antibody TRALI mechanisms, the impact of blood products on ARDS in massive transfusion patients, and accurate diagnosis of TRALI.
ANNALS OF THE AMERICAN THORACIC SOCIETY
(2022)
Review
Physiology
Wolfgang M. Kuebler, Nishaka William, Martin Post, Jason P. Acker, Mark J. Mcvey
Summary: Respiratory transfusion reactions, especially transfusion-related acute lung injury (TRALI), have significant morbidity and mortality. Current methods of diagnosing and treating TRALI are limited. EVs play a role in mediating TRALI by acting as triggers for the first and/ or second hit. Further research is needed to explore EVs as therapeutic targets and biomarkers for TRALI diagnosis.
AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY
(2023)
Article
Surgery
Samantha L. Ennis, Nick Olsen, Winnie W. Y. Tong, Louise Goddard, Narelle Watson, Lyanne Weston, Ayesha Iqbal, Purvesh Patel, Monique A. Malouf, Marshall L. Plit, David R. Darley
Summary: This study aimed to measure the association between DQ REM and the risk of CLAD and death after lung transplantation. The results showed that DQ REM was associated with CLAD, but after adjusting for time-dependent variables, DQ REM was not independently associated with CLAD. DQ REM was not associated with death. Therefore, the classification of DQ REM can identify patients at risk of poor outcomes and should be incorporated into clinical decision-making.
AMERICAN JOURNAL OF TRANSPLANTATION
(2023)
Review
Immunology
Yunhong Yu, Zhengqiu Lian
Summary: Transfusion-related acute lung injury (TRALI) is a severe adverse event and a leading cause of transfusion-associated death. Effective management strategies for the prevention and treatment of associated lung edema are urgently needed. Recent studies have advanced our understanding of TRALI pathogenesis and led to a decrease in TRALI-associated morbidity.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Anesthesiology
Manoj H. Iyer, Julia E. Kumar, Nicolas Kumar, Leonid Gorelik, Nasir Hussain, Erica Stein, Amar M. Bhatt, Sujatha Bhandary, Michael K. Essandoh, Antolin S. Flores
Summary: This scoping review summarizes the existing literature on transfusion-related acute lung injury (TRALI) during the perioperative period of liver transplantation. The review found that the incidence of TRALI after liver transplant was 0.68%, and a significant proportion of patients diagnosed with TRALI died during the postoperative period.
JOURNAL OF CARDIOTHORACIC AND VASCULAR ANESTHESIA
(2022)
Article
Medicine, General & Internal
Shikha Jha, Keval V. Patel, Amar Bukhari
Summary: The preeminent causes of blood transfusion-related morbidity and mortality are transfusion-associated circulatory overload (TACO) and transfusion-related acute lung injury (TRALI). Differentiating between TACO and TRALI poses a challenge in terms of underlying etiology. This case report presents a unique presentation of acute respiratory distress in a 64-year-old female.
CUREUS JOURNAL OF MEDICAL SCIENCE
(2022)
Review
Immunology
Zhengjian Wang, Fan Li, Jin Liu, Yalan Luo, Haoya Guo, Qi Yang, Caiming Xu, Shurong Ma, Hailong Chen
Summary: This study reviews the mechanisms of the microbiota-gut-lung axis in pancreatic-associated lung injury (PALI) and discusses potential therapeutic strategies for PALI by regulating the intestinal microbiota.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Immunology
Yi Liu, Rong Wang, Congkuan Song, Song Ding, Yifan Zuo, Ke Yi, Ning Li, Bo Wang, Qing Geng
Summary: Transfusion-related acute lung injury (TRALI) is a leading cause of death associated with blood transfusion. TRALI can be categorized into antibody-mediated and non-antibody-mediated types. Neutrophil extracellular traps (NETs) formed by activated neutrophils play a significant role in TRALI. Platelets, macrophages, endothelial cells, and complements also promote NET formation.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Immunology
Sheng Wang, Huanping Zhou, Li Zheng, Wanli Zhu, Lina Zhu, Di Feng, Juan Wei, Guannan Chen, Xiaohong Jin, Hao Yang, Xuan Shi, Xin Lv
Summary: Over the past 10 years, research on macrophages in acute lung injury (ALI) has shown a continuous increase, with China being a major producer of studies and the USA exerting significant influence in the field. Studies have mainly focused on basic research, with recent attention shifting towards pathways associated with the regulatory role of macrophages in inhibiting and attenuating ALI.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Ting You, Bihong Zhang
Summary: This study found that circular RNA circWDR33 plays a protective role in pulmonary microvascular endothelial cells by regulating the miR-217-5p/SERP1 axis, preventing inflammatory and apoptotic injury, permeability enhancement, and tubule formation arrest in sepsis-induced acute lung injury.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Kai Guo, Shuxuan Ma
Summary: TRALI, as a rare complication associated with transfusion medicine, has unclear pathogenesis and lacks specific therapies. Understanding the mechanisms of TRALI is crucial for the design of preventive and therapeutic strategies.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2021)
Review
Hematology
John-Paul Tung, Sara Chiaretti, Melinda M. Dean, Annette J. Sultana, Michael C. Reade, Yoke Lin Fung
Summary: Transfusion-related acute lung injury (TRALI) is a common complication of blood transfusion, caused by antibodies or biological response modifiers (BRMs). Multiple possible pathways for TRALI have been identified, including neutrophil activation, monocyte and neutrophil dependence, and endothelial cell and complement dependence. These pathways ultimately lead to the symptoms of TRALI. In addition to the known pathways, other pathways are likely to contribute to the pathogenesis of TRALI.
Article
Critical Care Medicine
Shuangchun Liu, Ronghai Lin, Xianchao Zhang, Yinyi Lv, Jie Zhu, Guang Chen, Yunting Du
Summary: This study investigated the pathophysiological mechanisms of TRALI using a rat model. The findings indicated that TRALI increased inflammatory cytokines and activated toll-like receptor 4/nuclear factor kappa B and mitogen-activated protein kinase signaling pathways. HMGB1 and RIP3 may serve as diagnostic markers for TRALI and promote inflammation through these signaling pathways.
Article
Critical Care Medicine
Xin Yuan, Peng Jiang, CongChao Qiao, Na Su, Pan Sun, Fangzhao Lin, Changqing Li
Summary: This study aimed to explore the effects of the platelet surface glycoprotein IIb/IIIa receptor antagonist tirofiban on coagulation and fibrinolytic abnormalities in a mouse model of antibody-mediated transfusion-associated acute lung injury (ALI). The results showed that tirofiban decreased lung injury indices and improved survival rates in the mouse model. Furthermore, tirofiban significantly reduced coagulation and fibrinolytic abnormalities compared to the model group.
Article
Pharmacology & Pharmacy
Yuxuan Wu, Hao Sun, Lianju Qin, Xiaomin Zhang, Hao Zhou, Yao Wang, Lumin Wang, Meng Li, Jiayin Liu, Jinsong Zhang
Summary: This study aimed to determine the effects of human amnion-derived mesenchymal stem cells (hAMSCs) on two different acute lung injury (ALI) mice models. The high-dose hAMSCs group significantly alleviated alveolar-capillary permeability, oxidative stress, inflammatory factors level, and histopathological damage. The therapeutic effect of hAMSCs might involve NF-kappa B signaling pathway inhibition.
FRONTIERS IN PHARMACOLOGY
(2023)
