Human iPSC‐derived microglia: A growing toolset to study the brain's innate immune cells

Genome-wide meta-analysis identifies new loci and functional pathways influencing Alzheimer’s disease risk

(2019) Iris E. Jansen et al.   NATURE GENETICS

Concise Review: Modeling Neurodegenerative Diseases with Human Pluripotent Stem Cell-Derived Microglia

(2019) Walther Haenseler et al.   STEM CELLS

Fibrinogen Induces Microglia-Mediated Spine Elimination and Cognitive Impairment in an Alzheimer’s Disease Model

(2019) Mario Merlini et al.   NEURON

Genetic meta-analysis of diagnosed Alzheimer’s disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing

(2019) Brian W. Kunkle et al.   NATURE GENETICS

Human Interleukin-34 facilitates microglia-like cell differentiation and persistent HIV-1 infection in humanized mice

(2019) Saumi Mathews et al.   Molecular Neurodegeneration

Progressive brain atrophy in chronically infected and treated HIV+ individuals

(2019) Talia M. Nir et al.   JOURNAL OF NEUROVIROLOGY

Neurocognitive impairment in well controlled HIV-infected patients. A cross sectional study

(2019) Irene Portilla et al.   AIDS RESEARCH AND HUMAN RETROVIRUSES

Galectin-3, a novel endogenous TREM2 ligand, detrimentally regulates inflammatory response in Alzheimer’s disease

(2019) Antonio Boza-Serrano et al.   ACTA NEUROPATHOLOGICA

Aged blood impairs hippocampal neural precursor activity and activates microglia via brain endothelial cell VCAM1

(2019) Hanadie Yousef et al.   NATURE MEDICINE

Microglia-neuron crosstalk: Signaling mechanism and control of synaptic transmission

(2019) Silvia Marinelli et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Individual brain organoids reproducibly form cell diversity of the human cerebral cortex

(2019) Silvia Velasco et al.   NATURE

Development of a Chimeric Model to Study and Manipulate Human Microglia In Vivo

(2019) Jonathan Hasselmann et al.   NEURON

Deletion of a Csf1r enhancer selectively impacts CSF1R expression and development of tissue macrophage populations

(2019) Rocío Rojo et al.   Nature Communications

Stem-cell-derived human microglia transplanted in mouse brain to study human disease

(2019) Renzo Mancuso et al.   NATURE NEUROSCIENCE

Human iPSC-derived microglia assume a primary microglia-like state after transplantation into the neonatal mouse brain

(2019) Devon S. Svoboda et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Repeated Mild Closed Head Injuries Induce Long-Term White Matter Pathology and Neuronal Loss That Are Correlated With Behavioral Deficits

(2018) Eric M. Gold et al.   ASN Neuro

Differential transcriptional response profiles in human myeloid cell populations

(2018) Luke M. Healy et al.   CLINICAL IMMUNOLOGY

An in vivo model of functional and vascularized human brain organoids

(2018) Abed AlFatah Mansour et al.   NATURE BIOTECHNOLOGY

Modelling microglial function with induced pluripotent stem cells: an update

(2018) Jennifer M. Pocock et al.   NATURE REVIEWS NEUROSCIENCE

A Combination of Ontogeny and CNS Environment Establishes Microglial Identity

(2018) F. Chris Bennett et al.   NEURON

APOE4 Causes Widespread Molecular and Cellular Alterations Associated with Alzheimer’s Disease Phenotypes in Human iPSC-Derived Brain Cell Types

(2018) Yuan-Ta Lin et al.   NEURON

Human induced pluripotent stem cell-derived glial cells and neural progenitors display divergent responses to Zika and dengue infections

(2018) Julien Muffat et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Microglia remodel synapses by presynaptic trogocytosis and spine head filopodia induction

(2018) Laetitia Weinhard et al.   Nature Communications

Diverse Brain Myeloid Expression Profiles Reveal Distinct Microglial Activation States and Aspects of Alzheimer’s Disease Not Evident in Mouse Models

(2018) Brad A. Friedman et al.   Cell Reports

Functional Studies of Missense TREM2 Mutations in Human Stem Cell-Derived Microglia

(2018) Philip W. Brownjohn et al.   Stem Cell Reports

Alterations in brain TREM2 and Amyloid-β levels are associated with neurocognitive impairment in HIV-infected persons on antiretroviral therapy

(2018) Jerel Adam Fields et al.   JOURNAL OF NEUROCHEMISTRY

Macrophages but not Astrocytes Harbor HIV DNA in the Brains of HIV-1-Infected Aviremic Individuals on Suppressive Antiretroviral Therapy

(2018) Allen Ko et al.   Journal of Neuroimmune Pharmacology

The Trem2 R47H Alzheimer’s risk variant impairs splicing and reduces Trem2 mRNA and protein in mice but not in humans

(2018) Xianyuan Xiang et al.   Molecular Neurodegeneration

Animal models of neurodegenerative diseases

(2018) Ted M. Dawson et al.   NATURE NEUROSCIENCE

An Overview of in vitro Methods to Study Microglia

(2018) Raissa Timmerman et al.   Frontiers in Cellular Neuroscience

Human Induced Pluripotent Stem Cell-Derived Microglia-Like Cells Harboring TREM2 Missense Mutations Show Specific Deficits in Phagocytosis

(2018) Pablo Garcia-Reitboeck et al.   Cell Reports

Human stem cell–derived monocytes and microglia-like cells reveal impaired amyloid plaque clearance upon heterozygous or homozygous loss of TREM2

(2018) Christel Claes et al.   Alzheimers & Dementia

Development and validation of a simplified method to generate human microglia from pluripotent stem cells

(2018) Amanda McQuade et al.   Molecular Neurodegeneration

Best Practices for Translational Disease Modeling Using Human iPSC-Derived Neurons

(2018) Sandra J. Engle et al.   NEURON

Microglia innately develop within cerebral organoids

(2018) Paul R. Ormel et al.   Nature Communications

Modeling neuro-immune interactions during Zika virus infection

(2017) Pinar Mesci et al.   HUMAN MOLECULAR GENETICS

Induced-Pluripotent-Stem-Cell-Derived Primitive Macrophages Provide a Platform for Modeling Tissue-Resident Macrophage Differentiation and Function

(2017) Kazuyuki Takata et al.   IMMUNITY

The TREM2-APOE Pathway Drives the Transcriptional Phenotype of Dysfunctional Microglia in Neurodegenerative Diseases

(2017) Susanne Krasemann et al.   IMMUNITY

Microglia in Alzheimer’s disease

(2017) David V. Hansen et al.   JOURNAL OF CELL BIOLOGY

Late onset Alzheimer’s disease genetics implicates microglial pathways in disease risk

(2017) Anastasia G. Efthymiou et al.   Molecular Neurodegeneration

Cell diversity and network dynamics in photosensitive human brain organoids

(2017) Giorgia Quadrato et al.   NATURE

Neurotoxic reactive astrocytes are induced by activated microglia

(2017) Shane A. Liddelow et al.   NATURE

Rare coding variants in PLCG2, ABI3, and TREM2 implicate microglial-mediated innate immunity in Alzheimer's disease

(2017) Rebecca Sims et al.   NATURE GENETICS

Transcriptomic analysis of purified human cortical microglia reveals age-associated changes

(2017) Thais F Galatro et al.   NATURE NEUROSCIENCE

Differentiation of human and murine induced pluripotent stem cells to microglia-like cells

(2017) Hetal Pandya et al.   NATURE NEUROSCIENCE

A common haplotype lowers PU.1 expression in myeloid cells and delays onset of Alzheimer's disease

(2017) Kuan-lin Huang et al.   NATURE NEUROSCIENCE

Immune hyperreactivity of Aβ plaque-associated microglia in Alzheimer's disease

(2017) Zhuoran Yin et al.   NEUROBIOLOGY OF AGING

iPSC-Derived Human Microglia-like Cells to Study Neurological Diseases

(2017) Edsel M. Abud et al.   NEURON

Diverse Requirements for Microglial Survival, Specification, and Function Revealed by Defined-Medium Cultures

(2017) Christopher J. Bohlen et al.   NEURON

DISC1 Regulates Neurogenesis via Modulating Kinetochore Attachment of Ndel1/Nde1 during Mitosis

(2017) Fei Ye et al.   NEURON

An environment-dependent transcriptional network specifies human microglia identity

(2017) David Gosselin et al.   SCIENCE

Association of HLA-DRB1 polymorphism with Alzheimer’s disease: a replication and meta-analysis

(2017) Rui-Chun Lu et al.   Oncotarget

CRISPR/Cas9-mediated heterozygous knockout of the autism gene CHD8 and characterization of its transcriptional networks in cerebral organoids derived from iPS cells

(2017) Ping Wang et al.   Molecular Autism

Directed Differentiation of Human Pluripotent Stem Cells to Microglia

(2017) Panagiotis Douvaras et al.   Stem Cell Reports

A Highly Efficient Human Pluripotent Stem Cell Microglia Model Displays a Neuronal-Co-culture-Specific Expression Profile and Inflammatory Response

(2017) Walther Haenseler et al.   Stem Cell Reports

Intracerebroventricular delivery of hematopoietic progenitors results in rapid and robust engraftment of microglia-like cells

(2017) Alessia Capotondo et al.   Science Advances

Excess α-synuclein compromises phagocytosis in iPSC-derived macrophages

(2017) Walther Haenseler et al.   Scientific Reports

Cerebrospinal fluid soluble TREM2 is higher in Alzheimer disease and associated with mutation status

(2016) Laura Piccio et al.   ACTA NEUROPATHOLOGICA

Transcriptional profiling of CD11c-positive microglia accumulating around amyloid plaques in a mouse model for Alzheimer's disease

(2016) Willem Kamphuis et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Dishing out mini-brains: Current progress and future prospects in brain organoid research

(2016) Iva Kelava et al.   DEVELOPMENTAL BIOLOGY

The “Big-Bang” for modern glial biology: Translation and comments on Pío del Río-Hortega 1919 series of papers on microglia

(2016) Amanda Sierra et al.   GLIA

Modeling complement-driven diseases in transgenic mice: Values and limitations

(2016) Yoshiyasu Ueda et al.   IMMUNOBIOLOGY

Zika virus infection and Guillain-Barré syndrome: a review focused on clinical and electrophysiological subtypes

(2016) Antonino Uncini et al.   JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY

microRNA-155 Regulates Alpha-Synuclein-Induced Inflammatory Responses in Models of Parkinson Disease

(2016) Aaron D. Thome et al.   JOURNAL OF NEUROSCIENCE

Efficient derivation of microglia-like cells from human pluripotent stem cells

(2016) Julien Muffat et al.   NATURE MEDICINE

TREM2 Haplodeficiency in Mice and Humans Impairs the Microglia Barrier Function Leading to Decreased Amyloid Compaction and Severe Axonal Dystrophy

(2016) Peng Yuan et al.   NEURON

Zika Virus

(2016) Lyle R. Petersen et al.   NEW ENGLAND JOURNAL OF MEDICINE

Self-Organizing 3D Human Neural Tissue Derived from Induced Pluripotent Stem Cells Recapitulate Alzheimer’s Disease Phenotypes

(2016) Waseem K. Raja et al.   PLoS One

Microglia–blood vessel interactions: a double-edged sword in brain pathologies

(2015) Nevenka Dudvarski Stankovic et al.   ACTA NEUROPATHOLOGICA

FOXG1-Dependent Dysregulation of GABA/Glutamate Neuron Differentiation in Autism Spectrum Disorders

(2015) Jessica Mariani et al.   CELL

TREM2 Lipid Sensing Sustains the Microglial Response in an Alzheimer’s Disease Model

(2015) Yaming Wang et al.   CELL

Mouse models rarely mimic the transcriptome of human neurodegenerative diseases: A systematic bioinformatics-based critique of preclinical models

(2015) Terry C. Burns et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

TREM2 deficiency eliminates TREM2+inflammatory macrophages and ameliorates pathology in Alzheimer’s disease mouse models

(2015) Taylor R. Jay et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Functional cortical neurons and astrocytes from human pluripotent stem cells in 3D culture

(2015) Anca M Paşca et al.   NATURE METHODS

Human cerebral organoids recapitulate gene expression programs of fetal neocortex development

(2015) J. Gray Camp et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

From the Cajal alumni Achúcarro and Río-Hortega to the rediscovery of never-resting microglia

(2015) Marie-Ève Tremblay et al.   Frontiers in Neuroanatomy

The Ischemic Environment Drives Microglia and Macrophage Function

(2015) Stefano Fumagalli et al.   Frontiers in Neurology

Altered microglial response to Aβ plaques in APPPS1-21 mice heterozygous for TREM2

(2014) Jason D Ulrich et al.   Molecular Neurodegeneration

Development and function of human innate immune cells in a humanized mouse model

(2014) Anthony Rongvaux et al.   NATURE BIOTECHNOLOGY

Colony-Stimulating Factor 1 Receptor Signaling Is Necessary for Microglia Viability, Unmasking a Microglia Progenitor Cell in the Adult Brain

(2014) Monica R.P. Elmore et al.   NEURON

The human side of microglia

(2014) Amy M. Smith et al.   TRENDS IN NEUROSCIENCES

Cerebral organoids model human brain development and microcephaly

(2013) Madeline A. Lancaster et al.   NATURE

Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer's disease

(2013) Jean-Charles Lambert et al.   NATURE GENETICS

Microglia emerge from erythromyeloid precursors via Pu.1- and Irf8-dependent pathways

(2013) Katrin Kierdorf et al.   NATURE NEUROSCIENCE

Identification of a unique TGF-β–dependent molecular and functional signature in microglia

(2013) Oleg Butovsky et al.   NATURE NEUROSCIENCE

A novel compound heterozygous mutation in TREM2 found in a Turkish frontotemporal dementia-like family

(2013) Rita Guerreiro et al.   NEUROBIOLOGY OF AGING

Self-organization of axial polarity, inside-out layer pattern, and species-specific progenitor dynamics in human ES cell-derived neocortex

(2013) T. Kadoshima et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Quantitating the subtleties of microglial morphology with fractal analysis

(2013) Audrey Karperien et al.   Frontiers in Cellular Neuroscience

Factors regulating microglia activation

(2013) Katrin Kierdorf et al.   Frontiers in Cellular Neuroscience

HIV-1 Pathogenesis: The Virus

(2013) R. Swanstrom et al.   Cold Spring Harbor Perspectives in Medicine

Neuron-glia crosstalk in health and disease: fractalkine and CX3CR1 take centre stage

(2013) G. K. Sheridan et al.   Open Biology

IL-34 is a tissue-restricted ligand of CSF1R required for the development of Langerhans cells and microglia

(2012) Yaming Wang et al.   NATURE IMMUNOLOGY

Microglia Sculpt Postnatal Neural Circuits in an Activity and Complement-Dependent Manner

(2012) Dorothy P. Schafer et al.   NEURON

Variant of TREM2 Associated with the Risk of Alzheimer's Disease

(2012) Thorlakur Jonsson et al.   NEW ENGLAND JOURNAL OF MEDICINE

TREM2 Variants in Alzheimer's Disease

(2012) Rita Guerreiro et al.   NEW ENGLAND JOURNAL OF MEDICINE

A Lineage of Myeloid Cells Independent of Myb and Hematopoietic Stem Cells

(2012) C. Schulz et al.   SCIENCE

Efficient differentiation and function of human macrophages in humanized CSF-1 mice

(2011) C. Rathinam et al.   BLOOD

Propentofylline, a CNS glial modulator does not decrease pain in post-herpetic neuralgia patients: In vitro evidence for differential responses in human and rodent microglia and macrophages

(2011) Russell P. Landry et al.   EXPERIMENTAL NEUROLOGY

Absence of Colony Stimulation Factor-1 Receptor Results in Loss of Microglia, Disrupted Brain Development and Olfactory Deficits

(2011) Bryna Erblich et al.   PLoS One

Generation of microglial cells from mouse embryonic stem cells

(2010) Clara Beutner et al.   Nature Protocols

Valproic acid induces microglial dysfunction, not apoptosis, in human glial cultures

(2010) Hannah M. Gibbons et al.   NEUROBIOLOGY OF DISEASE

Fate Mapping Analysis Reveals That Adult Microglia Derive from Primitive Macrophages

(2010) F. Ginhoux et al.   SCIENCE

Genome-wide association study identifies variants at CLU and CR1 associated with Alzheimer's disease

(2009) Jean-Charles Lambert et al.   NATURE GENETICS

Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer's disease

(2009) Denise Harold et al.   NATURE GENETICS

Mutant α-Synuclein Overexpression Mediates Early Proinflammatory Activity

(2009) Xiaomin Su et al.   NEUROTOXICITY RESEARCH