CRISPR/Cas9-mediated heterozygous knockout of the autism gene CHD8 and characterization of its transcriptional networks in cerebral organoids derived from iPS cells

Dysregulated ErbB4 Splicing in Schizophrenia: Selective Effects on Parvalbumin Expression

(2016) Daniel W. Chung et al.   AMERICAN JOURNAL OF PSYCHIATRY

Integrative transcriptome network analysis of iPSC-derived neurons from schizophrenia and schizoaffective disorder patients with 22q11.2 deletion

(2016) Mingyan Lin et al.   BMC Systems Biology

The Number of Parvalbumin-Expressing Interneurons Is Decreased in the Medial Prefrontal Cortex in Autism

(2016) Ezzat Hashemi et al.   CEREBRAL CORTEX

Epigenetic Treatment of Neuropsychiatric Disorders: Autism and Schizophrenia

(2016) Walter H. Moos et al.   DRUG DEVELOPMENT RESEARCH

Identification of novel genetic causes of Rett syndrome-likephenotypes

(2016) Fátima Lopes et al.   JOURNAL OF MEDICAL GENETICS

Genome-wide nucleosome specificity and function of chromatin remodellers in ES cells

(2016) Maud de Dieuleveult et al.   NATURE

Near-optimal probabilistic RNA-seq quantification

(2016) Nicolas L Bray et al.   NATURE BIOTECHNOLOGY

Chd8 mediates cortical neurogenesis via transcriptional regulation of cell cycle and Wnt signaling

(2016) Omer Durak et al.   NATURE NEUROSCIENCE

Expression and functional analysis of the Wnt/beta-catenin induced mir-135a-2 locus in embryonic forebrain development

(2016) Giuliana Caronia-Brown et al.   Neural Development

The role of telomeres and telomerase reverse transcriptase isoforms in pluripotency induction and maintenance

(2016) Jonathan H. Teichroeb et al.   RNA Biology

Autism and Cancer Share Risk Genes, Pathways, and Drug Targets

(2016) Jacqueline N. Crawley et al.   TRENDS IN GENETICS

RELN Mutations in Autism Spectrum Disorder

(2016) Dawn B. Lammert et al.   Frontiers in Cellular Neuroscience

Pathway Network Analyses for Autism Reveal Multisystem Involvement, Major Overlaps with Other Diseases and Convergence upon MAPK and Calcium Signaling

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Exonic deletions ofAUTS2in Chinese patients with developmental delay and intellectual disability

(2015) Yanjie Fan et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART A

De novo exon 1 deletion ofAUTS2gene in a patient with autism spectrum disorder and developmental delay: A case report and a brief literature review

(2015) Yi Liu et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART A

Alterations in Cortical Network Oscillations and Parvalbumin Neurons in Schizophrenia

(2015) Guillermo Gonzalez-Burgos et al.   BIOLOGICAL PSYCHIATRY

Genetic Risk for Schizophrenia: Convergence on Synaptic Pathways Involved in Plasticity

(2015) Jeremy Hall et al.   BIOLOGICAL PSYCHIATRY

Long Noncoding RNA-Directed Epigenetic Regulation of Gene Expression Is Associated With Anxiety-like Behavior in Mice

(2015) Paola A. Spadaro et al.   BIOLOGICAL PSYCHIATRY

Skating on thin ice: pragmatic prescribing for medication refractory schizophrenia

(2015) Derek K. Tracy et al.   BMC Psychiatry

CRNDE, a long-noncoding RNA, promotes glioma cell growth and invasion through mTOR signaling

(2015) Yunliang Wang et al.   CANCER LETTERS

FOXG1-Dependent Dysregulation of GABA/Glutamate Neuron Differentiation in Autism Spectrum Disorders

(2015) Jessica Mariani et al.   CELL

Mood Stabilizers in Children and Adolescents With Autism Spectrum Disorders

(2015) Roberto Canitano   CLINICAL NEUROPHARMACOLOGY

Evf2lncRNA/BRG1/DLX1 interactions reveal RNA-dependent inhibition of chromatin remodeling

(2015) Ivelisse Cajigas et al.   DEVELOPMENT

Lithium in the treatment of bipolar disorder: pharmacology and pharmacogenetics

(2015) M Alda   MOLECULAR PSYCHIATRY

Common genetic variants influence human subcortical brain structures

(2015) Derrek P. Hibar et al.   NATURE

Differential responses to lithium in hyperexcitable neurons from patients with bipolar disorder

(2015) Jerome Mertens et al.   NATURE

Long Noncoding RNA MEG3 Interacts with p53 Protein and Regulates Partial p53 Target Genes in Hepatoma Cells

(2015) Juanjuan Zhu et al.   PLoS One

The autism-associated chromatin modifier CHD8 regulates other autism risk genes during human neurodevelopment

(2015) Justin Cotney et al.   Nature Communications

CRISPR/Cas9-mediated heterozygous knockout of the autism gene CHD8 and characterization of its transcriptional networks in neurodevelopment

(2015) Ping Wang et al.   Molecular Autism

The autism-associated gene chromodomain helicase DNA-binding protein 8 (CHD8) regulates noncoding RNAs and autism-related genes

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A molecular model for neurodevelopmental disorders

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Altered Gene Expression in Schizophrenia: Findings from Transcriptional Signatures in Fibroblasts and Blood

(2015) Nadia Cattane et al.   PLoS One

The Novel Gene CRNDE Encodes a Nuclear Peptide (CRNDEP) Which Is Overexpressed in Highly Proliferating Tissues

(2015) Lukasz Michal Szafron et al.   PLoS One

ZNF804A Transcriptional Networks in Differentiating Neurons Derived from Induced Pluripotent Stem Cells of Human Origin

(2015) Jian Chen et al.   PLoS One

MicroRNA Profiling of Neurons Generated Using Induced Pluripotent Stem Cells Derived from Patients with Schizophrenia and Schizoaffective Disorder, and 22q11.2 Del

(2015) Dejian Zhao et al.   PLoS One

Molecular Convergence of Neurodevelopmental Disorders

(2014) Elizabeth S. Chen et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Convergence of Genes and Cellular Pathways Dysregulated in Autism Spectrum Disorders

(2014) Dalila Pinto et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Reelin gene variants and risk of autism spectrum disorders: An integrated meta-analysis

(2014) Zhenling Wang et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS

Prevalence of Autism Spectrum Disorder symptoms in children with neurofibromatosis type 1

(2014) Ellen Plasschaert et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS

Disruptive CHD8 Mutations Define a Subtype of Autism Early in Development

(2014) Raphael Bernier et al.   CELL

Deregulation of an imprinted gene network in prostate cancer

(2014) Teodora Ribarska et al.   Epigenetics

Preliminary Investigation of Lithium for Mood Disorder Symptoms in Children and Adolescents with Autism Spectrum Disorder

(2014) Matthew Siegel et al.   JOURNAL OF CHILD AND ADOLESCENT PSYCHOPHARMACOLOGY

Efficient strategy for the molecular diagnosis of intellectual disability using targeted high-throughput sequencing

(2014) Claire Redin et al.   JOURNAL OF MEDICAL GENETICS

De novo mutations in schizophrenia implicate chromatin remodeling and support a genetic overlap with autism and intellectual disability

(2014) S E McCarthy et al.   MOLECULAR PSYCHIATRY

Synaptic, transcriptional and chromatin genes disrupted in autism

(2014) Silvia De Rubeis et al.   NATURE

An AUTS2–Polycomb complex activates gene expression in the CNS

(2014) Zhonghua Gao et al.   NATURE

The contribution of de novo coding mutations to autism spectrum disorder

(2014) Ivan Iossifov et al.   NATURE

Biological insights from 108 schizophrenia-associated genetic loci

(2014)   NATURE

Heat Shock Alters the Expression of Schizophrenia and Autism Candidate Genes in an Induced Pluripotent Stem Cell Model of the Human Telencephalon

(2014) Mingyan Lin et al.   PLoS One

CHD8regulates neurodevelopmental pathways associated with autism spectrum disorder in neural progenitors

(2014) Aarathi Sugathan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Lithium and GSK-3β promoter gene variants influence cortical gray matter volumes in bipolar disorder

(2014) Francesco Benedetti et al.   PSYCHOPHARMACOLOGY

The emerging roles of TCF4 in disease and development

(2014) Marc P. Forrest et al.   TRENDS IN MOLECULAR MEDICINE

A de novo convergence of autism genetics and molecular neuroscience

(2014) Niklas Krumm et al.   TRENDS IN NEUROSCIENCES

Genome-wide association study reveals two new risk loci for bipolar disorder

(2014) Thomas W. Mühleisen et al.   Nature Communications

DAWN: a framework to identify autism genes and subnetworks using gene expression and genetics

(2014) Li Liu et al.   Molecular Autism

Frequent Disruption of Chromodomain Helicase DNA-Binding Protein 8 (CHD8) and Functionally Associated Chromatin Regulators in Prostate Cancer

(2014) Nathan A. Damaschke et al.   NEOPLASIA

Long non-coding RNA MEG3 inhibits NSCLC cells proliferation and induces apoptosis by affecting p53 expression

(2013) Kai-hua Lu et al.   BMC CANCER

Coexpression Networks Implicate Human Midfetal Deep Cortical Projection Neurons in the Pathogenesis of Autism

(2013) A. Jeremy Willsey et al.   CELL

Evf2 (Dlx6as) lncRNA regulates ultraconserved enhancer methylation and the differential transcriptional control of adjacent genes

(2013) E. G. Berghoff et al.   DEVELOPMENT

Glycogen synthase kinase 3 substrates in mood disorders and schizophrenia

(2013) Adam R. Cole   FEBS Journal

Colorectal Carcinomas With CpG Island Methylator Phenotype 1 Frequently Contain Mutations in Chromatin Regulators

(2013) Tomomitsu Tahara et al.   GASTROENTEROLOGY

Epigenome-wide ovarian cancer analysis identifies a methylation profile differentiating clear-cell histology with epigenetic silencing of the HERG K+ channel

(2013) Mine S. Cicek et al.   HUMAN MOLECULAR GENETICS

Analysis of miR-137 expression and rs1625579 in dorsolateral prefrontal cortex

(2013) Ilaria Guella et al.   JOURNAL OF PSYCHIATRIC RESEARCH

The Long Noncoding RNA RMST Interacts with SOX2 to Regulate Neurogenesis

(2013) Shi-Yan Ng et al.   MOLECULAR CELL

The long non-coding RNA Gomafu is acutely regulated in response to neuronal activation and involved in schizophrenia-associated alternative splicing

(2013) G Barry et al.   MOLECULAR PSYCHIATRY

Reelin, an extracellular matrix protein linked to early onset psychiatric diseases, drives postnatal development of the prefrontal cortex via GluN2B-NMDARs and the mTOR pathway

(2013) J Iafrati et al.   MOLECULAR PSYCHIATRY

Cerebral organoids model human brain development and microcephaly

(2013) Madeline A. Lancaster et al.   NATURE

The chromatin remodeller CHD8 is required for E2F-dependent transcription activation of S-phase genes

(2013) Alicia Subtil-Rodríguez et al.   NUCLEIC ACIDS RESEARCH

Knockdown of Human TCF4 Affects Multiple Signaling Pathways Involved in Cell Survival, Epithelial to Mesenchymal Transition and Neuronal Differentiation

(2013) Marc P. Forrest et al.   PLoS One

Transcriptome Comparison of Human Neurons Generated Using Induced Pluripotent Stem Cells Derived from Dental Pulp and Skin Fibroblasts

(2013) Jian Chen et al.   PLoS One

ALEX1 suppresses colony formation ability of human colorectal carcinoma cell lines

(2012) Hiroyoshi Iseki et al.   CANCER SCIENCE

Replication of GWAS-identified neuroblastoma risk loci strengthens the role of BARD1 and affirms the cumulative effect of genetic variations on disease susceptibility

(2012) Mario Capasso et al.   CARCINOGENESIS

Sequencing Chromosomal Abnormalities Reveals Neurodevelopmental Loci that Confer Risk across Diagnostic Boundaries

(2012) Michael E. Talkowski et al.   CELL

GENCODE: The reference human genome annotation for The ENCODE Project

(2012) J. Harrow et al.   GENOME RESEARCH

Loss of Gsx1 and Gsx2 function rescues distinct phenotypes in Dlx1/2 mutants

(2012) Bei Wang et al.   JOURNAL OF COMPARATIVE NEUROLOGY

MEG3 noncoding RNA: a tumor suppressor

(2012) Yunli Zhou et al.   JOURNAL OF MOLECULAR ENDOCRINOLOGY

PAX5-AUTS2: A recurrent fusion gene in childhood B-cell precursor acute lymphoblastic leukemia

(2012) Dagmar Denk et al.   LEUKEMIA RESEARCH

Genome-wide supported variant MIR137 and severe negative symptoms predict membership of an impaired cognitive subtype of schizophrenia

(2012) M J Green et al.   MOLECULAR PSYCHIATRY

Modeling psychiatric disorders at the cellular and network levels

(2012) K J Brennand et al.   MOLECULAR PSYCHIATRY

Patterns and rates of exonic de novo mutations in autism spectrum disorders

(2012) Benjamin M. Neale et al.   NATURE

Sporadic autism exomes reveal a highly interconnected protein network of de novo mutations

(2012) Brian J. O’Roak et al.   NATURE

Common variants at 12q15 and 12q24 are associated with infant head circumference

(2012) H Rob Taal et al.   NATURE GENETICS

Identification of common variants associated with human hippocampal and intracranial volumes

(2012) Jason L Stein et al.   NATURE GENETICS

The involvement of Reelin in neurodevelopmental disorders

(2012) Timothy D. Folsom et al.   NEUROPHARMACOLOGY

Decreased Reelin Expression in the Left Prefrontal Cortex (BA9) in Chronic Schizophrenia Patients

(2012) Gregor Habl et al.   NEUROPSYCHOBIOLOGY

Long non-coding RNAs function annotation: a global prediction method based on bi-colored networks

(2012) Xingli Guo et al.   NUCLEIC ACIDS RESEARCH

Modeling human cortical development in vitro using induced pluripotent stem cells

(2012) J. Mariani et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Functional Corneal Endothelium Derived from Corneal Stroma Stem Cells of Neural Crest Origin by Retinoic Acid and Wnt/β-Catenin Signaling

(2012) Shin Hatou et al.   STEM CELLS AND DEVELOPMENT

Integrative annotation of human large intergenic noncoding RNAs reveals global properties and specific subclasses

(2011) M. N. Cabili et al.   GENES & DEVELOPMENT

Genetic and expressional alterations of CHD genes in gastric and colorectal cancers

(2011) Min Sung Kim et al.   HISTOPATHOLOGY

Downregulation of zinc finger protein 132 in prostate cancer is associated with aberrant promoter hypermethylation and poor prognosis

(2011) Mette Opstrup Abildgaard et al.   INTERNATIONAL JOURNAL OF CANCER

Synaptic Wnt signaling—a contributor to major psychiatric disorders?

(2011) Nathan D. Okerlund et al.   Journal of Neurodevelopmental Disorders

Wnt5a Is a Transcriptional Target of Dlx Homeogenes and Promotes Differentiation of Interneuron Progenitors In Vitro and In Vivo

(2011) S. Paina et al.   JOURNAL OF NEUROSCIENCE

Histone H1 Recruitment by CHD8 Is Essential for Suppression of the Wnt- -Catenin Signaling Pathway

(2011) M. Nishiyama et al.   MOLECULAR AND CELLULAR BIOLOGY

Validation of schizophrenia-associated genes CSMD1, C10orf26, CACNA1C and TCF4 as miR-137 targets

(2011) E Kwon et al.   MOLECULAR PSYCHIATRY

Modelling schizophrenia using human induced pluripotent stem cells

(2011) Kristen J. Brennand et al.   NATURE

Genome-wide association study identifies five new schizophrenia loci

(2011)   NATURE GENETICS

Molecular regulation of telomerase activity in aging

(2011) Craig Nicholls et al.   Protein & Cell

Cognitive and Sensorimotor Gating Impairments in Transgenic Mice Overexpressing the Schizophrenia Susceptibility Gene Tcf4 in the Brain

(2010) Magdalena M. Brzózka et al.   BIOLOGICAL PSYCHIATRY

An SNP in an ultraconserved regulatory element affects Dlx5/Dlx6 regulation in the forebrain

(2010) L. Poitras et al.   DEVELOPMENT

Most genome-wide significant susceptibility loci for schizophrenia and bipolar disorder reported to date cross-traditional diagnostic boundaries

(2010) H. J. Williams et al.   HUMAN MOLECULAR GENETICS

β-Catenin Promoter ChIP-Chip Reveals Potential Schizophrenia and Bipolar Disorder Gene Network

(2010) Erika Pedrosa et al.   JOURNAL OF NEUROGENETICS

Reelin Regulates Postnatal Neurogenesis and Enhances Spine Hypertrophy and Long-Term Potentiation

(2010) L. Pujadas et al.   JOURNAL OF NEUROSCIENCE

Direct conversion of fibroblasts to functional neurons by defined factors

(2010) Thomas Vierbuchen et al.   NATURE

GSK3 signalling in neural development

(2010) Eun-Mi Hur et al.   NATURE REVIEWS NEUROSCIENCE

lncRNAdb: a reference database for long noncoding RNAs

(2010) Paulo P. Amaral et al.   NUCLEIC ACIDS RESEARCH

Altered Functional Connectivity in Frontal Lobe Circuits Is Associated with Variation in the Autism Risk Gene CNTNAP2

(2010) A. A. Scott-Van Zeeland et al.   Science Translational Medicine

Distinct Roles for Wnt-4 and Wnt-11 During Retinoic Acid-Induced Neuronal Differentiation

(2010) Carina Elizalde et al.   STEM CELLS

Disrupted in Schizophrenia 1 Regulates Neuronal Progenitor Proliferation via Modulation of GSK3β/β-Catenin Signaling

(2009) Yingwei Mao et al.   CELL

Lithium Pharmacodynamics and Pharmacogenetics: Focus on Inositol Mono Phosphatase (IMPase), Inositol Poliphosphatase (IPPase) and Glycogen Sinthase Kinase 3 Beta (GSK-3 Beta)

(2009) Alessandro Serretti et al.   CURRENT MEDICINAL CHEMISTRY

Maternally Expressed Gene 3 (MEG3) Noncoding Ribonucleic Acid: Isoform Structure, Expression, and Functions

(2009) Xun Zhang et al.   ENDOCRINOLOGY

Correlation of mRNA and protein in complex biological samples

(2009) Tobias Maier et al.   FEBS LETTERS

CHD8 suppresses p53-mediated apoptosis through histone H1 recruitment during early embryogenesis

(2009) Masaaki Nishiyama et al.   NATURE CELL BIOLOGY

Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources

(2009) Da Wei Huang et al.   Nature Protocols

Linkage, Association, and Gene-Expression Analyses Identify CNTNAP2 as an Autism-Susceptibility Gene

(2008) Maricela Alarcón et al.   AMERICAN JOURNAL OF HUMAN GENETICS

A Common Genetic Variant in the Neurexin Superfamily Member CNTNAP2 Increases Familial Risk of Autism

(2008) Dan E. Arking et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Progressive loss of PAX6, TBR2, NEUROD and TBR1 mRNA gradients correlates with translocation of EMX2 to the cortical plate during human cortical development

(2008) Nadhim Bayatti et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Adjunctive lithium and anticonvulsants for the treatment of schizophrenia: what is the evidence?

(2008) Leslie Citrome   Expert Review of Neurotherapeutics

TCF4Deletions in Pitt-Hopkins Syndrome

(2008) Irina Giurgea et al.   HUMAN MUTATION

DLX5expression is monoallelic andDlx5is up-regulated in theMecp2-null frontal cortex

(2008) Masaru Miyano et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

The Reelin Signaling Pathway Promotes Dendritic Spine Development in Hippocampal Neurons

(2008) S. Niu et al.   JOURNAL OF NEUROSCIENCE

CHD8 Is an ATP-Dependent Chromatin Remodeling Factor That Regulates  -Catenin Target Genes

(2008) B. A. Thompson et al.   MOLECULAR AND CELLULAR BIOLOGY

Systematic meta-analyses and field synopsis of genetic association studies in schizophrenia: the SzGene database

(2008) Nicole C Allen et al.   NATURE GENETICS

Bioinformatics enrichment tools: paths toward the comprehensive functional analysis of large gene lists

(2008) Da Wei Huang et al.   NUCLEIC ACIDS RESEARCH

A Genome-Wide Association Study of Schizophrenia Using Brain Activation as a Quantitative Phenotype

(2008) Steven G. Potkin et al.   SCHIZOPHRENIA BULLETIN